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| 1 | Retrospective study on mixed neuroendocrine non-neuroendocrine neoplasms from five European centres显示文摘BACKGROUND Mixed neuroendocrine non-neuroendocrine neoplasm(MiNEN)is a rare diagnosis,mainly encountered in the gastro-entero-pancreatic tract.There is limited knowledge of its epidemiology,prognosis and biology,and the best management for affected patients is still to be defined.AIM To investigate clinical-pathological characteristics,treatment modalities and survival outcomes of a retrospective cohort of patients with a diagnosis of MiNEN.METHODS Consecutive patients with a histologically proven diagnosis of MiNEN were identified at 5 European centres.Patient data were retrospectively collected from medical records.Pathological samples were reviewed to ascertain compliance with the 2017 World Health Organisation definition of MiNEN.Tumour responses to systemic treatment were assessed according to the Response Evaluation Criteria in Solid Tumours 1.1.Kaplan-Meier analysis was applied to estimate survival outcomes.Associations between clinical-pathological characteristics and survival outcomes were explored using Log-rank test for equality of survivors functions(univariate)and Cox-regression analysis(multivariable).RESULTS Sixty-nine consecutive patients identified;Median age at diagnosis:64 years.Males:63.8%.Localised disease(curable):53.6%.Commonest sites of origin:colon-rectum(43.5%)and oesophagus/oesophagogastric junction(15.9%).The neuroendocrine component was;predominant in 58.6%,poorly differentiated in 86.3%,and large cell in 81.25%,of cases analysed.Most distant metastases analysed(73.4%)were occupied only by a poorly differentiated neuroendocrine component.Ninety-four percent of patients with localised disease underwent curative surgery;53%also received perioperative treatment,most often in line with protocols for adenocarcinomas from the same sites of origin.Chemotherapy was offered to most patients(68.1%)with advanced disease,and followed protocols for pure neuroendocrine carcinomas or adenocarcinomas in equal proportion.In localised cases,median recurrence free survival(RFS);14.0 months(95%CI:9.2-24.4),and median overall survival(OS):28.6 months(95%CI:18.3-41.1).On univariate analysis,receipt of perioperative treatment(vs surgery alone)did not improve RFS(P=0.375),or OS(P=0.240).In advanced cases,median progression free survival(PFS);5.6 months(95%CI:4.4-7.4),and median OS;9.0 months(95%CI:5.2-13.4).On univariate analysis,receipt of palliative active treatment(vs best supportive care)prolonged PFS and OS(both,P<0.001).CONCLUSION MiNEN is most commonly driven by a poorly differentiated neuroendocrine component,and has poor prognosis.Advances in its biological understanding are needed to identify effective treatments and improve patient outcomes. | Melissa Frizziero Xin Wang Bipasha Chakrabarty Alexa Childs Tu V Luong Thomas Walter Mohid S Khan Meleri Morgan Adam Christian Mona Elshafie Tahir Shah Annamaria Minicozzi Wasat Mansoor Tim Meyer Angela Lamarca Richard A Hubner Juan W Valle Mairéad G McNamara | 2019 | World Journal of Gastroenterology2019，25，39： | 13 |
| 2 | Epigenetic profiles of pre-diabetes transitioning to type 2 diabetes and nephropathy显示文摘AIM: To examine DNA methylation profiles in a longitudinal comparison of pre-diabetes mellitus(Pre-DM) subjects who transitioned to type 2 diabetes mellitus(T2DM).METHODS: We performed DNA methylation study in bisulphite converted DNA from Pre-DM(n = 11) at baseline and at their transition to T2 DM using Illumina Infinium Human Methylation27 Bead Chip, that enables the query of 27578 individual cytosines at Cp G loci throughout the genome, which are focused on the promoter regions of 14495 genes.RESULTS: There were 694 Cp G sites hypomethylated and 174 Cp G sites hypermethylated in progression from Pre-DM to T2 DM, representing putative genes involved in glucose and fructose metabolism, inflammation, oxidative and mitochondrial stress, and fatty acid metabolism. These results suggest that this high throughput platform is able to identify hundreds of prospective Cp G sites associated with diverse genes that may reflect differences in Pre-DM compared with T2 DM. In addition, there were Cp G hypomethylation changes associated with a number of genes that may be associated with development of complications of diabetes, such as nephropathy. These hypomethylation changes were observed in all of the subjects.CONCLUSION: These data suggest that some epigenomic changes that may be involved in the progression of diabetes and/or the development of complications may be apparent at the Pre-DM state or during the transition to diabetes. Hypomethylation of a number of genes related to kidney function may be an early marker for developing diabetic nephropathy. | Thomas A Vander Jagt Monica H Neugebauer Marilee Morgan Donald W Bowden Vallabh O Shah | 2015 | World Journal of Diabetes2015，6，9： | 5 |
| 3 | Wave propagation in a mulitilayered laminated cross-ply composite plate 显示文摘 | Karunasena W Shah A H Datta S K | 1991 | ASME J Appl Mec1991，58，： | 2 |
| 4 | Modulation of β-lactam resistance in Staphylococcus aureus by catechins and gallates显示文摘 | Paul D Stapleton Saroj Shah James C Anderson Yukihiko Hara Jeremy M.T Hamilton-Miller Peter W Taylor | 2004 | International Journal of Antimicrobial Agents2004，，5： | 2 |
| 5 | Comparison of adjustable-and fixed-dose budesonide/formoterol pressurized metered-dose inhaler and fixed-dose fluticasone propionate/salmeterol dry powder inhaler in asthma patients显示文摘 | William W Busse Shailen R Shah Laura Somerville | 2008 | American Academy of Allergy2008，121，6： | 1 |
| 6 | Interfacial stress estimation using stress smoothing in laminated composites显示文摘 | CHEN D J SHAH D K CHAN W S | 1996 | Computers & Structures1996，58，4： | 1 |
| 7 | The prevalence of human papillomavirus type 58 in Chinese patients with cervical carcinoma and its influence on survival 显示文摘 | SHAH W HONGWEI C JIN Z | 2009 | Clin Oncol ( R Coll Radiol)2009，21，10： | 1 |
| 8 | The effective manage- ment of a leg hemangioma using ultrasound-guided inter- stitial photodynamic therapy 显示文摘 | Shah P Jerjes W Upile T | 2010 | Photodiagnosis and Photodynamic Therapy2010，7，3： | 1 |
| 9 | A variable speed mag- netic gear box using contra-rotating input shafts显示文摘 | SHAH L CRUDEN A WILLIAMS B W | 2011 | IEEE Trans- actions on Magnetics2011，47，2： | 1 |
| 10 | Plate heat exchangers and their design theory显示文摘 | Shah R K Focke W W | 1988 | Heat Transfer Equipment Design Hemisphere Washington1988，，： | 1 |
| 11 | Chromium-bearing waste slag: evaluation of leachability when exposed to simulated acid precipitation显示文摘 | Kilau Howard W Shah Ishwarlal | 1984 | ASTM Special Technical Publication1984，，： | 1 |
| 12 | Exploiting mobility for energy efficient data collection in sensor networks 显示文摘 | Jain S Shah R Brunette W | 2003 | Journal of Mobile Networks and Applications2003，11，3： | 1 |
| 13 | Management of duodenal and pancreaticobiliary perforations associated with peri- ampullary endoscopic procedures显示文摘 | Knudson K Raeburn C D McIntyre R C Jr Shah R J Chen Y K Brown W R | 2008 | Am J Surg2008，196，： | 1 |
| 14 | Surgical resection improves survival in the treatment of early gastric lymphomas 显示文摘 | Blair S Shah S Tamim W | 2000 | J Gastrointest Surg2000，4，3： | 1 |
| 15 | Adv Mater显示文摘 | Shah R K Kim J W Weitz D A | 2009 | 21:1 9492009，21，： | 1 |
| 16 | Mineralization and nitrification potentials of grassland soils at shallow depth during laboratory incubation显示文摘 | Abbasi M K Shah Z Adams W A | 2001 | Journal of Plant Nutrition and Soil Science2001，，164： | 1 |
| 17 | Grain boundary - mediated plasticity in nanocrystalline nickel显示文摘 | Shah Z W Stach E A Wiezorek J M K | 2004 | Science2004，305，： | 1 |
| 18 | The field synergy (coordination) principle and its applications in enhancing single phase convective heat transfer 显示文摘 | Guo Z Y Tao W Q Shah R K | 2005 | International Journal of Heat and Mass Transfer2005，48，9： | 1 |
| 19 | Acid,bile,and heat tolerance of free and microencapsulated probiotic bacteria显示文摘 | Ding W K Shah N P | 2007 | Food Microbiology and Safety2007，72，9： | 1 |
| 20 | Treatment outcomes among patients with multi-drug-resistant tuberculosis : systematic review and recta-analysis 显示文摘 | Orenstein E W Basu S Shah N S | 2009 | Lancet Infect Dis2009，9，3： | 1 |
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