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| 1 | Bone-targeted 2,6,9-trisubstituted purines:novel inhibitors of Src tyrosine kinase for the treatment of bone diseases显示文摘 | Wang Y Metcalf CA Shakespeare WC | 2003 | Bioorg Med Chem Left2003，13，： | 1 |
| 2 | AP24534, a pan-BCR-ABL inhibitor for chronic myeloid leukemia, potently inhibits the T315I mutant and overcomes mutation-based resistance 显示文摘 | O'Hare T Shakespeare WC Zhu X | 2009 | Cancer Cell2009，16，5： | 1 |
| 3 | AP24534, a pan-BCR-ABL inhibitor for chronic myeloid leukemia, potently inhibits the T315I mutant and overcomes mutation- based resistance显示文摘 | O'HARE T SHAKESPEARE WC ZHU X | 2009 | Cancer Cell2009，16，5： | 1 |
| 4 | AP24534, a pan-BCR-ABL inhibitor for chronic myeloid leukemia, potently inhibits the T315I mutant and overcomes mutation- based resistance显示文摘 | O'Hare T Shakespeare WC Zhu X | 2009 | Cancer Cell2009，16，40： | 1 |
| 5 | AP24534,a pan-BCR-ABL inhibitor for chronic myeloid leukemia,potently inhibits the T315I mutant and overcomes muta- tion-based resistance显示文摘 | O' Hare T Shakespeare WC Zhu X | 2009 | Cancer Cell2009，16，5： | 1 |
| 6 | An efficient synthesis of nilotinib (AMN107)显示文摘 | Huang WS Shakespeare WC | 2007 | Synthesis2007，2007，14： | 1 |
| 7 | An efficient synthesis of ni- lotinib (AMN107) 显示文摘 | Huang WS Shakespeare WC | 2007 | Synthesis2007，29，14： | 1 |
| 8 | Bone targe- ted Src kinase inhibitors:novel pyrrolo and pyrazolopyrimidine ana- logues 显示文摘 | Sundaramoorthi R Shakespeare WC Keenan TP | 2003 | Bioorg Med Chem Lett2003，13，18： | 1 |
| 9 | AP24534,a PanBCR-ABL inhibitor for chronic myeloid leukemia,potently inhibits the T315I mutant and overcomes mutation-based resistance显示文摘 | O'Hare T Shakespeare WC Zhu X | | 0，，05： | 1 |
| 10 | AP24534,a panBCR-ABL inhibitor for chronic myeloid leukemia,potently inhibits the T315I mutant and overcomes mutation-based resistance显示文摘 | O'Hare T Shakespeare WC Zhu X | 2009 | Cancer Cell2009，16，： | 1 |
| 11 | Activity of dual src-abl inhibitors highlights the role of bcr-abl kinase dynamics in drug resistance显示文摘 | Azam M Nardi V Shakespeare WC | 2006 | PNAS2006，103，24： | 1 |
| 12 | An efficient synthesis of nilotinib (AMN107) 显示文摘 | Huang WS Shakespeare WC | 2007 | Synthesis2007，2007，14： | 1 |
| 13 | SAR of carbon-linked,2-substituted purines:synthesis and characterization of AP23451 as a novel bone-targeted inhibitor of Src tyrosine kinase with in vivo anti-resorptive activity显示文摘 | Shakespeare WC Wang Y Bohacek R | 2008 | Chem Biol Drug Des2008，71，2： | 1 |
| 14 | AP-24534,a pan-BCRABL inhibitor for chronic myeloid leukemia,potently inhibits the T315I mutant and overcomes mutation-based resistance显示文摘 | O'Hare T Shakespeare WC Zhu X | 2009 | Cancer Cell2009，16，5： | 1 |
| 15 | AP24534,a panBCR-ABL inhibitor for chronic myeloid leukemia,potently inhibits the T315I mutant and overcomes mutation-based resistance显示文摘 | O'Hare T Shakespeare WC Zhu X | 2009 | Cancer Cell2009，16，5： | 1 |
| 16 | SAR of carbon- linked, 2-substituted purines: synthesis and characterization of AP23451 as a novel bone-targeted inhibitor of Src tyrosine kinase with in vivo anti-resorptive activity显示文摘 | Shakespeare WC Wang Y Bohacek R | 2008 | Chem Biol Drug Des2008，71，2： | 1 |
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