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| 1 | Neutrophil extracellular traps mediate the crosstalk between glioma progression and the tumor microenvironment via the HMGB1/RAGE/IL-8 axis显示文摘Objective:Neutrophil extracellular traps(NETs)produced by tumor-infiltrating neutrophils(TINs)are associated with poor prognosis in patients with several types of cancer.However,the mechanisms underlying the involvement of NETs in glioma progression remain largely unknown.This study aimed to elucidate the roles of NETs in biological processes that drive the crosstalk between glioma progression and the tumor microenvironment.Methods:Neutrophil infiltration and NETs formation were investigated in glioma tissue through immunohistochemistry,and their relationships with clinicopathological features and outcomes were statistically evaluated.The effects of NETs on glioma cell progression were studied in a co-culture system.In vivo and in vitro experiments validated the reactive oxygen species activity and cytokine production of TINs,as well as the ERK signaling pathway activation and the metastasis of gliomas.Results:Neutrophil infiltration and NETs formation were induced in high-grade glioma compared with low-grade glioma.NETs induced by TINs were determined to be an oncogenic marker of high-grade gliomas and to be involved in cell proliferation and invasion.NETs overproduction promoted glioma cell proliferation,migration,and invasion.Furthermore,HMGB1 was found to bind to RAGE and activate the NF-κB signaling pathway in vitro.In addition,NETs stimulated the NF-κB signaling pathway,thus promoting IL-8 secretion in glioblastoma.Subsequently,IL-8 recruited neutrophils which in turn mediated NETs formation via the PI3 K/AKT/ROS axis in TINs.Conclusions:Our results suggest that NETs produced by TINs mediate the crosstalk between glioma progression and the tumor microenvironment by regulating the HMGB1/RAGE/IL-8 axis.Targeting NETs formation or IL-8 secretion may be an effective approach to inhibit glioma progression. | Caijun Zha Xiangqi Meng Lulu Li Shan Mi Da Qian Ziwei Li Pengfei Wu Shaoshan Hu Shihong Zhao Jinquan Cai Yanhong Liu | 2020 | Cancer Biology & Medicine2020，17，1： | 19 |
| 2 | Correlation of Vascular Endothelial Growth Factor Production with Photochemical Reaction-induced Retinal Edema显示文摘 | Liang Shan Mi Zheng Yuan Zhang Yuan Qu Tian Niu Qing Gu Xin Xia | 2016 | Chinese Medical Journal2016，，24： | 9 |
| 3 | Anti-inflammatory and hepatoprotective effects of total flavonoid C-glycosides from Abrus mollis extracts显示文摘The aim of this study was to evaluate the anti-inflammatory and hepatoprotective effects of the total flavonoid C-glycosides isolated from Abrus mollis extracts(AME). In the anti-inflammatory tests, xylene-induced ear edema model in mice and carrageenan-induced paw edema model in rats were applied. The hepatoprotective effects of AME were evaluated with various in vivo models of acute and chronic liver injury, including carbon tetrachloride(CCl4)-induced hepatitis in mice, D-galactosamine(D-GalN)-induced hepatitis in rats, as well as CCl4-induced hepatic fibrosis in rats. In the acute inflammation experiment, AME significantly suppressed xylene-induced ear edema and carrageenan-induced paw edema, respectively. In the acute hepatitis tests, AME significantly attenuated the excessive release of ALT and AST induced by CCl4 and D-GalN. In CCl4-induced hepatic fibrosis model, AME alleviated liver injury induced by CCl4 shown by histopathological sections of livers and improved liver function as indicated by decreased liver index, serum ALT, AST, TBIL, and ALP levels and hydroxyproline contents in liver tissues, and increased serum ALB and GLU levels. These results indicated that AME possesses potent anti-inflammatory activity in acute inflammation models and hepatoprotective activity in both acute and chronic liver injury models. In conclusion, AME is a potential anti-inflammatory and hepatoprotective agent and a viable candidate for treating inflammation, hepatitis, and hepatic fibrosis. | CHEN Mi WANG Tao JIANG Zhen-Zhou SHAN Chun WANG Hao WU Mei-Juan ZHANG Shuang ZHANG Yun ZHANG Lu-Yong | 2014 | Chinese Journal of Natural Medicines2014，12，8： | 7 |
| 4 | Ecotoxicological effects of mixed pollutants resulted from e-wastes recycling and bioaccumulation of polybrominated diphenyl ethers in Chinese loach(Misgurnus anguillicaudatus)显示文摘To understand potential ecotoxicological effects of electrical and electronic equipment waste (e-waste) recycling and polybrominated diphenyl ethers (PBDEs) bioaccumulation in loaches, a semi-field experiment using Chinese loach (Misgurnus anguillicaudatus) as experimental fish was performed. Larval loaches were kept in net-cage for three months in an e-wastes recycling site and a reference site in Southeastern China. There was significant difference of the survival rate between the loaches from the e-wastes recycling site (27%, 19/70) and from reference site (70%, 49/70). Histopathological responses were also found in all the livers examined in loaches from the e-wastes recycling site. These results showed that mixed pollutants resulted from e-wastes recycling led to ecotoxicological effects on loaches. The bioaccumulation of polybrominated diphenyl ethers (PBDEs), the main pollutants in e-waste, in loaches was also studied, the mean concentration of total PBDEs in sediment was 6726.17 ng/g wet weight and in water samples was 4.08 ng/L (dissolved phase). BDE 209 was the dominant congener in sediment and with relatively high concentration in water. Relatively low concentration of BDE 209 (less than 0.01% of total PBDEs) and high concentration of BDE47 (up to 39.34% of total PBDEs) were detected in loaches. | QIN Xiaofei XIA Xijuan LI Yan ZHAO Yaxian YANG Zhongzhi FU Shan TI-AN Mi ZHAO Xingru QIN Zhanfen XU Xiaobai YANG Yongjian | 2009 | Journal of Environmental Sciences2009，21，12： | 6 |
| 5 | Unsteady Flow Variability Driven by Rotor-stator Interaction at Rotor Exit显示文摘Numerical investigation of the unsteady flow variability driven by rotorstator interaction in a transonic axial compressor is performed. Two models with close and far axial gap between rotor and stator rows are studied in the simulation. Particular attention is attached to the analysis of mechanisms involved in driving rotor wake oscillation, rotor wake skewing and flow angle fluctuation at rotor exit. The results show that smaller axial gap is favorable to enhance the interaction in the region between two adjacent rows, and the fluctuation of the static pressure difference between two sides of rotor wake is improved by potential field from down stator, which is the driving force for rotor wake oscillation. The interaction between rotor and stator is weakened by increasing axial distance, rotor wake shifts to suction side of rotor blade with 5%-10% of rotor pitch, the absolute value of flow angle at rotor exit is less than that in the case of close interspace for every time step, and the fluctuation amplitude is also decreased. | ZHAO Ben YANG Ce CHEN Shan QI Mingxu ZHOU Mi | 2012 | Chinese Journal of Aeronautics2012，25，6： | 5 |
| 6 | Effects of Outdoor Temperature on Blood Pressure in a Prospective Cohort of Northwest China显示文摘Objective The relationship between outdoor temperature and blood pressure(BP) has been inconclusive. We analyzed data from a prospective cohort study in northwestern China to investigate the effect of outdoor temperature on BP and effect modification by season.Methods A total of 32,710 individuals who participated in both the baseline survey and the first follow-up in 2011–2015 were included in the study. A linear mixed-effect model and generalized additive mixed model(GAMM) were applied to estimate the association between outdoor temperature and BP after adjusting for confounding variables.Results The mean differences in systolic blood pressure(SBP) and diastolic blood pressure(DBP)between summer and winter were 3.5 mm Hg and 2.75 mm Hg, respectively. After adjusting for individual characteristics, meteorological factors and air pollutants, a significant increase in SBP and DBP was observed for lag 06 day and lag 04 day, a 0.28 mm Hg(95% CI: 0.27–0.30) per 1 °C decrease in average temperature for SBP and a 0.16 mm Hg(95% CI: 0.15–0.17) per 1 °C decrease in average temperature for DBP, respectively. The effects of the average temperature on both SBP and DBP were stronger in summer than in other seasons. The effects of the average temperature on BP were also greater if individuals were older, male, overweight or obese, a smoker or drinker, or had cardiovascular diseases(CVDs), hypertension, and diabetes.Conclusions This study demonstrated a significant negative association between outdoor temperature and BP in a high-altitude environment of northwest China. Moreover, BP showed a significant seasonal variation. The association between BP and temperature differed by season and individuals' demographic characteristics(age, gender, BMI), unhealthy behaviors(smoking and alcohol consumption), and chronic disease status(CVDs, hypertension, and diabetes). | ZHENG Shan WANG Min Zhen CHENG Zhi Yuan KANG Feng NIE Yong Hong MI Xiu Ying LI Hai Yan JIN Lan ZHANG Ya Wei BAI Ya Na | 2021 | Biomedical and Environmental Sciences2021，34，2： | 5 |
| 7 | Is China facing an obesity epidemic and the consequences? The trends in obesity and chronic disease in China显示文摘 | Wang Y Mi J Shan XY | 2007 | Int J Obes(Lond)2007，31，1： | 1 |
| 8 | A programming model performance study using the N AS parallel benchmarks显示文摘 | SHAN H Z ' BLAGOJEVIC F MI S J | 2010 | Scientific Programming2010，，34： | 1 |
| 9 | Is China facing an obesi-ty epidemic and the consequences? The trends in obesityand chronic disease in China显示文摘 | Wang Y Mi J Shan X Y | 2007 | Int J Obes ( Lond )2007，31，1： | 1 |
| 10 | Is China facing an obesity epidemic and the consequences? The trends in obesity and chronic disease in China显示文摘 | WANG Y MI J SHAN X Y | 2007 | lnt J Obes (Lond)2007，31，1： | 1 |
| 11 | Simulation of microstructural evolution in directional solidification of Ti-45at.%Al alloy using cellular automaton method显示文摘The microstructural evolution of Ti-45 at.%Al alloy during directional solidification was simulated by applying a solute diffusion controlled solidification model.The obtained results have shown that under high thermal gradients the stable primary spacing can be adjusted via branching or competitive growth.For dendritic structures formed under a high thermal gradient,the secondary dendrite arms are developed not very well in many cases due to the branching mechanism under a constrained dendritic growth condition.Furthermore,it has been observed that,with increasing pulling velocity,there exists a cell/dendrite transition region consisting of cells and dendrites,which varies with the thermal gradient in a contradicting way,i.e.increase of the thermal gradient leading to the decrease of the range of the transition region.The simulations agree reasonably well with experiment results. | Wang Kuangfei Lu Shan Mi Guofa Li Changyun FU Hengzhi | 2010 | China Foundry2010，7，1： | 1 |
| 12 | Direct growth of special-shape graphene on different templates by remote catalyzation of Cu nanoparticles显示文摘A novel method avoiding the complex transfer process is proposed to directly grow low-defect and few-layer graphene on different insulating substrates(SiO_2, Al_2O_3, etc.) by remote catalyzation of Cu nanoparticles(NPs) using ambient pressure chemical vapor deposition(APCVD). The insulating substrates with special structure are used as templates to grow wrapped graphene sheets with special shapes.Hollow graphene species are obtained by removing the substrates. The prime feature of the proposed method is using Cu NPs as catalyst rather than metal foils. The Cu NPs play an important role in the remote catalyzation during the nucleation of graphene. This method can improve the quality and relatively decrease the growth temperature of the graphene on the insulating substrates, which displays the great potential of APCVD direct growth of graphene on dielectric substrates for electronic and photovoltaic applications. | Shuangshuang Han Fan Yang Liyue Liu Mi Zhou Yongkui Shan Dezeng Li | 2017 | Journal of Materials Science & Technology2017，33，8： | 1 |
| 13 | Is China facing an obesity epi- demic and the consequences? The trends in obesity and chronic disease in China显示文摘 | Wang Y Mi J Shan XY | 2007 | Int J Obes (Lond)2007，31，1： | 1 |
| 14 | Is China facing an obesity epidemicand the consequences? The trends in obesity and chronic disease in China显示文摘 | Wang Y Mi J Shan X | 2007 | Int J Obes(Lond)2007，31，： | 1 |
| 15 | Is China facing an obesity epidemic and the consequences? The trends in obesity and chronic disease in China显示文摘 | Wang Y Mi J Shan XY | 2007 | Int J Obes (Lond)2007，31，： | 1 |
| 16 | Is China facing an obesity epidemic and the consequences? The trends in obesity and chronic disease in China显示文摘 | Wang Y Mi J Shan XY | 2007 | Int J Obes (Lond)2007，31，1： | 1 |
| 17 | Role of external bacterial flora in the pathogenesis of acute postoperative end ophthalmitis 显示文摘 | Speaker MG Mi|eh FA Shan MK | 1991 | Ophthalmology1991，98，： | 1 |
| 18 | Is china facing an obesity epidemic and the consequences? The trends in obesity and chronic disease in China 显示文摘 | WANG Y MI J SHAN X Y | 2007 | Int J Obes2007，31，1： | 1 |
| 19 | Molecular Cloning and Characterization of a Cytokinin Dehydrogenase Gene from Upland Cotton (Gossypium hirsutum L.)显示文摘 | Qi-wei Zeng Shan Qin Shui-qing Song Mi Zhang Yue-hua Xiao Ming Luo Lei Hou Yan Pei | 2012 | Plant Molecular Biology Reporter2012，，1： | 1 |
| 20 | Is China facing an obesity epi- demic and the consequences? The trends in obesity and chronic disease in China显示文摘 | WANG Y MI J SHAN XY | 2007 | Int J Obes( Lond)2007，31，1： | 1 |
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