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| 1 | MicroRNA-193b modulates proliferation, migration, and invasion of non-small cell lung cancer cells显示文摘MicroRNAs 被报导了是仔细与人的肺癌症的发展有关。然而,在非小的房间肺癌症(NSCLC ) 的 microRNAs 的功能仍然保持大部分未定义。这里,我们在 NSCLC 调查了 microRNA-193b (miR-193b ) 的角色。我们的数据证明 miR-193b 与邻近的正常纸巾相比在 NSCLC 癌症纸巾是显著地下面调整的。有 miR-193b 的 NSCLC 房间线(A549 ) transfected 展出了显著地减少的增长,移植,和侵略能力什么时候与控制房间相比。相反, miR-193b 的抑制增加了 A549 房间的增长,迁居,和侵略。而且, miR-193b 镇压了在 A549 房间的 cyclin D1 和尿激类型 plasminogen 使活跃之物的表情。这些数据建议 miR-193b 是在 NSCLC 的肿瘤 suppressor。 | Huajun Hu Shangao Li Jun Liu Bin Ni | 2012 | Acta Biochimica et Biophysica Sinica2012，44，5： | 21 |
| 2 | Antiproliferative effect of octreotide on gastric cancer cells mediated by inhibition of Akt/PKB and telomerase显示文摘AIM: To investigate the antiproliferative effect of octreotide,a long-acting analogue of somatostatin, on gastric cancer cell line SGC7901 and its possible molecular mechanisms.METHODS: Gastric cancer cell line SGC7901 employed in the study was treated with 0.008, 0.04, 0.2, 1, 5 and 25μg@ml-1 of octreotide respectively for 24 h to evaluate the antiproliferative effect of somatostatin analog on the tumor cells by MTT assay method. To elucidate the underlying mechanism, the cells were exposed to 1 μg@ml-1 of octreotide for 0, 12, 24 and 48 h, when their Akt/PKB and telomerase activities were respectively determined using PCR-ELSIA and nonradioactive protein kinase assay protocols. The same experimental procedures were also performed in the control cells that were treated with corresponding vehicles instead of somatostatin analog.RESULTS: After exposed to octreotide for 24 h at the concentrations of more than 1 μg@ml-1 SGC7901 cells exhibited a dose-dependent inhibition of growth with the inhibiting rate to be as high as 34.66 % when 25 μg@ml-1 of octreotide was applied. The Akt/PKB and telomerase activity of SGC7901 cells was significantly inhibited when the cells were exposed to 1 μg@ml-1 of octreotide for 12, 24 and 48 h compared with that of their control counterparts (P<0.01),both of which exhibited in a time-dependent manner.CONCLUSION: The antiproliferative effect of octreotide on SGC7901 cells might be mediated by the inhibition of Akt/PKB and telomerase. | ShanGao Bao-PingYu YanLi Wei-GuoDong He-ShengLuo | 2003 | World Journal of Gastroenterology2003，9，10： | 12 |
| 3 | Mechanisms of acute cerebral infarctions in patients with middle cerebral artery stenosis: A diffusion‐weighted imaging and microemboli monitoring study显示文摘 | Ka SingWong ShanGao Yu LeungChan TjarkHansberg Wynnie W. M.Lam Dirk W.Droste RichardKay E. BerndRingelstein | 2002 | Ann Neurol2002，，1： | 2 |
| 4 | Accurate U‐Pb Age and Trace Element Determinations of Zircon by Laser Ablation‐Inductively Coupled Plasma‐Mass Spectrometry显示文摘 | HonglinYuan ShanGao XiaomingLiu HuimingLi DetlefGünther FuyuanWu | 2007 | Geostandards and Geoanalytical Research2007，，3： | 1 |
| 5 | Mechanisms of acute cerebral infarctions in patients with middle cerebral artery stenosis: A diffusion‐weighted imaging and microemboli monitoring study显示文摘 | Ka SingWong ShanGao Yu LeungChan TjarkHansberg Wynnie W. M.Lam Dirk W.Droste RichardKay E. BerndRingelstein | 2002 | Ann Neurol2002，，1： | 1 |
| 6 | The Trade-Off between Quantity and Quality in Family Fertility Decision:Evidence from China's Family Planning Policy显示文摘Based on the Chinese General Social Survey 2006 and 2008 data,this paper assesses the influence of the family planning policy on the qualitative development of children using education attainment and individual income of only children versus children with siblings as parameters.Our results show the following:(1)only children are better-educated than their counterparts with siblings;(2)only children earn higher income in comparison to their counterparts with siblings;(3)the income and education gaps between girls with and without siblings are greater than those between boys;(4)the education gaps between only children and children with siblings are greater for those born in the 1970s,but the income difference between only children and children with siblings is only significant for those born in the 1980s;and(5)the income and education gaps between only children and children with siblings are higher in urban regions.Results indicate that families with only one child invest more resources in children's quality under the family planning policy,which is consistent with the'quantity-quality trade-off'theory proposed by Gary Becker. | Shangao Wang Xu Tian Yingheng Zhou | 2021 | Frontiers of Economics in China-Selected Publications from Chinese Universities2021，16，1： | 0 |
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