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您的检索式：作者名="Shanhui Yin"
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| 1 | The antiatherogenic function of kallistatin and its potential mechanism显示文摘Atherosclerosis is the pathological basis of most cardiovascular diseases,the leading cause of morbidity and mortality worldwide.Kallistatin,originally discovered in human serum,is a tissuekallikrein-binding protein and a unique serine proteinase inhibitor.Upon binding to its receptor integrin p3,lipoprotein receptor-related protein 6,nucleolin,or Krüppel-like factor 4,kallistatin can modulate various signaling pathways and affect multiple biological processes,including angioge esis,inflammatory response,oxidative stress,and tumor growth.Circulating kallistatin levels are sign ificantly decreased in patie nts with coronary artery disease and show an in verse correlati on with its severity.Importantly,both in vitro and in vivo experime nts have dem on strated that kallistatin reduces atherosclerosis by inhibiting vascular in flammation,antagonizing endothelial dysfunction,and improving lipid metabolism.Thus,kallistatin may be a novel biomarker and a promising therapeutic target for atherosclerosis-related diseases.In this review,we focus on the antiatherogenic function of kallistatin and its potential mechanism. | Gang Wang Jin Zou Xiaohua Yu Shanhui Yin Chaoke Tang | 2020 | Acta Biochimica et Biophysica Sinica2020，52，6： | 2 |
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