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| 1 | 在有煽动性、非煽动性的腹的疼痛显型的孩子的 interleukin-6 和桅杆房间的反的关系显示文摘 AIM: To investigate interleukin-6 (IL-6), mast cells, enterochromaffin cells, 5-hydroxytryptamine, and substance P in the gastrointestinal mucosa of children with abdominal pain. METHODS: Formalin-fixed paraffin-embedded gas-trointestinal biopsy blocks from patients (n = 48) with non-inflammatory bowel disease (irritable bowel syndrome and functional abdominal pain) and inflammatory bowel disease were sectioned and stained for IL-6, mast cells, enterochromaffin cells, 5-hydroxytryptamine, and substance P. All children had chronic abdominal pain as part of their presenting symptoms. Biopsy phenotype was confirmed by a pathologist, blinded to patient information. Descriptive statistics, chi-square, and independent sample t tests were used to compare differences between the inflammatory and non-inflammatory groups. RESULTS: The cohort (n = 48), mean age 11.9 years (SD = 2.9), 54.2% females, 90% Caucasian, was comprised of a non-inflammatory (n = 26) and an inflammatory (n = 22) phenotype. There was a significant negative correlation between substance P expression and mast cell count (P = 0.05, r = -0.373). Substance P was found to be expressed more often in female patient biopsies and more intensely in the upper gastrointestinal mucosa as compared to the lower mucosa. There were significantly increased gastrointestinal mucosal immunoreactivity to IL-6 (P = 0.004) in the inflammatory phenotype compared to non-inflammatory. Additionally, we found significantly increased mast cells (P = 0.049) in the mucosa of the non-inflammatory phenotype compared to the inflammatory group. This difference was particularly noted in the lower colon biopsies. CONCLUSION: The findings of this study yield preliminary evidence in identifying biomarkers of undiagnosed abdominal pain in children and may suggest candidate genes for future evaluation. | Wendy A Henderson Ravi Shankar Tara J Taylor Arseima Y Del Valle-Pinero David E Kleiner Kevin H Kim Nader N Youssef | 2012 | World Journal of Gastrointestinal Pathophysiology2012，3，6： | 2 |
| 2 | The prospect of silencing disease using RNA interference显示文摘 | Shankar P Manjunath N Lieberman J | 2005 | JAMA2005，293，11： | 1 |
| 3 | Three dimensional simulation for an open channel flow with a constriction 显示文摘 | SHANKAR N J CHAN E S ZHANG Q Y | 2001 | Journal of Hydraulic Reserach2001，39，2： | 1 |
| 4 | Transform domain LMS algorithm显示文摘 | S Shankar Narayan Allen M P M J Narsimaha | 1983 | IEEE Trans ASSP1983，31，3： | 1 |
| 5 | Dynamical Behavior of Ratc-Bascd Flow Control Mechanisms显示文摘 | J C Bolot A U Shankar | 1990 | ACM SIGCOMM Computer Communication Review1990，20，4： | 1 |
| 6 | Highly efficient solar cells using Ti02 nanotube arrays sensitized with a donor-antenna dye 显示文摘 | Shankar K Bandara J Paulose M | 2008 | Nano Lett2008，8，6： | 1 |
| 7 | Association between serum gamma-glutamyltransferase level and prehypertension among US adults显示文摘 | Shankar A Li J | 2007 | Circ J2007，71，10： | 1 |
| 8 | Recent advances in the use of TiO2 nanotube and nanowire arrays for oxidative photoelectrochemistry显示文摘 | K Shankar J I Basham N K Allam | 2009 | J Phys Chem C2009，113，： | 1 |
| 9 | Perfluoroalkyl chemicals and elevated serum uric acid in US adults显示文摘 | Shankar A Xiao J Ducatman A | | 0，，02： | 1 |
| 10 | Positive relationship between plasma leptin level and hypertension显示文摘 | Shankar A Xiao J | | 0，，4： | 1 |
| 11 | Epidural anaesthesia and analgesia for liver resection 显示文摘 | Gray J Shankar S | 2014 | Anaesthesia2014，69，8： | 1 |
| 12 | Evaluating median cross-over likelihoods with clustered accident counts:an empirical inquiry using random effects negative binomial model显示文摘 | Shankar V N Albin R B Milton J C | 1998 | Transportation Research Record1998，1635，： | 1 |
| 13 | Association between serum gamma-glutamyl transferase level and prehypertension amongUS adults显示文摘 | Shankar A Li J | 2007 | Circ J2007，71，10： | 1 |
| 14 | The prospect of silencing disease using RNA interference 显示文摘 | Shankar P Manjunath N Lieberman J | 2005 | JAMA2005，293，11： | 1 |
| 15 | Perfluoroalkyl chemicals and chronic kidney disease in US adults显示文摘 | Shankar A Xiao J Ducatman A | | 0，，08： | 1 |
| 16 | A case study on optimization of biomass flow during single-screw extrusioncooking using genetic algorithm (GA) and response surface methodology显示文摘 | Shankar T J Sokhansan J S Bandyopadhyay S | 2008 | Food and Bio-process Technology2008，4，3： | 1 |
| 17 | The prospect of silencing disease using RNA interference 显示文摘 | Shankar P Manjunath 51 Lieberman J | 2005 | JAMA2005，293，11： | 1 |
| 18 | Subacute combined degenera- tion of the cord : Lateral column involvement seen on mri-an uncom- mon finding显示文摘 | Malhotra L Sethi S Shankar J | 2009 | The Intemet Journal of Radiology2009，10，： | 1 |
| 19 | Recent advances in the use of TiO2 nanotube and nanowire arrays for oxidative photoelectrochemistry显示文摘 | Shankar K Basham J I Allam N K | 2009 | The Journal of Physical Chemistry C2009，113，16： | 1 |
| 20 | Immunoblot analysis of proteins associated with self-assembled monolayer surfaces of defined chemistries显示文摘 | CORNELIUS R M SHANKAR S P BRASH J L etal | 2011 | J Biomed Mater Res A2011，98，1： | 1 |
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