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| 1 | Binding of the environment pollutant naphthol to bovine serum albumin 显示文摘 | WU Tuoqi WU Qin GUAN Shanyue | 2007 | Biomacromolecules2007，8，6： | 1 |
| 2 | Photogenerated-hole-induced rapid elimination of solid tumors by the supramolecular porphyrin photocatalyst显示文摘The rapid,complete,targeted and safe treatment for tumors remains a key issue in cancer therapy.A novel treatment of solid tumors by supramolecular photocatalyst Nano-SA-TCPP with the irradiation of600–700 nm wavelength is established.Solid tumors(100 mm3)can be eliminated within 10 min.The50-day mouse survival rate was increased from 0%to 100%after the photocatalytic therapy.The breakthrough was owing to the cell membrane rupture and the cytoplasmic loss caused by photogenerated holes inside cancer cells.The porphyrin-based photocatalysts can be internalized in a targeted manner by cancer cells due to the size selection effect,without entering the normal cells.The therapy has no toxicity or side effects for normal cells and organisms.Moreover,the photocatalytic therapy is effective for a variety of cancer cell lines.Because of its high efficiency,safety and universality,the photocatalytic therapy provides us with a new lancet to conquer the tumor. | Zijian Zhang Li Wang Weixu Liu Zihe Yan Yongfa Zhu Shuyun Zhou Shanyue Guan | 2021 | National Science Review2021，8，5： | 1 |
| 3 | Generation and application of replication-competent Venus-expressing H5N1,H7N9,and H9N2 influenza A viruses显示文摘The generation and application of replication-competent influenza A virus(IAV) expressing a reporter gene represent a valuable tool to elucidate the mechanism of viral pathogenesis and establish new countermeasures to combat the threat of influenza. Here, replication-competent IAVs with a neuraminidase(NA) segment harboring a fluorescent reporter protein, Venus, were generated in the background of H5N1, H7N9, and H9N2 influenza viruses, the three subtypes of viruses with imminent pandemic potential. All three reporter viruses maintained virion morphology, replicated with similar or slightly reduced titers relative to their parental viruses, and stably expressed the fluorescent signal for at least two passages in embryonated chicken eggs. As a proof of concept, we demonstrated that these reporter viruses,used in combination with a high-content imaging system, can serve as a convenient and rapid tool for the screening of antivirals and host factors involved in the virus life cycle. Moreover, the reporter viruses demonstrated similar growth properties and tissue tropism as their parental viruses in mice, among which the H7N9 NA-Venus virus could potentially be used in ex vivo studies to better understand H7N9 pathogenesis or to develop novel therapeutics. | guangwen wang jie zhang fandi kong qibing li jinliang wang shujie ma yuhui zhao libin liang junping li nan sun lizheng guan yuan zhou chenchen zhou shanyu huang zhigao bu li jiang hualan chen chengjun li | 2018 | Science Bulletin2018，63，3： | 1 |
| 4 | TFM imaging of aeroengine casing ring forgings with curved surfaces using acoustic field threshold segmentation and vector coherence factor显示文摘The aeroengine casing ring forgings have complex cross-section shapes,when the conventional ultrasonic or phased array is applied to detect such curved surfaces,the inspection images always have low resolution and even artifacts due to the distortion of the wave beam.In this article,taking a type of aeroengine casing ring forging as an example,the Total Focusing Method(TFM)algorithms for curved surfaces are investigated.First,the Acoustic Field Threshold Segmentation(AFTS)algorithm is proposed to reduce background noise and data calculation.Furthermore,the Vector Coherence Factor(VCF)is adopted to improve the lateral resolution of the TFM imaging.Finally,a series of 0.8 mm diameter Side-Drilled Holes(SDHs)are machined below convex and concave surfaces of the specimen.The quantitative comparison of the detection images using the conventional TFM,AFTS-TFM,VCF-TFM,and AFTS-VCF-TFM is implemented in terms of data volume,imaging Signal-to-Noise Ratio(SNR),and defect echo width.The results show that compared with conventional TFM,the data volume of AFTS-VCF-TFM algorithm for convex and concave is decreased by 32.39%and 73.40%,respectively.Moreover,the average SNR of the AFTS-VCF-TFM is gained up to 40.0 dB,while the average 6 dB-drop echo width of defects is reduced to 0.74 mm. | Shanyue GUAN Xiaokai WANG Lin HUA Yixuan LI | 2022 | Chinese Journal of Aeronautics2022，35，11： | 0 |
| 5 | Function toggle of tumor microenvironment responsive nanoagent for highly efficient free radical stress enhanced chemodynamic therapy显示文摘In contrast to reactive oxygen species(ROS),the generation of oxygen-irrelevant free radicals is oxygen-and H2O2-independent in cell,which can offer novel opportunities to maximum the chemodynamic therapy(CDT)efficacy.Herein,an H2O2-independent“functional reversion”strategy based on tumor microenvironment(TME)-toggled C-free radical generation for CDT is developed by confining astaxanthin(ATX)on the NiFe-layered double hydroxide(LDH)nanosheets(denoted as ATX/LDH).The unique ATX/LDH can demonstrate outstanding TME-responsive C-free radical generation performance by proton coupled electron transfer(PCET),owing to the specific ATX activation by unsaturated Fe sites on the LDH nanosheets formed under TME.Significantly,the Brönsted base sites of LDH hydroxide layers can promote the generation of neutral ATX C-free radicals by capturing the protons generated in the ATX activation process.Conversely,ATX/LDH maintain antioxidant performance to prevent normal tissue cancerization due to the synergy of LDH nanosheets and antioxidative ATX.In addition,C-free radical can compromise the antioxidant defense in cells to the maximum extent,compared with ROS.The free radicals burst under TME can significantly elevate free radical stress and induce cancer cell apoptosis.This strategy can realize TME-toggled C free radical generation and perform free radical stress enhanced CDT. | Xueting Yang Shuaitian Guo Li Wang Shanyue Guan Shuyun Zhou Jun Lu | 2022 | Nano Research2022，15，9： | 0 |
| 6 | Targeted alleviation of ischemic stroke reperfusion via atorvastatin-ferritin Gd-layered double hydroxide显示文摘In acute ischemic stroke therapy,potent neuroprotective agents are needed that prevent neural injuries caused by reactive oxygen species(ROS)during ischemic reperfusion.Herein,a novel 2D neuroprotective agent(AFGd-LDH)is reported,comprising Gd-containing layered double hydroxide nanosheets(Gd-LDH,as a drug nanocarrier/MRI contrast agent),atorvastatin(ATO,as a neuroprotective drug)and the ferritin heavy subunit(FTH,as a blood brain barrier transport agent).Experiments revealed AFGd-LDH to possess outstanding antioxidant activity,neuroprotective properties,blood‒brain barrier transit properties,and biocompatibility.In vitro studies demonstrated the ROS scavenging efficiency of AFGd‒LDH to be~90%,surpassing CeO_(2)(50%,a ROS scavenger)and edaravone(52%,a clinical neuroprotective drug).Ischemia‒reperfusion model studies in mice showed AFGd‒LDH could dramatically decrease apoptosis induced by reperfusion,reducing the infarct area by 67%and lowering the neurological deficit score from 3.2 to 0.9.AFGd-LDH also offered outstanding MRI performance,thus enabling simultaneous imaging and ischemia reperfusion therapy. | Li Wang Baorui Zhang Xueting Yang Shuaitian Guo Geoffrey I.N.Waterhouse Guangrong Song Shanyue Guan Aihua Liu Liang Cheng Shuyun Zhou | 2023 | Bioactive Materials2023，，2： | 0 |
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