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| 1 | Abnormal Metabolic Connectivity in Rats at the Acute Stage of Ischemic Stroke显示文摘Stroke at the acute stage is a major cause of disability in adults, and is associated with dysfunction of brain networks. However, the mechanisms underlying changes in brain connectivity in stroke are far from fully elucidated. In the present study, we investigated brain metabolism and metabolic connectivity in a rat ischemic stroke model of middle cerebral artery occlusion(MCAO)at the acute stage using18 F-fluorodeoxyglucose positron emission tomography. Voxel-wise analysis showed decreased metabolism mainly in the ipsilesional hemisphere, and increased metabolism mainly in the contralesional cerebellum. We used further metabolic connectivity analysis to explore the brain metabolic network in MCAO.Compared to sham controls, rats with MCAO showed most significantly reduced nodal and local efficiency in the ipsilesional striatum. In addition, the MCAO group showed decreased metabolic central connection of the ipsilesional striatum with the ipsilesional cerebellum, ipsilesional hippocampus, and bilateral hypothalamus. Taken together,the present study demonstrated abnormal metabolic connectivity in rats at the acute stage of ischemic stroke, which might provide insight into clinical research. | Shengxiang Liang Xiaofeng Jiang Qingqing Zhang Shaofeng Duan Tianhao Zhang Qi Huang Xi Sun Hua Liu Jie Dong Weilin Liu Jing Tao Shujun Zhao Binbin Nie Lidian Chens Baoci Shan | 2018 | Neuroscience Bulletin2018，34，5： | 5 |
| 2 | An Automatic Method for Generating an Unbiased Intensity Normalizing Factor in Positron Emission Tomography Image Analysis After Stroke显示文摘Positron emission tomography(PET) imaging of functional metabolism has been widely used to investigate functional recovery and to evaluate therapeutic efficacy after stroke. The voxel intensity of a PET image is the most important indicator of cellular activity, but is affected by other factors such as the basal metabolic ratio of each subject. In order to locate dysfunctional regions accurately,intensity normalization by a scale factor is a prerequisite in the data analysis, for which the global mean value is most widely used. However, this is unsuitable for stroke studies.Alternatively, a specified scale factor calculated from a reference region is also used, comprising neither hyper-nor hypo-metabolic voxels. But there is no such recognized reference region for stroke studies. Therefore, we proposed a totally data-driven automatic method for unbiased scale factor generation. This factor was generated iteratively until the residual deviation of two adjacent scale factors was reduced by < 5%. Moreover, both simulated and real stroke data were used for evaluation, and these suggested that our proposed unbiased scale factor has better sensitivity and accuracy for stroke studies. | Binbin Nie Shengxiang Liang Xiaofeng Jiang Shaofeng Duan Qi Huang Tianhao Zhang Panlong Li Hua Liu Baoci Shan | 2018 | Neuroscience Bulletin2018，34，5： | 2 |
| 3 | Facile preparation of nano-g-C_(3)N_(4)/UiO-66-NH_(2) composite as sorbent for high-efficient extraction and preconcentration of food colorants prior to HPLC analysis显示文摘In this work,the nano-g-C_(3)N_(4)/Ui O-66-NH_(2)composite was prepared by one-step solvothermal method.The as-prepared composite was characterized by scanning electron microscopy,Brunner-Emmet-Teller measurement,energy dispersive spectrometer,X-ray diffraction,and Fourier transform infrared spectroscopy.By using nano-g-C_(3)N_(4)/Ui O-66-NH_(2)composite as sorbent,a dispersive solid-phase extraction coupled with high-performance liquid chromatography was developed to sensitive analysis of food colorants including tartrazine,amaranth,carmine,sunset yellow,allura red and bright blue.The experiment parameters including the amount of sorbent,adsorption time,the p H of adsorption solution,desorption time,desorption solvent,the p H of desorption solution as well as the proportion between desorption solvent and buffer solvent were investigated.Under the optimized conditions,the limits of detection(S/N=3) and limits of quantitation (S/N=10) were determined in the ranges of 0.08-0.8 and 0.2-2.0 ng/m L,respectively.With the developed sample pretreatment method,carmine and brilliant blue were determined from blueberry juice by HPLC-DAD.The contents were calculated as 1.53μg/m L and0.17μg/mL,respectively. | Xiaowan Zhang Yixin Yang Peige Qin Lizhen Han Wenli Zhu Shaofeng Duan Minghua Lu Zongwei Cai | 2022 | Chinese Chemical Letters2022，33，2： | 2 |
| 4 | Preparation of collagen-coated electrospun nanofibers by remote plasma treatment and their biological properties显示文摘 | Yuanyuan Duan Zhongyi Wang Wei Yan Shaohai Wang Shaofeng Zhang Jun Jia | 2007 | Journal of Biomaterials Science Polymer Edition2007，，9： | 1 |
| 5 | Combined nanosuspensions from two natural active ingredients for cancer therapy with reduced side effects显示文摘Tumor drug resistance and systemic side effects of chemotherapeutic drugs are the main reasons for the failure of cancer treatment.In recent years,it was found that some natural active ingredients can reverse MDR and regulate body immunity to enhance the efficacy and reduce toxicity of chemotherapeutic drugs.In this paper,a new nanosuspensions,HCPT and QUR hybrid nanosuspensions(HQ-NPs),was prepared by the microprecipitation-high pressure homogenization method to reverse tumor drug resistance,reduce toxicity,and increase therapeutic efficacy.The in vitro investigation results showed that HQ-NPs had a unique shape(particle size was about 216.3±5.9 nm),changed crystalline,and different dissolution rates compared with HCPT-NPs and QUR-NPs,which is attributed to the strong intermolecular forces between HCPT and QUR as indicated by the results of the molecule dock.It was verified that the HQ-NPs could double the retention of HCPT in cells and enhance the cytotoxicity to A549/PTX cells in vitro tests compared with HCPT-NPs.We also found that HQ-NPs can significantly enhance the accumulation of HCPT in tumor sites,improve the antitumor activity of HCPT,and protect the immune organs and other normal tissues(P<0.01),compared with HCPT-NPs.Therefore,hybrid nanosuspensions can offer promising potential as the drug delivery system for HCPT and QUR to increase the therapeutic efficacy and reduce the toxicity of HCPT. | Yonghui Qiao Zhihao Wei Tingting Qin Rufeng Song Zhiqiang Yu Qi Yuan Juan Du Qingbing Zeng Lanlan Zong Shaofeng Duan Xiaohui Pu | 2021 | Chinese Chemical Letters2021，32，9： | 1 |
| 6 | A novel arc model for very fast transient overvoltage simulation in a 252 k V gas-insulated switchgear显示文摘 | ZHAN Huamao DUAN Shaofeng LI Chengrong | 2014 | IEEE Transactions on Plasma Science2014，42，10： | 1 |
| 7 | A novel arc model for very fast transient overvoltage simulation in a 252 k V gas-insulated switchgear显示文摘 | ZHAN Huamao DUAN Shaofeng LI Chengrong | 2014 | IEEE Transactions on Plasma Science2014，42，10： | 1 |
| 8 | Multi-arm polymeric nanocarrier as a nitric oxide delivery platform for chemotherapy of head and neck squamous cell carcinoma显示文摘 | Shaofeng Duan Shuang Cai Qiuhong Yang M. Laird Forrest | 2012 | Biomaterials2012，，11： | 1 |
| 9 | Knotted Wave Dislocation with Hopf Invariant显示文摘 | Zhang Pengming Li Xiguo Wu Shaofeng Duan Yishi | 2006 | 近代物理研究所和兰州重离子加速器实验室年报:英文版2006，，1： | 0 |
| 10 | Factors affecting the voxel-based analysis of diffusion tensor imaging显示文摘Diffusion tensor imaging(DTI)provides a unique method to reveal the integrity of white matter microstructure noninvasively.Voxel-based analysis(VBA),which is a highly reproducible and user-independent technique,has been used to analyze DTI data in a number of studies.Fractional anisotropy(FA),which is derived from DTI,is the most frequently used parameter.The parameter setting during the DTI data preprocessing might affect the FA analysis results.However,there is no reliable evidence on how the parameters affect the results of FA analysis.This study sought to quantitatively investigate the factors that might affect the voxel-based analysis of FA;these include the interpolation during spatial normalization,smoothing kernel and statistical threshold.Because it is difficult to obtain the true information of the lesion in the patients,we simulated lesions on the healthy FA maps.The DTI data were obtained from 20 healthy subjects.The FA maps were calculated using DTIStudio.We randomly divided these FA maps into two groups.One was used as a model patient group,and the other was used as a normal control group.Simulated lesions were added to the model patient group by decreasing the FA intensities in a specified region by 5%–50%.The model patient group and the normal control group were compared by two-sample t test statistic analysis voxelby-voxel to detect the simulated lesions.We evaluated these factors by comparing the difference between the detected lesion through VBA and the simulated lesion.The result showed that the space normalization of FA image should use the trilinear interpolation,and the smoothing kernel should be 2–3 times the voxel size of spatially normalized FA image.For lesions with small intensity change,FWE correction must be cautiously used.This study provided an important reference to the analysis of FA with VBA method. | Jianli Wang Binbin Nie Haitao Zhu Hua Liu Jingjuan Wang Shaofeng Duan Baoci Shan | 2014 | Chinese Science Bulletin2014，59，31： | 0 |
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