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| 1 | Improved dissolution and oral absorption by co-grinding active drug probucol and ternary stabilizers mixtures with planetary beads-milling method显示文摘The objective of this work is to construct a nanosuspension drug delivery system of probucol,a BCS II drug,in order to improve its dissolution and oral bioavailability.The wet milling procedure using planetary beads-milling equipment was utilized to grind the raw probucol to ultrafine nanoparticle/nanocrystal aqueous suspension that was further solidified by freeze-drying process.Cellulose derivatives of different substitution groups and molecular weights,including HPMC,HPC,and MC,were evaluated as the primary stabilizer of probucol nanosuspension.Ternary stabilizers system composed of a primary stabilizer(cellulose derivative,i.e.HPC),a nonionic surfactant(Pluronic R F68),and an anionic surfactant(SDS)was employed to obtain probucol nanosuspension of finer particle size and enhanced dissolution in aqueous media.The probucol nanosuspension with good physical stability showed no obvious change of particle size even after storing over 7 d at 4°C or 25°C.The solidified probucol nanosuspension with trehalose as the cryoprotectant showed the highest dissolution rate(>60%at 2 h)compared to other cryoprotectant.The in vivo pharmacokinetic evaluation indicated about 15-folds higher AUC value of the probucol nanosuspension compared to that of coarse probucol suspension after oral administration to rats.The probucol nanosuspension prepared by wet-milling and ternary stabilizers system may find wide applications for improving the dissolution and oral absorption of water-insoluble drugs. | Fang Li Linsen Li Shaoning Wang Yan Yang Jia Li Dongchun Liu Sijie Zhang Siling Wang Hui Xu | 2019 | Asian Journal of Pharmaceutical Sciences2019，14，6： | 5 |
| 2 | Introducing sulfur vacancies and in-plane SnS_(2)/SnO_(2) heterojunction in SnS_(2) nanosheets to promote photocatalytic activity显示文摘Due to the relatively sluggish charge carrier separation in metal sulfides,the photocatalytic activity of them is still far lower than expected.Herein,sulfur vacancies and in-plane SnS_(2)/SnO_(2) heterojunction were successfully introduced into the SnS_(2) nanosheets through high energy ball-milling.These defective structures were studied by the electron paramagnetic resonance,Raman spectra,X-ray photoelectron spectroscopy,and high-resolution transmission electron microscope analyses.The sulfur vacancies and in-plane heterojunctions strongly accelerate the separation of photoexcited electron-hole pairs,as confirmed by the photo luminesce nce emission spectra and time-resolved photoluminescence decay spectra.The introduction of sulfur vacancies and in-plane heterojunction in SnS_(2) nanosheets results in roughly six times higher photodegrading rate for methyl orange and four times higher photocatalytic reduction rate of Cr6+than those of pure SnS_(2) nanosheets. | Keyan Hu Chen Ming Yiting Liu Chong Zheng Shaoning Zhang Dong Wang Wei Zhao Fuqiang Huang | 2020 | Chinese Chemical Letters2020，31，10： | 0 |
| 3 | Manipulating oxygenate adsorption on N-doped carbon by coupling with CoSn alloy for bifunctional oxygen electrocatalyst显示文摘Highly active bifunctional oxygen electrocatalysts accelerate the development of high-performance Zn-air battery,but suffer from the mismatched activities of oxygen evolution reaction(OER)and oxygen reduced reaction(ORR).Herein,highly integrated bifunctional oxygen electrocatalysts,cobalt-tin alloys coated by nitrogen doped carbon(CoSn@NC)are prepared by MOFs-derived method.In this hybrid catalyst,the binary CoSn nanoalloys mainly contribute to highly active OER process while the Co(or Sn)-N-C serves as ORR active sites.Rational interaction between CoSn and NC donates more rapid reaction kinetics than Pt/C(ORR)and IrO_(2)(OER).Such CoSn@NC holds a promise as air-cathode electrocatalyst in Zn-air battery,superior to Pt/C+IrO_(2)catalyst.First-principles calculations predict that CoSn alloys can upgrade charge redistribution on NC and promote the transfer to reactants,thus optimizing the adsorption strength of oxygen-containing intermediates to boost the overall reactivity.The tuning of oxygenate adsorption by interactions between alloy and heteroatom-doped carbon can guide the design of bifunctional oxygen electrocatalysts. | Chenlong Dong Xilin Zhang Shaoning Zhang Siwei Zhao Xueyu Lin Xin Wang Yajing Zhang Fuqiang Huang | 2023 | Green Energy & Environment2023，8，5： | 0 |
| 4 | Unlocking efficient energy storage via regulating ion and electron-active subunits:an(SbS)_(1.15)TiS_(2)superlattice for large and fast Na^(+)storage显示文摘Alloying-type metal sulfides with high sodiation activity and theoretical capacity are promising anode materials for high energy density sodium ion batteries.However,the large volume change and the migratory and aggregation behavior of metal atoms will cause severe capacity decay during the charge/discharge process.Herein,a robust and conductive TiS_(2)framework is integrated with a high-capacity SbS layer to construct a single phase(SbS)_(1.15)TiS_(2)superlattice for both high-capacity and fast Na^(+)storage.The metallic TiS_(2)sublayer with high electron activity acts as a robust and conductive skeleton to buffer the volume expansion caused by conversion and alloying reaction between Na+and SbS sublayer.Hence,high capacity and high rate capability can be synergistically realized in a single phase(SbS)_(1.15)TiS_(2)superlattice.The novel(SbS)_(1.15)TiS_(2)anode has a high charge capacity of 618 mAh g^(-1)at 0.2 C and superior rate performance and cycling stability(205 mAh g^(-1)at 35 C after 2,000 cycles).Furthermore,in situ and ex situ characterizations are applied to get an insight into the multi-step reaction mechanism.The integrity of robust Na-Ti-S skeleton during(dis)charge process can be confirmed.This superlattice construction idea to integrate the Na^(+)-active unit and electron-active unit would provide a new avenue for exploring high-performance anode materials for advanced sodium-ion batteries. | Baixin Peng Tianxun Cai Shaoning Zhang Yuqiang Fang Zhuoran Lv Yusha Gao Fuqiang Huang | 2024 | Science China Chemistry2024，67，1： | 0 |
| 5 | Robust and Flexible Multimaterial Aerogel Fabric Toward Outdoor Passive Heating显示文摘Outdoor passive heating to maintain a constant human body temperature is critical for human activities.However,most traditional energy-exhausted heating systems and inefficient passive heating technologies are incapable of dealing with the cold outdoor environment.Developing fabrics with low thermal radiation and conduction to passively heat the human body is a viable way to overcome the constraints of existing passive heating strategies.Herein,a multimaterial aerogel fabric was developed to realize passive personal heating without any energy input.The multimaterial aerogel fabric was fabricated by coating an Ag layer on an aerogel composite fabric.The lightweight aerogel composite fabric,woven from aerogel composite fibers with multi-scale porous structure,exhibits excellent thermal insulation,self-cleaning,mechanical and thermal stability.Furthermore,by coating with an Ag layer,the multimaterial aerogel fabric exhibits both low thermal conductivity and low infrared emissivity at 7–14μm,demonstrating superior thermal insulating performance.As a result,the proposed multimaterial aerogel fabric with a thickness of only 1.29 mm is capable of improving the human body temperarure of 5.7℃ in a cold environment without energy input.This strategy offers a potential energy-saving alternative for future outdoor passive heating. | Jiawei Wu Manni Zhang Minyu Su Yuqi Zhang Jun Liang Shaoning Zeng Baishun Chen Li Cui Chong Hou Guangming Tao | 2022 | Advanced Fiber Materials2022，4，6： | 0 |
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