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| 1 | A comparison study of tungsten-bearing granite and related mineralization in the northern Jiangxi-southern Anhui provinces and southern Jiangxi Province in South China显示文摘The southern Jiangxi Province(SJP) and northern Jiangxi-southern Anhui provinces(NJSAP) are the two most important tungsten metallogenic districts in South China. The SJP district is a well-known tungsten producer in South China where distributes several ore concentrated areas such as the 'Chongyi-Dayu-Shangyou', 'Yudu' and 'Longnan-Quanan-Dingnan'areas, with many large and super large tungsten deposits including the famous Xihuashan, Piaotang, Pangushan and Dajishan deposits. In recent years, major prospecting breakthrough for W-polymetallic resources has been made in the NJSAP district.Several large and super large W-Cu(Mo) deposits, such as the Dahutang, Zhuxi, Dongyuan and Baizhangyan deposits, are discovered. These deposits are all genetically associated with the Yanshanian(Mesozoic) granitic magmatism. In this study, a systematic comparison of the temporal and spatial distribution, petrology, geochronology, and geochemical characteristics of the tungsten-bearing granites between the SJP and NJSAP districts has been made, with an aim to improving the understanding of the petrogenesis of the granites and associated metal enrichment mechanisms in the two tungsten ore districts in South China. The following conclusions can be drawn:(1) The ages of the tungsten-bearing granites and associated mineralization are different in the two districts, in the SJP district the ages are mainly concentrated in 165–150 Ma, whereas in the NJSAP district it displays two age periods, one is 150–140 Ma(Late Jurassic-Early Cretaceous), and the other is 135–120 Ma(Early Cretaceous).(2) The tungsten-bearing granites from both the NJSAP and SJP districts are highly fractionated granitic rocks, but the SJP granites have experienced higher degree of fractional crystallization and more extensive fluid metasomatism than the NJSAP granites.(3) The petrogeneses of the tungsten-bearing granites from the two districts are different, those from the NJSAP district originated from partial melting of less mature sandstone-mudstone intercalated with meta-volcanic rocks of the Neoproterozoic Shuangqiaoshan Group which are both W and Cu enriched, in contrast those from the SJP district were likely derived from the highly mature,clay-rich mudstones of the Mesoproterozoic age which are only W enriched. In summary, the different source rocks with different metal enrichment features and different magmatic evolution and fractional degrees for the granites in the two districts might be the key factors that controlled the different matallogenic characteristics of tungsten ore deposits in the two districts in South China. | SU HuiMin JIANG ShaoYong | 2017 | Science China Earth Sciences2017，60，11： | 19 |
| 2 | Spatial-Temporal Distribution, Geological Characteristics and Ore-Formation Controlling Factors of Major Types of Rare Metal Mineral Deposits in China显示文摘Rare metals including Lithium(Li),Beryllium(Be),Rubidium(Rb),Cesium(Cs),Zirconium(Zr),Hafnium(Hf),Niobium(Nb),Tantalum(Ta),Tungsten(W)and Tin(Sn)are important critical mineral resources.In China,rare metal mineral deposits are spatially distributed mainly in the Altay and Southern Great Xingán Range regions in the Central Asian orogenic belt;in the Middle Qilian,South Qinling and East Qinling mountains regions in the Qilian-Qinling-Dabie orogenic belt;in the Western Sichuan and Bailongshan-Dahongliutan regions in the Kunlun-Songpan-Garze orogenic belt,and in the Northeastern Jiangxi,Northwestern Jiangxi,and Southern Hunan regions in South China.Major ore-forming epochs include Indosinian(mostly 200-240 Ma,in particular in western China)and the Yanshanian(mostly 120-160 Ma,in particular in South China).In addition,Bayan Obo,Inner Mongolia,northeastern China,with a complex formation history,hosts the largest REE and Nb deposits in China.There are six major rare metal mineral deposit types in China:Highly fractionated granite;Pegmatite;Alkaline granite;Carbonatite and alkaline rock;Volcanic;and Hydrothermal types.Two further types,namely the Leptynite type and Breccia pipe type,have recently been discovered in China,and are represented by the Yushishan Nb-Ta-(Zr-Hf-REE)and the Weilasituo Li-Rb-Sn-W-Zn-Pb deposits.Several most important controlling factors for rare metal mineral deposits are discussed,including geochemical behaviors and sources of the rare metals,highly evolved magmatic fractionation,and structural controls such as the metamorphic core complex setting,with a revised conceptual model for the latter. | JIANG Shaoyong SU Huimin XIONG Yiqu LIU Tao ZHU Kangyu ZHANG Lu | 2020 | Acta Geologica Sinica(English Edition)2020，94，6： | 9 |
| 3 | Prevalence, Awareness, Treatment, and Control of Hypertension in China显示文摘 | Dongfeng Gu Kristi Reynolds Xigui Wu Jing Chen Xiufang Duan Paul Muntner Guanyong Huang Robert F. Reynolds Shaoyong Su Paul K. Whelton Jiang He | 2002 | Hypertension: Journal of the American Heart Association2002，，6： | 1 |
| 4 | Prevalence, Awareness, Treatment, and Control of Hypertension in China显示文摘 | Dongfeng Gu Kristi Reynolds Xigui Wu Jing Chen Xiufang Duan Paul Muntner Guanyong Huang Robert F. Reynolds Shaoyong Su Paul K. Whelton Jiang He | 2002 | Hypertension: Journal of the American Heart Association2002，，6： | 1 |
| 5 | Association study of ACE2 (angiotensin I-converting enzyme2) gene polymorphisms with coronary heart disease and myocardial infarction ina Chinese Han population显示文摘 | Wei YANG Wentao HUANG Shaoyong Su | 2006 | Clinical Science2006，111，： | 1 |
| 6 | Targeting a cryptic allosteric site of SIRT6 with small-molecule inhibitors that inhibit the migration of pancreatic cancer cells显示文摘SIRT6 belongs to the conserved NAD^(+)-dependent deacetylase superfamily and mediates multiple biological and pathological processes.Targeting SIRT6 by allosteric modulators represents a novel direction for therapeutics,which can overcome the selectivity problem caused by the structural similarity of orthosteric sites among deacetylases.Here,developing a reversed allosteric strategy Allo Reverse,we identified a cryptic allosteric site,Pocket Z,which was only induced by the bi-directional allosteric signal triggered upon orthosteric binding of NAD^(+).Based on Pocket Z,we discovered an SIRT6 allosteric inhibitor named JYQ-42.JYQ-42 selectively targets SIRT6 among other histone deacetylases and effectively inhibits SIRT6 deacetylation,with an IC50 of 2.33μmol/L.JYQ-42 significantly suppresses SIRT6-mediated cancer cell migration and pro-inflammatory cytokine production.JYQ-42,to our knowledge,is the most potent and selective allosteric SIRT6 inhibitor.This study provides a novel strategy for allosteric drug design and will help in the challenging development of therapeutic agents that can selectively bind SIRT6. | Qiufen Zhang Yingyi Chen Duan Ni Zhimin Huang Jiacheng Wei Li Feng Jun-Cheng Su Yingqing Wei Shaobo Ning Xiuyan Yang Mingzhu Zhao Yuran Qiu Kun Song Zhengtian Yu Jianrong Xu Xinyi Li Houwen Lin Shaoyong Lu Jian Zhang | 2022 | Acta Pharmaceutica Sinica B2022，12，2： | 0 |
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