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| 1 | Pre-treatment role of inosine triphosphate pyrophosphatase polymorphism for predicting anemia in Egyptian hepatitis C virus patients显示文摘AIM: To investigate and clarify, for the first time, the role of inosine triphosphate pyrophosphatase (ITPA ) polymorphism in Egyptian chronic hepatitis C virus (HCV) patients.METHODS:The human genomic DNA of all patients was extracted from peripheral blood cells in order to determine the single nucleotide polymorphism (SNP) of ITPA (rs1127354). SNP genotyping was performed by real time polymerase chain reaction (PCR, ABI TaqMan allelic discrimination kit) for 102 treatment-naive Egyptian patients with chronic HCV. All patients had no evidence of cardiovascular or renal diseases. They received a combination treatment of pegylated interferon α (PEG-IFNα) as a weekly subcutaneous dose plus an oral weight-adjusted dose of ribavirin (RBV). The majority received PEG-IFNα2a (70.6%) while 29.4% received PEG-IFNα2b. The planned duration of treatment was 24-48 wk according to the viral kinetics throughout the course of treatment. Pre-treatment liver biopsy was done for each patient for evaluation of fibrosis stage and liver disease activity. The basal viral load level was detected quantitatively by real time PCR while viral load throughout the treatment course was performed qualitatively by COBAS TaqMan assay. RESULTS: Ninety-three patients (91.2%) had ITPA SNP CC genotype and 9 (8.8%) had non-CC genotype (CA and AA). The percentage of hemoglobin (Hb) decline was higher for CC patients than for non-CC patients, particularly at weeks 4 and 8 (P=0.047 and 0.034, respectively). During the first 12 wk of treatment, CC patients had significantly more Hb decline > 3 g/dL than non-CC patients: 64.5% vs 22.2% at weeks 8 and 12, respectively, (P=0.024 and 0.038). Reduction of the amount of the planned RBV dose was significantly higher for CC patients than non-CC patients during the first 12 wk (18% ± 12.1% vs 8.5% ± 10.2%, P=0.021). The percentage of CC patients with RBV dose reduction was significantly greater than that of non-CC patients (77.4% vs 44.4%, P=0.044). Multivariate analysis identified only the percentage of RBV dose as a predictor for Hb decline. Platelet decline was significantly higher in non-CC patients than CC patients at weeks 12, 24 and 48 (P=0.018, 0.009 and 0.026, respectively). CONCLUSION: Rs1127354 ITPA polymorphism plays a decisive role in protecting against treatment-induced anemia and the need for RBV dose reduction in Egyptian HCV patients. | Walaa H Ahmed Norihiro Furusyo Saad Zaky Abeer Sharaf Eldin Hany Aboalam Eiichi Ogawa Masayuki Murata Jun Hayashi | 2013 | World Journal of Gastroenterology2013，19，9： | 2 |
| 2 | Two control schemes to enhance the dynamic performance of the STATCOM and SSSC显示文摘 | Norouzi A H Sharaf A M | 2005 | IEEE Transactions on Power Delivery2005，20，1： | 1 |
| 3 | Pheno and genotyping of Pasteurella multocida isolated from goat in Iran显示文摘 | Shayegh J Sharaf J D Namvar H | 2009 | African J Biotechnol2009，8，16： | 1 |
| 4 | A novel on-line MPPT search algorithm for PV arrays显示文摘 | ALTAS I H SHARAF A M | 1996 | IEEE Trans on Eenergy Conves1996，11，4： | 1 |
| 5 | Genotoxic effects of the foodcolor (carmoisine)on the chromosome of bone marrow cells of rat显示文摘 | Ali M Al–Ghor A K Sharaf H | 1998 | Toxicol Lett1998，95，： | 1 |
| 6 | Offline model-ing of nonlinear systems based on least squares support vector ma-chines显示文摘 | El Bardini M Khalil H M El Rabie N Sharaf M | 2009 | International Conference on Computer Engineering&Systems2009，5，10： | 1 |
| 7 | A novel maximum power fuzzy logic controller for photovoltaic solar energy systems显示文摘 | Altasa I H Sharaf A M | 2008 | Renewable Energy2008，33，3： | 1 |
| 8 | A novel on-line MPP search algorithm for PV arrays显示文摘 | ALTAS I H SHARAF A M | 1996 | IEEE Transactions on Energy Conversion1996，11，4： | 1 |
| 9 | Determination of guaifenesin in human serum by capillary gas chromatography and electron capture detection 显示文摘 | SHARAF M H STIFF D D | 2004 | J Pharm Biomed Anal2004，35，7： | 1 |
| 10 | A Novel Maximum Power Fuzzy Logic Controller for Photovoltaic Solar Energy Systems显示文摘 | Ahas I H Sharaf A M | 2008 | Renewable Energy2008，33，3： | 1 |
| 11 | A cross-sectional study of the relationships between illness insight, internalized stigma, and suicide risk in individuals with schizophrenia 显示文摘 | Amira Y Sharaf Laila H | 2012 | International Journal of Nursing Studies2012，49，： | 1 |
| 12 | Thalprzewalskiinone, a new oxobenzylisoquinoline alkaloid from Thalictrum przewalslaii 显示文摘 | A1-Rehaily A J Sharaf M H M Zemaitis M A | 1999 | J Nat Prod1999，62，1： | 1 |
| 13 | Optimal protection coordination for meshed distribution systems with DG using dual setting directional over-current relays显示文摘 | ZEINELDIN H H SHARAF H M IBRAHIM D K | 2015 | IEEE Trans on Smart Grid2015，6，1： | 1 |
| 14 | A novel maximum power fuzzy logic controller for photovoltaic solar energy systems显示文摘 | Altas I H Sharaf A M | 2008 | Renewable Energy2008，33，3： | 1 |
| 15 | ApoER2 and VLDLr are required for mediating Reelin signalling pathway for nor- mal migration and positioning of mesencephalic dopaminergic neurons显示文摘 | Sharaf A Book H H Spittau B | 2013 | PLoS One2013，8，71： | 1 |
| 16 | The philosophy of Auditing 显示文摘 | Mautz R K Sharaf H A | 1961 | American Accounting Association1961，，： | 1 |
| 17 | Two control scheme to enhance the dynamic performance of the STATCOM and SSSC 显示文摘 | NOROUZI A H SHARAF A M | 2005 | IEEE Trails on Power Delivery2005，20，1： | 1 |
| 18 | On the phytosociology of Wadi Araba in the Eastern Desert of Egypt显示文摘 | Sharaf EI Din A Shaltout K H | 1985 | Proceedings of the Egyptian Botanical Society1985，4，： | 1 |
| 19 | Two control schemes to enhance the dynamic performance of the STATCOM and SSSC显示文摘 | Norouzi A H Sharaf A M | 2005 | IEEE Trans on Power Delivery2005，20，1： | 1 |
| 20 | HE4 and mesothelin: novel biomarkers of ovarian carcinoma in patients with pelvic masses显示文摘 | Abdel-Azeez H A Labib H A Sharaf S M | 2010 | Asian Pac J Cancer Prev2010，11，1： | 1 |
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