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| 1 | Cytokine- and chemokine-induced inflammatory colorectal tumor microenvironment: Emerging avenue for targeted therapy显示文摘Colorectal cancer(CRC)is a predominant life-threatening cancer,with liver and peritoneal metastases as the primary causes of death.Intestinal inflammation,a known CRC risk factor,nurtures a local inflammatory environment enriched with tumor cells,endothelial cells,immune cells,cancer-associated fibroblasts,immunosuppressive cells,and secretory growth factors.The complex interactions of aberrantly expressed cytokines,chemokines,growth factors,and matrix-remodeling enzymes promote CRC pathogenesis and evoke systemic responses that affect disease outcomes.Mounting evidence suggests that these cytokines and chemokines play a role in the progression of CRC through immunosuppression and modulation of the tumor microenvironment,which is partly achieved by the recruitment of immunosuppressive cells.These cells impart features such as cancer stem cell-like properties,drug resistance,invasion,and formation of the premetastatic niche in distant organs,promoting metastasis and aggressive CRC growth.A deeper understanding of the cytokineand chemokine-mediated signaling networks that link tumor progression and metastasis will provide insights into the mechanistic details of disease aggressiveness and facilitate the development of novel therapeutics for CRC.Here,we summarized the current knowledge of cytokine-and chemokine-mediated crosstalk in the inflammatory tumor microenvironment,which drives immunosuppression,resistance to therapeutics,and metastasis during CRC progression.We also outlined the potential of this crosstalk as a novel therapeutic target for CRC.The major cytokine/chemokine pathways involved in cancer immunotherapy are also discussed in this review. | Ajaz A.Bhat Sabah Nisar Mayank Singh Bazella Ashraf Tariq Masoodi Chandra P.Prasad Atul Sharma Selma Maacha Thasni Karedath Sheema Hashem Syed Besina Yasin Puneet Bagga Ravinder Reddy Michael P.Frennaux Shahab Uddin Punita Dhawan Mohammad Haris Muzafar A.Macha | 2022 | Cancer Communications2022，42，8： | 8 |
| 2 | Downregulation of miRNA-21 and cancer stem cells after chemotherapy results in better outcome in breast cancer patients显示文摘Epigenetic modifications have been observed as a decline in miRNA-21 expression and breast cancer stem cell(CSC)population after 3 cycles of standard chemotherapy.The epigenetic response(miRNAs expression)and CSCs are also correlated in patients with Breast Cancer.In patients who tolerated chemotherapy well,miRNA-21(non-coding RNA)expression decreased significantly after three cycles of chemotherapy.The miRNA-21 expression in breast cancer tissue was quantified by quantitative PCR(real-time PCR)using the standard protocol.In addition,breast CSCs(CD44+/CD24-)were also decreased in these patients.The miRNA-21 regulates cell division,proliferation,and autophagy of cancerous cells(as it targets phosphatase and tensin homolog/AKT/transcription factor EB/programmed cell death 4/autophagy-related protein 5 and chemotherapy also produces similar effects),thereby contributing to these benefits.Therefore,when all of the targets on genes have been explored by mimic miRNA,chemotherapy combined with anti-miRNA21 therapy may prove useful in the care of cancer patients. | Shailendra Dwivedi Puneet Pareek Jeewan Ram Vishnoi Praveen Sharma Sanjeev Misra | 2022 | World Journal of Stem Cells2022，14，4： | 3 |
| 3 | Coexistence of pneumothorax and chilaiditi sign:A case report显示文摘We present a case of 50 year old male patient with coexistence of Pneumothorax and Chilaiditi sign.Chilaiditi sign is an incidental radiographic finding of a usually asymptomatic condition in which a part of intestine is located between the liver and diaphragm;however,the term'Chilaiditi syndrome'is used for symptomatic hepatodiaphragmatic interposition.The patient had no symptoms of abdominal pain,constipation,diarrhea,or emesis.Incidentally,Chilaiditi sign was diagnosed on chest radiography.Pneumothorax is defined as air in the pleural space.Pneumothoraces are classified as spontaneous or traumatic.Spontaneous pneumothorax is labelled as primary when no underlying lung disease is present,or secondary,when it is associated with pre-existing lung disease.Our case is the rare in the literature indicating the coexistence of Chilaiditi sign and pneumothorax. | Tangri Nitin Singhal Sameer Sharma Priyanka Mehta Dinesh Bansal Sachin Bhushan Neeraj Singla Sulbha Singh Puneet | 2014 | Asian Pacific Journal of Tropical Biomedicine2014，4，1： | 2 |
| 4 | Influence of Nd^3+ and Sm^3+ substitution on the magnetic properties of strontium ferrite sintered magnets显示文摘 | Puneet Sharma Amitabh Verma R K Sidhu O P Pandey | 2003 | Journal of Alloys and Compounds2003，361，： | 1 |
| 5 | Arterial pH,bicarbonate levels and base deficit at presentation as markers of predicting mortality in acute pancreatitis:a single-centre prospective study显示文摘Background.Arterial blood gas(ABG)parameters such as pH form part of multi-parameter scoring systems for predicting severe acute pancreatitis;however,literature on detailed evaluation of ABG alone in this context is scarce.Methods.Patients with acute pancreatitis presenting to our unit between January 2012 and November 2013 were prospectively studied.ABG analysis was done at admission and development of organ failure,any need for intervention,and mortality were noted.The association between various parameters of ABG analysis and the development of organ failure or local complications,need for interventions(endoscopic/radiological/surgical)and mortality were analysed.Results.Two hundred and five patients(mean age:39.33-13.85 years;61.0%males)were prospectively studied.The aetiology of acute pancreatitis was alcohol in 93 patients(45.4%)and gall stone disease in 73(35.6%).Organ failure developed in 71.2%patients and 83.9%had local complications.In 18%of patients,endoscopic/radiological/surgical interventions were needed and 14.6%died.The patients(n=35)with metabolic acidosis(pH<7.35)suffered higher frequency of organ failure,need for interventions and mortality.Patients with low arterial bicarbonate levels,as well as higher base deficit,also displayed higher frequency of organ failure,need for interventions and mortality.The receiver operating characteristic(ROC)curves for pH<7.35,bicarbonate<22 meq/L and base deficit of>4 meq/L for prediction of mortality were 0.771(95%CI:0.664–0.878),0.707(95%CI:0.622–0.791)and 0.780(95%CI:0.693–0.867),respectively.Conclusion.Arterial pH,bicarbonate levels,and base deficit at presentation are useful early markers for predicting adverse outcome in acute pancreatitis. | Vishal Sharma Thingbaijam Shanti Devi Ravi Sharma Puneet Chhabra Rajesh Gupta Surinder S.Rana Deepak K.Bhasin | 2014 | Gastroenterology Report2014，2，3： | 1 |
| 6 | Effect of wet milling process on the solid state of indomethacin and simvastatin 显示文摘 | Sharma Puneet Denny William A Garg Sanjay | 2009 | International Journal of Pharmaeeutics2009，380，12： | 1 |
| 7 | Influence of Nd3 + and Sm3 + substitution on the magnetic properties of strontium ferrite sintered magnets显示文摘 | Sharma Puneet Verma Amitabh Sidhu R K | 2003 | J Alloy Compd2003，361，： | 1 |
| 8 | Irmo- ration Trajectories for lnfonmtion Visualizations: Comparing Treemaps, Cone Tree, and Hyperbolic Trees 显示文摘 | Ben Shneiderman Cody l)unne Puneet Sharma Ping Wang | 2012 | Information Visualization2012，，： | 1 |
| 9 | Tailoring of structural,optical and electrical properties of anatase TiO_(2)via doping of cobalt and nitrogen ions显示文摘Pure(pristine)anatase and mono–doped and co–doped derivatives of TiO_(2)having nitrogen(N)and cobalt(Co)as dopants with respective fixed doping concentrations of 0.7 mol.%and 1.0 mol.%were synthesized using auto–combustion sol–gel technique.The doping effects at corresponding non–metal and transition metal sites of TiO_(2)on the basis of the structural,optical and electrical properties have been investigated.X–ray diffraction(XRD)measurement confirms the formation of pure anatase phase of TiO_(2)for all samples having I41/amd space group of tetragonal structure which has been also verified by the Raman spectroscopy measurement.Various crystallographic parameters have been calculated by performing Rietveld refinement of XRD data including average crystallite size that has been observed in the range of10–15 nm.Pure anatase phase indicates the incorporation of Co^(2+)into TiO_(2)lattice which assists the substitution of N in place of oxygen in co–doped TiO_(2).The band gap tuning towards the visible region from3.2 to 2.1 e V has been achieved with mono–doping and co–doping of the N and Co in TiO_(2)lattice.This can be described in terms of the formation of localized levels of N–2p and Co–3d states in mono–doping and an isolated intermediate band formation in co–doping case.Electrical properties have been investigated in details and explained as the synergetic effects of structural and inherent ionic characters of various dopants.The observed band gaps of all doped samples lie within the visible region which makes them pertinent as the solar energy harnessing materials for photocatalytic and photovoltaic applications. | Anchal Sharma Puneet Negi Ruhit Jyoti Konwar Hemaunt Kumar Yogita Verma Shailja Prakash Chandra Sati Bhargav Rajyaguru Himanshu Dadhich N.A.Shah P.S.Solanki | 2022 | Journal of Materials Science & Technology2022，，16： | 1 |
| 10 | Kinesthetic ability with osseointegrated implants 显示文摘 | Varun Dahiya Puneet Sharma Palwinder Kaur | 2012 | J Dent Implant2012，2，： | 1 |
| 11 | Kinesthetic ability with osseointegrated implants显示文摘 | Varun Dahiya Puneet Sharma Palwinder Kaur | 2012 | Journal of Dental Implants2012，，1： | 1 |
| 12 | 腹部超声、内镜超声与磁共振成像对于包裹性胰腺坏死碎片诊断价值的比较显示文摘背景:包裹性胰腺坏死(WOPN)是急性胰腺炎一个重要并发症,主要是通过内镜超声(EUS)或磁共振成像(MRI)等影像学检查来诊断,这些检查可清晰见到坏死碎片。而腹部超声(USG)对于这些坏死碎片的发现价值目前尚不清楚。方法:52例WOPN患者(其中男性37例,年龄38.9612.6岁)被前瞻性纳入研究,分别接受EUS、MRI和USG检查。这些检查于急性胰腺炎发病后11.765.5周进行,并于2天内完成。结果:所有患者均可通过EUS和MRI诊断WOPN,而有4例(7.6%)通过USG未能发现WOPN(其中3例是固体碎片为主的坏死灶,另1例坏死灶中存在空气)。在所有发现的WOPN中,三项检查均能检测到固体坏死碎片。EUS和USG在10例(20%)患者中检测到<10%的固体碎片,而MRI这一检测比例为27%(14例)。EUS和USG在33例(63%)患者中检测到的固体碎片在10%-40%之间,MRI的这一检测比例为58%(30例)。当固体固体碎片比例>40%时,EUS和MRI则更具优势,其在8例(15%)患者中检测到>40%的固体碎片,而USG这一检测比例为11%(5例)。EUS还可以发现坏死周围组织,而USG和MRI却不能。结论:USG能对大多数WOPN进行诊断,其准确率与EUS和MRI相当。然而,ESG的局限性在于检测WOPN周围组织及诊断固体碎片比例较高或内含空气的WOPN的能力不足。 | Surinder S Rana Vinita Chaudhary Ravi Sharma Vishal Sharma Puneet Chhabra Deepak K Bhasin | 2016 | Gastroenterology Report2016，4，1： | 1 |
| 13 | Evolution of serum atherogenic risk in liver transplant recipients: Role of lipoproteins and metabolic and inflammatory markers显示文摘 | Ravi Chhatrala M. Bilal Siddiqui R. Todd Stravitz Carolyn Driscoll Arun Sanyal Carol Sargeant Velimir Luketic Amit Sharma Richard Sterling Scott Matherly Puneet Puri M. Shadab Siddiqui | 2015 | Liver Transpl2015，，5： | 1 |
| 14 | CUL4A ubiquitin ligase: a promising drug target for cancer and other human diseases显示文摘 | Puneet Sharma Alo Nag | 2014 | Open Biology2014，，2： | 1 |
| 15 | Process parameter selection for strontium ferrite sintered magnets using Tagnchi L9 orthogonal design显示文摘 | Puneet Sharma Amitabh Verma Sidhu R K | 2005 | Mater Proc Techn2005，168，： | 1 |
| 16 | Pavitra Aggarwal: Web Services and GIS Technologies显示文摘 | Premal Mehta Puneet Sharma | | 0，，03： | 1 |
| 17 | Elastic modulus of 3D carbon/carbon composite using image-based finite element simulations and experiments显示文摘 | Rajneesh Sharma Puneet Mahajan Ramesh Kumar Mittal | 2012 | Composite Structures2012，，： | 1 |
| 18 | An unusual cause of simultaneous common bile and pancreatic duct dilation显示文摘Simultaneous dilation of both the common bile duct and the pancreatic duct(double-duct sign)is usually because of ampullary or pancreatic tumours.Here we report an unusual cause of double-duct dilation;we describe the case of a 49-year-old female who developed afferent loop syndrome after pylorus-preserving pancreaticoduodenectomy:crosssectional imaging of the abdomen revealed a double-duct sign. | Puneet Chhabra Surinder Singh Rana Vishal Sharma Ravi Sharma Rajesh Gupta Deepak Kumar Bhasin | 2015 | Gastroenterology Report2015，3，3： | 0 |
| 19 | Design and Analysis of Graphene Based Tunnel Field Effect Transistor with Various Ambipolar Reducing Techniques显示文摘The fundamental advantages of carbon-based graphene material,such as its high tunnelling probability,symmetric band structure(linear dependence of the energy band on the wave direction),low effective mass,and characteristics of its 2D atomic layers,are the main focus of this research work.The impact of channel thickness,gate under-lap,asymmetric source/drain doping method,workfunction of gate contact,and High-K material on Graphene-based Tunnel Field Effect Transistor(TFET)is analyzed with 20 nm technology.Physical modelling and electrical characteristic performance have been simulated using the Atlas device simulator of SILVACO TCAD with user-defined material syntax for the newly included graphene material in comparison to silicon carbide(SiC).The simulation results in significant suppression of ambipolar current to voltage characteristics of TFET and modelled device exhibits a significant improvement in subthreshold swing(0.0159 V/decade),the ratio of Ion/Ioff(1000),and threshold voltage(-0.2 V with highly doped p-type source and 0.2 V with highly doped n-type drain)with power supply of 0.5 V,which make it useful for low power digital applications. | Puneet Kumar Mishra Amrita Rai Nitin Sharma Kanika Sharma Nitin Mittal Mohd Anul Haq Ilyas Khan ElSayed M.Tag El Din | 2023 | Computers, Materials & Continua2023，，7： | 0 |
| 20 | The men’s health center:Disparities in gender specific health services among the top 50“best hospitals”in America显示文摘Objective:Gender-specific integrated health services have long existed in the arena of women’s health care,but men’s health centers(MHCs)have only recently emerged as a novel practice model.Here,we seek to evaluate the prevalence and format of MHCs found in the leading academic medical centers in the United States.Methods:The US News&World Report’s Top 50 Ranked Hospitals for Urology was used as our cohort.Data were gathered on the presence of MHCs and types of providers and conditions treated.An equivalent search was performed for women’s health centers(WHCs).Results:Sixteen of 50(32%)promoted some type of MHC,compared to 49 of 50(98%)offering a WHC.Eight of the top 15 ranked institutions(53%)had an MHC compared to eight of 35(23%)remaining programs.Six of 16 MHCs incorporated providers from a variety of medical disciplines,including urologists,internists,endocrinologists,cardiologists,and psychologists,while another six of 16 MHCs were staffed solely by urologists.Eight of 16 provided services for exclusively urologic issues,four of 16 offered additional services in treatment of other medical conditions,and four of 16 did not specify. | Jeremy Choy James A.Kashanian Vidit Sharma Puneet Masson James Dupree Brian Le Robert E.Brannigan | 2015 | Asian Journal of Urology2015，2，3： | 0 |
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