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| 1 | Patterns of in-hospital mortality and bleeding complications following PCI for very elderly patients: insights from the Dartmouth Dynamic Registry显示文摘BackgroundVery 老病人(年龄 85 年) 是人口的一个很快增加的片断。作为一个组,他们经历跟随经皮的冠的干预(一种总线标准) 的在里面医院死亡和流血复杂并发症的高率。然而,在流血和死亡在之间的关系老 unknown.MethodsRetrospective 评论在 Dartmouth-Hitchcock 从 2000 ~ 2015 在 17,378 连续一种总线标准过程上被执行医学中心。在索引一种总线标准承认期间流血的发生(流血要求的输送,存取地点 hematoma > 5 厘米, pseudoaneurysm,和 retroperitoneal 流血)? 并且在里面医院死亡为四个年龄组被报导(< 65 年, 65-74 年, 75-84 年,和 85 年) 。承受了谁的流血复杂并发症和那些的病人的死亡被计算, multivariate 分析为在里面医院被执行死亡。最后,知道流血的预言者在病人年龄之间被比较 < 85 年和年龄 17,378 个病人学习了的 85 years.ResultsOf,(5.9%) 1019 经历了流血,(2.1%) 369 死了在里面医院追随者一种总线标准。流血和在里面医院死亡的发生与增加年龄 monotonically 增加了(死亡:0.94% , 2.27% , 4.24% 和 4.58% ;流血:3.96% , 6.62% , 10.68% 和 13.99% 好久 < 65, 65-74, 75-84 和 85 年,分别地) 。除了病人年龄 85 年,在 multivariate 分析上,流血为所有年龄组与增加的死亡被联系[机会比率(95% CI ) :变老 < 65 年, 3.65 (1.99-6.74 ) ;年龄 65-74 年, 2.83 (1.62-4.94 ) ;年龄 75-84 年, 3.86 (2.56-5.82 ) ,年龄 85 年:1.39 (0.49-3.95 )] 有增加的 .ConclusionsBleeding 和死亡追随者一种总线标准增加变老。为老尽管有流血的高率,流血在里面医院死亡追随者一种总线标准不再是预兆的。 | Shawn X Li Hannah I Chaudry Jiyong Lee Theodore B Curran Vishesh Kumar Kendrew K Wong Bruce W Andrus James T DeVries | 2018 | Journal of Geriatric Cardiology2018，15，2： | 6 |
| 2 | Pancreatic cancer serum biomarker PC-594:Diagnostic performance and comparison to CA19-9显示文摘AIM:To investigate serum PC-594 fatty acid levels as a potential biomarker in North American pancreatic cancer(PaC) patients,and to compare its performance to CA19-9.METHODS:Using tandem mass spectrometry,we evaluated serum PC-594 levels from 84 North American patients with confirmed PaC and 99 cancer-free control subjects.We determined CA19-9 levels by ELISA.Significance between Pa C patients and controls,and association with clinical variables was determined by analysis of variance and t-tests.Diagnostic performance was evaluated by receiver-operator characteristic(ROC)curve analysis,and PC-594 correlation with age and CA19-9 determined by regression analysis.RESULTS:Mean PC-594 levels were 3.7 times lower in Pa C patients compared to controls(P < 0.0001).The mean level in PaC patient serum was 0.76 ± 0.07 μmol/L,and the mean level in control subjects was 2.79 ± 0.15 μmol/L.There was no correlation between PC-594 and age,disease stage or gender(P > 0.05).Using 1.25 μmol/L as a PC-594 threshold produced a relative risk(RR) of 9.4(P < 0.0001,95%CI:5.0-17.7).The area under the receiver-operator characteristic curve(ROCAUC) was 0.93(95%CI:0.91-0.95) for PC-594 and 0.85(95%CI:0.82-0.88) for CA19-9.Sensitivity at 90% specificity was 87% for PC-594 and 71% for CA19-9.Six Pa C patients with CA19-9 above 35 U/m L showed normal PC-594 levels,while 24 Pa C patients with normal CA19-9 showed low PC-594 levels.Eighty-five of the 99 control subjects(86%) showed normal levels of both markers.CONCLUSION:PC-594 biomarker levels are significantly reduced in North American Pa C patients,and showed superior diagnostic performance compared to CA19-9. | Shawn A Ritchie Bassirou Chitou Qingan Zheng Dushmanthi Jayasinghe Wei Jin Asuka Mochizuki Dayan B Goodenowe | 2015 | World Journal of Gastroenterology2015，21，21： | 3 |
| 3 | Use of amino-terminal pro-B-type natriuretic peptide to guide outpatient therapy of patients with chronic left ventricular systolic dysfunction 显示文摘 | JAMES L JANUZZI JR MD SHAFIQ U REHMAN M D ASIM A MOHAMMED M D ANJU BHARDWAJ M D LINDA BARAJAS R N JUSTINE BARAJAS HAN-NA KIM M D MPH AARON L BAGGISH M D RORY B WEINER M D ANNABEL CHEN-TOURNOUX MD JANE E MARSHALL RDCS STEPHANIE A MOORE M D WILLIAM D CARLSON M D GREGORY D LEWIS M D JORDAN SHIN M D DOROTHY SULLIVAN ANP KIMBERLY PARKS D O THOMAS J WANG M D SHAWN A GREGORY M D SHANMUGAM UTHAMALINGAM M D MARC J SEMIGRAN M D | 2011 | J Am Coll Cardiol2011，58，18： | 1 |
| 4 | A genetic linkage map for hazelnut( Corylus avellana L)based on RAPD and SSR markers显示文摘 | Shawn A M Rebecca N B Eduardo R N | | 0，，02： | 1 |
| 5 | Maize HapMap2 identifies extant variation from a genome in flux 显示文摘 | Jer-Ming Chia Chi Song Peter J Bradbury Denise Cos- tich Natalia de Leon John Doebley Robert J Elshire Brandon Gaut Laura Geller Jeffrey C Glaubitz Michael Gore Kate E Guill Jim Holland Matthew B Hufford Jinsheng Lai Meng Li Xin Liu Yanli Lu Richard Mc- Combie Rebecca Nelson Jesse Poland Boddupalli M Prasanna Tanja Pyhajarvi Tingzhao Rong Rajandeep S Sekhon Qi Sun Maud I Tenaillon Feng Tian Jun Wang Xun Xu Zhiwu Zhang Shawn M Kaeppler Jef- frey Ross-lbarra Michael D McMullen Edward S Buck- ler Gengyun Zhang Yunbi Xu Doreen Ware | 2012 | Nat Genet2012，，44： | 1 |
| 6 | Template Synthesis of Bismuth Telluride Nanowires显示文摘 | Shawn A S Brinda B I Charles R M | 1999 | Advanced Materials1999，11，5： | 1 |
| 7 | High-temperature wells with lost-circulation demands and reverse-circulation techniques using foames-cement systems: Two case histories显示文摘 | Robert M Daniel L B Shawn R | | SPE 845630，200，： | 1 |
| 8 | Electrical, optical, and morphological properties of P3HT-MWNT nanocompo- sites prepared by in situ polymerization显示文摘 | Viney S Li Zhongrui Shawn B | 2009 | J Phys Chem C2009，113，19： | 1 |
| 9 | Capripoxvirus tissue tropism and shedding:A quantitative study in experimentally infected sheep and goats显示文摘 | Timothy R B Shawn L B Geoff R P | 2008 | Virology2008，，371： | 1 |
| 10 | Simulations of relative multiple spacecraft dynamics and control with MATAB-Simulink and satellite tool Kit显示文摘 | Shawn B McCamish Marcello Romano | 2007 | American Institute of Aeronautics and Astronautics2007，6805，： | 1 |
| 11 | Treatment of inor ganic contaminants using permeable reetive barriers 显示文摘 | David W B Carol J P Shawn G B | 2000 | Journal of Contaminant Hydrology2000，45，2： | 1 |
| 12 | Assessment of Genetic Diversity of Pawpaw (Asimina triloba) Cultivars with Intersimple Sequence Repeat Markers显示文摘 | Kirk W P Sheri B C Shawn P B | 2003 | Journal of the American Society for Horticultural Science2003，128，4： | 1 |
| 13 | The Apaf - 1 apoptosome : a large caspase - activating complex 显示文摘 | Kelvin Cain Shawn B Bratton | 2002 | Biochimie2002，84，： | 1 |
| 14 | Effect of dietary lipid level and protein energy ratio on growth and body composition of largemouth bass Micropterus salmoides 显示文摘 | Leigh A B Shawn D C James H T | 2005 | Journal of the World Aquaculture Society2005，36，1： | 1 |
| 15 | Alternating-direction implicit (ADI) formulation of the finite-difference time-domain (FDTD) method:algorithm and material dispersion implementation显示文摘 | Shawn W S Christopher L H Alpesh U B | 2003 | IEEE Trans on Electromagnetic Compatibility2003，45，2： | 1 |
| 16 | Highlighting heavy oil显示文摘 | HUSSEIN A JOAO F SHAWN T BOB B CHAD B BRENT B | 2006 | Oilfield Review2006，18，2： | 1 |
| 17 | The Apraf-1 apoptosome:a large caspase-activating complex显示文摘 | Kelvin Cain Shawn B Bratton Gerald M Cohen | 2002 | Biochimie2002，9，23： | 1 |
| 18 | The green tea polyphenol EGCG potentiates the anti-proliferative activity of c-Met and Epidermal growth factor receptor inhibitors in non-small cell lung cancer cells显示文摘 | Shawn AM Patrick B David TC | 2009 | Clin Cancer Res2009，15，15： | 1 |
| 19 | The Efficacy of Salvage Logging in Reducing Subsequent Fire Severity in Conifer- dominated Forests of Minnesota,USA显示文摘 | Shawn F Theresa J John B B | 2011 | Ecological Applications2011，21，6： | 1 |
| 20 | Capripoxvirus tissue tropism and shedding: a quantitative study in experimentally in- fected sheep and goats显示文摘 | Timothy R B Shawn L B Geoff R P | 2008 | Virology2008，371，： | 1 |
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