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| 1 | Hepatitis D and hepatocellular carcinoma显示文摘Hepatitis D virus(HDV) is a defective circular shape single stranded HDV RNA virus with two types of viral proteins,small and large hepatitis D antigens,surrounded by hepatitis B surface antigen.Superinfection with HDV in chronic hepatitis B is associated with a more threatening form of liver disease leading to rapid progression to cirrhosis.In spite of some controversy in the epidemiological studies,HDV infection does increase the risk of hepatocellular carcinoma(HCC) compared to hepatitis B virus(HBV) monoinfection.Hepatic decompensation,rather than development of HCC,is the first usual clinical endpoint during the course of HDV infection.Oxidative stress as a result of severe necroinflammation may progress to HCC.The large hepatitis D antigen is a regulator of various cellular functions and an activator of signal transducer and activator of transcription(STAT)3 and the nuclear factor kappa B pathway.Another proposed epigenetic mechanism by which HCC may form is the aberrant silencing of tumor suppressor genes by DNA Methyltransferases.HDV antigens have also been associated with increased histone H3 acetylation of the clusterin promoter.This enhances the expression of clusterin in infected cells,increasing cell survival potential.Any contribution of HBV DNA integration with chromosomes of infected hepatocytes is not clear at this stage.The targeted inhibition of STAT3 and cyclophilin,and augmentation of peroxisome proliferatoractivated receptor γ have a potential therapeutic role in HCC. | Zaigham Abbas Minaam Abbas Sarim Abbas Lubna Shazi | 2015 | World Journal of Hepatology2015，7，5： | 5 |
| 2 | A Synopsis on the Role of Tyrosine Hydroxylase in Parkinson’s Disease显示文摘 | Shams Tabrez Nasimudeen R. Jabir Shazi Shakil Nigel H. Greig Qamre Alam Adel M. Abuzenadah Ghazi A. Damanhouri Mohammad A. Kamal | 2012 | CNS&Neurological Disorders - Drug Targets (Formerly Current Drug Targets - CNS&Neurological Disorders)2012，，4： | 1 |
| 3 | Risk factors for acquisition of extended spectrum beta lactamase producing Escherichia coli and Klebsiella pneumoniae in North-Indian hospitals显示文摘 | Sibhghatulla S Jamale F Shazi S | 2015 | Saudi J Biolog Sci2015，22，1： | 1 |
| 4 | Dynamic model for subcritical combining flows in channel junctions显示文摘 | Shabayek Shazy Steffler Peter Hicks Faye | 2002 | Journal of Hydraulic Engineering2002，128，9： | 1 |
| 5 | Autonomic nervous system function in infants and adolescents: impact of autonomic tests on heart rate variability 显示文摘 | Longin E Dimitfiadis C Shazi S | 2009 | Pediatr Cardiol2009，30，3： | 1 |
| 6 | Crystal Structure and Interaction of Phycocyanin with β-Secretase: A Putative Therapy for Alzheimerμs Disease显示文摘 | Niraj Kumar Singh Syed S. Hasan Jitendra Kumar Isha Raj Amrin A. Pathan Asha Parmar Shazi Shakil Samudrala Gourinath Datta Madamwar | 2014 | CNS & Neurological Disorders - Drug Targets2014，，： | 1 |
| 7 | Aminoglycosides versus bacteria – a description of the action, resistance mechanism, and nosocomial battleground显示文摘 | Shazi Shakil Rosina Khan Raffaele Zarrilli Asad U. Khan | 2008 | Journal of Biomedical Science2008，，1： | 1 |
| 8 | Improving approach flow hydraulics at pump intakes 显示文摘 | Shazy A Shabayek | 2010 | International Journal of Civil & EnvironmentalEngineering2010，10，6： | 1 |
| 9 | Co-treatment with pegylated interferon alfa-2a and entecavir for hepatitis D: a randomized trial显示文摘AIM: To investigate the efficacy of pegylated interferon alfa(PEG-IFNα) therapy with and without entecavir in patients with chronic hepatitis D. METHODS: Forty hepatitis D virus(HDV) RNA positive patients were randomized to receive either PEG-IFNα-2a 180 μg weekly in combination with entecavir 0.5 mg daily(n = 21) or PEG-IFNα alone(n =19). Patients who failed to show 2 log reduction in HDV RNA level at 24 wk of treatment, or had detectable HDV RNA at 48 wk of therapy were considered as treatment failure. Treatment was continued for 72 wk in the rest of the patients. All the patients were followed for 24 wk post treatment. Intention to treat analysis was performed.RESULTS: The mean age of the patients was 26.7 ± 6.8 years, 31 were male. Two log reduction in HDV RNA levels at 24 wk of therapy was achieved in 9(43%) patients receiving combination therapy and 12(63%) patients receiving PEG-IFNα alone(P = 0.199). Decline in hepatitis B surface antigen(HBs Ag) levels was insignificant. At the end of treatment, HDV RNA was negative in 8 patients(38%) receiving combination therapy and 10 patients(53%) receiving PEG-IFNα-2a alone. Virological response persisted in 7(33%) and 8(42%) patients, respectively at the end of the 24 wk follow-up period. One responder patient in the combination arm lost HBs Ag and became hepatitis B surface antibody positive. Six out of 14 baseline hepatitis B e antigen reactive patients seroconverted and four of these seroconverted patients had persistent HDV RNA clearance.CONCLUSION: Administration of PEG-IFNα-2a with or without entecavir, resulted in persistent HDV RNA clearance in 37% of patients. The addition of entecavir did not improve the overall response. | Zaigham Abbas Mohammad Sadik Memon Muhammad Amir Umer Minaam Abbas Lubna Shazi | 2016 | World Journal of Hepatology2016，8，14： | 1 |
| 10 | Trust as a predictor of innovation network ties in project teams显示文摘 | Shazi R Gillespie N Steen J | 2015 | International Journal of Project Management2015，，33： | 1 |
| 11 | Analysis of diabetic foot ulcers in a tertiary care hospital-a clinico-microbiological perspective显示文摘Objective:To assess potential risk factors for diabetic foot ulcers infected with multidrug-resistant-organisms(MDROs)and to investigate antibiotic susceptibility patterns and extended-spectrum-β-lactamase(ESBL)-production in bacteria isolated from these ulcers.Methods:Seventy-seven diabetic foot ulcer-patients were studied in a consecutive series.Forty-four study factors were recorded for each patient.Specimens were obtained by scraping the ulcer base or the deep portion of the wound edge with a sterile curette.The soft tissue specimens were quickly sent to the laboratory and processed for microbial pathogens.Gram-negative bacterial isolates were tested for ESBL production by double-disc-diffusion method.The association of study variables with MDRO and non-MDRO infection status of ulcers was tested by Student's t test or Fisher's exact test using SPSS(version 11.5,Chicago).Results:An alarming number of patients were MDRO-positive(72.7%).ESBL-positive strains constituted 19.8% of total isolates.Staphylococcal isolates identified as methicillin-resistant Staphylococcus aureus(MRSA)and vancomycin-resistant Staphylococcus aureus(VRSA),were 3.7%(n=8)and 0.5%(n=1)respectively.Twenty-two study factors were found to be significantly associated with MDRO infection status of ulcers in the univariate analysis.Multiple logistic regressions proved that MDRO status was the only significant,independent predictor of glycemic control(Odds ratio = 4.22,P<0.01).Conclusion:It is concluded that MDRO infected patients have poor glycemic control.Imipenem and linezolid can be suggested as the drugs of choice in the described setting. | Shazi Shakil Shaista Alvi Mujahid Beg Asad U.Khan | 2010 | 海南医学院学报2010，16，2： | 0 |
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