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| 1 | Urinary nuclear magnetic resonance spectroscopy of a Bangladeshi cohort with hepatitis-B hepatocellular carcinoma: A biomarker corroboration study显示文摘AIM: To establish if a distinct urinary metabolic profile could be identified in Bangladeshi hepatitis-B hepatocellular carcinoma(HCC) patients compared to cirrhosis patients and controls. METHODS: Urine samples from 42 Bangladeshi patients with HCC(39 patients with hepatitis-B HCC), 47 with cirrhosis on a background of hepatitis B, 46 with chronic hepatitis B, and seven ethnically-matched healthy controls were analyzed using nuclear magnetic resonance(NMR) spectroscopy. A full dietary and medication history was recorded for each subject. The urinary NMR data were analyzed using principal component analysis(PCA) and orthogonal partial leastsquared discriminant analysis(OPLS-DA) techniques. Differences in relative signal levels of the most discriminatory metabolites identified by PCA and OPLSDA were compared between subject groups using an independent samples Kruskal-Wallis one-way analysis of variance(ANOVA) test with all pairwise multiple comparisons. Within the patient subgroups, the MannWhitney U test was used to compare metabolite levels depending on hepatitis B e-antigen(HBe Ag) status and treatment with anti-viral therapy. A BenjaminiHochberg adjustment was applied to acquire the level of significance for multiple testing, with a declared level of statistical significance of P < 0.05.RESULTS: There were significant differences in age(P < 0.001), weight(P < 0.001), and body mass index(P < 0.001) across the four clinical subgroups. Serum alanine aminotransferase(ALT) was significantly higher in the HCC group compared to controls(P < 0.001); serum α-fetoprotein was generally markedly elevated in HCC compared to controls; and serum creatinine levels were significantly reduced in the HCC group compared to the cirrhosis group(P = 0.004). A threefactor PCA scores plot showed clustering of the urinary NMR spectra from the four subgroups. Metabolites that contributed to the discrimination between the subgroups included acetate, creatine, creatinine, dimethyamine(DMA), formate, glycine, hippurate, and trimethylamine-N-oxide(TMAO). A comparison of relative metabolite levels confirmed that carnitine was significantly increased in HCC; and creatinine, hippurate, and TMAO were significantly reduced in HCC compared to the other subgroups. HBe Ag negative patients showed a significant increase in creatinine(P = 0.001) compared to HBe Ag positive patients in the chronic hepatitis B subgroup, whilst HBe Ag negative patients showed a significant decrease in DMA(P = 0.004) in the cirrhosis subgroup compared to HBe Ag positive patients. There were no differences in metabolite levels in HCC patients who did or did not receive antiviral treatment. CONCLUSION: Urinary NMR changes in Bangladeshi HCC were identified, corroborating previous findings from Egypt and West Africa. These findings could form the basis for the development of a cost-effective HCC dipstick screening test. | I Jane Cox Abil E Aliev Mary ME Crossey Mahvish Dawood Mamun Al-Mahtab Sheikh M Akbar Salimur Rahman Antonio Riva Roger Williams Simon D Taylor-Robinson | 2016 | World Journal of Gastroenterology2016，22，16： | 4 |
| 2 | The development of live load for long span bridges显示文摘 | Nowak A S Lutomirska M Sheikh Ibrahim F I | 2010 | Bridge Structures-Assessment Design&Construction2010，6，1： | 1 |
| 3 | Role of ultrasonography in blunt abdominal trauma,a prospective study显示文摘 | Al-Zayat I Sheikh M Mousa I Behbe-hani A | 1996 | Eur J Surg1996，162，： | 1 |
| 4 | The development of live load for long span bridges 显示文摘 | Nowak A S Lutomirska M Sheikh Ibrahim F I | 2010 | Bridge Structures--Assessment Design & Construction2010，6，1： | 1 |
| 5 | Comparison of visual recovery and refractive stability between femtosecond laser-assisted cataract surgery and standard phacoemulsification:six-month follow-up显示文摘 | Conrad-Hengerer I Al Sheikh M Hengerer F H | 2015 | Journal of Cataract&Refractive Surgery2015，41，7： | 1 |
| 6 | Comparison of visual recovery and refractive stability between femtosecond laser-assisted cataract surgery and standard phacoemulsification : six-month follow-up 显示文摘 | Conrad-Hengerer I Al Sheikh M Hengerer FH | 2015 | J Cataract Refract Surg2015，41，： | 1 |
| 7 | The response of Limousine x Friesian steers fed silage and concentrates to the addition of supplemental yeast culture (Yea-Sacc) and/or an antibiotic additive (Avotan)显示文摘 | Edwards I E Toops J H El Sheikh M | 1991 | Journal of Animal Production1991，51，： | 1 |
| 8 | Ultrasonographic diagnosis in abdominal tuberculosis显示文摘 | Sheikh M Moosa I Hussein FM | 1999 | Australas Radiol1999，43，2： | 1 |
| 9 | Amino acid composition of spring wheat and losses of lysine during chapatti baking显示文摘 | Anjum F M Ahmad I Butt M S Sheikh M A Pasha I | 2005 | Journal of Food Composition and Analysis2005，18，6： | 1 |
| 10 | Effect of hemorrhagie shoek and reperfusion on the respiratory quotient in swine显示文摘 | Cohen I L Sheikh F M Perkins R J | 1995 | Crit Care Med1995，23，3： | 1 |
| 11 | Spinal dural arteriovenous fistula mimicking prostate hyperplasia 显示文摘 | Sheikh S I Busl K M Ning M | 2011 | J Emerg Med2011，41，6： | 1 |
| 12 | Effect of solution pH, ionic strength, and temperature on adsorption behavior of reactive dyes on activated carbon 显示文摘 | Al - Degs Y S El - Barghouthi M I El - Sheikh A H | 2008 | Dyes and Pigmems2008，77，： | 1 |
| 13 | Hepatitis C virus infection:molecular pathways to metabolic syndrome显示文摘 | SHEIKH M Y CHOI J QADRI I | 2008 | Hepatology2008，47，6： | 1 |
| 14 | Effect of hemorrhagic shock and reperfusion on the respiratory quotient in swine显示文摘 | Cohen I L Sheikh F M Perkins R J | 1995 | Crit Care Med1995，23，5： | 1 |
| 15 | Spacecraft navigation using x-ray pulsars显示文摘 | Sheikh S I Pines D J Ray P S Wood K S Lovellette M N Wolff M T | 2006 | Journal of Guidance Control and Dynamics2006，29，1： | 1 |
| 16 | Amino acid compo- sition of spring wheat and losses of lysine during chapatti baking显示文摘 | Anjum F M Ahmad I Sheikh M A | 2005 | Journal of Food Composition and Analysis2005，18，： | 1 |
| 17 | Effect of rainwater harvesting on the establishment of tree species 显示文摘 | Sheikh M I Shah B H Aleem A | 1984 | Forest Ecology and Management1984，8，314： | 1 |
| 18 | Smoothing controlof wind generator output fluctuations by PWM voltage source con-verter and chopper controlled SMES 显示文摘 | MR I Sheikh S M Muyeen R Takahashi | 2011 | European Transactions onElectrical Power2011，21，1： | 1 |
| 19 | Enhancing Privacy and Security of RFID System with Serverless Authentication and Search Protocols in Pervasive Environments 显示文摘 | HOQUE M E RAHMAN F SHEIKH I | 2010 | Wire- less Pers Commun2010，55，： | 1 |
| 20 | Efficacy of Dexmedetomidine in suppressing cardiovascular and hormonal re- sponses to general anaesthesia for caesarean delivery : a dose - re- sponse study显示文摘 | EL TAHAN M R MOWAFI H A AL SHEIKH I H | 2012 | Int J Obstet Anesth2012，21，3： | 1 |
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