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| 1 | 男性性功能障碍、男性不育与神经系统疾病之间的关系显示文摘正常的性功能和生殖功能很大程度上依赖于神经系统功能的正常发挥。男性神经系统受损可导致勃起功能障碍、射精障碍和精液异常,进而导致不育。出现这些受损的主要原因有盆腔和腹腔损伤、糖尿病、先天性脊柱异常,多发性硬化症和脊髓受损。勃起功能障碍已经可以通过越来越具侵入式的治疗方法而有所改善,从药物疗法、注射疗法到外科的阴茎植入术。病情较轻的逆行射精患者可以用药物来逆转条件进行治疗,对病情较重的患者,则在射精后从其膀胱中收取精液。对于中度的不射精者,可以采用药物治疗:而对于严重者,则可采用阴茎震荡刺激和电射精等辅助射精技术。假如这些措施都失败了,可尝试采用手术方法取精液。对于一些脊髓受损的男性,假如环境条件和精液质量足够好,可在家中采用阴茎震荡刺激,然后将精液放入伴侣阴道内。其他方法就要求助于辅助生殖技术了,包括宫内受精和体外受精(用ICSI或者不用)。选用何种方法在很大程度上依赖于患者精液中活性精子的数量。 | Mikkel Fode Sheila Krogh-Jespersen Nancy L Brackett Dana A Ohl Charles M Lynne Jens Sonksen | 2012 | Asian Journal of Andrology2012，14，1： | 7 |
| 2 | Translational pancreatic cancer research:a comparative study on patient-derived xenograft models显示文摘AIM To assess the viability of orthotopic and heterotopic patient-derived pancreatic cancer xenografts implanted into nude mice.METHODS This study presents a prospective experimental analytical follow-up of the development of tumours in mice upon implantation of human pancreatic adenocarcinoma samples. Specimens were obtained surgically from patients with a pathological diagnosis of pancreatic adenocarcinoma. Tumour samples from pancreatic cancer patients were transplanted into nude mice in three different locations(intraperitoneal, subcutaneous and pancreatic). Histological analysis(haematoxylin-eosin and Masson's trichrome staining) and immunohistochemical assessment of apoptosis(TUNEL), proliferation(Ki-67), angiogenesis(CD31) and fibrogenesis(α-SMA) were performed. When a tumour xenograft reached the target size, it was reimplanted in a new nude mouse. Three sequential tumour xenograft generations were generated(F1, F2 and F3).RESULTS The overall tumour engraftment rate was 61.1%. The subcutaneous model was most effective in terms of tissue growth(69.9%), followed by intraperitoneal(57.6%) and pancreatic(55%) models. Tumour development was faster in the subcutaneous model(17.7 ± 2.6 wk) compared with the pancreatic(23.1 ± 2.3 wk) and intraperitoneal(25.0 ± 2.7 wk) models(P = 0.064). There was a progressive increase in the tumour engraftment rate over successive generations for all three models(F1 28.1% vs F2 71.4% vs F3 80.9%, P < 0.001). There were no significant differences in tumour xenograft differentiation and cell proliferation between human samples and the three experimental models among the sequential generations of tumour xenografts. However, a progressive decrease in fibrosis, fibrogenesis, tumour vascularisation and apoptosis was observed in the three experimental models compared with the human samples. All three pancreatic patient-derived xenograft models presented similar histological and immunohistochemical characteristics.CONCLUSION In our experience, the faster development andgreatest number of viable xenografts could make the subcutaneous model the best option for experimentation in pancreatic cancer. | Mercedes Rubio-Manzanares Dorado Luis Miguel Marín Gómez Daniel Aparicio Sánchez Sheila Pereira Arenas Juan Manuel Praena-Fernández Juan Jose Borrero Martín Francisco Farfán López Miguel ángel Gómez Bravo Jordi Muntané Relat Javier Padillo Ruiz | 2018 | World Journal of Gastroenterology2018，24，7： | 2 |
| 3 | Competitive Intelligence: A Practitioner,Academic and Inter - disciplinary Perspective 显示文摘 | Calof Jonathan L Wright Sheila | 2008 | European Journal of Marketing2008，42，78： | 1 |
| 4 | Adapting parentchild interaction therapy for young children with separation anxiety disorder显示文摘 | Donna B Pincus Sheila M Eyberg Molly L Choate | 2005 | Education and Treatment of Children2005，28，2： | 1 |
| 5 | Bring Semantics to Web Services显示文摘 | SHEILA A MARTIN D L | 2003 | IEEE Intelligent Systems2003，18，1： | 1 |
| 6 | An analysis of mass casualty incidents in the setting of mass gatherings and special events 显示文摘 | Sheila A T Adam L Ronald R B | 2014 | Disaster Med Public Health Prep2014，7，1： | 1 |
| 7 | Outcomes of Parent-Child Interaction Therapy : A Comparison of Treatment Completers and Study Dropouts One to Three Years Later 显示文摘 | Boggs Stephen R Eybert Sheila M Edwards Daniel L | 2005 | Child and Family Behavior Therapy2005，26，4： | 1 |
| 8 | The effects of ponazuril on development of apicomplexans in vitro显示文摘 | Mitchell Sheila M Zajac Anne M Davis Wendell L | 2005 | Journal of Eukaryotic Microbiology2005，52，3： | 1 |
| 9 | Catecbol-O-methyl-transferase (COMT)-mediated metabolism of catechol estrogens: comparison of wild-type and variant COMT Isoforms 显示文摘 | SHEILA D NADY R ROY MOND L | 2001 | Cancer Research2001，，61： | 1 |
| 10 | Comparison of propofol and midazolam for sedation in aritically patients显示文摘 | Aitkenhead Alam R Peppeman Michael L Williams Sheila M | 1989 | Lancet1989，232，8665： | 1 |
| 11 | Efficacy of ponazuril in vitro and in preventing and treating Toxoplasma gondii infections in mice显示文摘 | Mitchell Sheila M Zajac Anne M Davis Wendell L | 2004 | Journal of Parasitology2004，90，3： | 1 |
| 12 | The effectiveness of the Bobath concept instroke rehabilitation:what is the evidence显示文摘 | Boudesijn J K Sheila L Bernadette L | 2009 | Stroke2009，40，4： | 1 |
| 13 | Topical tetracaine prior to arterial puncture: a randomized, placebo-controlled clinical trial显示文摘 | Shawn D Aaron Katherine L Vandemheen Sheila A Naftel Mary-Jo Lewis Marc A Rodger | 2003 | Respiratory Medicine2003，，11： | 1 |
| 14 | Catechol-O-methyltransferase ( COMT)-mediated metabolism of catechol estrogens:comparison of wild-type and variant COMT Isoforms显示文摘 | Sheila D Nady R Roy mond L | 2001 | Cancer Research2001，61，： | 1 |
| 15 | The development of a naturalistic data collection system to perform critical incident analysis: an investigation of safety and fatigue issues in long-haul trucking显示文摘 | Dingus Thomas A Neale Vicki L Klauer Sheila G | 2006 | Accident Analysis and Prevention2006，38，6： | 1 |
| 16 | Bring Semantics to Web Services显示文摘 | Sheila A Martin D L | 2003 | IEEE Intelligent Systems2003，18，1： | 1 |
| 17 | A high performance liquid chromatographic determination of major phenolic compounds in tobacco smoke显示文摘 | Carmella H Risnert Sheila L Cash | 1990 | J Chromat Sci1990，28，： | 1 |
| 18 | Caring-human science philosophy in nursing education:Beyond the curriculum revolution显示文摘 | Sheila L Martha R Rahel N | 2006 | Inter J Human Caring2006，10，4： | 1 |
| 19 | An enzymatically active artificial redox coenzyme based on synthetic dye template 显示文摘 | Sheila B M Christopher R L | 1997 | Enzyme and Microbial Technology1997，20，： | 1 |
| 20 | A high-performance liquid chromatographic determination of major phenolic compounds in tobacco smoke显示文摘 | CHARLES H R SHEILA L C | 1990 | J Chromatogr Sci1990，28，： | 1 |
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