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| 1 | Microglia regulation of synaptic plasticity and learning and memory显示文摘Microglia are the resident macrophages of the central nervous system.Microglia possess varied morphologies and functions.Under normal physiological conditions,microglia mainly exist in a resting state and constantly monitor their microenvironment and survey neuronal and synaptic activity.Through the C1 q,C3 and CR3'Eat Me'and CD47 and SIRPα'Don't Eat Me'complement pathways,as well as other pathways such as CX3 CR1 signaling,resting microglia regulate synaptic pruning,a process crucial for the promotion of synapse formation and the regulation of neuronal activity and synaptic plasticity.By mediating synaptic pruning,resting microglia play an important role in the regulation of experience-dependent plasticity in the barrel cortex and visual cortex after whisker removal or monocular deprivation,and also in the regulation of learning and memory,including the modulation of memory strength,forgetfulness,and memory quality.As a response to brain injury,infection or neuroinflammation,microglia become activated and increase in number.Activated microglia change to an amoeboid shape,migrate to sites of inflammation and secrete proteins such as cytokines,chemokines and reactive oxygen species.These molecules released by microglia can lead to synaptic plasticity and learning and memory deficits associated with aging,Alzheimer's disease,traumatic brain injury,HIV-associated neurocognitive disorder,and other neurological or mental disorders such as autism,depression and post-traumatic stress disorder.With a focus mainly on recently published literature,here we reviewed the studies investigating the role of resting microglia in synaptic plasticity and learning and memory,as well as how activated microglia modulate disease-related plasticity and learning and memory deficits.By summarizing the function of microglia in these processes,we aim to provide an overview of microglia regulation of synaptic plasticity and learning and memory,and to discuss the possibility of microglia manipulation as a therapeutic to ameliorate cognitive deficits associated with aging,Alzheimer's disease,traumatic brain injury,HIV-associated neurocognitive disorder,and mental disorders. | Jessica Cornell Shelbi Salinas Hou-Yuan Huang Miou Zhou | 2022 | Neural Regeneration Research2022，17，4： | 26 |
| 2 | Toward targeting inflammasomes: insights into their regulation and activation显示文摘Inflammasomes are multi-component signaling complexes critical to the initiation of pyroptotic cell death in response to invading pathogens and cellular damage.A number of innate immune receptors have been reported to serve as inflammasome sensors.Activation of these sensors leads to the proteolytic activation of caspase-1,a proinflammatory caspase responsible for the cleavage of proinflammatory cytokines interleukin-1β and interleukin-18 and the effector of pyroptotic cell death,gasdermin D.Though crucial to the innate immune response to infection,dysregulation of inflammasome activation can lead to the development of inflammatory diseases,neurodegeneration,and cancer.Therefore,clinical interest in the modulation of inflammasome activation is swiftly growing.As such,it is imperative to develop a mechanistic understanding of the regulation of these complexes.In this review,we divide the regulation of inflammasome activation into three parts.We discuss the transcriptional regulation of inflammasome components and related proteins,the post-translational mechanisms of inflammasome activation,and advances in the understanding of the structural basis of inflammasome activation. | Shelbi Christgen David E.Place Thirumala-Devi Kanneganti | 2020 | Cell Research2020，30，4： | 17 |
| 3 | Indirect traumatic optic neuropathy:modeling optic nerve injury in the context of closed head trauma显示文摘Traumatic optic neuropathy:Traumatic brain injury is one of the leading causes of disability and mortality in the United States.It impacts people of all ages and demographics,particularly younger males and members of the military.Vision loss is commonly associated with traumatic brain injuries of all severities and can leave patients permanently disabled.This vision loss can be caused by injury to the visual system at multiple levels,including the eyes,optic nerves,and many different sites in the brain and brainstem(Sen,2017).Despite the far-reaching effects of visual impairment after traumatic brain injury,its incidence after traumatic brain injury is not well measured,and few successful treatments have been identified or implemented. | Emma G.Burke Shelby M.Cansler Nathan K.Evanson | 2019 | Neural Regeneration Research2019，14，4： | 14 |
| 4 | Gastric cancer in Alaska Native people: A cancer health disparity显示文摘AIM To evaluate recent trends in gastric cancer incidence, response to treatment, and overall survival among Alaska Native(AN) people. METHODS A retrospective analysis of the Alaska Native Medical Center patient database was performed. Patient history, clinical, pathological, response to treatment and patient outcomes were collected from one-hundred and thirty-two AN gastric cancer patients. The Surveillance, Epidemiology and End Result database 18 was used to collect comparison United States non-Hispanic White(NHW) and AN gastric cancer patient data between 2006-2014.RESULTS AN gastric cancer patients have a higher incidence rate, a poorer overall survival, and are diagnosed at a significantly younger age compared to NHW patients. AN patients differ from NHW patients in greater prevalence of non-cardia, diffuse subtype, and signet ring cell carcinomas. AN females were more likely to be diagnosed with later stage cancer, stage IV, compared to AN males. Diminished overall survival was observed among AN patients with increasing stage, O+ blood type, < 15 lymph nodes examined at resection, and no treatment. This study is the first report detailing the clinicopathologic features of gastric cancer in AN people with outcome data.CONCLUSION Our findings confirm the importance of early detection, treatment, and surgical resection for optimizing AN patient outcomes. Further research on early detection markers are warranted. | Holly A Martinson Nancy J Shelby Steven R Alberts Matthew J Olnes | 2018 | World Journal of Gastroenterology2018，24，25： | 6 |
| 5 | Corn growth and nitrogen nutrition after additions of biochars with varying properties to a temperate soil显示文摘 | Shelby Rajkovich Akio Enders Kelly Hanley Charles Hyland Andrew R. Zimmerman Johannes Lehmann | 2012 | Biology and Fertility of Soils2012，，3： | 2 |
| 6 | Social learning contributions to the etiology and treatment of functional abdominal pain and inflammatory bowel disease in children and adults显示文摘This paper reviews empirical work on cognitive and social learning contributions to the etiology and treatment of illness behavior associated with functional abdominal pain and inflammatory bowel disease. A particular emphasis is placed on randomized controlled trials, the majority of which are multi-modal in orientation, incorporating elements of cognitive behavioral therapy, social learning, and relaxation. Based on this review, we offer methodological and clinical suggestions: (1) Research investigations should include adequate sample sizes, long-term follow-up assessments, and a credible, active control group. (2) Standard gastrointestinal practice should include, when appropriate, learning opportunities for patients and family members, for example, instruction regarding the encouragement of wellness behavior. | Rona L Levy Shelby L Langer William E Whitehead | 2007 | World Journal of Gastroenterology2007，13，17： | 2 |
| 7 | A comparison of the relative efficiency of ICSI and extended culture with epididymal sperm versus testicular sperm in patients with obstructive azoospermia显示文摘This is a retrospective cohort study comparing blastocyst transfer outcomes following intracytoplasmic sperm injection utilizing epididymal versus testicular sperm for men with obstructive azoospermia.All cases at a single center between 2012 and 2016 were included.Operative approach was selected at the surgeon’s discretion and included microepididymal sperm aspiration or testicular sperm extraction.Blastocyst culture was exclusively utilized prior to transfer.The primary outcome was live birth rate.Secondary outcomes included fertilization rate,blastulation rate,euploidy rate,and implantation rate.A mixed effects model was performed.Seventy-six microepididymal sperm aspiration cases and 93 testicular sperm extraction cases were analyzed.The live birth rate was equivalent(48.6%vs 50.5%,P=0.77).However,on mixed effects model,epididymal sperm resulted in a greater likelihood of fertilization(adjusted OR:1.37,95%CI:1.05–1.81,P=0.02)and produced a higher blastulation rate(adjusted OR:1.41,95%CI:1.1–1.85,P=0.01).As a result,the epididymal sperm group had more supernumerary blastocysts available(4.3 vs 3,P<0.05).The euploidy rate was no different.Pregnancy rates were no different through the first transfer cycle.However,intracytoplasmic sperm injection following microepididymal sperm aspiration resulted in a greater number of usable blastocysts per patient.Thus,the true benefit of epididymal sperm may only be demonstrated via a comparison of cumulative pregnancy rates after multiple transfers from one cohort. | Scott J Morin Brent M Hanson Caroline R Juneau Shelby A Neal Jessica N Landis Richard T Scott Jr James M Hotaling | 2020 | Asian Journal of Andrology2020，22，2： | 2 |
| 8 | ASGE Bariatric Endoscopy Task Force systematic review and meta-analysis assessing the ASGE PIVI thresholds for adopting endoscopic bariatric therapies显示文摘 | Barham K. Abu Dayyeh Nitin Kumar Steven A. Edmundowicz Sreenivasa Jonnalagadda Michael Larsen Shelby Sullivan Christopher C. Thompson Subhas Banerjee | 2015 | Gastrointestinal Endoscopy2015，，3： | 2 |
| 9 | Endoscopic bariatric therapies显示文摘 | Barham K. Abu Dayyeh Steven A. Edmundowicz Sreenivasa Jonnalagadda Nitin Kumar Michael Larsen Shelby Sullivan Christopher C. Thompson Subhas Banerjee | 2015 | Gastrointestinal Endoscopy2015，，5： | 2 |
| 10 | Formation and propeties of rare earth aluminosilicate glasses显示文摘 | Kohli J T Shelby J E | 1991 | Phy Chem Glasses1991，32，2： | 1 |
| 11 | Evaluation of a three-exposure mouse bone marrow micronucleus protocol: Results with 49 chemicals 显示文摘 | SHELBY M D EREXSON G L HOOK G J | 1993 | Environ Molec Mutag1993，21，： | 1 |
| 12 | Experimental verification of a negative index of refraction显示文摘 | Shelby R A Smith D R Schuha S | 2001 | Science2001，292，： | 1 |
| 13 | Factors influencing mortality in hip fractures显示文摘 | Lorhan PH Shelby EA | 1964 | Anesth Analg1964，43，： | 1 |
| 14 | Induction of rat UDP-glucuronosyhransferas- es in liver and duodenum by microsomal enzyme inducers that activate various transcriptional pathways 显示文摘 | Shelby MKKlaassen CD | 2006 | Drug Metab Dispos2006，34，10： | 1 |
| 15 | Experimental Verification of a Negative Index of Refraction显示文摘 | SHELBY R A SMITH D R SCHULTZ S | 2001 | Science2001，292，： | 1 |
| 16 | Experimental Verification of a Negative Index of Refraction显示文摘 | SHELBY R A SMITH D R SCHULTZ S | 2001 | Science2001，292，5514： | 1 |
| 17 | Experimental verification of a negative index of refraction显示文摘 | SHELBY R A SMITH D R SCHULTZ S | 2001 | Science2001，292，10： | 1 |
| 18 | Experimental verification of a negative index of refraction显示文摘 | SHELBY R A SMITH D R SCHULTZ S | 2001 | Science2001，292，4： | 1 |
| 19 | The Commitment-Trust Theory of Relationship Marketing 显示文摘 | Morgan Robert M Shelby D Hunt | 1994 | Journal of Marketing1994，58，7： | 1 |
| 20 | Bacillomycin D:an iturin with antifungal activity against Aspergillus flavus显示文摘 | Moyne A L Shelby R Cleveland T E | 2001 | J Appl Microbiol2001，90，： | 1 |
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