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| 1 | Sleep deprivation increase the expression of inducible heat shock protein 70 in rat gastric mucosa显示文摘AIM To .investigate if sleep deprivation is able to increase the expression of inducible heat shock protein 70 in gastric mucosa and its possible role in mucosal defense.METHODS Rats for sleep disruption were placed inside a computerized rotating drum, gastric mucosa was taken from rats with 1, 3 and 7 d sleep deprivation. RT-PCR,immunohistochemistry and Western blotting were used to determine the expression of heat shock protein 70.Ethanol (500 mL@ L 1, I.g.) was used to induce gastric muceea damage.RESULTS RT-PCR, Western blotting and immunostaining confirmed that the sleep deprivation as a stress resulted in significantly greater expression of inducible heat shock protein 70 in gastric mucosa of rats. After the 500mL@ L-1 ethanol challenge, the ulcer area found in the rats with 7 d sleep deprivation (19.15 ± 4.2) mm2 was significantly lower (P<0.01) than the corresponding control (53.7 ± 8.1) mm2.CONCLUSION Sleep deprivation as a stress, in addition to lowering the gastric mucosal barrier, is able to stimulate the expression of inducible heat shock protein 70 in gastric mucosa of rats, the heat shock protein 70 may play an important role in gastric mucosal protection. | Xi-Zhong Shen Marcel W.L. Koo Chi-Hin Cho Department of Gastroenterology,Zhongshan Hospital,Fudan University,136 Yixueyuan Road,Shanghai 200032,ChinaDepartment of Pharmacology.Faculty of Medicine,University of Hong Kong,5 Sassoon Road,Pokfulam,Hong Kong,ChinaSupported by .Dr.Marcel W.L.Koo,Department of Pharmacology,FacuLty of Medicine,the University of Hong Kong,5 Sassoon Road,Hong Kong,China.Wlkoo@hkusua.hku.hk | 2001 | World Journal of Gastroenterology2001，7，4： | 14 |
| 2 | 周予同论经史关系之演变──纪念周先生诞辰百周年显示文摘本文系听周予同先生讲课的笔记整理稿。文中论述了史之起源问题,以及经史关系演变的四个阶段。两汉时代,“史附于经”;魏晋至隋唐,“史次于经”;南来至清末,“经等于史”;五四运动以后,“经属于史”。对于这种演变过程的社会原因,也作了精辟的分析。 | Reorganized and Noted by Xu Daoxun &. Shen Lihua | 1998 | 复旦学报(社会科学版)1998，40，1： | 9 |
| 3 | Parallel algorithm for real-time contouring from grid DEM on modern GPUs显示文摘A real-time algorithm for constructing contour maps from grid DEM data is pre-sented.It runs completely within the programmable 3D visualization pipeline.The interpolation is paralleled by rasterizer units in the graphics card,and contour line extraction is paralleled by pixel shader.During each frame of the rendering,we first make an elevation gradient map out of original terrain vertex data,then figure out the final contour lines with image-space processing,and directly blend the results on the original scene to obtain a final scene with contour map using alpha-blending.We implement this method in our global 3D-digitalearth system with Direct3D?9.0c API and tested on some consumer level PC platforms.For arbitrary scene with certain LOD level,the process takes less than 10 ms,giving topologically correct,anti-aliased contour lines. | CHEN Zhuo,SHEN Lei,ZHAO YanQing & YANG ChongJun State Key Laboratory of Remote Sensing Science,Jointly Sponsored by the Institute of Remote Sensing Applications of Chinese Academy of Sciences and Beijing Normal University,Beijing 100101,China | 2010 | Science China(Technological Sciences)2010，53，S1： | 3 |
| 4 | The relationship between body mass index and physical activity levels in relation to bone mineral density in premenopausal and postmenopausal women 显示文摘 | Wee J Sng BY Shen L | 2013 | Arch Osteoporos2013，8，： | 1 |
| 5 | Andrographolide cau- ses apoptosis via inactivation of STAT3 and Akt and poten- tiates antitumor activity of gemcitabine in pancreatic cancer 显示文摘 | Bao GQ Shen BY Pan CP | 2013 | Toxicol Lett2013，222，1： | 1 |
| 6 | Current research in perineu- ral invasion of cholangioeareinoma显示文摘 | Shen FZ Zhang BY Feng YJ | 2010 | J Exp Clin Cancer Res2010，29，10： | 1 |
| 7 | Over- expression of myocilin in cultured human trabecular meshwork cells显示文摘 | Wentz-Hunter K Shen X Okazaki K Tanihara H Yue BY | 2004 | Exp Cell Res2004，297，1： | 1 |
| 8 | Liquefying panniculitis associated with intraductal papillary mucinous neoplasm显示文摘 | Qian DH Shen BY Zhan X | 2011 | JRSM Short Rep2011，2，5： | 1 |
| 9 | Improvement of xylosefermentation in respiratory-deficient xylose-fermentingSaccharomyces cerevisiae显示文摘 | Peng BY Shen Y Li XW | 2012 | Metabolic Engineering2012，14，1： | 1 |
| 10 | Early treatment response of fluocinolone (retisert) implantation in patients with uveitic macular edema: an optical coherence tomography study显示文摘 | Shen BY Punjabi OS Lowder CY | 2013 | Retina2013，33，4： | 1 |
| 11 | Clinical and pathological analysis of 27 patients with combined hepatocellular- cholangiocarcinoma in an Asian center 显示文摘 | Zhan Q Shen BY Deng XX | 2012 | J Hepatobiliary Pancreat Sei2012，19，4： | 1 |
| 12 | Liquid crystalline and monot ropic phase behaviors of 2,3,6,7,10,11-hexa (4-octyloxybenzoyloxy) triphenylene discotic molecules显示文摘 | Tang BY Ge J J Zhang A Calhoun B Chu P Wang H Shen Z Harris F W Cheng S Z D | | 0，，01： | 1 |
| 13 | Andrographolide causes apoptosis via inactivation of STAT3 and akt and potentiates antitumor activity of gemcitabine in pancreatic cancer显示文摘 | Bao GQ Shen BY Pan CP | 2013 | Toxicol Lett2013，222，1： | 1 |
| 14 | Radical resection of gallbladdercancer:could it be robotic?显示文摘 | Shen BY Zhan Q Deng XX | 2012 | Surg Endosc2012，26，11： | 1 |
| 15 | Radical resection of gallblad- der cancer: could it be robotic? 显示文摘 | Shen BY Zhan Q Deng XX | 2012 | Surg Endosc2012，26，11： | 1 |
| 16 | Current research in perineural invasion of cholangioeareinortm显示文摘 | SHEN FZ ZHANG BY FENG YJ | 2010 | J Exp Clin Cancer Res2010，29，： | 1 |
| 17 | Current research in perineural invasion of cholangiocarcinoma 显示文摘 | Shen FZ Zhang BY Feng YJ | 2010 | J Exp Clin Cancer Res2010，29，： | 1 |
| 18 | SKP1 - CULLIN1 - F - box (SCF) -mediated DRG2 degradation facilitated chemotherapeutic drugs induced apoptosis in hepatocellular carcinoma cells 显示文摘 | Chen J Shen BY Dang XX | 2012 | Biochem Biophys Res Commun2012，420，3： | 1 |
| 19 | Early experience for the robotic duodenum-preserving pancreatic head resec- tion显示文摘 | Peng CH Shen BY Deng XX | 2012 | World J Surg2012，36，5： | 1 |
| 20 | Effects of lipo-prostaglandin E1 on pulmonary hemodynamics and clinical outcomes in patients with pulmonary arterial hypertension显示文摘 | Shen JY He B Wang BY | 2005 | Chest2005，128，2： | 1 |
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