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| 1 | Liver transplantation for a giant mesenchymal hamartoma of the liver in an adult: Case report and review of the literature显示文摘Mesenchymal hamartomas of the liver(MHLs) in adults are rare and potentially premalignant lesions, which present as solid/cystic neoplasms. We report a rare case of orthotopic liver transplantation in a patient with a giant MHL. In 2013, a 34-year-old female sought medical advice after a 2-year history of progressive abdominal distention and respiratory distress. Physical examination revealed an extensive mass in the abdomen. Computed tomography(CT) of her abdomen revealed multiple liver cysts, with the diameter of largest cyst being 16 cm × 14 cm. The liver hilar structures were not clearly displayed. The adjacent organs were compressed and displaced. Initial laboratory tests, including biochemical investigations and coagulation profile, were unremarkable. Tumor markers, including levels of AFP, CEA and CA19-9, were within the normal ranges. The patient underwent orthotopic liver transplantation in November 2013, the liver being procured from a 40-year-old man after cardiac death following traumatic brain injury. Warm ischemic time was 7.5 min and cold ischemic time was 3 h. The recipient underwent classical orthotopic liver transplantation. The recipient operative procedure took 8.5 h, the anhepatic phase lasting for 1 h without the use of venovenous bypass. The immunosuppressive regimen includedintraoperative induction with basiliximab and high-dose methylprednisolone, and postoperative maintenance with tacrolimus, mycophenolate mofetil, and prednisone. The recipient's diseased liver weighed 21 kg(dry weight) and measured 41 cm × 32 cm × 31 cm. Histopathological examination confirmed the diagnosis of an MHL. The patient did not experience any acute rejection episode or other complication. All the laboratory tests returned to normal within one month after surgery. Three months after transplantation, the immunosuppressive therapy was reduced to tacrolimus monotherapy, and the T-tube was removed after cholangiography showed no abnormalities. Twelve months after transplantation, the patient remains well and is fulfilling all normal activities. Adult giant MHL is extremely rare. Symptoms, physical signs, laboratory results, and radiographic imaging are nonspecific and inconclusive. Surgical excision of the lesion is imperative to make a definite diagnosis and as a cure. Liver transplantation should be considered as an option in the treatment of a non-resectable MHL. | Jiang Li Jin-Zhen Cai Qing-Jun Guo Jun-Jie Li Xiao-Ye Sun Zhan-Dong Hu David KC Cooper Zhong-Yang Shen | 2015 | World Journal of Gastroenterology2015，21，20： | 3 |
| 2 | MR imaging findings of enteroviral encephaloymelitis:an outbreak in Taiwan显示文摘 | Shen WC Chiu HH Chow KC | 1999 | AJNR Am J Neuroradiol1999，20，10： | 1 |
| 3 | MR imaging findings of entero- viral encephaloymelitis: an outbreak in Taiwan显示文摘 | Shen WC Chiu HH Chow KC | 1999 | Am J Neuroradi- ol1999，20，10： | 1 |
| 4 | LactobaciUus rham- nosus Strain GG Prevents Enterohemorrhagic Escherichia coli O157 :H7 - Induced Changes in Epithelial Barrier Function 显示文摘 | Johnson Henry KC Donato KA Shen Tu G | 2008 | Infect Immun2008，76，4： | 1 |
| 5 | 3-OH flavone inhibition of epidermal growth factor-induced proliferation through blocking prostaglandin E2 production 显示文摘 | Shen SC Ko CH Hsu KC | 2004 | Int J Cancer2004，108，： | 1 |
| 6 | Clinical implications and riskfactors of extended-spectrum beta-lactamase-producing Kleb-siella pneumoniae infection in children:a case-control retro-spective study in a medical center in southern Taiwan显示文摘 | Kuo KC Shen YH Hwang KP | 2008 | JMicrobiol Immunol Infect2008，40，3： | 1 |
| 7 | Nitrification driven by bacteria andnot Archaea in nitrogen-rich grassland soils显示文摘 | Di HJ Cameron KC Shen JP Winefield CS O’CallaghanM Bowatte S He JZ | 2009 | NatureGeoscience2009，2，62： | 1 |
| 8 | Dendritic cell: activation and maturation-applications for cancer immunotherapy显示文摘 | Shen KC Pietersz GA Wright MD | 2005 | Curr Med Chem2005，12，15： | 1 |
| 9 | MR imaging findings of enteroviral encephaloymelitis:an outbreak in Taiwan显示文摘 | Shen WC Chiu HH Chow KC | | 0，，： | 1 |
| 10 | Clinical implications and risk factors of extended-spectrum beta-lactamase-producing Kleb- siella pneumoniae infection in children: a case-control retro- spective study in a medical center in southern Taiwan 显示文摘 | Kuo KC Shen YH Hwang KP | 2007 | J M i- crobiol Immunol Infect2007，40，3： | 1 |
| 11 | Recent progress in protein subcellularlocation prediction显示文摘 | Chou KC Shen HB | 2007 | Analytical Biochemistry2007，370，1： | 1 |
| 12 | Cell-PLoc: a package of Web servers forpredicting subcellular localization of proteins in variousorganisms显示文摘 | Chou KC Shen HB | 2008 | Nature Protocols2008，3，2： | 1 |
| 13 | MR imaging findings of enteroviral encephalomyelitis: an outbreak in taiwan 显示文摘 | Shen WC Chiu HH Chow KC | 1999 | AJNR1999，20，： | 1 |
| 14 | Nitrification driven by bacteria and not archaea in nitrogen-rich grassland soils显示文摘 | Di H J Cameron KC Shen JP | 2009 | Nature Geoscience2009，2，9： | 1 |
| 15 | Lactoba- cillus rhamnosus strain GG prevents enterohemorrhagic Escherichia coli 0157 : H7 - induced changes in epithelial barrier function 显示文摘 | Johnson - Henry KC Donato KA Shen TG | 2008 | Infect Immun2008，76，4： | 1 |
| 16 | MR imaging findings of emeroviral encephaloymelifis:an outbreak in Taiwan显示文摘 | Shen WC Chiu HH Chow KC el al | 1999 | AJNR Am J Neuroradiol1999，20，： | 1 |
| 17 | MR imaging findings of enteroviral encephaloymelitis:an outbreak in Taiwan 显示文摘 | Shen WC Chiu HH Chow KC | 1999 | AJNR Am J Neuroradiol1999，20，10： | 1 |
| 18 | Lipid clearing agents in steroid-induced osteoporosis显示文摘 | WANG GJ CHUNG KC SHEN WJ | 1995 | J Formosan Med Assoc1995，94，10： | 1 |
| 19 | Nitrification driven by bacteria and not archaea in nitrogen rich grassland soils 显示文摘 | Di H J Cameron KC Shen JP | 2009 | Nature Geoscience2009，2，： | 1 |
| 20 | Electronic Structures and Related Properties of Complexes M(tap)32+(M:Fe,Ru,Os)显示文摘 | Zheng KC Wang JP Shen Y | 2002 | J Chem Soc Dalton Trans2002，，1： | 1 |
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