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| 1 | Prognostic significance of combined fibrinogen concentration and neutrophil-to-lymphocyte ratio in patients with resectable non-small cell lung cancer显示文摘Objective:Cancer-associated inflammation and coagulation cascades play vital roles in cancer progression and survival.In this study,we investigated the significance of the combination of preoperative fibrinogen and the neutrophil-to-lymphocyte ratio(NLR)in predicting the survival of patients with non-small cell lung cancer(NSCLC).Methods:We retrospectively enrolled 589 patients with NSCLC who underwent surgery.The univariate and multivariate Cox survival analyses were used to evaluate the prognostic indicators,including the combination of fibrinogen and NLR(F-NLR).The cut-off values for fibrinogen,NLR,and clinical laboratory variables were defined by the receiver operating characteristic(ROC)curve analysis.According to the ROC curve,the recommended cut-off values for fibrinogen and the NLR were 3.48 g/L and 2.30,respectively.Patients with both a high NLR(≥2.30)and hyperfibrinogenemia(≥3.48 g/L)were given a score of 2,whereas those with one or neither were scored as 1 or 0,respectively.Results:Our results showed that F-NLR was an independent prognostic indicator for disease-free survival(DFS)[hazard ratio(HR),1.466;95%confidence interval(CI),1.243–1.730;P<0.001]and overall survival(OS)(HR,1.512;95%CI,1.283–1.783;P<0.001).The five-year OS rates were 66.1%,53.5%,and 33.3%for the F-NLR=0,F-NLR=1,and F-NLR=2,respectively(P<0.001).Correspondingly,their five-year DFS rates were 62.2%,50.3%,and 30.4%,respectively(P<0.001).In the subgroup analyses of the pathological stages,the F-NLR level was significantly correlated with DFS and OS in stage I and IIIA cancers.Conclusions:Preoperative F-NLR score can be used as a valuable prognostic marker for patients with resectable early-stage NSCLC. | Wuhao Huang Shengguang Wang Hua Zhang Bin Zhang Changli Wang | 2018 | Cancer Biology & Medicine2018，15，1： | 27 |
| 2 | Simultaneous determination of ten taste and odor compounds in drinking water by solid-phase microextraction combined with gas chromatography-mass spectrometry显示文摘Taste and odor(T&O)problems in drinking water frequently occur because of many compounds present in the water,of which trans-1,10-dimethyl-trans-9-decalol(geosmin)and 2-methylisoborneol(MIB)are well-known.In this study,a fast and efective method was established for simultaneous determination of 10 T&O compounds,including geosmin,MIB,2,4,6-trichloroanisole(TCA),2-methylbenzofuran,2-isopropyl-3-methoxypyrazine(IPMP),2-isobutyl-3-methoxypyrazine(IBMP),cis-3-hexenyl acetate,trans,trans-2,4-heptadienal,trans,cis-2,6-nonadienal,and trans-2-decenal in water samples by headspace solid-phase microextraction(SPME)coupled with gas chromatography-mass spectrometry.An orthogonal array experimental design was used to optimize the efects of SPME fiber,extraction temperature,stirring rate,NaCl content,extraction time,and desorption time.The limits of detection ranged from 0.1 to 73 ng/L were lower than or close to the odor threshold concentrations(OTCs).All the 10 T&O compounds were detected in the 14 water samples including surface water,treatment process water and tap water,taken from a waterworks in Lianyungang City,China.MIB and geosmin were detected in most samples at low concentration.Six T&O compounds(IPMP,IBMP,trans,cis-2,6-nonadienal,2-methylbenzofuran,trans-2-decenal,and TCA)were efectively decreased in water treatment process(sedimentation and filtration)that is diferent from cis-3-hexenyl acetate,MIB and geosmin.It is noted that the TCA concentrations at 15.9–122.3 ng/L and the trans,cis-2,6-nonadienal concentrations at 79.9–190.1 ng/L were over 10 times higher than their OTCs in tap water.The variation of the analytes in the all water samples,especially distribution system indicated that distribution system cannot be ignored as a T&O compounds source. | Xichao Chen Qian Luo Shengguang Yuan Zi Wei Hanwen Song Donghong Wang Zijian Wang | 2013 | Journal of Environmental Sciences2013，25，11： | 21 |
| 3 | Serpentinization, abiogenic organic compounds, and deep life显示文摘The hydrocarbons and other organic compounds generated through abiogenic or inorganic processes are closely related to two science subjects,i.e.,energy resources and life’s origin and evolution.'The earth’s primordial abiogenic hydrocarbon theory'and'the serpentinization of abiogenic hydrocarbon theory'are the two mainstream theories in the field of related studies.Serpentinization generally occurs in slow expanding mid-ocean ridges and continental ophiolites tectonic environment,etc.The abiogenic hydrocarbons and other organic compounds formed through the serpentinization of ultramafic rocks provide energy and raw materials to support chemosynthetic microbial communities,which probably was the most important hydration reaction for the origin and early evolution of life.The superposition of biological and abiological processes creates big challenge to the identification of the abiogenic organic materials in serpentinite-hosted ecosystem.Whether abiotic(inorganic)process can form oil and gas resource is a difficult question that has been explored continuously by scientific community for more than a century but has not yet been solved.However,some important progress has been made.The prospecting practice of abiogenic hydrocarbons in commercial gases from the Songliao Basin,China,provides an important example for exploring abiogenic natural gas resources. | WANG XianBin OUYANG ZiYuan ZHUO ShengGuang ZHANG MingFeng ZHENG GuoDong WANG YongLi | 2014 | Science China Earth Sciences2014，57，5： | 11 |
| 4 | Abiogenic hydrocarbons in commercial gases from the Songliao Basin,China显示文摘This paper discusses the kinetic fractionation, composition and distribution characteristics of carbon and hydrogen isotopes for various alkane gases formed in different environments, by different mecha- nisms and from different sources in nature. It is demonstrated that the biodegradation or thermode- gradation of complex high-molecule sedimentary organic material can form microbial gas or thermogenic gas. The δ 13C1 value ranges from -110‰ to -50‰ for microbial gases but from -50‰ to -35‰ (even heavier) for thermogenic gases. Controlled by the kinetic isotope fractionation, both microbial and thermogenic gases have δ 13C and δ D values characterized by normal distribution, i.e. δ 13C1< δ 13C2< δ 13C3< δ 13C4 and δ DCH4< δ DC2H6< δ DC3H8<δ DC4H10, and by a positive correlation between the δ 13C and δ D values. Simple carbonbearing molecules (CH4, CO and CO2) can form abiogenic alkane gases via polymerization in the abiological chemical process in nature, with δ 13C1 heavier than -30‰. Moreover, controlled by the kinetic isotope fractionation, abiogenic alkane gases are characterized by a reverse distribution of δ 13C values and a normal trend of δ D values, namely δ 13C1> δ 13C2> δ 13C3> δ 13C4 and δ DCH4<δ DC2H6< δ DC3H8< δ DC4H10. The δ 13C values and δ D values are negatively correlated. Natural gases from 26 commercial gas wells distributed in the Xujiaweizi and Yingshan-Miaotaizi faulted depressions in the Songliao Basin, China, show δ13C1 values ranging from -30.5‰ to -16.7‰ with a very narrow δ D range between -203‰―-196‰. These gases are characterized by a reverse distribution of δ 13C values but a normal distribution of δ D values, and a negative correlation between their δ 13C and δ D values, indicating an abiological origin. The present study has revealed that abiogenic hydrocarbons not only exist in nature but also can make significant contribution to commercial gas reserviors. It is estimated that the reserve volume of alkane gases with abiogenic characteristics in these 26 gas wells in the Songliao Basin is over 500×108 m3. The prospecting practice in the Songliao Basin has demonstrated that abiogenic alkane gases are of a promising resource, and it provides an example for the investigation of and search for abiogenic commercial natural gases worldwide. | WANG XianBin GUO ZhanQian TUO JinCai GUO HongYan LI ZhenXi ZHUO ShengGuang JIANG HongLiang ZENG LongWei ZHANG MingJie WANG LianSheng LIU ChunXue YAN Hong LI LiWu ZHOU XiaoFeng WANG YongLi YANG Hui WANG Guang | 2009 | Science China Earth Sciences2009，52，2： | 6 |
| 5 | Stable isotope dimethyl labeling combined with LTQ mass spectrometricdetection, a quantitative proteomics technology used in liver cancer research显示文摘 | Bo Tang Yang Li Liang Zhao Shengguang Yuan Zhenran Wang Bo Li Qian Chen | 2013 | Biomedical Reports2013，，4： | 1 |
| 6 | Magnetic beads-based electrochemiluminescence immunosensor for determination of cancer markers using quantum dot functionalized PtRu alloys as labels 显示文摘 | ZHANG Yan GE Shengguang WANG Shaowei | 2012 | Analyst2012，137，9： | 1 |
| 7 | Community Structure of Endophytic Bacteria in Chestnut, Castanea mollissima显示文摘[Objective]The paper was to detect the species of endophytic bacteria in Chestnut (Castanea mollissima).[Method]The 16S rDNA-V4 region of endophytic bacteria in chestnut(sample name BL) was sequenced by Illumina Mi Seq high-throughput sequencing technology. The number of sequences and operational taxonomic units(OTUs) for each sample was sorted and calculated using Qiime and Mothur software. The abundance and α-diversity of species were analyzed.[Result]The number of effective sequences and OTUs were 21 167 /191. The rarefaction curves showed that adequate sampling was achieved,and the number of OTUs was close to saturation. The endophytic bacteria of chestnut belonged to 10 genera,including Koribacter(3. 48%),Solibacter(2. 59%),Bradyrhizobium(3. 57%), Rhodoplanes(7. 41%), Methylobacterium(4. 20%), Agrobacterium(19. 73%), Kaistobacter( 2. 05%), Sphingomonas(18. 66%),Acidovorax(35. 98%),and Methylibium(2. 32%). The dominant species were Acidovorax,Agrobacterium and Sphingomonas.[Conclusion]Illumina high-throughput sequencing technology provided more accurate and scientific data resources for the study of endophytic bacteria in chestnut. | Chen Zebin Li Bing Xia Tiyuan Wang Dingkang Yu Lei Xu Shengguang Liu Jiani Zhang Yongfu | 2016 | Plant Diseases and Pests2016，7，4： | 0 |
| 8 | A nomogram-based immune-serum scoring system predicts overall survival in patients with lung adenocarcinoma显示文摘Objective:The immunoscore,which is used to quantify immune infiltrates,has greater relative prognostic value than tumor,node,and metastasis(TNM)stage and might serve as a new system for classification of colorectal cancer.However,a comparable immunoscore for predicting lung adenocarcinoma(LUAD)prognosis is currently lacking.Methods:We analyzed the expression of 18 immune features by immunohistochemistry in 171 specimens.The relationship of immune marker expression and clinicopathologic factors to the overall survival(OS)was analyzed with the Kaplan-Meier method.A nomogram was developed by using the optimal features selected by least absolute shrinkage and selection operator(LASSO)regression in the training cohort(n=111)and evaluated in the validation cohort(n=60).Results:The indicators integrated in the nomogram were TNM stage,neuron-specific enolase,carcino-embryonic antigen,CD8 center of tumor(CT),CD8 invasive margin(IM),Fox P3 CT,and CD45 ROCT.The calibration curve showed prominent agreement between the observed 2-and 5-year OS and that predicted by the nomogram.To simplify the nomogram,we developed a new immune-serum scoring system(I-SSS)based on the points awarded for each factor in the nomogram.Our I-SSS was able to stratify same-stage patients into different risk subgroups.The combination of I-SSS and TNM stage had better prognostic value than the TNM stage alone.Conclusions:Our new I-SSS can accurately and individually predict LUAD prognosis and may be used to supplement prognostication based on the TNM stage. | Qiujuan Huang Tongyuan Qu Lisha Qi Changxu Liu Yuhong Guo Qianru Guo Guangning Li Yalei Wang Wenshuai Zhang Wei Zhao Danyang Ren Leina Sun Shengguang Wang Bin Meng Baocun Sun Bin Zhang Wenjuan Ma Wenfeng Cao | 2021 | Cancer Biology & Medicine2021，18，2： | 0 |
| 9 | Investigation on the oil transfer behaviors and the air–oil interfacial flow patterns in a ball bearing under different capillary conditions显示文摘Lubricant oil is crucial to the rolling bearings as the main medium of lubricating, cooling, cleaning, and so on. The oil starvation in and around the contacts is harmful to the performance and fatigue life of rolling bearings. Therefore, it is of necessity to understand the behaviors of oil transfer and the patterns of air-oil two-phase flow in bearings, especially with the influence of different capillary properties. This work established a transient air-oil two-phase flow model in a ball bearing based on computational fluid dynamics (CFD). Groups of cases are implemented to investigate the behaviors of oil transfer and air-oil flow under different capillary conditions with speed, surface tension, and viscosity. Flow patterns are classified by the morphological features of the air-oil flow. Staged phenomena are analyzed with flow patterns and reach good agreements with the observations from experiments. It is found that the oil distribution and air-oil flow behaviors in a ball bearing are strongly related to the speed and the ratio of oil viscosity and air-oil surface tension (μ_(oil/σ)). The flow maps imply that the levels of capillary number (Ca) may be the boundaries and the critical points of flow pattern transition between the different flow patterns in bearing. | Hongbai CHEN He LIANG Wenzhong WANG Shengguang ZHANG | 2023 | Friction2023，11，2： | 0 |
| 10 | Self-selective memristor-enabled in-memory search for highly efficient data mining显示文摘Similarity search,that is,finding similar items in massive data,is a fundamental computing problem in many fields such as data mining and information retrieval.However,for large-scale and high-dimension data,it suffers from high computational complexity,requiring tremendous computation resources.Here,based on the low-power self-selective memristors,for the first time,we propose an in-memory search(IMS)system with two innovative designs.First,by exploiting the natural distribution law of the devices resistance,a hardware locality sensitive hashing encoder has been designed to transform the realvalued vectors into more efficient binary codes.Second,a compact memristive ternary content addressable memory is developed to calculate the Hamming distances between the binary codes in parallel.Our IMS system demonstrated a 168energy efficiency improvement over all-transistors counterparts in clustering and classification tasks,while achieving a software-comparable accuracy,thus providing a low-complexity and low-power solution for in-memory data mining applications. | Ling Yang Xiaodi Huang Yi Li Houji Zhou Yingjie Yu Han Bao Jiancong Li Shengguang Ren Feng Wang Lei Ye Yuhui He Jia Chen Guiyou Pu Xiang Li Xiangshui Miao | 2023 | InfoMat2023，5，5： | 0 |
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