|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Dendritic cell-based vaccination with lentiviral vectors encoding ubiquitinated hepatitis B core antigen enhances hepatitis B virus-specific immune responses in vivo显示文摘肝炎 B 病毒(HBV ) 的活动特定的细胞毒素的 T 淋巴细胞(CTL ) 戏在 HBV 的清理的一个占优势的角色。树枝状的房间(DC ) 是关键介绍抗原的房间并且在有免疫力的回答的开始起一个重要作用。我们以前验证了有效地编码 ubiquitinated 肝炎 B 核心抗原(LV-Ub-HBcAg ) 的那 lentiviral 向量导致成熟的 transduced DC,和成熟 DC 高效地导致了 T 房间极化到 Th1 并且产生了 HBcAg 特定的 CTL 前 vivo。在这研究,在 BALB/c 老鼠的 LV-Ub-HBcAg 的 HBV 特定的有免疫力的回答(H-2K d ) 被评估。LV-Ub-HBcAg 的直接注射增加了 cytokines IL-2 和 IFN- 的生产,这被显示出,得到了强壮的抗体回答,并且显著地产生了 IFN-+ 有在 BALB/c 老鼠的 HBV 特定的 CTL 回答的 CD8 + T 房间。另外, LV-Ub-HBcAg 的直接注射导致了有势力 anti-HBV 免疫者回答,类似于得到由的那些在 vitro-transduced DC。在结论,基于 DC 的治疗学的疫苗的 LV-Ub-HBcAg 得到了特定的抗体免疫者回答并且在 vivo 导致了柔韧的特定的 CTL 活动。 | Shenglan Dai Meng Zhuo Linlin Song Xiaohua Chen Yongsheng Yu Zhenghao Tang Guoqing Zang | 2015 | Acta Biochimica et Biophysica Sinica2015，47，11： | 9 |
| 2 | Novel transient-energy-based directional pilot protection method for HVDC line显示文摘This paper proposes a novel directional pilot protection method based on the transient energy for bipolar HVDC line.Supposing the positive direction of current is from DC bus to the DC line,in the case of an internal line fault,the transient energies detected on both sides of the line are all negative within a short time,which denotes the positive direction fault;while for an external fault,the transient energy on one end is positive,which means a negative direction fault,but the transient energy on the opposite end is negative,which indicates that the fault direction is positive.According to these characteristics,an integration criterion identifying fault direction is constructed.In addition,through setting a fixed energy threshold,the faulted line and lightning disturbance can also be discriminated.Simulation results from UHVDC transmission system show the validity of the proposed protection method. | Guibin Zou Qiang Huang Shenglan Song Bingbing Tong Houlei Gao | 2017 | Protection and Control of Modern Power Systems2017，2，1： | 1 |
| 3 | Comparative evaluation of commercial Douchi by different molds:biogenic amines,non-volatile and volatile compounds显示文摘To provide new insights into the development and utilization of Douchi artificial starters,three common strains(Aspergillus oryzae,Mucor racemosus,and Rhizopus oligosporus)were used to study their influence on the fermentation of Douchi.The results showed that the biogenic amine contents of the three types of Douchi were all within the safe range and far lower than those of traditional fermented Douchi.Aspergillus-type Douchi produced more free amino acids than the other two types of Douchi,and its umami taste was more prominent in sensory evaluation(P<0.01),while Mucor-type and Rhizopus-type Douchi produced more esters and pyrazines,making the aroma,sauce,and Douchi flavor more abundant.According to the Pearson and PLS analyses results,sweetness was significantly negatively correlated with phenylalanine,cysteine,and acetic acid(P<0.05),bitterness was significantly negatively correlated with malic acid(P<0.05),the sour taste was significantly positively correlated with citric acid and most free amino acids(P<0.05),while astringency was significantly negatively correlated with glucose(P<0.001).Thirteen volatile compounds such as furfuryl alcohol,phenethyl alcohol,and benzaldehyde caused the flavor difference of three types of Douchi.This study provides theoretical basis for the selection of starting strains for commercial Douchi production. | Aijun Li Gang Yang Zhirong Wang Shenglan Liao Muying Du Jun Song Jianquan Kan | 2024 | Food Science and Human Wellness2024，13，1： | 0 |
| 4 | Impact of the Urban Heat Island Effect on Ozone Pollution in Chengdu City,China显示文摘With the advancement of urbanization,the urban heat island effect and ozone pollution have become hot issues in urban research.The urban heat island effect can impact ozone conversion,but its mechanism of action is unclear.In this study,the effects of the urban heat island effect on ozone concentration in Chengdu City,China,were investigated by comparing the ozone concentration under different heat island levels with ozone data from March 2020 to February 2021 and the temperature and wind field data of ERA5-Land during the same period.The results showed that:1)regarding the distribution characteristics,the ozone concentration in Chengdu presented a‘high in summer and low in winter’distribution.The ozone concentration in summer(189.54µg/m^(3))was nearly twice that in winter(91.99µg/m^(3)),and the ozone diurnal variation presented a‘single peak and single valley’distribution,with a peak at 16:00.2)For the characteristics of the heat island effect,the heat island intensity in Chengdu was obviously higher in spring than in other seasons,and the diurnal variation showed a‘single peak and single valley’distribution,with the peak and trough values appearing at 9:00 and 17:00,respectively.Spatially,the eastern part of Chengdu was a heat island,while the western and northwestern parts were mostly cold island.3)The correlation analysis between heat island intensity and ozone concentration showed a significant positive correlation but with a 7–8 h time lag.Ambient air temperature was not the main factor affecting ozone concentration.The heat island effect impacts the ozone concentration in two ways:changing the local heat budget to promote ozone generation and forming local urban wind,which promotes ozone diffusion or accumulation and forms different areas of low and high ozone values. | SHI Haoyuan SONG Xingtao ZENG Shenglan | 2023 | Chinese Geographical Science2023，33，6： | 0 |
| 5 | Preparation and Performance of Pueraria lobata Root Powder/Polylactic Acid Composite Films显示文摘Petroleum-based materials,such as plastic,are characterized by adverse environmental pollution;as a result,researchers have sought alternative degradable plastics that are environmentally friendly,such as polylactic acid(PLA).PLA has shown great potential to replace petroleum-based plastics.In this study,seven different samples of unmodified Pueraria lobata root powder(PRP)with different contents(i.e.,0,5,10,15,20,25,and 30 wt%)and three different modified PRPs(i.e.,treated with NaOH,NaOH-KH-550,and Formic)were used to reinforce polylactic acid(PLA)via solution casting process.These prepared PRP/PLA composite films were characterized using SEM,FTIR,UV-visible spectra analysis,TG,DSC,weight loss measurement(wt%),and mechanical measurements.The results showed that the PRP modified with KH-550(PRPK)intensified the interaction in the interface region between the PRP and the PLA matrix,thus increasing the tensile strength(54.5 MPa),elongation at break(2.8%),and Young’s modulus(3310 MPa)of the PRPK/PLA biofilms.Contact angle measurement showed that the PRP treatments contributed to the hydrophobicity of films.The transparency of PRP-10/PLA film atλ_(800)was 11.09%,and its UVA and UVB transmittance were 3.28 and 1.16,respectively.After blending PLA with PRP,the PRP/PLA composite films exhibited excellent biodegradability.In summary,PRPK improved the mechanical properties of PLA and prevented the films from ultraviolet light,suggesting that PRPK-5/PLA film could be used as packaging materials. | Shuang Zhao Shenglan Chen Shuan Ren Gang Li Ke Song Jie Guo Shima Liu Jian He Xianwu Zhou | 2023 | Journal of Renewable Materials2023，11，6： | 0 |
| 6 | Breaking the strength–ductility trade-off in additively manufactured aluminum alloys through grain structure control by duplex nucleation显示文摘Achieving a homogeneous equiaxed grain structure and breaking the strength–ductility trade-off in additively manufactured aluminum alloys is a great challenge.In this paper,we propose a novel duplex nucleation mechanism that combines ex situ TiB_(2) and in situ Al_(3)Ti for controlling the grain structure of additively manufactured AlCuMgTi-TiB_(2) composites.We conducted thermodynamic calculations and phase-field simulations to elucidate the duplex nucleation-based grain structure control.The Al_(3)Ti-coated TiB_(2) inoculant system formed via duplex nucleation during solidification enabled the formation of a ho-mogeneous ultrafine equiaxed microstructure in both the as-fabricated and heat-treated states.Different from the AlCuMgTi alloy,the TiB_(2)-reinforced AlCuMgTi composites produced via laser powder bed fusion were amenable to the simultaneous enhancement of strength and ductility.The proposed alloy design approach and duplex nucleation mechanism can guide the tailoring of the microstructure and mechanical properties of additively manufactured aluminum parts. | Jinliang Zhang Jianbao Gao Shenglan Yang Bo Song Lijun Zhang Jian Lu Yusheng Shi | 2023 | Journal of Materials Science & Technology2023，，21： | 0 |
| 7 | Preclinical and early clinical studies of a novel compound SYHA1813 that efficiently crosses the blood-brain barrier and exhibits potent activity against glioblastoma显示文摘Glioblastoma(GBM)is the most common and aggressive malignant brain tumor in adults and is poorly controlled.Previous studies have shown that both macrophages and angiogenesis play significant roles in GBM progression,and co-targeting of CSF1R and VEGFR is likely to be an effective strategy for GBM treatment.Therefore,this study developed a novel and selective inhibitor of CSFIR and VEGFR,SYHA1813,possessing potent antitumor activity against GBM.SYHA1813 inhibited VEGFR and CSFIR kinase activities with high potency and selectivity and thus blocked the cell viability of HUVECs and macrophages and exhibited anti-angiogenetic effects both in vitro and in vivo.SYHA1813 also displayed potent in vivo antitumor activity against GBM in immune-competent and immune-deficient mouse models,including temozolomide(TMZ)insensitive tumors.Notably,SYHA1813 could penetrate the blood-brain barrier(BBB)and prolong the survival time of mice bearing intracranial GBM xenografts.Moreover,SYHA1813 treatment resulted in a synergistic antitumor efficacy in combination with the PD-1 antibody.As a clinical proof of concept,SYHA1813 achieved confirmed responses in patients with recurrent GBM in an ongoing first-in-human phase I trial.The data of this study support the rationale for an ongoing phase I clinical study(ChiCTR2100045380). | Yingqiang Liu Zhengsheng Zhan Zhuang Kang Mengyuan Li Yongcong Lv Shenglan Li Linjiang Tong Fang Feng Yan Li Mengge Zhang Yaping Xue Yi Chen Tao Zhang Peiran Song Yi Su Yanyan Shen Yiming Sun Xinying Yang Yi Chen Shanyan Yao Hanyu Yang Caixia Wang Meiyu Geng Wenbin Li Wenhu Duan Hua Xie Jian Ding | 2023 | Acta Pharmaceutica Sinica B2023，13，12： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员