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| 1 | Adenosine monophosphate-activated protein kinase attenuates cardiomyocyte hypertrophy through regulation of FOXO3a/MAFbx signaling pathway显示文摘心肌质量的控制被认为被蛋白质合成和降级的动态平衡决定。最近的研究表明了表明小径戏的那萎缩相关的 forkhead 盒子 O 3a (FOXO3a )/muscle 萎缩 F 盒子(MAFbx ) 在解朊作用的调整的一个中央角色并且在 cardiomyocyte 肥大上施加禁止的效果。在这研究,我们测试了假设激活 monophosphate 的蛋白质 kinase (AMPK ) 激活稀释的那腺苷由调整表明小径和它的下游的蛋白质降级的 FOXO3a/MAFbx 的 cardiomyocyte 肥大。结果证明有 5-aminoimidazole-4-carboxamide ribonucleoside (AICAR ) 的 AMPK 的激活稀释了血管收缩素 II (Ang II ) 导致的 cardiomyocyte 肥大。AICAR 的 antihypertrophic 效果被 AMPK 禁止者混合物 C 弄钝。另外, AMPK 戏剧性地增加了抄写因素 FOXO3a 的活动,起来调整它的下游的 ubiquitin ligase MAFbx 的表示,和提高的 cardiomyocyte 解朊作用。同时,在 MAFbx 是由有 MAFbx-siRNA 的 cardiomyocytes 的 transfection 的 silenced 以后,蛋白质降级和 cardiomyocyte 肥大上的 AMPK 的效果被堵住。这些结果显示 AMPK 由经由表明小径的 FOXO3a/MAFbx 激活蛋白质降级在 cardiomyocyte 肥大的抑制起一个重要作用。 | Baolin Chen Qiang WU Zhaojun Xiong Yuedong Ma Sha Yu Dandan Chen Shengwen Huang Yugang Dong | 2016 | Acta Biochimica et Biophysica Sinica2016，48，9： | 4 |
| 2 | Effects of the Process Parameters on Austenitic Stainless Steel by TIG-Flux Welding显示文摘TIG (钨插图气体) 的过程参数的效果焊接形态学,尖失真,铁酸盐内容并且在奥氏体的不锈钢的热裂开上的 -fluxwelding 被调查。焊接过程的自然发生的 TIG 通过激活流动在板上生产祷告的薄层被用于类型 304stainless 钢焊接 joint.TiO_2, SiO_2, Fe_2O_3, Cr_2O_3, ZnO 和 MnO_2 被用作激活的流动。试验性的结果显示焊接的 TIG 流动能增加焊接深度 / 宽度比率和还原剂 theHAZ (热影响了地区) 变化,因此,焊接的尖失真能被减少。在 TIG 流动焊接以内的保留的铁酸盐内容被增加,这也被发现,并且在为奥氏体的类型焊接金属的不锈钢减少热裂开的趋势有有益的效果。在在 TIG 流动的穿入的阳极点然后实质的增加的电流密度焊接的 A 血浆列收缩增加能被获得。 | Heryueh HUANG Shengwen SHYU Kuanghung TSENG Changpin GHOU | 2006 | Journal of Materials Science & Technology2006，22，3： | 3 |
| 3 | Physically-based model of ink diffusion in Chinese ink paintings 显示文摘 | Shengwen Huang Der Lor Way Zen chuang Shih | 2003 | Journal of WSCG (S1213-6972)2003，10，3： | 1 |
| 4 | Application of cross-hole radar tomography in karst area显示文摘 | TAN Hanhua HUANG Jiahui QI Shengwen | 2011 | Environmental Earth Sciences2011，66，1： | 1 |
| 5 | Physical-based model of ink diffusion in Chinese ink paintings 显示文摘 | Huang Shengwen Way Derlor Shih Zenehung | 2003 | Journal of WSCG2003，10，3： | 1 |
| 6 | High order DBR GaSb based single longitude mode diode lasers at 2 μm wavelength显示文摘The GaSb-based distributed Bragg reflection(DBR) diode laser with 23 rd-order gratings have been fabricated by conventional UV lithography and inductively coupled plasma(ICP) etching. The ICP etching conditions were optimized and the relationship among etching depth, duty ratio and side-mode suppression ratio(SMSR) was studied. The device with a ridge width of 100 μm, gratings period of 13 μm and etching depth of 1.55 μm as well as the duty ratio of 85% was fabricated, its maximum SMSR reached 22.52 dB with uncoated cavity facets under single longitudinal operation mode at room temperature. | Hao Luo Cheng'ao Yang Shengwen Xie Xiaoli Chai Shushan Huang Yu Zhang Yingqiang Xu Zhichuan Niu | 2018 | Journal of Semiconductors2018，39，10： | 0 |
| 7 | Ultrathin lead-free double perovskite cesium silver bismuth bromide nanosheets显示文摘Two-dimensional (2D) lead halide perovskites nanostructures have drawn great fundamental interest and displayed excellent properties for various optoelectronic applications. However, the toxicity of lead remains a concern for their large-scale utilizations. Bismuth halide double perovskites stand out as a class of promising candidates for lead-free halide perovskites. In this work, we demonstrate the first synthesis of lead-free 2D halide double perovskite nanosheets. The synthesized Cs2AgBiBr6 nanosheets exhibited thicknesses in the range of 3–5 nm and lateral dimensions of ∼ 200 nm. The nanosheets showed a strong absorption peak centered at ∼ 430 nm and the photoluminescence emission observed at ∼ 630 nm. We also explored dimensionality control from zero-dimensional nanocubes to 2D nanosheets and investigated the preferential growth of Cs2AgBiBr6 over other related compounds such as Cs3Bi2Br9 and CsAgBr2. Our study reveals that Cs2AgBiBr6 nanosheets are interesting 2D material for potential optoelectronic applications and provides a guideline for the controllable synthesis of multi-component compounds with tunable morphology, dimensionality and phase. | Jianmei Huang Shengwen Zou Jia Lin Zhiwei Liu Mingjing Qi | 2021 | Nano Research2021，14，11： | 0 |
| 8 | Long noncoding RNA PCED1B-AS1 promotes erythroid differentiation coordinating with GATA1 and chromatin remodeling显示文摘Erythropoiesis is a complex and sophisticated multi-stage process regulated by a variety of factors,including the transcription factor GATA1 and non-coding RNA.GATA1 is regarded as an essential transcriptional regulator promoting transcription of erythroidspecific genes—such as long non-coding RNAs(lncRNA).Here,we comprehensively screened lncRNAs that were potentially regulated by GATA1 in erythroid cells.We identified a novel lncRNA—PCED1B-AS1—and verified its role in promoting erythroid differentiation of K562 erythroid cells.We also predicted a model in which PCED1B-AS1 participates in erythroid differentiation via dynamic chromatin remodeling involving GATA1.The relationship between lncRNA and chromatin in the process of erythroid differentiation remains to be revealed,and in our study we have carried out preliminary explorations. | Junwei Zhu Yunxiao Ren Yuanyuan Han Tingting Jin Yanming Li Xiuyan Ruan Hongzhu Qu Shengwen Huang Zhaojun Zhang Xiangdong Fang | 2019 | Blood Science2019，1，2： | 0 |
| 9 | Geological evaluation for the carbon dioxide geological utilization and storage(CGUS)site:A review显示文摘Carbon dioxide(CO_(2))geological utilization and storage(CGUS)is the key link of CO_(2)capture,utilization,and storage(CCUS).The accurate characterization of the geological body structure is a vital prerequisite of CGUS.This paper gives a review of the multi-scale three-dimensional geological structure characterization and site selection of CO_(2)storage.It shows that there is a lack of systematic and high-precision methods for transparency characterization of multi-scale three-dimensional engineering geological structure and hydrogeological structure of a CO_(2)storage site.There is no clear understanding of the fracture evolution and gas-liquid migration process of multi-scale geological body structure under the disturbance of CO_(2)injection.There is a lack of sufficient quantitative methods for the dynamic evaluation of CO_(2)geological storage potential.The geological suitability evaluation method for site selection of CO_(2)storage is rough and has poor applicability,which is difficult to satisfy the urgent needs of CGUS site selection in the whole process of CO_(2)sequestration industrialization in the future.Thus,it is required to conduct studies on the transparency characterization of geological body structure and intelligent site selection for CO_(2)storage,which is of great importance for CGUS engineering practice. | Shengwen QI Bowen ZHENG Zan WANG Haijun ZHAO Zhendong CUI Tianming HUANG Songfeng GUO Lei FU Pingchuan DONG | 2023 | Science China Earth Sciences2023，66，9： | 0 |
| 10 | Protective effects of Longhu Rendan on chronic liver injury and fibrosis in mice显示文摘Background and aim:Liver fibrosis resulting from persistent liver injury represents a major healthcare problem globally.Traditional Chinese medicine has played an essential role in the treatment of liver fibrosis in recent years.Thus,this study aims to assess the effect of Longhu Rendan(LHRD),a Chinese traditional patent medicine,on liver fibrosis and its potential mechanism.Methods:The liver fibrosis in mice was induced via the intraperitoneal injection of carbon tetrachloride(CCl4)for 6 weeks or bile duct ligation for 15 days.Various methods were used to judge the therapeutic effect of LHRD.Results:LHRD significantly suppressed the activity of serum index of abnormal liver function,liver cell apoptosis,and necrosis,attenuating liver injury.Moreover,LHRD treatment alleviated liver fibrotic features,such as the reduction of collagen deposition and hepatic stellate cell activation as well as profibrotic gene expression.Mechanistically,LHRD treatment inhibited nuclear transcription factorkappa B signaling and inflammatory gene expression and diminished the production of reactive oxygen species and 4-hydroxynonenal,along with the downregulation of NADPH oxidase 4.Conclusions:Overall,the present study demonstrates that LHRD ameliorates liver injury and fibrosis via the inhibition of inflammation and oxidative stress in mice,indicating that LHRD is a potential medicine for the treatment of liver fibrosis. | Guizhi Yang Shengwen Li Jiahua Jin Yuanyuan Xuan Liqin Ding Minxia Huang Jun Liu Biye Wang Tian Lan | 2022 | Liver Research2022，6，2： | 0 |
| 11 | Dynamic response of mountain tunnel,bridge,and embankment along the Sichuan-Tibet transportation corridor to active fault based on model tests显示文摘The Sichuan-Tibet transportation corridor is prone to numerous active faults and frequent strong earthquakes.While extensive studies have individually explored the effect of active faults and strong earthquakes on different engineering structures,their combined effect remains unclear.This research employed multiple physical model tests to investigate the dynamic response of various engineering structures,including tunnels,bridges,and embankments,under the simultaneous influence of cumulative earthquakes and stick-slip misalignment of an active fault.The prototype selected for this study was the Kanding No.2 tunnel,which crosses the Yunongxi fault zone within the Sichuan-Tibet transportation corridor.The results demonstrated that the tunnel,bridge,and embankment exhibited amplification in response to the input seismic wave,with the amplification effect gradually decreasing as the input peak ground acceleration(PGA)increased.The PGAs of different engineering structures were weakened by the fault rupture zone.Nevertheless,the misalignment of the active fault may decrease the overall stiffness of the engineering structure,leading to more severe damage,with a small contribution from seismic vibration.Additionally,the seismic vibration effect might be enlarged with the height of the engineering structure,and the tunnel is supposed to have a smaller PGA and lower dynamic earth pressure compared to bridges and embankments in strong earthquake zones crossing active faults.The findings contribute valuable insights for evaluating the dynamic response of various engineering structures crossing an active fault and provide an experimental reference for secure engineering design in the challenging conditions of the Sichuan-Tibet transportation corridor. | HUANG Beixiu QIAO Sijia CHEN Xulei LI Lihui QI Shengwen | 2024 | Journal of Mountain Science2024，21，1： | 0 |
| 12 | Investigation on the Deformation and Failure Patterns of Loess Cut Slope Based on the Unsaturated Triaxial Test in Yan'an,China显示文摘The large-scale implementation of the Gully Stabilization and Land Reclamation(GSLR)project induces various failures of loess slopes due to excavation in Yan'an,China.However,the deformation and failure behavior of these excavated loess slopes have not been fully understood.In this study,field investigation was undertaken for analyzing the distributions and failure features of excavation-induced loess slope failures.It is found that plastic failure mainly occurs in Q_(3) loess layers and brittle failure in Q_(2).To understand the underlying failure mechanism,a series of triaxial shear tests were conducted on intact Q_(3) and Q_(2) loess samples that with different water contents,namely natural water content(natural),dry side of the natural value(drying 5%),and wet side(wetting 5%).The characteristics of stress-strain curves and failure modes of the samples were analyzed.Results show that the stress-strain curves of Q_(2) samples are dominated by strain-softening characteristics,while Q_(3) samples mainly exhibit strain-harden features except in the drying state.Correspondingly,shear failures of Q_(3) specimens are mainly caused by shear crack planes(single,X or V-shaped).For Q_(2) loess,the dominance of tensile cracks is observed on the surface of damaged specimens.These disclose the different failure modes of excavated slopes located in different strata,that is,the arc sliding failure of Q_(3) loess slopes and the stepped tensile failure of Q_(2) loess slopes,and are helpful in the design and management of the ongoing GSLR projects in the Loess Plateau. | Lina Ma Shengwen Qi Songfeng Guo Qiangbing Huang Xiaokun Hou | 2024 | Journal of Earth Science2024，35，1： | 0 |
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