|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | TNF alpha gene and protein expression in alveolar macrophages in acute and chronic hyperoxia-indueed lung injury显示文摘 | Horinouchi H Wang CC Shepherd KE | 1996 | Am J Respir Cell Mol Biol1996，14，： | 1 |
| 2 | Glucose modulation of insulin mRNA levels is dependent on transcription factor PDX-1 and occurs independently of changes in intracellular Ca^2+ 显示文摘 | Macfarlane WM Shepherd RM Cosgrove KE | 2000 | Diabetes2000，49，3： | 1 |
| 3 | Systematic review of surgery in malignant bowel obstruction in advanced gynecological and gastrointestinal cancer 显示文摘 | Feuer D J Broadley KE Shepherd JH | 1999 | Gynecol Oncol1999，75，： | 1 |
| 4 | Genetics and pathophysiology of hyperinsulinism in infancy显示文摘 | Cosgrove KE Shepherd RM Fernandez EM Natarajan A Lindley KJ Aynsley-Green A | 2004 | Horm Res2004，61，： | 1 |
| 5 | Hyperinsulinism in infancy:From basic science to clinical disease显示文摘 | Dunne MJ Cosgrove KE Shepherd RM Aynsley-Green A Lindley KJ | 2004 | Physiol Rev2004，84，1： | 1 |
| 6 | Systematic review of surgery in malignant bowel obstruction in advanced gynecological and gastrointestinal cancer 显示文摘 | Broadiey KE Shepherd JH | 1999 | Gynecol Oncol1999，75，3： | 1 |
| 7 | Hyperinsulinism in infancy:from basic science to clinical disease显示文摘 | Dunne MJ Cosgrove KE Shepherd RM | 2004 | Physiol Rev2004，84，： | 1 |
| 8 | Hyperinsulinism in infancy:from basic science to clinical disease显示文摘 | Dunne MJ Cosgrove KE Shepherd RM | | 0，，： | 1 |
| 9 | TNF alpha gene and protein expression in alveolar macrophages in acute and chronic hyperoxia- induced lung injury显示文摘 | Horinouchi H Wang CC Shepherd KE | 1996 | Am J Respir Cell Mol Biol1996，14，6： | 1 |
| 10 | Glucose modulation of insulin mRNA levels is dependent on transcription factor PDX-1 and occurs independently of changes in intracellular Ca显示文摘 | Maefarlane WM Shepherd RM Cosgrove KE | 2000 | Diabetes2000，49，： | 1 |
| 11 | Hyperinsulinism in infancy :From basic science to clinical disease 显示文摘 | Dunne MJ Cosgrove KE Shepherd RM Aynsley-Green A Lindley KJ | 2004 | Physiol Rev2004，84，1： | 1 |
| 12 | Hyperinsulinism in infancy:from basic science to clinical disease显示文摘 | Dunne MJ Cosgrove KE Shepherd RM | 2004 | Physiol Rev2004，84，： | 1 |
| 13 | 显示文摘 | Macfarlane WM Shepherd RM Cosgrove KE | 2000 | Diabetes2000，49，： | 1 |
| 14 | Systematic review of surgery in malignant bowel obstruction in advanced gynecological and gastrointestinal cancer显示文摘 | Feuer DJ Broadley KE Shepherd JH | | 0，，03： | 1 |
| 15 | Hyperinsulin-ism in infancy:From basic science to clinical disease显示文摘 | Dunne MJ Cosgrove KE Shepherd RM | 2004 | Physi-ol Rev2004，84，1： | 1 |
| 16 | TNF alpha gene and protein expression in alveolar macrophages in acute and chronic hyperoxia-induced lung injury显示文摘 | Wang CC Shepherd KE | 1996 | Am J Respir Cell Mol Biol1996，14，6： | 1 |
| 17 | Hyperin?sulinism in infancy: from basic science to clinical disease显示文摘 | Dunne MJ Cosgrove KE Shepherd RM | 2004 | Physiol Rev2004，84，1： | 1 |
| 18 | Surgery for the resolution of symptoms in malignant bowel obstruction in ad- vanced gynaecological and gastrointestinal cancer 显示文摘 | Feuer D J Broadley KE Shepherd JH | 2000 | Co-chrane Database Syst Rev2000，，： | 1 |
| 19 | Systematic review of surgery in malignant bowel obstruction in advanced gynecological and gastrointestinal cancer显示文摘 | Feuer DJ Broadley KE Shepherd JH | 1999 | Gynecol Oncol1999，75，3： | 1 |
| 20 | Identification, structure modification, and characterization of potential small-molecule SGK3 inhibitors with novel scaffolds显示文摘The serum and glucocorticoid-regulated kinase (SGK) family has been implicated in the regulation of many cellular processes downstream of the PI3K pathway. It plays a crucial role in PI3K-mediated tumorigenesis, making it a potential therapeutic target for cancer. SGK family consists of three isoforms (SGK1, SGK2, and SGK3), which have high sequence homology in the kinase domain and similar substrate speci?city with the AKT family. In order to identify novel compounds capable of inhibiting SGK3 activity, a high-throughput screening campaign against 50,400 small molecules was conducted using a fuorescence-based kinase assay that has a Z' factor above 0.5. It identiifed 15 hits (including nitrogen-containing aromatic, favone, hydrazone, and naphthalene derivatives) with IC50 values in the low micromolar to sub-micromolar range. Four compounds with a similar scaffold (i.e., a hydrazone core) were selected for structural modi?cation and 18 derivatives were synthesized. Molecular modeling was then used to investigate the structure-activity relationship (SAR) and potential protein–ligand interactions. As a result, a series of SGK inhibitors that are active against both SGK1 and SGK3 were developed and important functional groups that control their inhibitory activity identified. | Grace Qun Gong Ke Wang Xin-Chuan Dai Yan Zhou Rajesh Basnet Yi Chen De-Hua Yang Woo-Jeong Lee Christina Maree Buchanan Jack Urquhart Flanagan Peter Robin Shepherd Ying Chen Ming-Wei Wang | 2018 | Acta Pharmacologica Sinica2018，39，12： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员