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| 1 | P53 rs1042522 and CD95 rs1800682 genetic variations in HCV-4a response to antiviral therapy显示文摘Current estimates indicate that the hepatitis C(HCV)is the leading cause of mortality around the world,with infection rates steadily increasing in Egypt.The dual therapy for this silent epidemic with pegylated-interferon-a2b/ribavirin has markedly improved the success rates in genotype-4 patients.It was reported that apoptosis plays a vital mechanistic role in limiting viral replication.P53,a key regulator of apoptosis,induces CD95 gene expression and subsequently initiates apoptotic cascade to be activated.The current study examined the impact of P53 rs1042522 and CD95 rs1800682 polymorphisms on the treatment response.Three groups of 240 volunteers were enrolled in this study;86 in sustained virological responders group,74 in non-responders group,and 80 in control group.All patients had HCV genotype-4a and were interferon treatment naı¨ve.Quantizations of HCV-RNA by qRT-PCR and histological scores were performed for all patients.In addition,genotyping of HCV-RNA,P53 rs1042522 Arg/Pro and CD95 rs1800682 A/G polymorphisms were investigated in all subjects.It was resulted that P53 Pro/Pro homozygous genotype has high significant increase,while CD95 A/A homozygous genotype has high significant decrease when comparing non-responders with responders.Finally,it was concluded that Pro variant of P53 rs1042522 may be used as a genetic predictor for non-responsiveness,while A/A variant of CD95 rs1800682 may be used as a sensitive biomarker for responsiveness to antiviral therapy of HCV genotype-4a infection.In addition,low prolactin,high total testosterone,and high GH levels may provide promising biomarkers for early prediction of the response when associated with these genetic polymorphisms. | Ahmed A.Abd-Rabou Emad F.Eskander Mervat S.Mohamed Shaymaa M.M.Yahya Ashraf El Sherbini Olfat G.Shaker | 2015 | Genes & Diseases2015，2，2： | 1 |
| 2 | Evaluation of the use of microemulsions as eluents in high- performance liquid chromatography显示文摘 | EL - SHERBINY D EL - ASHRY S MUSTAFA M | 2003 | J Sep Sci2003，26，67： | 1 |
| 3 | Thinning and Spring Back Prediction of Sheet Metal in the Deep Drawing Process 显示文摘 | ZEIN H EL SHERBINY M ABD-RABOU M | 2014 | Materials & Design2014，53，： | 1 |
| 4 | Subendometrial blood flow changes by 3-dimensional power Doppler ultrasound after hysteroscopic lysis of severe intrauterine adhesions:preliminary study显示文摘 | Mohamed Amer MI Omar OH El Sherbiny Hamed M | 2015 | J Minim Invasive Gynecol2015，22，3： | 1 |
| 5 | Evaluation of the use ofmi- croemulsions as eluents in high-performance liquid chromatography 显示文摘 | Sherbiny EL Ashr~ EL Mustafa M | 2003 | J Sep Sci2003，26，： | 1 |
| 6 | Diagnostic value ofserum kallikrein-related peptidases 6 and 10 versus CA125 in ovar-ian cancer 显示文摘 | El Sherbini MA Sallam MM Shaban EA | 2011 | IntJ Gynecol Cancer2011，21，4： | 1 |
| 7 | Subendometrial blood flow changes by 3-dimensional power Dopplerultrasound after hysteroscopic lysis of severe intrauterine adhesions:preliminary study 显示文摘 | Mohamed Amer MI Omar OH El Sherbiny Hamed M | 2015 | J Minim Invasive Gynecol2015，22，3： | 1 |
| 8 | Assessment of ovarian stromal blood flow after metformin treatment in women with poly- cystic ovary syndrome显示文摘 | Makled A K El Sherbiny M Elkabadty R | 2014 | Arch Gynecol Obstet2014，289，4： | 1 |
| 9 | G0/G1arrest and S phase inhibition of human cancer cell lines by inositol hexaphosphate(IP6)显示文摘 | EL Sherbiny YM Cox MC Ismail ZA | 2001 | Anticancer Res2001，21，： | 1 |
| 10 | Three‐dimensional power D oppler and endometrial volume as predictors of malignancy in patients with postmenopausal bleeding显示文摘 | Ahmed K. Makled Sherif F. Elmekkawi Tamer A. El‐Refaie Mohammed A. El‐Sherbiny | 2013 | J Obstet Gynaecol Res2013，，： | 1 |
| 11 | Assessment of ovarian stromal blood flow after metformin treatment in women with polycystic ovary syndrome显示文摘 | Makled A K El Sherbiny M EIkabarity R | 2014 | Arch Gynecol Obstet2014，289，4： | 1 |
| 12 | Grafting study and anti- fungal activity of a carboxymethyl cellulose derivative 显示文摘 | El - Sherbiny I M Salama A Sarhan A A | 2009 | Int J Polymc Mat2009，589，： | 1 |
| 13 | 显示文摘 | EL Sherbiny YM | 2001 | Antican Res2001，21，4： | 1 |
| 14 | Measurement of electron density utilizing the H α -line from laser produced plasma in air显示文摘 | A.M. El Sherbini H. Hegazy Th.M. El Sherbini | 2006 | Spectrochimica Acta Part B: Atomic Spectroscopy2006，，5： | 1 |
| 15 | Detubularized sigmoid neobladder versus delubular ized W-shaped Ileal neobladder as a bladder substitute after radical cystectomy for carcinoma of the urinary bladder:a study of 60 patients 显示文摘 | Bassiouny M Zaghloul A S El Sherbiny M | 2004 | J Egypl Natl Canc Inst2004，16，2： | 1 |
| 16 | Outpatienthysteroscopy: a routine investigation before assisted reproductivetechniques?显示文摘 | El -Mazny A Abou -Salem N El -Sherbiny W | 2011 | Fertil Steril2011，95，1： | 1 |
| 17 | AC and DC studies of the pitting corrosion of Al in perchlorate solutions显示文摘 | AMIN M A ABDEL R S S EL SHERBINI E E F | 2006 | Electrochim Acta2006，51，： | 1 |
| 18 | Diagnostic value of serum kallikrein-related peptidases 6 and 10 versus CA125 in ovarian cancer显示文摘 | El Sherbini MA Sallam MM Shaban EA | 2011 | IntJ Gynecol Cancer2011，2，4： | 1 |
| 19 | Soluble VEGF/sFLtl ratio is an independent predictor of AML patient out come 显示文摘 | Aref S El Sherbiny M Goda T | 2005 | Hematology2005，10，2： | 1 |
| 20 | Treatment of urethral defeces skin, buccal or bladder mucosa, tube or patch? An experimental study in dogs 显示文摘 | El - sherbiny MT Bol - Enein H Dawaba MS | 2002 | J Urol2002，167，5： | 1 |
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