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| 1 | The wonders of BMP9:From mesenchymal stem cell differentiation,angiogenesis,neurogenesis,tumorigenesis,and metabolism to regenerative medicine显示文摘Although bone morphogenetic proteins(BMPs)initially showed effective induction of ectopic bone growth in muscle,it has since been determined that these proteins,as members of the TGF-b superfamily,play a diverse and critical array of biological roles.These roles include regulating skeletal and bone formation,angiogenesis,and development and homeostasis of multiple organ systems.Disruptions of the members of the TGF-b/BMP superfamily result in severe skeletal and extra-skeletal irregularities,suggesting high therapeutic potential from understanding this family of BMP proteins.Although it was once one of the least characterized BMPs,BMP9 has revealed itself to have the highest osteogenic potential across numerous experiments both in vitro and in vivo,with recent studies suggesting that the exceptional potency of BMP9 may result from unique signaling pathways that differentiate it from other BMPs.The effectiveness of BMP9 in inducing bone formation was recently revealed in promising experiments that demonstrated efficacy in the repair of critical sized cranial defects as well as compatibility with bone-inducing bio-implants,revealing the great translational promise of BMP9.Furthermore,emerging evidence indicates that,besides its osteogenic activity,BMP9 exerts a broad range of biological functions,including stem cell differentiation,angiogenesis,neurogenesis,tumorigenesis,and metabolism.This review aims to summarize our current understanding of BMP9 across biology and the body. | Sami Mostafa Mikhail Pakvasa Elam Coalson Allen Zhu Alex Alverdy Hector Castillo Jiaming Fan Alex Li Yixiao Feng Di Wu Elliott Bishop Scott Du Mia Spezia Alissa Li Ofir Hagag Alison Deng Winny Liu Mingyang Li Sherwin S·Ho Aravind Athiviraham Michael J·Lee Jennifer Moriatis Wolf Guillermo A·Ameer Hue H·Luu Rex C·Haydon Jason Strelzow Kelly Hynes Tong-Chuan He Russell R·Reid | 2019 | Genes & Diseases2019，6，3： | 15 |
| 2 | Neuroimaging the brain-gut axis in patients with irritable bowel syndrome显示文摘AIM:To summarize and synthesize current literature on neuroimaging the brain-gut axis in patients with irritable bowel syndrome(IBS).METHODS:A database search for relevant literature was conducted using Pub Med,Scopus and Embase in February 2015.Date filters were applied from the year2009 and onward,and studies were limited to those written in the English language and those performed upon human subjects.The initial search yielded 797articles,out of which 38 were pulled for full text review and 27 were included for study analysis.Investigations were reviewed to determine study design,methodology and results,and data points were placed in tabular format to facilitate analysis of study findings across disparate investigations.RESULTS:Analysis of study data resulted in the abstraction of four key themes:Neurohormonal differences,anatomic measurements of brain structure and connectivity,differences in functional responsiveness of the brain during rectal distention,and confounding/correlating patient factors.Studies in this review noted alterations of glutamate in the left hippocampus(HIPP),commonalities across IBS subjects in terms of brain oscillation patterns,cortical thickness/gray matter volume differences,and neuroanatomical regions withincreased activation in patients with IBS:Anterio cingulate cortex,mid cingulate cortex,amygdala anterior insula,posterior insula and prefrontal cortex.A striking finding among interventions was the substantia influence that patient variables(e.g.,sex,psychologica and disease related factors)had upon the identification of neuroanatomical differences in structure and con nectivity.CONCLUSION:The field of neuroimaging can provide insight into underlying physiological differences that distinguish patients with IBS from a healthy population. | Kristen R Weaver Lee Anne B Sherwin Brian Walitt Gail D'Eramo Melkus Wendy A Henderson | 2016 | World Journal of Gastrointestinal Pharmacology and Therapeutics2016，7，2： | 8 |
| 3 | ADA与EASD对2型糖尿病高血糖处理:治疗启动与评定的新共识方案显示文摘在不到一年时间由同一批专家代表ADA和EASD先后起草和发布了两次关于'2型糖尿病高血糖处理的共识声明'同时发表在2008年1月和12月的《Diabetes Care》和《Diabetologia》上。第一次共识声明内容主要围绕TZDs药物的安全性,本刊作了摘译转载(参阅《中国糖尿病杂志》2008年第7期)。第二次修订的共识声明,关注点为降糖药的新分级,论据及观点比较清晰,故仍摘译供读者参考。 | Nathan DM Buse JB Davidson MB Ferrannini E Holman RR Sherwin R Zinman B 钱荣立(摘译) | 2009 | 中国糖尿病杂志2009，17，1： | 2 |
| 4 | Is there evidence of selection in the dopamine receptor D4 gene in Australian invasive starling populations?显示文摘 | Lee Ann ROLLINS Michael R. WHITEHEAD Andrew R WOOLNOUGH Ron SINCLAIR William B. SHERWIN | 2015 | Current Zoology2015，61，3： | 2 |
| 5 | The use of GIS to develop a probability-based trunk mains burst risk model 显示文摘 | Cooper N R Blakey G Sherwin C | 2000 | Urban Water2000，2，2： | 1 |
| 6 | Prizes and incentives in elimination tournaments显示文摘 | SHERWIN R | 1986 | American Economic Review1986，76，4： | 1 |
| 7 | Do low-dose corticosteroids improve mortality or shock reversal in patients with septic shock显示文摘 | Sherwin RL Garcia AJ Bilkovski R | 2012 | A systematic review and position statement prepared for J Emerg Med2012，43，1： | 1 |
| 8 | Traditional and novel reservoir management techniques to enhance water quality for subsequent potable water treatment显示文摘 | Bayley R Ta C T Sherwin C J | 2001 | Particle Removal from Reservoirs and Other Surface Waters2001，1，1： | 1 |
| 9 | Rank-order tournaments as optimum labor contracts 显示文摘 | LAZEAR E P SHERWIN R | 1981 | Journal of Political Economy1981，，5： | 1 |
| 10 | Differential association of birth weight with cardiovascular risk variables in African-Americans and Whites: the Bogalusa heart study显示文摘 | Mzayek F Sherwin R Fonseca V | 2004 | Ann Epidemiol2004，14，4： | 1 |
| 11 | Rank-order tournaments as optimum labor contracts 显示文摘 | LAZEAR E P SHERWIN R | 1981 | Journal of Political Economy1981，，89： | 1 |
| 12 | Simultaneous insulinlike growth factor I and insulin resistance in obese Zucker rats显示文摘 | JACOB R J SHERWIN R S GREENAWALT K | 1992 | Diabetes1992，41，6： | 1 |
| 13 | The endometrial response to chorionic gonadotropin is blunted in a baboon model of endometriosis 显示文摘 | Sherwin J R A Hastings J M Jackson K S | 2010 | Endocrinology2010，151，： | 1 |
| 14 | Metabolic effects of IGF- 1 and insulin in spontaneously diabetic BB/W rats 显示文摘 | Jacob R Barrett E Sherwin RS | 1991 | Am J Physiol1991，260，： | 1 |
| 15 | Fluid dynamic loading on curved riser pipes 显示文摘 | Miliou A Sherwin S J Graham J M R | 2003 | Journal of Offshore Mechanics and Arctic Engineering2003，125，3： | 1 |
| 16 | Contortostatin, a dimeric disintegrin from Agkistrodon contortrlx, inhibits breast cancer progression 显示文摘 | Zhou Q Sherwin R P Parrish C | 2000 | Breast Cancer Res Treat2000，61，： | 1 |
| 17 | Regulation of S-Adenosylmethionine levels in Saccharomyces cerevisiae显示文摘 | SHERWIN Y C DEAN R A | 2003 | J Biol Chem2003，278，43： | 1 |
| 18 | The association of near-in- frared spectroscopy-derived tissue oxygenation measurements with sepsis syndromes, organ dysfunction and mortality in emergency de- partment patients with sepsis显示文摘 | Shapiro NI Arnold R Sherwin R | 2011 | Crit Care2011，15，5： | 1 |
| 19 | Metabolic engineering in yeast demonstrates that S-adenosylmethionine controls flux through the methylenetetrahydrofolate reductase reaction in vivo显示文摘 | SANJA R SHERWIN Y C FATMA K | 2002 | J Biol Chem2002，277，6： | 1 |
| 20 | Identification of novel genesregulated by chorionic gonadotropin in baboon endometrium during the window of implantation显示文摘 | Sherwin J R Sharkey A M Cameo P | | 0，，2： | 1 |
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