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| 1 | Real-time fault detection method based on belief rule base for aircraft navigation system显示文摘Real-time and accurate fault detection is essential to enhance the aircraft navigation system's reliability and safety. The existent detection methods based on analytical model draws back at simultaneously detecting gradual and sudden faults. On account of this reason, we propose an online detection solution based on non-analytical model. In this article, the navigation system fault detection model is established based on belief rule base (BRB), where the system measuring residual and its changing rate are used as the inputs of BRB model and the fault detection function as the output. To overcome the drawbacks of current parameter optimization algorithms for BRB and achieve online update, a parameter recursive estimation algorithm is presented for online BRB detection model based on expectation maximization (EM) algorithm. Furthermore, the proposed method is verified by navigation experiment. Experimental results show that the proposed method is able to effectively realize online parameter evaluation in navigation system fault detection model. The output of the detection model can track the fault state very well, and the faults can be diagnosed in real time and accurately. In addition, the detection ability, especially in the probability of false detection, is superior to offline optimization method, and thus the system reliability has great improvement. | Zhao Xin Wang Shicheng Zhang Jinsheng Fan Zhiliang Min Haibo | 2013 | Chinese Journal of Aeronautics2013，26，3： | 13 |
| 2 | A case study of development and application of a streamlined control and response modeling system for PM_(2.5)attainment assessment in China显示文摘This article describes the development and application of a streamlined air control and response modeling system with a novel response surface modeling-linear coupled fitting method and a new module to provide streamlined model data for PM_(2.5) attainment assessment in China.This method is capable of significantly reducing the dimensions required to establish a response surface model,as well as capturing more realistic response of PM_(2.5) to emission changes with a limited number of model simulations.The newly developed module establishes a data link between the system and the Software for Model Attainment Test—Community Edition(SMAT-CE),and has the ability to rapidly provide model responses to emission control scenarios for SMAT-CE using a simple interface.The performance of this streamlined system is demonstrated through a case study of the Yangtze River Delta(YRD) in China.Our results show that this system is capable of reproducing the Community Multi-Scale Air Quality(CMAQ) model simulation results with maximum mean normalized error < 3.5%.It is also demonstrated that primary emissions make a major contribution to ambient levels of PM_(2.5) in January and August(e.g.,more than50%contributed by primary emissions in Shanghai),and Shanghai needs to have regional emission control both locally and in its neighboring provinces to meet China's annual PM_(2.5)National Ambient Air Quality Standard.The streamlined system provides a real-time control/response assessment to identify the contributions of major emission sources to ambient PM_(2.5)(and potentially O_3 as well) and streamline air quality data for SMAT-CE to perform attainment assessments. | Shicheng Long Yun Zhu Carey Jang Che-Jen Lin Shuxiao Wang Bin Zhao Jian Gao Shuang Deng Junping Xie Xuezhen Qiu | 2016 | Journal of Environmental Sciences2016，28，3： | 9 |
| 3 | High-throughput droplet microfluidic synthesis of hierarchical metal-organic framework nanosheet microcapsules显示文摘Using two-dimensional(2D)metal-organic framework(MOF)nanosheets as new building blocks to create more complex architectures at the mesoscopic/macroscopic scale has attracted extensive interest in recent years.Nevertheless,it remains a great challenge to assemble MOF nanosheets into hierarchical hollow structures so far.In this paper,we describe a successful example of hierarchical MOF nanosheet microcapsules,with precisely controlled sizes,produced on large scale within minutes with a continuous droplet microfluidic strategy.Following a reaction/diffusion growth mechanism,the microcapsule shells feature a continuous smooth inner layer and a porous outer layer.Such hierarchical structure enables the encapsulation of magnetite nanoparticles inside and loading of dense gold nanoparticles outside the microcapsules,which exhibit highly efficient heterogeneous catalytic activity and easy recyclability.The present microfluidic assembly method offers a new pathway for preparing hierarchical MOF nanosheet structures,with the potential for extension to the formation of other 2D nanosheets in general. | Songting Wu Zhong Xin Shicheng Zhao Shengtong Sun | 2019 | Nano Research2019，12，11： | 6 |
| 4 | Cancer metabolism and tumor microenvironment:fostering each other?显示文摘The changes associated with malignancy are not only in cancer cells but also in environment in which cancer cells live.Metabolic reprogramming supports tumor cells’high demand of biogenesis for their rapid proliferation,and helps tumor cells to survive under certain genetic or environmental stresses.Emerging evidence suggests that metabolic alteration is ultimately and tightly associated with genetic changes,in particular the dysregulation of key oncogenic and tumor suppressive signaling pathways.Cancer cells activate HIF signaling even in the presence of oxygen and in the absence of growth factor stimulation.This cancer metabolic phenotype,described firstly by German physiologist Otto Warburg,ensures enhanced glycolytic metabolism for the biosynthesis of macromolecules.The conception of metabolite signaling,i.e.,metabolites are regulators of cell signaling,provides novel insights into how reactive oxygen species(ROS)and other metabolites deregulation may regulate redox homeostasis,epigenetics,and proliferation of cancer cells.Moreover,the unveiling of noncanonical functions of metabolic enzymes,such as the moonlighting functions of phosphoglycerate kinase 1(PGK1),reassures the importance of metabolism in cancer development.The metabolic,microRNAs,and ncRNAs alterations in cancer cells can be sorted and delivered either to intercellular matrix or to cancer adjacent cells to shape cancer microenvironment via media such as exosome.Among them,cancer microenvironmental cells are immune cells which exert profound effects on cancer cells.Understanding of all these processes is a prerequisite for the development of a more effective strategy to contain cancers. | Yiyuan Yuan Huimin Li Wang Pu Leilei Chen Dong Guo Hongfei Jiang Bo He Siyuan Qin Kui Wang Na Li Jingwei Feng Jing Wen Shipeng Cheng Yaguang Zhang Weiwei Yang Dan Ye Zhimin Lu Canhua Huang Jun Mei Hua-Feng Zhang Ping Gao Peng Jiang Shicheng Su Bing Sun Shi-Min Zhao | 2022 | Science China(Life Sciences)2022，65，2： | 5 |
| 5 | A highly active novel β-nucleating agent for isotactic polypropylene显示文摘 | Shicheng Zhao Zhi Cai Zhong Xin | 2008 | Polymer2008，，11： | 2 |
| 6 | Essential role of Msx1 in regulating anterior-posterior patterning of the secondary palate in mice显示文摘Development of the secondary palate displays molecular heterogeneity along the anterior-posterior axis;however, the underlying molecular mechanism remains largely unknown. MSX1 is an anteriorly expressed transcription repressor required for palate development. Here, we investigate the role of Msx1 in regional patterning of the secondary palate. The Wnt1-Cre-mediated expression of Msx1(Rosa Msx1^(Wnt1-Cre))throughout the palatal mesenchyme leads to cleft palate in mice, associated with aberrant cell proliferation and cell death. Osteogenic patterning of the hard palate in Rosa Msx1^(Wnt1-Cre)mice is severely impaired, as revealed by a marked reduction in palatine bone formation and decreased expression of the osteogenic regulator Sp7. Overexpression and knockout of Msx1 in mice show that the transcription repressor promotes the expression of the anterior palate-specific Alx1 but represses the expression of the medialposterior palate genes Barx1, Meox2, and Tbx22. Furthermore, Tbx22 constitutes a direct Msx1 target gene in the secondary palate, suggesting that Msx1 can directly repress the expression of medial-posterior specific genes. Finally, we determine that Sp7 is downstream of Tbx22 in palatal mesenchymal cells,suggesting that a Msx1/Tbx22/Sp7 axis participates in the regulation of palate development. Our findings unveil a novel role for Msx1 in regulating the anterior-posterior growth and patterning of the secondary palate. | Shicheng Zhu Hanjing Song Liangjun Zhong Suman Huo Yukun Fang Wanxin Zhao Xueqin Yang Zhong-Min Dai Rui He Mengsheng Qiu Zunyi Zhang Xiao-Jing Zhu | 2022 | Journal of Genetics and Genomics2022，49，1： | 2 |
| 7 | Combined effect of erganic phosphate sodium and nanoclay en the mechanical properties and crystallization behavior of isotactic pelypropylene 显示文摘 | Zhao Shicheng Xin Zhong Zhang Jing | 2012 | J Appl Polym Sci2012，123，： | 1 |
| 8 | A Highly Active Novel β-Nucleating Agent for Isotactic Polypropylene 显示文摘 | Zhao Shicheng Cai Zhi Xin Zhong | 2008 | Polymer2008，49，11： | 1 |
| 9 | Fertilizer recommendation for maize in China based on yield response and agronomic efficiency显示文摘 | Xinpeng Xu Ping He Mirasol F. Pampolino Adrian M. Johnston Shaojun Qiu Shicheng Zhao Limin Chuan Wei Zhou | 2014 | Field Crops Research2014，，： | 1 |
| 10 | Nucleation Characteristics of the α/β Compounded Nucleating Agents and Their Influences on Crystallization Behavior and Mechanical Properties of lsotac- tic Polypropylene 显示文摘 | Zhao Shicheng Xin Zhong | 2010 | J Polym Sci Part B: Polym Phys2010，48，6： | 1 |
| 11 | Nutrient requirements for maize in China based on QUEFTS analysis显示文摘 | Xinpeng Xu Ping He Mirasol F. Pampolino Limin Chuan Adrian M. Johnston Shaojun Qiu Shicheng Zhao Wei Zhou | 2013 | Field Crops Research2013，，： | 1 |
| 12 | Estimating nutrient uptake requirements for wheat in China显示文摘 | Limin Chuan Ping He Jiyun Jin Shutian Li Cynthia Grant Xinpeng Xu Shaojun Qiu Shicheng Zhao Wei Zhou | 2013 | Field Crops Research2013，，： | 1 |
| 13 | Long-term effects of potassium fertilization and straw return on soil potassium levels and crop yields in north-central China显示文摘 | Zhao Shicheng He Ping Qiu Shaojun | 2014 | Field Crops Research2014，169，： | 1 |
| 14 | Fabrication and photoelectrochemical properties of porous ZnWO 4 film显示文摘 | Xu Zhao Wenqing Yao Yan Wu Shicheng Zhang Haipeng Yang Yongfa Zhu | 2006 | Journal of Solid State Chemistry2006，，8： | 1 |
| 15 | Determination of palaeotemperatare and palaeogeothermal gradient in Qinshui basin显示文摘 | Ren Zhanli Wang Shicheng Zhao Zhongyuan | 2000 | Progress in Natural Science2000，10，4： | 1 |
| 16 | A Highly Active Novelβ-Nucleating Agent for Isotactic Polypropylene显示文摘 | Zhao Shicheng Cai Zhi Xin Zhong | 2008 | Polymer2008，49，11： | 1 |
| 17 | Study on an intelligent fault-tolerant technique for multiple satellite configured navigation under highly dynamic conditions显示文摘The probability of pseudo-range information being faulty will increase when there is increased noise in the receiver due to highly dynamic conditions. In this paper, an intelligent fault-tolerant federated Kalman filter (IFFKF) is presented to solve the problem of invalid position information as a result of the uncertainty in the category and quantity of failed satellites in a multiple configured satellite system. At the same time, a corresponding intelligent fault-tolerant system structure based on a cell-level fusion mode of operation was designed. Furthermore, a fault diagnosis strategy is proposed to deal with gradually or suddenly changing faults. By monitoring the residual and the residual rate, an observation quality gene is obtained using a fuzzy logic control system, and the local filter is adaptively adjusted on-line. Consequently, any filtering divergence arising from a gradually changing fault can, to a large extent, be prevented. The results show that the proposed algorithm and structure can achieve reliable positioning by fully utilizing new multiple satellites, monitoring and managing the gradual fault, as well as detecting and isolating any sudden fault in a synchronous manner. As such, the proposed algorithm has the potential to improve the reliability of a multiple satellite configured navigation system. | WANG ShiCheng ZHAO Xin MIN HaiBo LIU ZhiGuo SI XiaoSheng | 2011 | Science China(Information Sciences)2011，54，3： | 1 |
| 18 | Effective treatment of SARS-CoV-2-infected rhesus macaques by attenuating inflammation显示文摘Dear Editor,The COVID-19 pandemic caused by the SARS-CoV-2 virus has caused a significant public health crisis worldwide.Recent studies show that excessive inflammatory response is critical for SARS-CoV-2 pathogenesis and COVID-19 severity,'which can lead to acute lung injury(ALI)and acute respiratory distress syndrome(ARDS).2 One major factor for acute inflammation in SARS-CoV-2 infection is the inflammatory macrophages,which has been considered important for the production of large amounts of proinflammatory cytokines.'Autopsy identifhed an intense infltra-tion of macrophages in the lung tissues of fatal COVID-19 patients. | Shuaiyao Lu Jingjing Zhao Jiebin Dong Hongqi Liu Yinhua Zhu Honggang Li Liping Liu Yun Yang Shicheng Sun Yifan Song Yuan Zhao Ruiping She Tuoping Luo Hongkui Deng Xiaozhong Peng | 2021 | Cell Research2021，31，2： | 1 |
| 19 | Nucleation Characteristics of the α/β Compounded Nucleating Agents and Their Influences on Crystallization Behavior and Mechanical Properties of Isotactic Polypropylene 显示文摘 | Zhao Shicheng Xin Zhong | 2010 | J Polym Sci Part B : Polym Phys2010，48，6： | 1 |
| 20 | Nutrient requirements for maize in China based on QUEFTS analysis显示文摘 | Xinpeng Xu Ping He Mirasol F. Pampolino Limin Chuan Adrian M. Johnston Shaojun Qiu Shicheng Zhao Wei Zhou | 2013 | Field Crops Research2013，，： | 1 |
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