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| 1 | Transplantation of engineered exosomes derived from bone marrow mesenchymal stromal cells ameliorate diabetic peripheral neuropathy under electrical stimulation显示文摘Diabetic peripheral neuropathy(DPN)is a long-term complication associated with nerve dysfunction and uncontrolled hyperglycemia.In spite of new drug discoveries,development of effective therapy is much needed to cure DPN.Here,we have developed a combinatorial approach to provide biochemical and electrical cues,considered to be important for nerve regeneration.Exosomes derived from bone marrow mesenchymal stromal cells(BMSCs)were fused with polypyrrole nanoparticles(PpyNps)containing liposomes to deliver both the cues in a single delivery vehicle.We developed DPN rat model and injected intramuscularly the fused exosomal system to understand its long-term therapeutic effect.We found that the fused system along with electrical stimulation normalized the nerve conduction velocity(57.60±0.45 m/s)and compound muscle action potential(16.96±0.73 mV)similar to healthy control(58.53±1.10 m/s;18.19±1.45 mV).Gastrocnemius muscle morphology,muscle mass,and integrity were recovered after treatment.Interestingly,we also observed paracrine effect of delivered exosomes in controlling hyperglycemia and loss in body weight and also showed attenuation of damage to the tissues such as the pancreas,kidney,and liver.This work provides a promising effective treatment and also contribute cutting edge therapeutic approach for the treatment of DPN. | Anamika Singh Alok Raghav Parvaiz Ahmad Shiekh Ashok Kumar | 2021 | Bioactive Materials2021，6，8： | 4 |
| 2 | 一例罕见的子宫原始神经外胚层瘤病例报道(英文)显示文摘Primitive neuroectodermal tumor (PNET) of uterus is the rare of the rarest among the tumors of female genital tract. We herein reported a 32 years old female operated for lower abdominal lump,which was diagnosed,as PNET later confirmed by immunohistochemistry (IHC). She was lost to follow-up and presented 10 months later with recurrence. She was treated with cyclical combination chemotherapy followed by definitive surgery and is in complete remission at present. | Syed Nisar Ahmad Shiekh Aejaz Aziz Rangreze Imran Manzoor Ahmad Banday Gul Mohammad A.R.Lone Parveen Reshi Nisar Ahmad Wani Shaheena Parveen | 2010 | The Chinese-German Journal of Clinical Oncology2010，9，6： | 2 |
| 3 | Pro- teomic evaluation of biological nanoparticles isolated from human kidney stones and calcified arteries显示文摘 | Shiekh F A Charlesworth J E Kim S H | 2010 | Ac- ta Biomaterialia2010，6，10： | 1 |
| 4 | Classical and quantum properties of two-dimensional black holes显示文摘 | Mann R B Shiekh A Tarasov L | 1990 | Nucl Phys1990，341，： | 1 |
| 5 | Government Spy or a Terrorist? Dilemmas of a Post-9/11 Academic Researcher 显示文摘 | Irum Shiekh | 2007 | Amerasia Journal2007，，3： | 1 |
| 6 | Anxiolytic effect ofprogesterone is mediated by the neurosteroidallopregnanolone at brain GABAA receptors 显示文摘 | BITRAN D SHIEKH M MCLEOD M | 1995 | JNeuroendocrinol?1995，7，3： | 1 |
| 7 | Lithogenesis:induction of renal calcifications by nanobacteria显示文摘 | Shiekh FA Khullar M Singh SK | 2006 | Urol Res2006，34，1： | 1 |
| 8 | Super-capacitor based energy storage system for improved load frequency control显示文摘 | Mairajuddin M Shameem A L Shiekh J 1 | 2009 | Electric Power Systems Research2009，，79： | 1 |
| 9 | Key role of alkalinephosphatase for development of human-derived nanoparticles invitro显示文摘 | Hunter LW Shiekh FA Pisimisis GT | 2011 | Acta Biomater2011，7，3： | 1 |
| 10 | Patient preference for cardiac catheterization via the transfemoral approach abstract显示文摘 | Cooper CJ Shiekh RA Blaesing LD | | 0，，： | 1 |
| 11 | Effect of transradial access on quality of life and cost of cardiac catheterization:a randomized comparison显示文摘 | Cooper CS E1 shiekh RA Cohen DJ | 1999 | Am Heart J1999，138，： | 1 |
| 12 | Super-capacitor based energy storage system for improved load frequency control显示文摘 | Mairajuddin M Shameem A L Shiekh J I | 2009 | Electric Power System Research2009，，79： | 1 |
| 13 | Super-capacitor based energy storage system for improved load frequency control显示文摘 | Mairajuddin M Shameem A L Shiekh J I | 2009 | Electric Power Systems Research2009，79，1： | 1 |
| 14 | Reduced nitrate lev-el in individuals with hypertension and diabetes显示文摘 | Shiekh GA Ayub T Khan SN | 2011 | JCardiovasc Dis Res2011，2，3： | 1 |
| 15 | Super-capacitor based energy storage system for improved load frequency control显示文摘 | Mairajuddin M Shameem A L Shiekh J I | 2009 | Elec- tric Power Systems Research2009，79，1： | 1 |
| 16 | US experience of transradial coronary stenting utilizing Palmaz-Shatz stents显示文摘 | EL SHIEKH R BURKET M W MOUHAFFEL A | 1997 | Cathet Cardiovas Diagn1997，40，： | 1 |
| 17 | Lithogenesis: induction of renal calcifications by nanobacteria 显示文摘 | Shiekh F A Khullar M Singh S K | 2006 | Urol Res2006，34，1： | 1 |
| 18 | Lithogenesis:induction of renal calcifications by nanobaeteria显示文摘 | Shiekh F A Khullar M Singh S K | 2006 | Urol Res2006，34，1： | 1 |
| 19 | Super-capacitorbased energy storage system for improved load frequency control显示文摘 | MAIRAJ U D M SHAMEEM A L SHIEKH J I | 2009 | Electric Power Systems Research2009，79，1： | 1 |
| 20 | Beam column moment connection for composite frame 显示文摘 | Shiekh T M Deierlrin G G | 1989 | Journal of Structural Engineering1989，115，11： | 1 |
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