|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Magnifying colonoscopy as a non-biopsy technique for differential diagnosis of non-neoplastic and neoplastic lesions显示文摘瞄准:为了澄清与放大结肠镜检查观察的粘膜地窟模式是否对可行,把非肿瘤的息肉与肿瘤的息肉区分开来。方法:从通过 2000 年 3 月的 1999 年 6 月,有 210 损害的 180 个连续病人与放大结肠镜诊断了(CF-200Z,天堂光有限公司,东京,日本) 被注册。有 0.2% 靛青洋红染料的放大和多彩石印版内视镜检查法为粘膜地窟观察被用于每损害。损害出现打字我和 II 地窟模式被活体检视组织学地认为非肿瘤、检验,而损害证明到 V 地窟模式的类型 III 被移开内视镜的联盟者或通过手术。内视镜的诊断和 histologic 诊断的关联然后被调查。结果:在内视镜检查法, 24 损害证明我或 II 坑模式,和 186 损害显示出的一种类型打 III 到 V 坑模式。与 histologic 检查, 26 损害作为非肿瘤的息肉被诊断,并且 184 损害作为肿瘤的息肉被诊断。全面诊断精确性是 99.1%(208/210 ) 。敏感和特性是 92.3%(24/26 ) 并且 99.8%(184/186 ) 分别地。结论:放大结肠镜检查能作为一种非活体检视技术被使用区分肿瘤、非肿瘤的息肉。 | Shigeharu Kato Kuang I Fu Yasushi Sano Takahiro Fujii Yutaka Saito Takahisa Matsuda Ikuro Koba Shigeaki Yoshida Takahiro Fujimori | 2006 | World Journal of Gastroenterology2006，12，9： | 31 |
| 2 | Vitamin D and calcium are required at the time of denosumab administration during osteoporosis treatment显示文摘To evaluate the differences in outcomes of treatment with denosumab alone or denosumab combined with vitamin D and calcium supplementation in patients with primary osteoporosis. Patients were split into a denosumab monotherapy group(18 cases) or a denosumab plus vitamin D supplementation group(combination group; 23 cases). We measured serum bone alkaline phosphatase(BAP), tartrate-resistant acid phosphatase(TRACP)-5 b and urinary N-terminal telopeptide of type-I collagen(NTX) at baseline, 1 week, as well as at 1 month and 2, 4, 8 and 12 months. We also measured bone mineral density(BMD) of L1–4 lumbar vertebrae(L)-BMD and bilateral hips(H)-BMD at baseline and at 4, 8 and 12 months. There was no significant difference in patient background. TRACP-5 b and urinary NTX were significantly suppressed in both groups from 1 week to 12 months(except at 12 months for NTX). In the combination group, TRACP-5 b was significantly decreased compared with the denosumab monotherapy group at 2 and 4 months(P < 0.05).BAP was significantly suppressed in both groups at 2–12 months. L-BMD significantly increased at 8 and12 months(8.9%) in the combination group and at 4, 8 and 12 months(6.0%) in the denosumab monotherapy group, compared with those before treatment. H-BMD was significantly increased in the combination group(3.6%) compared with the denosumab group(1.2%) at 12 months(P < 0.05). Compared with denosumab monotherapy, combination therapy of denosumab with vitamin D and calcium stopped the decrease in calcium caused by denosumab, inhibited bone metabolism to a greater extent, and increased BMD(especially at the hips). | Yukio Nakamura Takako Suzuki Mikio Kamimura Kohei Murakami Shota Ikegami Shigeharu Uchiyama Hiroyuki Kato | 2017 | Bone Research2017，5，4： | 11 |
| 3 | AM50镁合金多道次热轧中动态再结晶过程的有限元模拟及实验研究(英文)显示文摘通过开发用于组织模拟的用户程序,采用有限元软件DEFORM-3D模拟AM50镁合金多道次热轧过程中的组织转变,并通过与实验结果的对比分析证明该用户程序模拟多道次轧制的可行性。结果表明:多道次热轧有助于镁板的晶粒细化及均匀再结晶组织的获得,精轧前的板坯温度对终轧后的晶粒尺寸影响很大,但对晶粒尺寸的分布情况影响不明显。开发的用户程序亦可应用于其他类型多道次热变形过程的模拟研究。 | 丁汉林 王天一 杨磊 Shigeharu KAMADO | 2013 | Transactions of Nonferrous Metals Society of China2013，23，9： | 8 |
| 4 | Effects of trace Gd concentration on texture and mechanical properties of hot-rolled Mg-2Zn-xGd sheets显示文摘The effects of Gd concentration(0.1,0.3,0.7 wt%)on the microstructure,texture and mechanical properties of rolled and annealed Mg-2Zn-xGd sheets have been investigated aiming to develop low cost and high ductile Mg-Zn-Gd sheets.Dynamic recrystallization,static recrystallization and grain growth during hot rolling process and annealing process were delayed with increase of Gd concentration,leading to fine grain microstructure.The rolled 0.1 wt%Gd sheet showed strong basal texture which remained stable after annealing process and exhibited medium elongation of about 25%.In contrast,the rolled 0.3 wt%Gd sheet had weak basal texture which transformed to non-basal texture with double peaks tilted about±48°to the transverse direction due to the static recrystallization during annealing process.Consequently,the annealed sheets exhibited higher elongation of 40%along the rolling direction and 50%along the transverse direction due to the existence of non-basal texture.It is suggested that the minimum effective concentration for texture randomization in the Mg-2Zn-xGd alloy is about 0.3 wt%. | Hong Yan Rongshi Chen Nan Zheng Jun Luo Shigeharu Kamado Enhou Han | 2013 | Journal of Magnesium and Alloys2013，1，1： | 7 |
| 5 | 一种新型网膜对SARS冠状病毒的抑制作用显示文摘利用光触媒钛羟基磷灰石网膜 (PTAF)具有吸附和酶催化的特点 ,研究其对SARS病毒的抑制作用 .实验结果表明在紫外照射条件下 ,PTAF膜对SARS冠状病毒的抑制率为 10 0 % .在没有紫外照射的条件下 ,PTAF膜对SARS冠状病毒的抑制率为 99 99% ,与对照组相比 ,PTAF膜抑制病毒的效率是HAF膜的 10 0 0倍以上 .研究结果提示 ,PTAF在预防SARS冠状病毒及其他病毒性疾病流行方面有潜在的应用价值 . | 韩伟 张泮河 曹务春 杨东玲 SHIGEHARU TAIRA YOSHIO OKAMOTO JUN-ICHIRO ARAI 阎锡蕴 | 2004 | 生物化学与生物物理进展2004，31，11： | 6 |
| 6 | Ca添加对镁合金板材组织和织构的影响(英文)显示文摘采用多道次轧制方法制备AM60(Mg-6.0Al-0.3Mn,质量分数%)和ZXM200(Mg-1.6Zn-0.5Ca-0.2Mn)镁合金板材,并研究镁合金板材的力学性能和织构特征。研究表明,在添加Ca的镁合金轧板中,细小的再结晶晶粒表现出特定的取向特征,从而改变了轧板的整体织构特征;固溶至镁基体中的Ca元素促使晶粒c轴由板坯法线方向向板宽方向偏转,亦可明显弱化板材织构。这导致了含Ca的镁合金板材表现出与稀土镁合金类似的织构特征。 | 丁汉林 张鹏 程广萍 Shigeharu KAMADO | 2015 | Transactions of Nonferrous Metals Society of China2015，25，9： | 6 |
| 7 | Mild closed head traumatic brain injury-induced changes in monoamine neurotransmitters in the trigeminal subnuclei of a rat model:mechanisms underlying orofacial allodynias and headache显示文摘Our recent findings have demonstrated that rodent models of closed head traumatic brain injury exhibit comprehensive evidence of progressive and enduring orofacial allodynias, a hypersensitive pain response induced by non-painful stimulation. These allodynias, tested using thermal hyperalgesia, correlated with changes in several known pain signaling receptors and molecules along the trigeminal pain pathway, especially in the trigeminal nucleus caudalis. This study focused to extend our previous work to investigate the changes in monoamine neurotransmitter immunoreactivity changes in spinal trigeminal nucleus oralis, pars interpolaris and nucleus tractus solitaries following mild to moderate closed head traumatic brain injury, which are related to tactile allodynia, touch-pressure sensitivity, and visceral pain. Our results exhibited significant alterations in the excitatory monoamine, serotonin, in spinal trigeminal nucleus oralis and pars interpolaris which usually modulate tactile and mechanical sensitivity in addition to the thermal sensitivity. Moreover, we also detected a robust alteration in the expression of serotonin, and inhibitory molecule norepinephrine in the nucleus tractus solitaries, which might indicate the possibility of an alteration in visceral pain, and existence of other morbidities related to solitary nucleus dysfunction in this rodent model of mild to moderate closed head traumatic brain injury. Collectively, widespread changes in monoamine neurotransmitter may be related to orofacial allodynhias and headache after traumatic brain injury. | Golam Mustafa Jiamei Hou Rachel Nelson Shigeharu Tsuda Mansura Jahan Naweed S.Mohammad Joseph V.Watts Floyd J.Thompson Prodip Bose | 2017 | Neural Regeneration Research2017，12，6： | 5 |
| 8 | Endocytoscopic narrow-band imaging efficiency for evaluation of inflammatory activity in ulcerative colitis显示文摘AIM:To assess the efficacy of endocytoscopic narrowband imaging(EC-NBI)for evaluating the severity of inflammation in ulcerative colitis(UC).METHODS:This retrospective study was conducted at a single tertiary care referral center.We included UC patients who underwent colonoscopy with endocytoscopy from July 2010 to December 2013.ECNBI was performed,and the images were evaluated by assessing visibility,increased vascularization,and the increased calibers of capillaries and were classified as Obscure,Visible or Dilated.Obscure was indicative of inactive disease,while Visible and Dilated were indicative of acute inflammation.This study received Institutional Review Board approval.The primary outcome measures included the diagnostic ability of EC-NBI to distinguish between active and inactive UC on the basis of histological activity.The conventional endoscopic images were classified according to the Mayo endoscopic score.A score of 0 or 1 indicated inactive disease,whereas a score of 2 indicated active disease.RESULTS:Fifty-two patients were enrolled.There was a strong correlation between the EC-NBI findings and the histological assessment(r=0.871,P<0.01).The sensitivity,specificity,positive predictive value,negative predictive value,and accuracy of EC-NBI for diagnosing acute inflammation were 84.0%,100%,87.1%,100%,and 92.3%,respectively,while those for the Mayo endoscopic score were 100%,40.7%,100%,61.0%,and 69.2%,respectively.Compared with conventional endoscopy,EC-NBI was superior in diagnostic specificity,negative predictive value,and accuracy(P<0.001,P=0.001 and P=0.047,respectively).CONCLUSION:The EC-NBI finding of capillaries in the rectal mucosa was strongly correlated with histological inflammation and aided in the differential diagnosis between active and inactive UC. | Yasuharu Maeda Kazuo Ohtsuka Shin-ei Kudo Kunihiko Wakamura Yuichi Mori Noriyuki Ogata Yoshiki Wada Masashi Misawa Akihiro Yamauchi Seiko Hayashi Toyoki Kudo Takemasa Hayashi Hideyuki Miyachi Fuyuhiko Yamamura Fumio Ishida Haruhiro Inoue Shigeharu Hamatani | 2015 | World Journal of Gastroenterology2015，21，7： | 4 |
| 9 | FEM analysis for hot rolling process of AM60 alloy显示文摘<正>The rolling of AM60 sheets for 50%reduction was analyzed with DEFORM to investigate the hot deformation process. The simulated results show that the sheet velocities at the entrance(21 mm/s) and at the exit(37 mm/s) are less and larger than roll velocity,respectively.From the entrance to the neutral point,the velocity at the sheet surface is greater than that at the middle point of sheet in thickness,while that from the neutral point to the exit shows the opposite pattern.The effective strain of the sheet increases from the entrance to the exit due to the continuous reduction in thickness.In addition,the effective strain at the sheet surface reaches to 1.0 and is larger than that of 0.8 at the middle point of sheet.The difference of effective strain in thickness direction has a much stronger effect on the recrystallized fraction than on the recrystallized grain size.The minimum temperature of 347℃is obtained at the surface contacting directly with roll and the maximum temperature 388℃at the middle point of sheet in thickness. | 丁汉材 KANAMORI Nao HONMA Tomoyuki KAMADO Shigeharu KOJIMA Yo | 2008 | 中国有色金属学会会刊:英文版2008，18，A01： | 4 |
| 10 | Alpha-fetoprotein-producing colon cancer with atypical bulky lymph node metastasis显示文摘Alpha-fetoprotein (AFP)-producing colorectal cancer is extremely rarely reported until now. All of the reported cases harboring synchronous hematogenous spread including liver and/or lung metastasis had a poor prognosis and died within 12 mo. We here describe a 71-year old man with AFP-producing colon cancer who presented with an unusual bulky lymph node metastasis instead of hematogenous spread. He underwent adjuvant chemotherapy in addition to curative surgical resection, which prolonged his survival. | Kuangi Fu Akihiro Kobayashi Norio Saito Yasushi Sano Shigeharu Kato Hiroaki Ikematsu Takahiro Fujimori Yasushi Kaji Shigeaki Yoshida | 2006 | World Journal of Gastroenterology2006，12，47： | 3 |
| 11 | Pneumoscrotum: A rare manifestation of perforation associated with therapeutic colonoscopy显示文摘Pneumoscrotum is uncommon and also rarely reported as a complication associated with colonic perforation. A case of colonic perforation in delayed fashion associated with EMR, revealed by pneumoscrotum, is reported and the associated literatures are reviewed. A 52-year-old male received piecemeal EMR for a laterally spreading tumor 35 mm in size in our hospital. He complained of enlargement of the scrotum and revisited our hospital the day after the procedure. A diagnosis of pneumoscrotum was made, and as most such cases have been reported to be associated with pneumoperitoneum, colonic perforation was suspected. Free air but no fluid collection was found by abdominal computed tomography, and delayed colonic perforation was diagnosed. However, as there were no clinical signs of peritoneal irritation,conservative treatment was administered and the patient recovered uneventfully. Pneumoscrotum could be a sign of colonic perforation after EMR, and treatment should be carefully chosen. | Kuang-I Fu Yasushi Sano Shigeharu Kato Takahiro Fujii Masanori Sugito Masato Ono Norio Saito Kiyotaka Kawashima Shigeaki Yoshida Takahiro Fujimori | 2005 | World Journal of Gastroenterology2005，11，32： | 3 |
| 12 | Efficiency of endocytoscopy in differentiating types of serrated polyps显示文摘 | Makoto Kutsukawa Shin-ei Kudo Nobunao Ikehara Yushi Ogawa Kunihiko Wakamura Yuichi Mori Katsuro Ichimasa Masashi Misawa Toyoki Kudo Yoshiki Wada Takemasa Hayashi Hideyuki Miyachi Haruhiro Inoue Shigeharu Hamatani | 2014 | Gastrointestinal Endoscopy2014，，4： | 3 |
| 13 | Influence of size and distribution of W phase on strength and ductility of high strength Mg-5.1Zn-3.2Y-0.4Zr-0.4Ca alloy processed by indirect extrusion显示文摘A high strength Mg-5.1Zn-3.2Y-0.4Zr-0.4Ca(wt%) alloy containing W phase(Mg_3Y_2Zn_3) prepared by permanent mold direct-chill casting is indirectly extruded at 350?C and 400?C, respectively. The extruded alloys show bimodal grain structure consisting of fine dynamic recrystallized(DRXed) grains and unrecrystallized coarse regions containing fine W phase and β2' precipitates. The fragmented W phase particles induced by extrusion stimulate nucleation of DRXed grains, leading to the formation of fine DRXed grains, which are mainly distributed near the W particle bands along the extrusion direction. The alloy extruded at 350?C exhibits yield strength of 373 MPa, ultimate tensile strength of 403 MPa and elongation to failure of 5.1%. While the alloy extruded at 400?C shows lower yield strength of 332 MPa,ultimate tensile strength of 352 MPa and higher elongation to failure of 12%. The mechanical properties of the as-extruded alloys vary with the distribution and size of W phase. A higher fraction of DRXed grains is obtained due to the homogeneous distribution of micron-scale broken W phase particles in the alloy extruded at 400?C, which can lead to higher ductility. In addition, the nano-scale dynamic W phase precipitates distributed in the un DRXed regions are refined at lower extrusion temperature. The smaller size of nano-scale W phase precipitates leads to a higher fraction of un DRXed regions which contributes to higher strength of the alloy extruded at 350?C. | Hansi Jiang Xiaoguang Qiao Chao Xu Shigeharu Kamado Kun Wu Mingyi Zheng | 2018 | Journal of Materials Science & Technology2018，34，2： | 2 |
| 14 | Ultrasound demonstration of mammographically detected microcalcifications in patients with ductal carcinomain situ of the breast显示文摘 | Takeshi Nagashima Hideyuki Hashimoto Keiko Oshida Shigeharu Nakano Naoto Tanabe Takashi Nikaido Keiji Koda Masaru Miyazaki | 2005 | Breast Cancer2005，，3： | 2 |
| 15 | Residual risk of transfusion‐transmitted hepatitis B virus (HBV) infection caused by blood components derived from donors with occult HBV infection in Japan显示文摘 | Rikizo Taira Masahiro Satake Shun’ya Momose Satoru Hino Yoshiharu Suzuki Hiroyuki Murokawa Shigeharu Uchida Kenji Tadokoro | 2013 | Transfusion2013，，7： | 2 |
| 16 | Influence of substrate surface roughness on light scattering of TiO2 optical thin films显示文摘 | Toshinori Harada Hiroshi Murotani Shigeharu Matumoto Hiromitu Honda | 2013 | Chinese Optics Letters2013，11，13： | 2 |
| 17 | Fundamental Magnesium Researches in Japan显示文摘 | Kojima Yo Kamado Shigeharu | 2005 | Materials Science Forum2005，，488： | 2 |
| 18 | Microstructural examination of oxide layers formed on an oxide dispersion strengthened ferritic steel exposed to supercritical water显示文摘 | Yun Chen Kumar Sridharan Todd R. Allen Shigeharu Ukai | 2006 | Journal of Nuclear Materials2006，，1： | 2 |
| 19 | Two-year clinical outcome of denosumab treatment alone and in combination with teriparatide in Japanese treatment-naive postmenopausal osteoporotic women显示文摘This randomized prospective study aimed to evaluate the clinical outcome of denosumab treatment alone and in combination with teriparatide in treatment-naive postmenopausal Japanese female patients with osteoporosis. Thirty patients were randomly assigned to two groups:(1) denosumab group(denosumab alone, n=13); and(2) combination group(denosumab+teriparatide, n=17). Serum bone-specific alkaline phosphatase(BAP), serum tartrate-resistant acid phosphatase(TRACP)-5b, urinary cross-linked N-terminal telopeptides of type I collagen(NTX), and bone mineral density(BMD) of L1–4 lumbar vertebrae(L-BMD)and bilateral total hips(H-BMD) were determined at the first visit and at various time points up to 24 months post-treatment to determine percentage changes. Serum TRACP-5b and urinary NTX were equally suppressed in both groups and maintained at low levels, with slight increases at 12, 18 and 24 months. BAP was significantly decreased in both groups from 4 to 24 months, with significant differences between the groups at 4, 8 and 15 months(P<0.05). L-BMD was significantly increased at most time points in both groups, with a significant difference between the combination group and denosumab group at 24 months(17.2% increase versus 9.6% increase; P<0.05). There was no significant difference in H-BMD between the two groups, although the levels tended to be higher in the combination group than in the denosumab group(9.5% increase versus 5.6% increase). These findings suggest that denosumab+teriparatide combination therapy may represent an important treatment for primary osteoporotic patients at high risk of vertebral fracture. | Yukio Nakamura Takako Suzuki Mikio Kamimura Shota Ikegami Kohei Murakami Shigeharu Uchiyama Akira Taguchi Hiroyuki Kato | 2017 | Bone Research2017，5，2： | 2 |
| 20 | Assessment of vascular injury in patients with stroke by measurement of pulse wave velocity显示文摘 | TAKAHIRO N HIROKI O SHIGEHARU S | 2004 | Journal of Stroke and Cerebrovascular Diseases2004，13，2： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员