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| 1 | Perceived risk as a barrier to appropriate diagnosis of irritable bowel syndrome显示文摘AIM:To evaluate perceived risk,diagnostic testing,and acceptance of a diagnosis of irritable bowel syndrome(IBS)among the Korean laypersons.METHODS:We designed a conceptual framework to evaluate the health-seeking behavior of subjects based on a knowledge,attitude,and practice model.We developed a vignette-based questionnaire about IBS based on a literature review and focused group interviews.The vignette described a 40-year-old woman who meets the RomeⅢcriteria for IBS without red-flag signs.It was followed by questions about demographic characteristics,health behaviors,IBS symptoms,risk perception,perceived need for diagnostic tests,and acceptance of a positive diagnosis of IBS.Weplanned a nationwide survey targeting laypersons without IBS and between the ages of 20 and 69 years.Survey participants were selected by quota sampling stratified by gender,age,and nationwide location.A multivariate logistic model was constructed based on literature reviews,univariate analysis,and a stepwise selection method to investigate correlations between the perceived risk,need for diagnostic tests,and acceptance of a positive diagnosis.RESULTS:Of 2354 eligible households,1000 subjects completed the survey and 983 subjects were analyzed,excluding those who met symptom criteria for IBS.After reading the IBS vignette,the majority of subjects(86.8%)responded that the patient was at increased risk of severe disease.The most frequent concern was colon cancer(59.8%),followed by surgical condition(51.5%).Most subjects responded the patient needs diagnostic tests(97.2%).Colonoscopy was the most commonly required test(79.5%).Less than half of the respondents requested a stool examination(45.0%),blood test(40.7%),abdominal ultrasound(36.0%),or computed tomography(20.2%).The subjects who felt increased risk were more likely to see a need for colonoscopy[adjusted odds ratio(a OR)=2.10,95%CI:1.38-3.18].When asked about the positive diagnosis,the most frequent response was that'the patient would not be reassured'(65.7%).The increased risk perception group was less likely to be reassured by a positive diagnosis of IBS,compared to the other respondents(a OR=0.52,95%CI:0.34-0.78).CONCLUSION:For IBS diagnosis,increased risk perception is a possible barrier to the appropriate use of diagnostic tests and to the patient’s acceptance of a positive diagnosis. | Eunmi Ahn Ki Young Son Dong Wook Shin Min Kyu Han Hyejin Lee Ah Reum An Eun Ho Kim Be Long Cho | 2014 | World Journal of Gastroenterology2014，20，48： | 2 |
| 2 | Molecular tumor targeting of gelonin by fusion with F3 peptide显示文摘 | Song-Hee HAM Kyoung Ah MIN Meong Cheol SHIN | 2017 | Acta Pharmacologica Sinica2017，38，6： | 2 |
| 3 | Enhancement of bone regeneration by gene delivery of BMP2/Runx2 bicistronic vector into adipose-derived stromal cells显示文摘 | Suk-Jun Lee Sun-Woong Kang Hyun-Jin Do Inbo Han Dong Ah Shin Jae-Hwan Kim Soo-Hong Lee | 2010 | Biomaterials2010，，21： | 1 |
| 4 | Pediatric Patients With Multifocal Papillary Thyroid Cancer Have Higher Recurrence Rates Than Adult Patients: A Retrospective Analysis of a Large Pediatric Thyroid Cancer Cohort Over 33 Years显示文摘 | Young Ah Lee Hae Woon Jung Hwa Young Kim Hoonsung Choi Hyun-Young Kim J. Hun Hah Do Joon Park June-Key Chung Sei Won Yang Choong Ho Shin Young Joo Park | 2015 | The Journal of Clinical Endocrinology & Metabolism2015，，4： | 1 |
| 5 | Chlorogenic acid, an antioxidant principle from the aerial parts of Artemisia iwayomogi that acts on 1,1-diphenyl-2-picrylhydrazyl radical显示文摘 | Soon Shin Kim Chung Kyu Lee Sam Sik Kang Hyun Ah Jung Jae Sue Choi | 1997 | Archives of Pharmacal Research1997，，： | 1 |
| 6 | Lipase- catalyzed production of phytosteryl estersand their crystallization behavior in corn oil 显示文摘 | Phuong- Lan Vu Jung- Ah Shin | 2004 | Food Research International2004，，37： | 1 |
| 7 | Neuronal Properties, In Vivo Effects, and Pathology of a Huntington’s Disease Patient‐Derived Induced Pluripotent Stem Cells显示文摘 | Iksoo Jeon Nayeon Lee Jia‐Yi Li In‐Hyun Park Kyoung Sun Park Jisook Moon Sung Han Shim Chunggab Choi Da‐Jeong Chang Jihye Kwon Seung‐Hun Oh Dong Ah Shin Hyun Sook Kim Jeong Tae Do Dong Ryul Lee Manho Kim Kyung‐Sun Kang George Q. Daley Patrik Brundin Jihwa | 2012 | STEM CELLS2012，，9： | 1 |
| 8 | Glycation-induced inactivation of antioxidant enzymes and modulation of cellular redox status in lens cells 显示文摘 | Shin AH Oh CJ Park JW | 2006 | Arch Pharm Res2006，29，7： | 1 |
| 9 | Using low tube voltage (80kVp) quadruple phase liver CT for the detection of hepatocellular carcinoma: Two-year experience and comparison with Gd-EOB-DTPA enhanced liver MRI显示文摘 | Chang Hee Lee Kyeong Ah Kim Jongmee Lee Yang Shin Park Jae Woong Choi Cheol Min Park | 2012 | European Journal of Radiology2012，，： | 1 |
| 10 | Complete mesocolic cxeisian with D3 lymph node dissection in laparoscopic colectomy h:r stages II and III colon cancer: long-term oncologic outcomes in 168 pa- tients 显示文摘 | Shin JW Amar AH Kim SH | 2014 | Tech Coloprocto12014，18，9： | 1 |
| 11 | Dynamics and control of solution levels in a high temperature generator for an absorption chiller显示文摘 | Jeong Ah Seo Younggy Shin Jae Dong Chung | 2012 | International Journal of Refrigeration2012，，4： | 1 |
| 12 | Simulation of dynamics and control of a double-effect LiBr–H 2 O absorption chiller显示文摘 | Younggy Shin Jung Ah Seo Hyun Wook Cho Sang Chul Nam Jin Hee Jeong | 2009 | Applied Thermal Engineering2009，，13： | 1 |
| 13 | Transporter-mediated bile acid uptake causes Ca 2+ -dependent cell death in rat pancreatic acinar cells显示文摘 | Joo Young Kim Kyung Hwan Kim Jin Ah Lee Wan Namkung An–Qiang Sun Meena Ananthanarayanan Frederick J. Suchy Dong Min Shin Shmuel Muallem Min Goo Lee | 2002 | Gastroenterology2002，，7： | 1 |
| 14 | Serum leptin and adiponectin levels correlate with exercise-induced bronchoconstriction in children with asthma显示文摘 | Baek HS Kim YD Shin JH et ah | | 0，，01： | 1 |
| 15 | Subclinical atherosclerosis in a community-based elderly cohort: The Korean Longitudinal Study on Health and Aging显示文摘 | Soo Lim Hyung Jin Choi Hayley Shin Ah Reum Khang Seon Mee Kang Ji Won Yoon Sung Hee Choi In Kyong Jeong Sung Il Cho Kyong Soo Park Hak Chul Jang | 2011 | International Journal of Cardiology2011，，1： | 1 |
| 16 | Lipase-catalyzed production of phytosteryl esters and their crystallization behavior in corn oil 显示文摘 | Phuong Lan Vu Jung Ah Shin Chi Hwan Lim | 2004 | Food Research International2004，37，2： | 1 |
| 17 | Dual roles of human BUBRI,a mitotic check point kinase,in the monitoring of chromosomal instability显示文摘 | Shin HJ Back KH Jeon AH | | 0，，6： | 1 |
| 18 | Dual roles of human BubR1,a mitotic checkpoint kinase,in the monitoring of chromosomal instability显示文摘 | Shin HJ Baek KH Jeon AH | | 0，，： | 1 |
| 19 | Glycation-induced inactivation of an- tioxidant enzymes and modulation of cellular redox status in lens cells显示文摘 | Shin AH Oh C J Park JW | 2006 | Arch Pharm Res2006，29，7： | 1 |
| 20 | Oral chemotherapy for second-line treatment in patients with gemcitabine-refractory advanced pancreatic cancer显示文摘BACKGROUND There is no standard therapy for second-line treatment of gemcitabine-refractory pancreatic cancer patients with poor performance status.A combination of chemotherapy drugs 5-fluorouracil(5-FU),leucovorin,irinotecan,and oxaliplatin(FOLFIRINOX)or 5-fluorouracil/leucovorin plus nanoliposomal irinotecan can be considered as second-line treatment for such patients;however,due to toxicity,none of the regimens are recommended for patients with poor performance.Capecitabine or S-1 has relatively low toxicity and can be considered a treatment option for gemcitabine-refractory pancreatic cancer.AIM To investigate the efficacy and toxicity of oral chemotherapy as second-line treatment in patients with pancreatic cancer.METHODS Patients who had progressive disease after first-line gemcitabine-based chemotherapy were retrospectively analyzed between January 2011 and December 2018.They were treated with capecitabine or S-1 as the second-line treatment.Capecitabine was administered as a 2500 mg/m2 divided dose on days 1-14,followed by a 1-wk rest.S-1 was taken orally based on the patient’s body surface area for 28 d,followed by 2-wk of rest.Progression-free survival and overall survival were used to compare efficacy of capecitabine and S-1.RESULTS Of the 81 patients,41 were treated with capecitabine and 40 with S-1.The median time to treatment failure in both groups was 1.5 mo(P=0.425).The objective response rate was similar in the two groups:9.8%with capecitabine and 2.5%with S-1(P=0.359).Median progression-free survival was longer in the S-1 group than in the capecitabine group(S-12.7 mo,capecitabine 2.0 mo,P=0.003).There was no significant difference in the median overall survival between the capecitabine and S-1 groups(4.3 mo vs 5.0 mo,P=0.092).Grade 3 or 4 hand-foot syndrome was significantly more common in the capecitabine group than in the S-1 group(14.6%vs 0%,P=0.026).CONCLUSION Capecitabine or S-1 can be used as a second-line treatment for patients with advanced pancreatic cancer with poor performance status after progression to a gemcitabine-based regimen. | Se Jun Park Hyunho Kim Kabsoo Shin Myung Ah Lee Tae Ho Hong | 2019 | World Journal of Gastrointestinal Oncology2019，11，11： | 1 |
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