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| 1 | Features of extrahepatic metastasis after radiofrequency ablation for hepatocellular carcinoma显示文摘BACKGROUND Extrahepatic metastasis(EHM)of hepatocellular carcinoma(HCC)is associated with poor outcomes.However,the clinical features and risk factors of EHM of HCC after radiofrequency ablation(RFA)remain unclear.AIM To elucidate the characteristics and risk factors of EHM after RFA for HCC.METHODS From January 2008 to December 2017,we retrospectively enrolled 661 patients who underwent RFA as first-line treatment for HCC at 2 tertiary hospitals.The inclusion criteria were age≥18 years,a diagnosis of HCC,and treatment-naivety.Abdominal computed tomography(CT)or magnetic resonance imaging(MRI)and alpha-fetoprotein measurements were routinely performed at 1 mo after RFA and followed-up at intervals of 3-6 mo.Univariate analyses were performed using the chi-squared test or Student’s t-test,and univariate and multivariate analyses were performed via logistic regression,as appropriate.RESULTS EHM was diagnosed in 44 patients(6.7%)during a median follow-up period of 1204 days.The 10-year cumulative rate of HCC recurrence and EHM was 92.7%and 33.7%,respectively.Initial recurrence was most often intrahepatic,and the rate of extrahepatic recurrence at initial recurrence was only 1.2%.The median time to the diagnosis of EHM was 2.68 years,and 68.2%of patients developed EHM within 2 years of the first recurrence,regardless of recurrence-free survival and 75.0%of patients developed EHM within 5 years after first recurrence.EHM was mostly diagnosed via abdominal CT/MRI in 33(75.0%)and 38 of 44 patients(86.4%)with EHM had either positive abdominal CT scan results or serum AFP level elevation.In multivariate analysis,recurrence-free survival<2 years,ablation zone/tumor size<2,and alpha-fetoprotein level>400 IU/mL were associated with a high EHM risk.CONCLUSION EHM occurs following multiple intrahepatic recurrences after RFA and combined contrast-enhanced abdominal CT and serum AFP were useful for surveillance.Patients especially with high-risk factors require close follow-up for EHM. | Jae H Yoon Young J Goo Chae-Jun Lim Sung K Choi Sung B Cho Sang S Shin Chung H Jun | 2020 | World Journal of Gastroenterology2020，26，32： | 3 |
| 2 | Modification of Mg2Si morphology in squeeze cast Mg-Al-Zn-Si alloys by Ca or P addition 显示文摘 | Kim J J Kim K H Shin K S | 1999 | Scripta Materialia1999，41，3： | 3 |
| 3 | The quality of reconstructed 3D images in mutidetector-row helical CT: experimental study involving scan parameters显示文摘 | Shin J H Lee H K Choi C G | 2002 | Korean J Radiol2002，3，1： | 2 |
| 4 | Operating characteristics of aerated submerged biofilm reactors for drinking water treatment 显示文摘 | Lim K H Shin H S | 1997 | Wat Sci Tech1997，36，12： | 2 |
| 5 | Microstructure-mechanical property relationship in hot isostatically pressed alumina and zirconia-toughened alumina 显示文摘 | Shin D W Orr K K Schubert H | 1990 | J Am Ceram Soc1990，73，5： | 2 |
| 6 | Insulinoma: pathophysiology, localization and management显示文摘 | Joyce J Shin Phillip Gorden Steven K Libutti | 2010 | Future Oncol2010，，2： | 2 |
| 7 | Damping mechanism and application of Fe-Mn Base Alloy 显示文摘 | Jee K K Jang W Y Baik S H Shin M C | 1999 | Materials Science and Engineering1999，，273275： | 2 |
| 8 | Antibacterial activity of bovine lactoferrin and its peptides against enterohaemorrhagic Escherichia coli O157:H7显示文摘 | SHIN K YAMAUCHI K | 1998 | The Society for Applied Microbiology1998，26，： | 2 |
| 9 | Low resistivity indium tin oxide films deposited by unbalanced DC magnetron sputtering 显示文摘 | Shin S H Shin J H Park K J | 1999 | Thin Solid Films1999，341，12： | 1 |
| 10 | Cecropin A - magainin 2 hybrid peptides having potent antimicrobial activity with low hemolytic effect显示文摘 | Shin S Y Kang J H Lee M K | 1998 | Biochem Mol Biol Int1998，44，6： | 1 |
| 11 | Transmit power allocation for a modified V-BLAST system显示文摘 | Nam S H Shin O S Lee K B | 2004 | IEEE Transactions on Communications2004，52，7： | 1 |
| 12 | Effect of shear stress on granulation in oxygen aerobic upflow sludge bed reactors 显示文摘 | Shin H S Lira K H Park H S | 1992 | Water Sci Technol1992，26，34： | 1 |
| 13 | Combining Feature Reduction and Case Selection in Building CBR Classifiers 显示文摘 | LI Yah Simon C K Shin Sankar K Pal | 2006 | IEEE Transactions on Knowledge and data Engineering2006，18，3： | 1 |
| 14 | Anti-allergic effects of Sanguisorba officinalis on animal models of allergic reactions显示文摘 | SHIN T Y LEE K B KIM S H TA Y | 2002 | Immunopharmacology & Immunotoxicology2002，24，3： | 1 |
| 15 | hnage Metamorphosis Using Snakes and Freeform Deformations 显示文摘 | Lee S Chwa K Shin S | 1995 | Proeeedings of SIGGRAPH Los Angeles CA USA1995，1995，： | 1 |
| 16 | Abstracting Access Patterns of Dynamic Memory Using Regular Expressions 显示文摘 | Jeon J Shin K Han H | 2008 | ACM Transactions on Architecture and Code Optimization2008，5，4： | 1 |
| 17 | The BLUE Active Queue Management Algorithms显示文摘 | Feng W Shin K G Kandlur D D | 2002 | ACM Transactions on Networking2002，，10： | 1 |
| 18 | Medullary thyroid carcinoma: comparison with papillary thyroid carcinoma and application of current sonographic cdteria显示文摘 | Lee S Shin J H Han B K | 2010 | AJR Am J Roentgenol2010，194，4： | 1 |
| 19 | Effects of limiting nutrients and N: P ratios on the phytoplankton growth in a shallow hypertrophic reservoir显示文摘 | Kim H S Hwang S J Shin J K | 2007 | Hydrobiologia2007，581，： | 1 |
| 20 | Reduction of dislocations in GaN epilayers grown on Si(111)substrate using SixNy inserting layer显示文摘 | Lee K J Shin E H Lin K Y | 2004 | Appl Phys Lett2004，85，9： | 1 |
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