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| 1 | Diagnostic value of PIVKA-Ⅱ and alpha-fetoprotein in hepatitis B virus-associated hepatocellular carcinoma显示文摘AIM: To determine the cutoff values and to compare the diagnostic role of alpha-fetoprotein(AFP) and prothrombin induced by vitamin K absence-Ⅱ(PIVKA-Ⅱ) in chronic hepatitis B(CHB).METHODS: A total of 1255 patients with CHB, including 157 patients with hepatocellular carcinoma(HCC), 879 with non-cirrhotic CHB and 219 with cirrhosis without HCC, were retrospectively enrolled. The areas under the receiver operating characteristic(AUROC) curves of PIVKA-Ⅱ, AFP and their combination were calculated and compared.RESULTS: The optimal cutoff values for PIVKA-Ⅱ and AFP were 40 m AU/m L and 10 ng/m L, respectively, for the differentiation of HCC from nonmalignant CHB. The sensitivity and specificity were 73.9% and 89.7%, respectively, for PIVKA-Ⅱ and 67.5% and 90.3% for AFP, respectively. The AUROC curves of both PIVKA-Ⅱ and AFP were not significantly different(0.854 vs 0.853, P = 0.965) for the differentiation of HCC from nonmalignant CHB, whereas the AUROC of PIVKA-Ⅱ was significantly better than that of AFP in patients with cirrhosis(0.870 vs 0.812, P = 0.042). When PIVKA-Ⅱ and AFP were combined, the diagnostic power improved significantly compared to either AFP or PIVKA-Ⅱ alone for the differentiation of HCC from nonmalignant CHB(P < 0.05), especially when cirrhosis was present(P < 0.05).CONCLUSION: Serum PIVKA-Ⅱ might be a better tumor marker than AFP, and its combination with AFP may enhance the early detection of HCC in patients with CHB. | Seung In Seo Hyoung Su Kim Won Jin Kim Woon Geon Shin Doo Jin Kim Kyung Ho Kim Myoung Kuk Jang Jin Heon Lee Joo Seop Kim Hak Yang Kim Dong Joon Kim Myung Seok Lee Choong Kee Park | 2015 | World Journal of Gastroenterology2015，21，13： | 60 |
| 2 | Severe acute pancreatitis due to tamoxifen-induced hypertriglyceridemia with diabetes mellitus显示文摘The side effects of tamoxifen are generally mild, including the effect on lipoprotein metabolism. However, there are few cases of severe tamoxifen induced hypertriglyceridemia. Hypertriglyceridemia is a marked risk factor for acute pancreatitis and approximately 2% to 5% of cases of acute pancreatitis are related to drugs. We report on tamoxifen-induced hypertriglyceridemia and acute pancreatitis in a 40 years old woman with type 2 diabetes mellitus occurred by dexamethasone. She was treated with insulin infusion and fenofibrate, and goserelin acetate was started instead of tamoxifen after discharge from the hospital. Also, probable pathogenic hypotheses about the correlation between tamoxifen and dexamethasone induced type 2 diabetes mellitus on severe acute pancreatitis are provided. Clinicians should take care of risks of severe acute pancreatitis on using tamoxifen, especially for patients with dexamethasone induced diabetes mellitus. These individuals should undergo pre-post tamoxifen lipid screening and careful history taking of drugs, including dexamethasone. | Young Ae Kim Sol Lee Ji Woong Jung Yu Jin Kwon Gyeong Bok Lee Dong Gue Shin Sang Su Park Jin Yun Yong-Seog Jang Dong Hui Cho | 2014 | Chinese Journal of Cancer Research2014，26，3： | 12 |
| 3 | Synthesis and properties of Cr-Al-Si-N films deposited by hybrid coating system with high power impulse magnetron sputtering (HIPIMS) and DC pulse sputtering显示文摘The CrN and Cr-Al-Si-N films were deposited on Si wafer and SUS 304 substrates by a hybrid coating system with high power impulse magnetron sputtering (HIPIMS) and a DC pulse sputtering using Cr and AlSi targets under N2/Ar atmosphere.By varying the sputtering current of the AlSi target in the range of 0-2.5 A,both the Al and Si contents in the films increased gradually from 0 to 19.1% and 11.1% (mole fraction),respectively.The influences of the AlSi cathode DC pulse current on the microstructure,phase constituents,mechanical properties,and oxidation behaviors of the Cr-Al-Si-N films were investigated systematically.The results indicate that the as-deposited Cr-Al-Si-N films possess the typical nanocomposite structure,namely the face centered cubic (Cr,Al)N nano-crystallites are embedded in the amorphous Si3N4 matrix.With increasing the Al and Si contents,the hardness of the film first increases from 20.8 GPa for the CrN film to the peak value of 29.4 GPa for the Cr0.23Al0.14Si0.07 N film,and then decreases gradually.In the meanwhile,the Cr0.23Al0.14Si0.07N film also possesses excellent high-temperature oxidation resistance that is much better than that of the CrN film at 900 or 1000 °C. | Min Su KANG Tie-gang WANG Jung Ho SHIN Roman NOWAK Kwang Ho KIM | 2012 | 中国有色金属学会会刊:英文版2012，22，S3： | 11 |
| 4 | Clinical and endoscopic characteristics of drug-induced esophagitis显示文摘AIM: To investigate clinical, endoscopic and pathological characteristics of drug-induced esophagitis.METHODS: Data for patients diagnosed with drug-induced esophagitis from April 2002 to May 2013 was reviewed. Patients diagnosed with malignancy, viral or fungal esophagitis were excluded. Clinical, endoscopic and pathological characteristics of patients diagnosed with drug-induced esophagitis were analyzed.RESULTS: Seventy-eight patients were diagnosed with drug-induced esophagitis. Their mean age was 43.9 ± 18.9 years and 35.9% were male. Common symptoms were chest pain(71.8%), odynophagia(38.5%) and dysphagia(29.5%). The endoscopic location was in the middle third of esophagus in 78.2%. Endoscopic findings were ulcer(82.1%), erosion(17.9%), ulcer with bleeding(24.4%), coating with drug material(5.1%), impacted pill fragments(3.8%) and stricture(2.6%). Kissing ulcers were observed in 43.6%. The main causative agents were antibiotics and non-steroidal antiinflammatory drugs. All the patients were treated with proton pump inhibitors(PPIs) or sucralfate, and the causative drugs were discontinued. Nineteen patients with drug-induced esophagitis were followed up with endoscopy and revealed normal findings, scars or healing ulcers.CONCLUSION: Drug-induced esophagitis mainly presents as chest pain, odynophagia and dysphagia, and may be successfully treated with PPIs and discontinuation of the causative drug. Kissing ulcers were observed in 43.6%. | Su Hwan Kim Ji Bong Jeong Ji Won Kim Seong-Joon Koh Byeong Gwan Kim Kook Lae Lee Mee Soo Chang Jong Pil Im Hyoun Woo Kang Cheol Min Shin | 2014 | World Journal of Gastroenterology2014，20，31： | 7 |
| 5 | Safety of endoscopic ultrasound-guided ethanol ablation for pancreatic cystic lesions: A single-center experience of 214 patients显示文摘Background:Endoscopic ultrasound-guided ethanol ablation(EUS-EA)for pancreatic cystic lesions(PCLs)has been used in recent years as a feasible treatment modality for low malignant probability PCLs or patients considered high-risk for surgery.The present study aimed to confirm the safety of EUS-EA and to find predictive factors for adverse event(AE).Methods:A retrospective review was performed from the prospectively maintained database of patients who underwent EUS-EA for PCLs from June 2006 to April 2018 at Seoul National University Hospital.The primary outcomes of the study were the rates of AEs and severe AEs by EUS-EA.The secondary outcome was the predictive factors of AEs including acute pancreatitis and abdominal pain.Results:A total of 214 patients were evaluated and the diagnoses of PCLs according to cystic fluid analysis and clinical features were as follows:serous cystic neoplasm(32.2%),mucinous cystic neoplasm(26.6%),branch duct type intraductal papillary mucinous neoplasm(BD-IPMN)(29.4%),and pseudocyst(11.7%).Three patients(1.4%)experienced severe AEs.Overall,AEs occurred in 71(33.2%)patients.BD-IPMN(OR:2.87;95%CI:1.05–7.84;P=0.040),multilocular cysts(OR:3.59;95%CI:1.09–11.85;P=0.036),suspected ethanol leakage during procedure(OR:10.68;95%CI:1.98–57.53;P=0.006),and sticky cystic fluid(OR:3.83;95%CI:1.20–12.24;P=0.024)were predictive factors for post-procedural acute pancreatitis.PCLs of uncinate process(OR:2.99;95%CI:1.22–7.35;P=0.017)and PCLs with exophytic portion(OR:3.70;95%CI:1.96–7.01;P<0.001)were predictive factors for post-procedural abdominal pain.Conclusions:EUS-EA is a safe procedure with a very low rate of severe AEs.It seems possible to predict the AEs according to the features of the procedure and PCLs. | Jin Ho Choi Sang Hyub Lee Young Hoon Choi Min Su You Bang-Sup Shin Woo Hyun Paik Ji Kon Ryu Yong-Tae Kim | 2019 | Hepatobiliary & Pancreatic Diseases International2019，18，6： | 6 |
| 6 | Prevalence of upper gastrointestinal bleeding risk factors among the general population and osteoarthritis patients显示文摘AIM To assess the prevalence of possible risk factors of upper gastrointestinal bleeding(UGIB) and their agegroup specific trend among the general population and osteoarthritis patients.METHODS We utilized data from the National Health InsuranceService that included claims data and results of the national health check-up program. Comorbid conditions(peptic ulcer, diabetes, liver disease, chronic renal failure, and gastroesophageal reflux disease), concomitant drugs(aspirin, clopidogrel, cilostazol, non-steroidal anti-inflammatory drugs, steroid, anticoagulants, and SSRI), personal habits(smoking, and alcohol consumption) were considered as possible UGIB risk factors. We randomly imputed the prevalence of infection in the data considering the age-specific prevalence of Helicobacter pylori(H. pylori) infection in Korea. The prevalence of various UGIB risk factors and the age-group specific trend of the prevalence were identified. Prevalence was compared between osteoarthritis patients and others.RESULTS A total of 801926 subjects(93855 osteoarthritis patients) aged 20 and above were included. The prevalence of individual and concurrent multiple risk factors became higher as the age increased. The prevalence of each comorbid condition and concomitant drug were higher in osteoarthritis patients. Thirty-five point zero two percent of the overall population and 68.50% of osteoarthritis patients had at least one or more risk factors of UGIB. The prevalence of individual and concurrent multiple risk factors in younger age groups were also substantial. Furthermore, when personal habits(smoking, and alcohol consumption) and H. pylori infection were included, the prevalence of concurrent multiple risk factors increased greatly even in younger age groups.CONCLUSION Prevalence of UGIB risk factors was high in elderly population, but was also considerable in younger population. Patient with osteoarthritis was at higher UGIB risk than those without osteoarthritis. Physicians s h o u ld c o n s id e r in d i v i d u a li z e d r i s k a s s e s s m e n t regardless of age when prescribing drugs or performing procedures that may increase the risk of UGIB, and take necessary measures to reduce modifiable risk factors such as H. pylori eradication or lifestyle counseling. | Sang Hyuck Kim Jae Moon Yun Chong Bum Chang Heng Piao Su Jong Yu Dong Wook Shin | 2016 | World Journal of Gastroenterology2016，22，48： | 6 |
| 7 | Enhanced efficiency in lead-free bismuth iodide with post treatment based on a hole-conductor-free perovskite solar cell显示文摘Despite the excellent merits of lead perovskite solar cells,their instability and toxicity still present a bottleneck for practical applications.Bismuth perovskite has emerged as a candidate for photovoltaic (PV) applications,because it not only has a low toxicity but is also stable in air.However,the power conversion efficiency (PCE) remains an unsolved problem.We performed band gap tuning experiments to improve the efficiency.The absorption of ABi3I10 structure films was extended within the visible region,and the optical band gap was decreased considerably compared to that for Cs3Bi2I9.Furthermore,we explained the correlation between the structure and the optical properties via a first-principles study.A device employing CsBi3I10 as a photoactive layer exhibits a PCE of 1.51% and an excellent ambient stability over 30 days. | Jongmoon Shin Maengsuk Kim Sujeong Jung Chang Su Kim Jucheol Park Aeran Song Kwun-Bum Chung Sung-Ho Jin Jun Hee Lee Myungkwan Song | 2018 | Nano Research2018，11，12： | 4 |
| 8 | Inhibition of matrix metalloproteinases expression in human dental pulp cells by all-trans retinoic acid显示文摘All-trans retinoic acid(ATRA) inhibits matrix metalloproteinase(MMP)-2 and MMP-9 in synovial fibroblasts, skin fibroblasts,bronchoalveolar lavage cells and cancer cells, but activates MMP-9 in neuroblast and leukemia cells. Very little is known regarding whether ATRA can activate or inhibit MMPs in human dental pulp cells(HDPCs). The purpose of this study was to determine the effects of ATRA on the production and secretion of MMP-2 and-9 in HDPCs. The productions and messenger RNA(mRNA) expressions of MMP-2 and-9 were accessed by gelatin zymography and real-time polymerase chain reaction(PCR), respectively. ATRA was found to decrease MMP-2 level in a dose-dependent manner. Significant reduction in MMP-2 mRNA expression was also observed in HDPCs treated with 25 mmol?L21ATRA. However, HDPCs treated with ATRA had no effect on the pattern of MMP-9 produced or secreted in either cell extracts or conditioned medium fractions. Taken together, ATRA had an inhibitory effect on MMP-2 expression in HDPCs,which suggests that ATRA could be a candidate as a medicament which could control the inflammation of pulp tissue in vital pulp therapy and regenerative endodontics. | Jin Man Kim Sang Wook Kang Su-Mi Shin Duck Su Kim Kyong-Kyu Choi Eun-Cheol Kim Sun-Young Kim | 2014 | International Journal of Oral Science2014，6，3： | 3 |
| 9 | Pemetrexed in Previously Treated Non-small Cell Lung Cancer Patients with Poor Performance Status显示文摘Background and objective Pemetrexed have been approved for the treatment of patients affected by advanced non-small cell lung cancner(NSCLC) in progression after first-line chemotherapy.We evaluated the activity and feasibility of pemetrexed in previously treated NSCLC.Methods Patients with histologically or cytologically confirmed NSCLC were evaluated from April 2007 to March 2009.The patients had relapsed or progressed after prior chemotherapy treatment.Pemetrexed(500 mg/m2) was administered intravenously once every 3 weeks after progression to prior chemotherapy.The tumor response was evaluated according to RECIST criteria by chest CT at every 2 cycles of chemotherapy.Results A total 61 patients were eligible for analysis.Performance status of them(100%) was over 2.The response rate and disease control rate were 14.7% and 37.7% respectively.Non-squamous cell carcinoma histology was significantly associated with a superior response rate(P=0.045) and disease control rate(P=0.008).The median survival time and the median progression free survival(PFS) time were 6.11 months and 2.17 months,respectively.Comparing the efficacy of pemetrexed in these two settings [second-line versus(12/61) more than third(49/61)],there was no significant difference in regard to median survival(11.18 months vs 11.46 months,P=0.922,5),but PFS was more longer in third-or further-line groups than second-line group(1.39 months vs 2.25 months,P=0.015,3).Conclusion Pemetrexed is a feasible regimen in previously treated NSCLC with poor performance status. | Sun Young JUNG Su Jin YOO Ji Young SHIN Ji Won PARK Jeong Eun LEE Hee Sun PARK Ju Ock KIM Sun Young KIM | 2011 | 中国肺癌杂志2011，14，1： | 3 |
| 10 | Evidence from a familial case suggests maternal inheritance of primary biliary cholangitis显示文摘Primary biliary cholangitis(PBC) is an idiopathic autoimmune liver disease characterized by chronic cholestasis and destruction of the intrahepatic bile ducts. Similar to other autoimmune diseases, the pathogenesis of PBC is considered to be a complex etiologic phenomenon involving the interaction of genetic and environmental factors. Although a number of common variants associated with PBC have been reported from genome-wide association studies, a precise genetic mechanism underlying PBC has yet to be identified. Here, we describe a family with four sisters who were diagnosed with PBC. After the diagnosis of the index patient who was in an advanced stage of PBC, one sister presented with acute hepatitis, and two sisters were subsequently diagnosed with PBC. Notably, one half-sister with a different mother exhibited no evidence of PBC following clinical investigation. Our report suggests the possibility of a maternal inheritance of PBC susceptibility. Moreover, judging from the highpenetrance of the disease observed in this family, we inferred that a pathogenic genetic variant might be the cause of PBC development. We describe a family that exhibited diverse clinical presentations of PBC that included asymptomatic stages with mildly increased liver enzyme levels and symptomatic stages with acute hepatitis or advanced liver fibrosis. Additional studies are needed to investigate the role of genetic factors in the pathogenesis of this rare autoimmune disease. | Saeam Shin In Ho Moh Young Sik Woo Sung Won Jung Jin Bae Kim Ji Won Park Ki Tae Suk Hyoung Su Kim Mineui Hong Sang Hoon Park Myung Seok Lee | 2017 | World Journal of Gastroenterology2017，23，39： | 3 |
| 11 | Risk Factors and Prognosis of Pulmonary Complications After Endoscopic Submucosal Dissection for Gastric Neoplasia显示文摘 | Chan Hyuk Park Hyunzu Kim Young Ae Kang In Rae Cho Bun Kim Su Jin Heo Suji Shin Hyuk Lee Jun Chul Park Sung Kwan Shin Yong Chan Lee Sang Kil Lee | 2013 | Digestive Diseases and Sciences2013，，2： | 2 |
| 12 | Genetic variations in the PRKAA1 and ZBTB20 genes and gastric cancer susceptibility in a Korean population显示文摘 | Hye‐Rim Song Hee Nam Kim Sun‐Seog Kweon Jin‐Su Choi Hyun Jeong Shim Sang Hee Cho Ik Joo Chung Young‐Kyu Park Soo Hyun Kim Yoo‐Duk Choi Kyung Woong Joo Min‐Ho Shin | 2013 | Mol Carcinog2013，，1： | 2 |
| 13 | Nanoengineered Shear-Thinning Hydrogel Barrier for Preventing Postoperative Abdominal Adhesions显示文摘More than 90%of surgical patients develop postoper-ative adhesions,and the incidence of hospital re-admissions can be as high as 20%.Current adhesion barriers present limited efficacy due to difficulties in application and incompatibility with minimally invasive interventions.To solve thisclinical limitation,we developed an injectable and sprayable shear-thinning hydrogel barrier(STHB)composed of silicate nanoplatelets and poly(ethylene oxide).We optimized this technology to recover mechanical integrity after stress,enabling its delivery though inject-able and sprayable methods.We also demonstrated limited cell adhesion and cytotoxicity to STHB compositions in vitro.The STHB was then tested in a rodent model of peritoneal injury to determine its e cacy preventing the formation of postoperative adhesions.After two weeks,the peritoneal adhesion index was used as a scoring method to determine the formation of postoperative adhesions,and STHB formulations presented superior e cacy compared to a commercially available adhesion barrier.Histological and immunohistochemical examination showed reduced adhesion formation and minimal immune infiltration in STHB formulations.Our technology demonstrated increased e cacy,ease of use in complex anatomies,and compatibility with di erent delivery methods,providing a robust universal platform to prevent postoperative adhesions in a wide range of surgical interventions. | Guillermo U.Ruiz-Esparza Xichi Wang Xingcai Zhang Sofia Jimenez-Vazquez Liliana Diaz-Gomez Anne-Marie Lavoie Samson Afewerki Andres AFuentes-Baldemar Roberto Parra-Saldivar Nan Jiang Nasim Annabi Bahram Saleh Ali K.Yetisen Amir Sheikhi Thomas H.Jozefiak Su Ryon Shin Nianguo Dong Ali Khademhosseini | 2021 | Nano-Micro Letters2021，13，12： | 2 |
| 14 | Effects of Strain Induced Martensitic Transformation on the Cavitation Erosion Resistance and Incubation Time of Fe-Cr-Ni-C Alloys 显示文摘 | Myung Chul Park Ki Nam Kim Gyeong Su Shin | 2012 | Wear2012，，： | 1 |
| 15 | Association study of microRNA polymorphisms with risk of idiopathic recurrent spontaneous abortion in Korean women显示文摘 | Young Joo Jeon Yi Seul Choi HyungChul Rah Su Yeoun Kim Dong Hee Choi Sun Hee Cha Ji Eun Shin Sung Han Shim Woo Sik Lee Nam Keun Kim | 2011 | Gene2011，，2： | 1 |
| 16 | Role of three-dimensional power Doppler in the antenatal diagnosis of placenta accreta:comparison with gray-scale and color Doppler techniques 显示文摘 | Shin JC Palacios JM Su YN | 2009 | Ultrasound Obstet Gynecol2009，33，2： | 1 |
| 17 | Liquid-phase adsorption and desorption of phenol onto activated carbons with ultrasound显示文摘 | Juang Ruey Shin Lin Su Hsia Cheng Ching Hsien | 2006 | Ultrasonics Sonochemistry2006，13，3： | 1 |
| 18 | Caffeoylglyeolic and caffeoyl- amino acid derivatives, halfmers of L-chicorie acid, as new HIV-1 integrase inhibitors 显示文摘 | Lee SU Shin CG Lee CK | 2007 | Med Chem2007，42，： | 1 |
| 19 | Bioactive activities of natural products against herpesvirus infection显示文摘 | Myoungki Son Minjung Lee Gi-Ho Sung Taeho Lee Yu Su Shin Hyosun Cho Paul M. Lieberman Hyojeung Kang | 2013 | Journal of Microbiology2013，，5： | 1 |
| 20 | Antiviral efficacy of lamivudine versus entecavir in patients with hepatitis B virus-related advanced hepatocellular carcinoma显示文摘 | Shin SH Kim SU Park JY | 2012 | Journal of Gastroenterology and Hepatology2012，27，： | 1 |
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