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| 1 | Absolute monocyte and lymphocyte count prognostic score for patients with gastric cancer显示文摘AIM:To measure the prognostic significance of absolute monocyte count/absolute lymphocyte count prognostic score(AMLPS) in patients with gastric cancer.METHODS:We retrospectively examined the combination of absolute monocyte count(AMC) and absolute lymphocyte count(ALC) as prognostic variables in a cohort of 299 gastric cancer patients who underwent surgical resection between 2006 and 2013 and were followed at a single institution.Both AMC and ALC were dichotomized into two groups using cut-off points determined by receiving operator characteristic curve analysis.An AMLPS was generated,which stratified patients into three risk groups:low risk(both low AMC and high ALC),intermediate risk(either high AMC or low ALC),and high risk(both high AMC and low ALC).The primary objective of the study was to validate the impact of AMLPS on both disease-free survival(DFS) and overall survival(OS),and the second objective was to assess the AMLPS as an independent prognostic factor for survival in comparison with known prognostic factors.RESULTS:Using data from the entire cohort,the most discriminative cut-off values of AMC and ALC selected on the receiver operating characteristic curve were 672.4/μL and 1734/μL for DFS and OS.AMLPS risk groups included 158(52.8%) patients in the lowrisk,128(42.8%) in the intermediate-risk,and 13(4.3%) in the high-risk group.With a median followup of 37.2 mo(range:1.7-91.4 mo),five-year DFS rates in the low-,intermediate-,and high-risk groups were 83.4%,78.7%,and 19.8%,respectively.And fiveyear OS rates in the low-,intermediate-,and high-risk groups were 89.3%,81.1%,and 14.4%,respectively.On multivariate analysis performed with patient- and tumor-related factors,we identified AMLPS,age,and pathologic tumor-node-metastasis stage as the most valuable prognostic factors impacting DFS and OS.CONCLUSION:AMLPS identified patients with a poor DFS and OS,and it was independent of age,pathologic stage,and various inflammatory markers. | Wan Kyu Eo Da Wun Jeong Hye Jung Chang Kyu Yeoun Won Sung Il Choi Se Hyun Kim Sung Wook Chun Young Lim Oh Tae Hwa Lee Young Ok Kim Ki Hyung Kim Yong Il Ji Ari Kim Heung Yeol Kim | 2015 | World Journal of Gastroenterology2015，21，9： | 6 |
| 2 | Decreased Beclin-1 expression is correlated with the growth of the primary tumor in patients with squamous cell carcinoma and adenocarcinoma of the lung显示文摘 | Kyu Yeoun Won Gou Young Kim Sung-Jig Lim Youn Wha Kim | 2012 | Human Pathology2012，，1： | 2 |
| 3 | Association study of microRNA polymorphisms with risk of idiopathic recurrent spontaneous abortion in Korean women显示文摘 | Young Joo Jeon Yi Seul Choi HyungChul Rah Su Yeoun Kim Dong Hee Choi Sun Hee Cha Ji Eun Shin Sung Han Shim Woo Sik Lee Nam Keun Kim | 2011 | Gene2011，，2： | 1 |
| 4 | Robust image watermarking using local invariant features显示文摘 | Lee Hae - Yeoun Kim Hyungshin Lee Heung - Kyu | 2006 | Optical Engineering2006，45，3： | 1 |
| 5 | Inhibition of Proliferation of Prostate Cancer Cell Line DU-145 in vitro and in vivo Using Salvia miltiorrhiza Bunge显示文摘Objective:To investigate the antiproliferative activity of Salvia miltiorrhiza Bunge.(SM)on the castration-resistant prostate cancer(CRPC)cell line DU-145 in vitro and in vivo.Methods:Prostate cancer cell line(DU-145)and normal prostate cell line(RWPE-1)were treated with SM at different concentrations(3.125,12.5,25 and 50μg/mL)to investigate the antiproliferative effects.DNA laddering analysis was performed to investigate the apoptosis of DU-145 cells.Molecular mechanism was investigated by Western blot analysis of p53,Bcl-2,prostate specific antigen(PSA),and androgen receptor(AR).Six-week-old male BALB/c nude mice were randomly divided into normal control group(n=101)and treated group(n=101)which administered 500 mg/kg SM for 2 weeks.Tumor volumes were measured.Results:Treatment with SM resulted in a dose-dependent decrease in cell number of DU-145 cells in comparison with RWPE-1.DNA laddering analysis indicated the apoptosis of DU-145 cells.Treatment with SM increased the expression of p53 and reduced the expression of Bcl-2 proteins.The levels of PSA were considerably reduced in SM-treated group compared to the controls,and a decrease in AR expression was observed when cells were treated with SM in the same pattern as a reduction in PSA.In the tumour xenograft study,SM given once a day for 2 weeks significantly inhibited tumour growth.Conclusion:SM might contribute to the anticancer actions such as induction of apoptosis and inhibition of proliferation of prostate cancer cells. | Woong Jin Bae Jin Bong Choi Kang Sup Kim U Syn Ha Sung Hoo Hong Ji Youl Lee Tae-Kon Hwang Sung Yeoun Hwang WANG Zhi-ping Sae Woong Kim | 2020 | Chinese Journal of Integrative Medicine2020，26，7： | 1 |
| 6 | Suppression of Oxidative Stress of Modified Gongjin-Dan (WSY^1075) in Detrusor Underactivity Rat Model Bladder Outlet Induced by Obstruction显示文摘Objective: To investigate the anti-oxidative stress and preventive effect of modified Gongjin-dan(WSY-1075) in a detrusor underactivity rat model. Methods: Rats were randomly allocated to three groups: shamoperated(control), bladder outlet obstruction-induced detrusor underactivity(BOO-DU), and BOO-DU with WSY-1075(WSY) groups. WSY-1075 was oral y administrated to rats 200 mg daily for 2 weeks prior to the operation and 4 weeks after the operation. Bladder outlet obstruction was surgical y induced in rats by ligation around the urethra avoiding total obstruction. Cystometrography was conducted on rats in each group for examination of bladders. Results: Compared with the control group, bladder outlet obstruction led to a significant increase in oxidative stress with consequent changes to molecular composition, and decrease in maximal detrusor pressure(P<0.05). WSY-1075 treatment significantly suppressed oxidative stress and prevented degenerative and dysfunctional changes in bladder, as compared with BOO-DU group(P<0.05). Conclusion: WSY-1075 had beneficial effect on prevention of BOO-DU. | Jin-Woo Jung Seung Hwan Jeon Woong Jin Bae Su Jin Kim Mun Su Chung Byung II Yoon Sae Woong Choi U Syn Ha Sung Yeoun Hwang Sae Woong Kim | 2018 | Chinese Journal of Integrative Medicine2018，24，9： | 1 |
| 7 | The influence of forest therapy camp on depression in alcoholics 显示文摘 | Shin W S Shin C S Yeoun P S | 2011 | Environ Health Prey Med2011，27，11： | 1 |
| 8 | Epipolarity Analysis for Linear Pushbroom Imagery显示文摘 | Lee Hae -Yeoun Park W | 2001 | International Symposium on Remote Sensing2001，17，： | 1 |
| 9 | MicroRNA-199b-5p is involved in the Notch signaling pathway in osteosarcoma显示文摘 | Kyu Yeoun Won Youn Wha Kim Hyun-Sook Kim Seung Kwan Lee Woon-Won Jung Yong-Koo Park | 2013 | Human Pathology2013，，8： | 1 |
| 10 | Clinicopathologic correlation of beclin-1 and bcl-2 expression in human breast cancer显示文摘 | Kyu Yeoun Won Gou Young Kim Youn Wha Kim Jeong Yoon Song Sung-Jig Lim | 2010 | Human Pathology2010，，1： | 1 |
| 11 | Intracranial Pial Arteriovenous Fistulas显示文摘 | Ji Yeoun Lee Young-Je Son Jeong Eun Kim | 2008 | J Korean Neurosurg Soc2008，44，2： | 1 |
| 12 | Iris and trabecular meshwork pigment changes after posterior chamber phakie intraoeular lens implantation 显示文摘 | Yeoun Sook Chun MD | 2006 | J Cataract Refract Surg2006，32，4： | 1 |
| 13 | De novo hepatitis B virus infection after pediatric liver transplantations with hepatitis B core antibody‐positive donors: A single‐center 20‐yr experience显示文摘 | Yeoun Joo Lee Seak Hee Oh Kyung Mo Kim Seung Min Song Jung‐Man Namgoong Dae Yeon Kim Sung‐Gyu Lee | 2015 | Pediatr Transplantation2015，，3： | 1 |
| 14 | Forest experience and psychological health benefits: the state of the art and future prospect in Korea显示文摘 | Shin W S Yeoun P S Yoo R W | 2010 | Environmental Health and Preventive Medicine2010，15，1： | 1 |
| 15 | Tear Cytokines and Chemokines in Patients with Demodex Blepharitis显示文摘 | Jee T K Seok H L Yeoun S C | | 0，，01： | 1 |
| 16 | Forest experience and psychological health benefits: the state of the art and future prospect in Korea显示文摘 | Won Sop Shin Poung Sik Yeoun Rhi Wha Yoo Chang Seob Shin | 2010 | Environmental Health and Preventive Medicine2010，，1： | 1 |
| 17 | Transsylvian-Transcisternal Selective Lesionectomy for Pediatric Lesional Mesial Temporal Lobe Epilepsy显示文摘 | Ji Yeoun Lee Ji Hoon Phi Kyu-Chang Wang Byung-Kyu Cho Seung-Ki Kim | 2011 | Neurosurgery2011，，3： | 1 |
| 18 | An algorithm for automatic 2D quadrilateral mesh generation with line constraints 显示文摘 | Kyu Yeul Lee Doo Yeoun Cho Tac Wan Kim | 2003 | Computer - Aided Design2003，35，： | 1 |
| 19 | Iris and trabecular meshwork pigment changes after posterior chamber phakic intraocular lens implantation显示文摘 | Yeoun Sook Chun In Ki Park Hyeon Il Lee Jong Ho Lee Jae Chan Kim | 2006 | Journal of Cataract & Refractive Surgery2006，，9： | 1 |
| 20 | WYND显示文摘 | Yeoun Soo Kim-Godwin Hee Chong Baek Christine A | 2010 | J Prof Nuts2010，26，4： | 1 |
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