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| 1 | 儿童肺炎链球菌的血清型及对抗生素的耐药性显示文摘目的 对本校儿科医院住院病例进行肺炎链球菌的血清型和耐药性监测。方法 收集因呼吸道感染而住院的病例痰标本和病史资料 ,同时采集部分患儿的血标本 ,分离与鉴定标本中的肺炎链球菌。荚膜肿胀试验进行血清分型 ;E test测定对青霉素的最低抑菌浓度。结果 共收集到 10 13例患儿的资料 ,分离出 112株肺炎链球菌。 19F、2 3F、6A、14和 6B等 5种血清型占 81.3% ( 91/112 ) ,其他类型的血清型占 11.6 % ( 13/112 )。另有 7.1% ( 8/112 )的肺炎链球菌不能分型。只有 1例血标本检测到肺炎链球菌 ,这可能与患儿入院前的抗菌素广泛使用有关。对青霉素中度和高度耐药的肺炎链球菌比例分别为 5 0 .9%和 8.0 % ;对氨苄青霉素、头孢唑林、头孢克洛、头孢曲松、红霉素、氯林可霉素和氯霉素的耐药率分别为 5 8.6 %、6 .6 %、2 5 .0 %、6 .6 %、85 .7%、6 6 .7%和 2 8.2 %。在 6 6例对青霉素耐药的菌株中 ,以 9F血清型最为多见 ,其次为 2 3F和 14。结论 肺炎链球菌是导致上海地区儿童呼吸道感染的重要病原菌 ,主要由 5种血清型组成 。 | 赵根明 BLACK Steve SHINEFIELD Henry 王传清 张颖华 林玉尊 姜庆五 | 2004 | 复旦学报(医学版)2004，31，4： | 17 |
| 2 | Effectiveness of heptavalent pneumococcal conjugate vaccine in children younger than 5 years of age for prevention of pneumonia:updated analysis using World Health Organization standardized interpretation of chest radiographs显示文摘 | HANSEN J BLACK S SHINEFIELD H | 2006 | Pediatr Inf Dis J2006，25，9： | 1 |
| 3 | Efficacy,safety and immunogenicity of heptavalent pneumococcal conjugate vaccine in chikdren显示文摘 | Black S Shinefield H Fireman B | 2000 | Pediatr Infect Dis J2000，19，： | 1 |
| 4 | Serotype distributiong and antimicrobial resistance pattern in Streptococcus pneumoniae isolates from hospitalized pediatric patients with respiratory infections in Shanghai,China显示文摘 | Zhao GM Black S Shinefield H | 2003 | Pediatr Infect Dis J2003，22，： | 1 |
| 5 | Impact of the pneumococcal conjugate vaccine on otitis media显示文摘 | Fireman B Black SB Shinefield HR | 2003 | Pedialr Infect Dis J2003，22，1： | 1 |
| 6 | Use of a Conjugate Polysaccharide Vaccine inthe Prevention of Invasive Staphylococcal Disease:Is an AdditionalVaccine Needed or Possible显示文摘 | Shinefield Henry R | 2006 | Vaccine2006，24，2： | 1 |
| 7 | Effectiveness of heptavalent pneumococcal conjugate vaccine in children younger than 5 years of age for prevention of pneumonia:updated analysis using World Health Organization standardized interpretation of chest radiographs显示文摘 | Hansen J Black S Shinefield H | 2006 | PediatrInf Dis J2006，25，9： | 1 |
| 8 | Safety of cold-adapted live attenuated influenza vaccine in a large cohort of children and adolescents显示文摘 | Bergen R Black S Shinefield H | 2004 | Pediatr Infect Dis2004，23，2： | 1 |
| 9 | Ten year follow-up of healthy children who received one or two injections of varicella vaccine显示文摘 | KUTER B MATTHEWS H SHINEFIELD H | 2004 | Pediatr Infect Dis J2004，23，2： | 1 |
| 10 | Efficacy of pneumococcal conjugate vaccines in large scale field trials 显示文摘 | Shinefield HR Black S | 2000 | Pediatr Infect Dis J2000，19，4： | 1 |
| 11 | Ten year follow - up of healthy children who received one or two injections of varicella vaccine 显示文摘 | Kuter B Matthews H Shinefield H | 2004 | J Pediatr Infect Dis2004，23，： | 1 |
| 12 | Efficacy, safety and immunogenicity of heptavalent pneumococcal conjugate vaccine in children显示文摘 | Black S Shinefield H Fireman B | 2000 | Pediatr Infect Dis J2000，19，3： | 1 |
| 13 | Safety and immu-nogenicity of a measles, mumps, rubella and varicella vaccine given with combined Haemophilus influenzae type b conjugate/hepatitis B vaccines and combined diphtheria- tetanus-acellular pertussis vaccines 显示文摘 | Shinefield H Black S Thear M | 2006 | Pediatr Infect Dis J2006，25，4： | 1 |
| 14 | Use of a conjugate polysaccharidevaecine in the prevention of invasive staphylococcal disease: is an additional vaeeine needed or possible? 显示文摘 | Shinefield HR | 2006 | Vaccine2006，24，2： | 1 |
| 15 | Clinical effectiveness of seven-valent pneumococcal conjugate vaccine (prevenar) against invasive pneumococcal diseases :prospeets for children in France 显示文摘 | Black S Shinefield H Cohen R | 2004 | Arch Pediatr2004，11，7： | 1 |
| 16 | Overview of the development and current use of C RM ( 197 ) conjugate vaccines for pediatric use显示文摘 | Shinefield HR | 2010 | Vaccine2010，28，27： | 1 |
| 17 | Ten year follow-up of healthy children who received one or two injections of varicella vac- cine显示文摘 | KUTER B MATI'HEWS H SHINEFIELD H | 2004 | Pediatr Infect Dis J2004，23，2： | 1 |
| 18 | Serotype distribution and antimicrobial resistance patterns in Streptococcus pneumoniae isolates from hospitalized pediatric patients with respiratory infections in Shanghai China显示文摘 | Zhao GM Black S Shinefield H | | 0，，04： | 1 |
| 19 | Efficacy, safety and imunogeni-city of heptavalent pneumococcal conjugate vaccine in children 显示文摘 | Black S Shinefield H Fireman B | 2000 | Peditatr Infect Dis2000，19，3： | 1 |
| 20 | Safety and immunogenicity of a combination: measles, mumps, rubella and varicella vaccine (ProQuad) 显示文摘 | Kuter BJ Brown ML Hartzel J Williams WR EvesiKaren A Black S Shinefield H Reisinger KS Marchant CD Sullivan BJ Thear M Klopfer S Xu J Gress JO Sch6del F Study Group for ProQuad | 2006 | Hum Vaccin2006，2，5： | 1 |
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