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| 1 | Management of hepatitis B virus infection during treatment for hepatitis B virus-related hepatocellular carcinoma显示文摘Although liver resection is considered the most effective treatment for hepatocellular carcinoma(HCC), treatment outcomes are unsatisfactory because of the high rate of HCC recurrence. Since we reported hepatitis B e-antigen positivity and high serum hepatitis B virus(HBV) DNA concentrations are strong risk factors for HCC recurrence after curative resection of HBV-related HCC in the early 2000 s, many investigators have demonstrated the effects of viral status on HCC recurrence and post-treatment outcomes. These findings suggest controlling viral status is important to prevent HCC recurrence and improve survival after curative treatment for HBV-related HCC. Antiviral therapy after curative treatment aims to improve prognosis by preventing HCC recurrence and maintaining liver function. Therapy with interferon and nucleos(t)ide analogs may be useful for preventing HCC recurrence and improving overall survival in patients who have undergone curative resection for HBV-related HCC. In addition, reactivation of viral replication can occur after liver resection for HBV-related HCC. Antiviral therapy can be recommended for patients to prevent HBV reactivation. Nevertheless, further studies are required to establish treatment guidelines for patients with HBVrelated HCC. | Shoji Kubo Shigekazu Takemura Shogo Tanaka Hiroji Shinkawa Takayoshi Nishioka Akinori Nozawa Masahiko Kinoshita Genya Hamano Tokuji Ito Yorihisa Urata | 2015 | World Journal of Gastroenterology2015，21，27： | 19 |
| 2 | Hepatitis B virus infection in Indonesia显示文摘Approximately 240 million people are chronically infected with hepatitis B virus(HBV),75% of whom reside in Asia. Approximately 600000 of infected patients die each year due to HBV-related diseases or hepatocellular carcinoma(HCC). The endemicity of hepatitis surface antigen in Indonesia is intermediate to high with a geographical difference. The risk of HBV infection is high in hemodialysis(HD) patients,men having sex with men,and health care workers. Occult HBV infection has been detected in various groups such as blood donors,HD patients,and HIVinfected individuals and children. The most common HBV subgenotype in Indonesia is B3 followed by C1. Various novel subgenotypes of HBV have been identified throughout Indonesia,with the novel HBV subgenotypes C6-C16 and D6 being successfully isolated. Although a number of HBV subgenotypes have been discovered in Indonesia,genotyperelated pathogenicity has not yet been elucidated in detail. Therefore,genotype-related differences in the prognosis of liver disease and their effects on treatments need to be determined. A previous study conducted in Indonesia revealed that hepatic steatosis was associated with disease progression. Pre-S2 mutations and mutations at C1638 T and T1753 V in HBV/B3 have been associated with advanced liver diseases including HCC. However,drug resistance to lamivudine,which is prominent in Indonesia,remains obscure. Although the number of studies on HBV in Indonesia has been increasing,adequate databases on HBV infection are limited. We herein provided an overview of the epidemiology and clinical characteristics of HBV infection in Indonesia. | Shoji Kubo Shigekazu Takemura Shogo Tanaka Hiroji Shinkawa Takayoshi Nishioka Akinori Nozawa Masahiko Kinoshita Genya Hamano Tokuji Ito Yorihisa Urata | 2015 | World Journal of Gastroenterology2015，21，38： | 2 |
| 3 | Inhibition Of platelet aggregation and the release of P-selectin cron platelets by cilostazd 显示文摘 | Kariyazono H Nakamura K shinkawa T | 2001 | Thromb Res2001，101，： | 1 |
| 4 | Expression of Transcription Factor E2F-1 in Pancreatic Ductal Carcinoma: An Immunohistochemical Study显示文摘 | Kazuto Yamazaki Takayuki Yajima Toshitaka Nagao Hiroki Shinkawa Fukuo Kondo Kyota Hanami Akira Asoh Isamu Sugano Yasuo Ishida | 2003 | Pathology - Research and Practice2003，，1： | 1 |
| 5 | Inhibition of platelet aggregation and the release of P-selectin cron platelets by cilostazol 显示文摘 | Kariyazono H Nakamura K Shinkawa T | 2001 | Thromb Res2001，101，6： | 1 |
| 6 | Purification and Characterization of RNA Polymerase Holoenzyme (E-SigmaB) from Vegetative Phase Mycelia of Streptomyces griseus显示文摘 | SHINKAWA H FUJITA N SHIINA T et a1 | 1995 | Journal of Biochemistry1995，118，3： | 1 |
| 7 | Prevalent connexin 26 gene (GJB2) mutations in Japanese显示文摘 | Abe S Usarni S Shinkawa H | 2000 | J Med Genet2000，37，1： | 1 |
| 8 | One-stage definitive repair of pulmonary atresia with intact ventricular septum and hypoplastic right ventricle显示文摘 | Shinkawa T Yamagishi M Shuntoh K | 2005 | J Thorac Cardiovasc Surg2005，130，4： | 1 |
| 9 | Primary structural features of rosaceous S-RNases associated with gametophytic self-incompatibility显示文摘 | Takeshi Ishimizu Toyohide Shinkawa Fumio Sakiyama Shigemi Norioka | 1998 | Plant Molecular Biology1998，，6： | 1 |
| 10 | Silent cerebral infarction in a community - based autopsy series in Japan: the hisayama study显示文摘 | Shinkawa A Veda K Kiyohara Y | 1995 | Stroke1995，26，： | 1 |
| 11 | Role of O-linked carbohydrate of human urinary trypsin inhibitor on its lysosomal membrane-stabilizing property显示文摘 | Kato Y Kudo M Shinkawa T | 1998 | Biochem Biophys Res Commun1998，243，： | 1 |
| 12 | Inhibition of platelet aggregation and the release, of P-selectin eran platelets by cilostazol显示文摘 | Kariyazono H Nakamura K Shinkawa T | 2001 | Thromb Res2001，101，9： | 1 |
| 13 | Abscisic acid induced freezing tolerance in chilling-sensitive suspension cultures and seedlings of rice 显示文摘 | Shinkawa R Morishita A Amikura K Machida R Murakawa H Kuchitsu K Ishikawa M | 2013 | BMC Research Notes2013，6，1： | 1 |
| 14 | Role of O-linked carbo- hydrate of humman uninary trypsin inhibitor on its lygosomal membrane stabilizing property显示文摘 | Kato Y Kudo M ShinKawa T | 1998 | Biochem Piophys Rescommun1998，243，2： | 1 |
| 15 | Histopathology of the inner ear in Usher's syndrome as observed bylight and electron microscopy显示文摘 | 5,Shinkawa H Nadol JB | 1986 | Ann Otol Rhinol Larygol1986，95，： | 1 |
| 16 | Phylogeny of Luehdorfia butterflies in ferred from mitochondrial ND5 gene sequences显示文摘 | Makita H Shinkawa T Ohta K | 2000 | Entomological Science2000，3，2： | 1 |
| 17 | Inhibition of platelet aggregation and the release of P-selectin cron platelets by cilostazol 显示文摘 | Kariyazomo H Nakamura K Shinkawa T | 2001 | Thromb Res2001，101，6： | 1 |
| 18 | Identification of the major protein components of rice egg cells显示文摘 | Uchiumi T Shinkawa T Isobe T | 2007 | J Plant Res2007，120，4： | 1 |
| 19 | The autopsy of Patients with silent cerebral in fartion in the south of Japan显示文摘 | Shinkawa A | 1995 | Stroke1995，26，： | 1 |
| 20 | Prediction of progression in patients with mild cognitive impairment using IMP-SPECT显示文摘 | Okamura N Shinkawa M Arai H | | 0，，12： | 1 |
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