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| 1 | Changes in choroidal thickness in healthy pediatric individuals: a longitudinal study显示文摘● AIM: To investigate the changes in the choroidal thickness in healthy pediatric children in a longitudinal study, and to determine the ocular and systemic parameters that were significantly correlated with the changes in the choroidal thickness.● METHODS: This study included 64 eyes of 34 healthy Japanese children with a mean age(±SD) of 4.4(±0.4)y(range, 3.6-5.8 y) at baseline. Swept-source optical coherence tomography(SS-OCT) was used to record images of the retina and choroid at the baseline and after a mean followup period of about 1.5 y. The 3 D raster scan protocol was used to construct the choroidal thickness map. Mean choroidal thickness was calculated for each of the nine sectors of the Early Treatment Diabetic Retinopathy Study grid. Best-corrected visual acuity, axial length, body height, and weight were also measured. Changes in measurements were defined as the baseline values subtracted from the values at the final visit. A generalized estimating equation was used to eliminate the effect of within-subject intereye correlations.● RESULTS: The mean central choroidal thickness was significantly reduced during the follow-up period(baseline, 301.8±8.6 μm; final visit, 286.6±8.0 μm, P<0.001). The decrease in the choroidal thickness was greatest in the central sector, followed by the sectors of the inner and outer rings. The inner and outer rings had diameters of 1 to 3 mm and 3 to 6 mm, respectively. The changes in the choroidal thickness in the central, inner ring, and outer ring sectors were significantly and negatively correlated with the age, baseline body height, baseline body weight, and elongation of the axial length.● CONCLUSION: These results indicate that the choroidal thickness among preschool-aged Japanese children decreased significantly during the follow-up period. The choroidal thinning is significantly associated with the elongation of axial length. These characteristics should be considered in the evaluation of choroidal thickness in younger children with retinochoroidal disorders. | Eiko Ohsugi Yoshinori Mitamura Kayo Shinomiya Masanori Niki Hiroki Sano Toshihiko Nagasawa Yukiko Shimizu Daisuke Nagasato Hitoshi Tabuchi | 2018 | International Journal of Ophthalmology(English edition)2018，11，7： | 2 |
| 2 | Upregulated expression of chemokines in herniated nucleus pulposus resorption显示文摘 | Haro H Shinomiya K Komori H | 1996 | Spine1996，21，： | 1 |
| 3 | Evaluation of cervical diskography in pain origin and provocation显示文摘 | Shinomiya K Nakao K Shindoh S | 1993 | J Spinal Disord1993，6，5： | 1 |
| 4 | DMY is a Y-specific DM-domain gene required for male development in the medaka fish显示文摘 | Matsuda M Nagahama Y Shinomiya A | 2002 | Nature2002，417，6888： | 1 |
| 5 | Induction of lymphocyte apoptosis by a novel immunosuppressant FTY720: relation with Fas, Bcl- 2 and Bax expression 显示文摘 | LIX K SHINOMIYA T ENOSAWA S | 1997 | Transplant1997，29，12： | 1 |
| 6 | DMY is a Y-specific DM-domain gene required for male development in the medaka fish显示文摘 | Matsuda M Nagahama Y Shinomiya A | | 0，，6888： | 1 |
| 7 | 显示文摘 | Ogura M Shinomiya S Tateno J | 2000 | Chem Lett2000，882，： | 1 |
| 8 | Development of the Chitosan Tube Prepared from Crab Tendon for Nerve Regeneration显示文摘 | Itoh S Yamaguchi I Shinomiya K | 2003 | Science and Technology of Advanced Materials2003，，4： | 1 |
| 9 | The natural history of her- niated nucleus pulposus with radiculopathy 显示文摘 | Komori H Shinomiya K Nakai O | 1996 | Spine (Phila Pa 1976)1996，21，2： | 1 |
| 10 | Field survey of sex-rever-sals in the medaka,Oryzias latipes:genotypic sexing of wild popula-tions显示文摘 | Shinomiya A Otake H Togashi K | | 0，，06： | 1 |
| 11 | Cyclosporin A eye drops inhibit fibrosis and inflammatory cell infiltration in murine type Ⅰ allergic conjunctivitis without affecting the early-phase reaction显示文摘 | Shii D Nakagawa S Shinomiya K | | 0，，06： | 1 |
| 12 | Effects of kava-kava extract on the sleep-wake cycle in sleep-disturbed rats显示文摘 | Shinomiya K Inoue T Utsu Y | 2005 | Psychopharmacology(Berl)2005，180，3： | 1 |
| 13 | Protein separation by nonsynchronous coil planet centrifuge with aqueous-aqueous polymer phase systems显示文摘 | Shinomiya K Kabasawa Y Yanagidaira K | 2003 | J Chromatography A2003，1005，： | 1 |
| 14 | Effects of valerian extract on the sleep-wake cycle in sleep-disturbed rats显示文摘 | Shinomiya K Fujimura K Kim Y | 2005 | Acta Med Okayama2005，59，3： | 1 |
| 15 | Correlation between telomerase activity and DNA ploidy in gastric cancer显示文摘 | Okusa Y shinomiya N Ichikura T | 1998 | Oncology1998，55，3： | 1 |
| 16 | Alkali-treatment technique-New method for modification of structural and acid-catalytic properties of ZSM-5 zeolites显示文摘 | OGURA M SHINOMIYA S Y TATENO J NARA Y NOMURA M EIKUCHI E MATSUKATA M | 2001 | Appl Catal A:Gen2001，219，12： | 1 |
| 17 | The natural history of herniated nucleus pulposus with radicular pain显示文摘 | KOMORI H SHINOMIYA K NAKAI O | 1996 | Spine1996，21，： | 1 |
| 18 | Enhancement of DDP cytoxicity by caffeine is characterized by apoptotic cell death显示文摘 | SHINOMIYA N SHNOMIYA M | 1994 | Exp Cell Res1994，210，： | 1 |
| 19 | The Natural History of Herniated Nucleus Pulpous with Radiculopathy 显示文摘 | Komori H Shinomiya K Nakai O | 2006 | Spine2006，21，2： | 1 |
| 20 | Role of surgery in hypertensive intracerebral hematoma,A comparative study of 305 nonsurgical and 154 surgical cases显示文摘 | Kanno T Sano H shinomiya Y | 1984 | J Neurosurg1984，61，6： | 1 |
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