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| 1 | Strategies to prevent hypertrophic scar formation:a review of therapeutic interventions based on molecular evidence显示文摘Once scar tissues mature,it is impossible for the surrounding tissue to regenerate normal dermal tissue.Therefore,it is essential to understand the fundamental mechanisms and establish effective strategies to inhibit aberrant scar formation.Hypertrophic scar formation is considered a result of the imbalance between extracellular matrix synthesis and degradation during wound healing.However,the underlying mechanisms of hypertrophic scar development are poorly understood.The purpose of this review was to outline the management in the early stage after wound healing to prevent hypertrophic scar formation,focusing on strategies excluding therapeutic agents of internal use.Treatment aimed at molecular targets,including cytokines,will be future options to prevent and treat hypertrophic scars.More basic studies and clinical trials,including combination therapy,are required to investigate the mechanisms and prevent hypertrophic scar formation. | Eri Shirakami Sho Yamakawa Kenji Hayashida | 2020 | Burns & Trauma2020，8，1： | 18 |
| 2 | Chemoprevention of colorectal cancer by targeting obesity-related metabolic abnormalities显示文摘Obesity and its related metabolic disorders, including insulin resistance and chronic inflammation, increase the risk of colorectal cancer(CRC). This observation suggests that the metabolic abnormalities associated with obesity can be effective targets for preventing the development of CRC in obese individuals. In recent years, many studies using obese and diabetic animal models have been conducted to investigate the chemoprevention of CRC using pharmaceutical or nutritional interventions. Pitavastatin, a medicine used to treat hyperlipidemia, prevents the development of obesityrelated colorectal carcinogenesis by attenuating chronic inflammation. Anti-hypertensive medicines, such as captopril and telmisartan, also suppress the formation of colonic preneoplastic lesions in obese and diabetic mice. In addition, several phytochemicals, including green tea catechins, have been reported to improve metabolic disorders and prevent the development of various cancers, including CRC. Moreover, the administration of branched-chain amino acids, which improves protein malnutrition and prevents the progression of hepatic failure, is effective for suppressing obesityrelated colon carcinogenesis, which is thought to be associated with improvements in insulin resistance. In the present article, we summarize the detailed relationship between metabolic abnormalities and the development of CRC. This review also outlines recent evidence, in particular drawing from basic and clinical examinations using either pharmaceutical or nutritional intervention that suggests that targeting metabolic alterations may be an effective strategy for preventing the development of CRC in obese individuals. | Yohei Shirakami Masahito Shimizu Masaya Kubota Hiroshi Araki Takuji Tanaka Hisataka Moriwaki Mitsuru Seishima | 2014 | World Journal of Gastroenterology2014，20，27： | 2 |
| 3 | Effect of single-dose dexmedetomidine on emergence agitation and recovery profiles after sevoflurane anesthesia in pediatric ambulatory surgery显示文摘 | Masami Sato Gotaro Shirakami Misako Tazuke-Nishimura Shogo Matsuura Keiji Tanimoto Kazuhiko Fukuda | 2010 | Journal of Anesthesia2010，，5： | 2 |
| 4 | Rapid ventricular induction of brain natriuretic peptide gene expression in experimental acute myocardial infarction显示文摘 | Hama N Itoh H Shirakami G | 1995 | Circulation1995，92，6： | 1 |
| 5 | Rapid ventricular induc- tion of brain na - triuretic gene expression in experimental acute myocardial infartion 显示文摘 | Hama N Itoh H Shirakami G | 1995 | Grculation1995，92，： | 1 |
| 6 | Rapid ventricular induction of brain natriuretic peptide gene expression in experimental acute my- ocardial infarction 显示文摘 | Hama N Itoh H Shirakami G | 1995 | Circulation1995，92，6： | 1 |
| 7 | Insulin down-regulates resistin mRNA through the synthesis of protein(s) that could accelerate the degradation of resistin mRNA in 3T3-L1 adipocytes显示文摘 | J. Kawashima K. Tsuruzoe H. Motoshima A. Shirakami K. Sakai Y. Hirashima T. Toyonaga E. Araki MD PhD | 2003 | Diabetologia2003，，2： | 1 |
| 8 | Positive End-Expiratory Pressure Ventilation Decreases Plasma Atrial and Brain Natriuretic Peptide Levels in Humans显示文摘 | Gotaro Shirakami Tatsuo Magaribuchi Koh Shingu Shin-ichi Suga Sunao Tamai Kazuwa Nakao Kenjiro Mori | 1993 | Anesthesia & Analgesia1993，，6： | 1 |
| 9 | Rapid ventricular induction of brain natriuretic peptide gene expression in experimental acute myocardial infarction显示文摘 | HAMA N ITOH H SHIRAKAMI G | 1995 | Circulation1995，92，： | 1 |
| 10 | Rapid ventrieular induction of brain natriuretic peptides gene expression in experimental acute myocardial infarctlon显示文摘 | Hama N hoh H Shirakami G et cd | 1995 | Circulation1995，92，6： | 1 |
| 11 | Positive end-expiratory pres- sure ventilation decrease plasma atrial and brain natriuretic peptide levels in humans显示文摘 | Shirakami G Magaribuchi T Shingu K | 1993 | Anesth Analg1993，77，6： | 1 |
| 12 | Effect of sin-gle-dose dexmedetomidine on emergence agitation and recovery profiles after sevoflurane anesthesia in pediatric ambulatory surgery显示文摘 | Sato M Shirakami G Tazuke-Nishimura M | | 0，，5： | 1 |
| 13 | Rapid ventricular induction of brain natriuretic peptide gene expression in experimental acute myocardiol infarction 显示文摘 | Hama N Itoh H Shirakami G | 1995 | Circulation1995，92，6： | 1 |
| 14 | Rapid ventricular induction of brain natriuretic peptide gene expression in experimental acute myocardial infarction显示文摘 | Hama N Itoh H Shirakami G | 1995 | Circulation1995，92，： | 1 |
| 15 | Effects of anesthesia and surgery on plasma endothelin levels Anesth显示文摘 | Shirakami G Magaribuchi T Shingu K | 1995 | Analg1995，80，： | 1 |
| 16 | Involvement of bradykinin in acute exercise-induced increase of glucose uptake and GLUT-4 translocation in skeletal muscle: Studies in normal and diabetic humans and rats显示文摘 | Tetsuya Taguchi Hideki Kishikawa Hiroyuki Motoshima Kohji Sakai Toshihiko Nishiyama Kazuaki Yoshizato Atsuhisa Shirakami Tetsushi Toyonaga Tetsuya Shirotani Eiichi Araki Motoaki Shichiri | 2000 | Metabolism2000，，7： | 1 |
| 17 | Rapid ventricular induction of brain natriuretic peptide gene expression in experimental acute myocardial infarction显示文摘 | Hama N Itoh H Shirakami G | 1995 | Circulation1995，92，6： | 1 |
| 18 | Rapid ventricular induction of brain natriuretic peptide gene expression in experimental acute myocardial infarction 显示文摘 | HAMA N ITOH H SHIRAKAMI G | 1995 | Circulation1995，92，： | 1 |
| 19 | Targeting receptor tyrosine kinases for chemoprevention by green tea catechin EGCG显示文摘 | Shimizu M Shirakami Y Moriwaki H | 2008 | Int J Mol Sci2008，9，6： | 1 |
| 20 | Rapid ventricular induction of brain natriuretic peptide gene expression in experimental acute myocardial infarction显示文摘 | Hama N hob H Shirakami G | 2005 | Circulation2005，92，6： | 1 |
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