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| 1 | Probiotics in hepatology:An update显示文摘The gut-liver axis plays an important role in the pathogenesis of various liver diseases.Probiotics are living bacteria that may be used to correct disorders of this axis.Notable progress has been made in the study of probiotic drugs for the treatment of various liver diseases in the last decade.It has been proven that probiotics are useful for hepatic encephalopathy,but their effects on other symptoms and syndromes of cirrhosis are poorly studied.Their effectiveness in the treatment of metabolic associated fatty liver disease has been shown both in experimental models and in clinical trials,but their effect on the prognosis of this disease has not been described.The beneficial effects of probiotics in alcoholic liver disease have been shown in many experimental studies,but there are very few clinical trials to support these findings.The effects of probiotics on the course of other liver diseases are either poorly studied(such as primary sclerosing cholangitis,chronic hepatitis B and C,and autoimmune hepatitis)or not studied at all(such as primary biliary cholangitis,hepatitis A and E,Wilson's disease,hemochromatosis,storage diseases,and vascular liver diseases).Thus,despite the progress in the study of probiotics in hepatology over the past decade,there are many unexplored and unclear questions surrounding this topic. | Roman Maslennikov Vladimir Ivashkin Irina Efremova Elena Poluektova Elena Shirokova | 2021 | World Journal of Hepatology2021，13，9： | 2 |
| 2 | Gut-liver axis in cirrhosis:Are hemodynamic changes a missing link?显示文摘Recent evidence suggests that the condition of the gut and its microbiota greatly influence the course of liver disease,especially cirrhosis.This introduces the concept of the gut-liver axis,which can be imagined as a chain connected by several links.Gut dysbiosis,small intestinal bacterial overgrowth,and intestinal barrier alteration lead to bacterial translocation,resulting in systemic inflammation.Systemic inflammation further causes vasodilation,arterial hypotension,and hyperdynamic circulation,leading to the aggravation of portal hypertension,which contributes to the development of complications of cirrhosis,resulting in a poorer prognosis.The majority of the data underlying this model were obtained initially from animal experiments,and most of these correlations were further reproduced in studies including patients with cirrhosis.However,despite the published data on the relationship of the disorders of the gut microbiota with the complications of cirrhosis and the proposed pathogenetic role of hemodynamic disorders in their development,the direct relations between gut dysbiosis and hemodynamic changes in this disease are poorly studied.They remain a missing link in the gut-liver axis and a challenge for future research. | Roman Maslennikov Vladimir Ivashkin Irina Efremova Elena Poluektova Elena Shirokova | 2021 | World Journal of Clinical Cases2021，9，31： | 2 |
| 3 | Calcium carbonate precipitation by anoxygenic phototrophic bacteria显示文摘 | Bundeleva I A Shirokova L S Benezeth P | 2012 | Chemical Geology2012，291，： | 1 |
| 4 | Use of electrical conductivity in stead of soluble salts for soil salinity monitoring in central Asia显示文摘 | Shirokova Y Forkutsa I Sharafutdinova N | 2000 | Irrigaion and Drainage System2000，14，： | 1 |
| 5 | Transfer and tunneling of Ca2+ from sarcoplasmic reticulum to mitochondria in skeletal muscle显示文摘 | Shkryl VM Shirokova N | 2006 | J Biol Chem2006，281，3： | 1 |
| 6 | The business model and firm performance : The case of Russian food serv- ice ventures 显示文摘 | Morris M Shirokova G Shatalov A | 2013 | Journal of Small Business Management2013，51，1： | 1 |
| 7 | Kinetics of oxidation of an arabinogalactan from larch in an aqueous medium in the presence of hydrogen peroxide显示文摘 | Borisov I M Shirokova E N Medvedeva S A | 2004 | Russian Chemical Bulletin2004，53，2： | 1 |
| 8 | Mitochondrial redox state and Ca^2+ sparks in permeabilized mammalian skeletal muscle 显示文摘 | Isaeva E Shkryl V Shirokova N | 2005 | J Physiol2005，565，3： | 1 |
| 9 | New phosphonoformic acid derivatives of 3'-azido-3'-deoxythymidine显示文摘 | Jasko MV Khandazhinskaya AL | 2004 | Rus J Bioorg Chem2004，30，3： | 1 |
| 10 | Use of electrical conductivity instead of soluble salts for soil salinity monitoring in entral Asia 显示文摘 | SHIROKOVA Y FORKUTSA I SHARAFUTDINOVA N | 2000 | Irriga- tion and Drainage Systems2000，14，3： | 1 |
| 11 | lntracellular metabolism and pharmacokinetics of 5'-hydrogenphosphonate of 3'-azido-2', 3'-dideoxythymidine, a prodrug of 3'-azido-2',3'-dideoxythymidine 显示文摘 | Skoblov Y Karpenko I Shirokova E | 2004 | Antiviral Res2004，63，： | 1 |
| 12 | The Business Model and Firm Performance: The Case of Russian Food Service Ventures显示文摘 | MORRIS M SHIROKOVA G SHATALOV A | 2013 | Journal of Small Business Management2013，51，1： | 1 |
| 13 | 显示文摘 | Shirokova E A Jasko M V Khandazhinskaya A L | 2004 | J Med Chem2004，47，14： | 1 |
| 14 | Detonation pressure of explosive charges applied in spacecraft division sys- tems 显示文摘 | Kotomin A A Shirokova N P Dushenok S A | 2011 | Solar System Research2011，45，7： | 1 |
| 15 | Hydrated calcium silicates显示文摘 | Toropov N A Borisenko A I Shirokova P V | 1953 | Russian Chemical Bulletin1953，，1： | 1 |
| 16 | The business model and firm performance: the case of Russian food service ventures 显示文摘 | MICHAEL H MORRIS SHIROKOVA G SHATALOV A | 2013 | Journal of Small Busi- ness Management2013，51，1： | 1 |
| 17 | Uncharged AZT and IMT derivatives of phosphonoformic and phosphonoacetic acid as anti-HIV pronucleosides 显示文摘 | Shirokova E A | 2004 | J Med Chem2004，47，14： | 1 |
| 18 | Effect of probiotics on hemodynamic changes and complications associated with cirrhosis:A pilot randomized controlled trial显示文摘BACKGROUND Bacterial translocation exacerbates the hyperdynamic circulation observed in cirrhosis and contributes to a more severe disease course.Probiotics may reduce bacterial translocation and may therefore be useful to redress the circulatory imbalance.AIM To investigate the effect of probiotics on hemodynamic parameters,systemic inflammation,and complications of cirrhosis in this randomized placebocontrolled trial.METHODS This single-blind randomized placebo-controlled study included 40 patients with Child-Pugh class B and C cirrhosis;24 patients received probiotics(Saccharomyces boulardii)for 3 mo,and 16 patients received a placebo over the same period.Liver function and the systemic hemodynamic status were evaluated pre-and postintervention.Echocardiography and simultaneous blood pressure and heart rate monitoring were performed to evaluate systemic hemodynamic indicators.Cardiac output and systemic vascular resistance were calculated.RESULTS Following a 3-mo course of probiotics in comparison to the control group,we observed amelioration of hyperdynamic circulation[a decrease in cardiac output(P=0.026)and an increase in systemic vascular resistance(P=0.026)]and systemic inflammation[a decrease in serum C-reactive protein levels(P=0.044)],with improved liver function[an increase in serum albumin(P=0.001)and a decrease in the value of Child-Pugh score(P=0.001)]as well as a reduction in the severity of ascites(P=0.022),hepatic encephalopathy(P=0.048),and cholestasis[a decrease in serum alkaline phosphatase(P=0.016)and serum gamma-glutamyl transpeptidase(P=0.039)activity]and an increase in platelet counts(P<0.001)and serum sodium level(P=0.048).CONCLUSION Probiotic administration was associated with amelioration of hyperdynamic circulation and the associated complications of cirrhosis. | Roman Maslennikov Irina Efremova Vladimir Ivashkin Maria Zharkova Elena Poluektova Elena Shirokova Konstantin Ivashkin | 2022 | World Journal of Hepatology2022，14，8： | 1 |
| 19 | Use of electrical conductivity instead of soluble salts for soil salinity monitoring in central Asia显示文摘 | SHIROKOVA Y FORKUTSA I SHARAFUTDINOVA N | 2000 | Irrigation and Drainage Systems2000，14，3： | 1 |
| 20 | The business model and firm performance: The case of Russian food service ven- tures显示文摘 | Morris M H Shirokova G Shatalov A | 2013 | Journal of Small Business Management2013，51，1： | 1 |
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