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| 1 | Clinical usefulness of biochemical markers of liver fibrosis in patients with nonalcoholic fatty liver disease显示文摘AIM: Nonalcoholic steatohepatitis (NASH) is a severe form of nonalcoholic fatty liver disease (NAFLD), and progresses to the end stage of liver disease. Biochemical markers of liver fibrosis are strongly associated with the degree of histological liver fibrosis in patients with chronic liver disease.However, data are few on the usefulness of markers in NAFLD patients. The aim of this study was to identify better noninvasive predictors of hepatic fibrosis, with special focus on markers of liver fibrosis, type Ⅵ collagen 7S domain and hyaluronic acid.METHODS: One hundred and twelve patients with histologically proven NAFLD were studied.RESULTS: The histological stage of NAFLD correlated with several clinical and biochemical variables, the extent of hepatic fibrosis and the markers of liver fibrosis were relatively strong associated. The best cutoff values to detect NASH were assessed by using receiver operating characteristic analysis: type Ⅵ collagen 7S domain ≥5.0 ng/mL, hyaluronic acid ≥43 ng/mL. Both markers had a high positive predictive value: type Ⅵ collagen 7S domain, 86% and hyaluronic acid,92%. Diagnostic accuracies of these markers were evaluated to detect severe fibrosis. Both markers showed high negative predictive values: type Ⅵ collagen 7S domain (≥5.0 ng/mL),84% and hyaluronic acid (≥50 ng/mL), 78%, and were significantly and independently associated with the presence of NASH or severe fibrosis by logistic regression analysis.CONCLUSION: Both markers of liver fibrosis are useful in discriminating NASH from fatty liver alone or patients with severe fibrosis from patients with non-severe fibrosis. | Hiroshi Sakugawa Tomofumi Nakayoshi Kasen Kobashigawa Tsuyoshi Yamashiro Tatsuji Maeshiro Satoru Miyagi Joji Shiroma Akiyo Toyama Tomokuni Nakayoshi Fukunori Kinjo Atsushi Saito | 2005 | World Journal of Gastroenterology2005，11，2： | 9 |
| 2 | Different natural courses of chronic hepatitis B with genotypes B and C after the fourth decade of life显示文摘AIM: To investigate the different impact of genotypes B and C on the development of liver cirrhosis (LC) among different age groups of patients with chronic hepatitis B (CH-B). METHODS: We examined the outcome of 121 patients with CH-B, divided by age and genotype. Univariate analyses were used to compare different groups. The Cox proportional hazard model was employed to evaluate factors affecting the development of LC. RESULTS: In patients < 30 years old, there were no significant predictors for development of LC. However, in patients ≥ 30 years old, genotype C was the only significant predictor. In the genotype C group, 8 of 12 patients who progressed to LC were 30-49 years old at initial diagnosis of chronic hepatitis (7 patients were positive for HBeAg). In the genotype B group, 4 of 8 patients who developed LC were ≥ 50 years old at initial diagnosis and were HBeAg-negative. CONCLUSION: The rate of development of LC was comparable in patients infected with genotypes B and C when CH-B occurred at < 30 years old. However, CH-B patients infected with genotype C showed poor prognosis if they were 30-49 years old and were positive for HBeAg. Age-specific natural course of CH-B should be considered when patients with CH-B are treated with antiviral drugs. | Tatsuji Maeshiro Shingo Arakaki Takako Watanabe Hajime Aoyama Joji Shiroma Tsuyoshi Yamashiro Tetsuo Hirata Akira Hokama Fukunori Kinjo Tomofumi Nakayoshi Tomokuni Nakayoshi Masashi Mizokami Jiro Fujita Hiroshi Sakugawa | 2007 | World Journal of Gastroenterology2007，13，34： | 7 |
| 3 | Binaural integration abilities in bilateral cochlear implant user显示文摘Bilateral Cochlear implants(CIs) improved speech intelligibility, speech perception in background noise, and sound localization in quiet and noisy situations. However, it is unclear whether these advantages essentially result in binaural integration of acoustic stimuli from each ear. In this study, we investigated the effectiveness of binaural integration by bilateral CIs placement using binaural hearing tests and subjective auditory perceptual assessment. A 61-year-old bilateral CIs subject underwent the following four tests: the Japanese Hearing in Noise Test(HINT-J), the dichotic listening test(DLT), the Rapidly Alternating Speech Perception(RASP) test, and subjective auditory perceptual assessment. The HINTJ score was significantly higher for bilateral CIs than for a unilateral CI. However, DLT and the RASP test revealed contradictory results.Subjective auditory perceptual assessment revealed active and bright impressions for bilateral hearing, which were also noisy and strong compared with those for unilateral hearing. The results of this study revealed that bilateral CIs improved speech perception in background noise and an improved auditory impression, although the bilateral integration abilities were not improved. This was probably because the patient was required to combine information from the two ears into a single perception in DLT and the RASP test. More longitudinal data should be collected and analyzed in future studies to evaluate the long-term effects of bilateral CIs. | Chie Obuchi Masae Shiroma Sayaka Ogane Kimitaka Kaga | 2015 | Journal of Otology2015，10，4： | 2 |
| 4 | Corneal opacity and cataract: triple procedure versus secondary approach显示文摘 | Shimmura S Ohashi Y SHiroma H | 2003 | Cornea2003，22，3： | 1 |
| 5 | Effect of physical inactivity on major non-communicable diseases world- wide : an analysis of burden of disease and life expectancy 显示文摘 | Lee IM Shiroma E J Lohelo F | 2012 | Lancet2012，380，9838： | 1 |
| 6 | Effect of physical inactivity on major non-communicable diseases worldwide: ananalysis of burden of disease and life expectancy 显示文摘 | Lee IM Shiroma E J Lobelo F | 2012 | Lancet2012，380，9838： | 1 |
| 7 | Uneven changes in circulating blood cell counts with adrenergic stimulation to the canine spleen显示文摘 | Ojiri Y Noguchi K Shiroma N | 2002 | Clin Exp Pharmacol Physiol2002，29，12： | 1 |
| 8 | Flicker perimetry in healthy subjects: influence of age and gender, learning effect and short-term fluctuation 显示文摘 | Bernardi L Costa VP Shiroma LO | 2007 | Arq Bras Oftalmol2007，70，1： | 1 |
| 9 | A study of raphide microstructure in relation to irritation显示文摘 | Sakai W S Shiroma S S Nagao M A | | 0，，02： | 1 |
| 10 | Elf ect of physical inactivity on major non - communicable diseases worldwide: an analysis of burden of disease and life expectancy显示文摘 | I - Min Lee Eric J Shiroma Felipe Lobelo | 2012 | Lancet2012，380，： | 1 |
| 11 | Effect of physical inactivity on major non-communicable disease worldwide: an analysis of burden of disease and life expectancy显示文摘 | Lee IM Shiroma EJ Lobelo F | 2012 | Lancet2012，380，9838： | 1 |
| 12 | A study of raphide microstructure in relation to irritation显示文摘 | SAKAI W S SHIROMA S S | 1984 | Scanning Electron Microscopy1984，，： | 1 |
| 13 | Deafness due to A1555G mitoehondrial mutation without use of aminoglycoside显示文摘 | Matsunaga T Kumanomido H Shiroma M | 2004 | Laryngoscope2004，114，： | 1 |
| 14 | Effect of physical inactivity on major non-communicable diseases worldwide: an analysis of burden of disease and life expectancy显示文摘 | I-Min Lee Eric J Shiroma Felipe Lobelo Pekka Puska Steven N Blair Peter T Katzmarzyk | 2012 | The Lancet . 2012 (9838)2012，，9838： | 1 |
| 15 | A case of x-linked agarmnaglobulinemia with progressive encephalitis显示文摘 | Shiroma N Omi T Hasegawa H | 2004 | Pediatr Neurol2004，31，： | 1 |
| 16 | Effect of physical in-activity on major non-communicable diseases worldwide:an analysis of burden of disease and life expectancy显示文摘 | Lee MI Shiroma EJ Lobelo F et al | 2012 | The Lancet2012，380，9938： | 1 |
| 17 | Nonholonomic control of a three-dof planar underactuated manipulator显示文摘 | Arai H Tanie K Arid N Shiroma | 1998 | IEEE Trans on Robotics and Automation1998，14，5： | 1 |
| 18 | Effect of physical inactivity on ma jot non-communicable diseases worldwide: An analysis of bur- den of disease and life expectancy显示文摘 | LEE I M SHIROMA E J | 2012 | Lancet2012，380，： | 1 |
| 19 | Effect of physical inactiv-ity on major non-communicable diseases worldwide:an analy-sis of burden of disease and life expectancy显示文摘 | Lee IM Shiroma EJ Lobelo F | 2012 | Lancet2012，380，9838： | 1 |
| 20 | Metrorrhagia after intravitreal injection of bevacizumab 显示文摘 | Rodrigues EB Shiroma H Meyer CH | 2007 | Acta Ophthalmol Stand2007，85，8： | 1 |
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