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您的检索式：作者名="Shirui Jiang"
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| 1 | Type I CRISPR-Cas targets endogenous genes and regulates virulence to evade mammalian host immunity显示文摘定期聚类短 palindromic 重复的 interspaced (CRISPR ) 在细菌和 archaea 的 -CRISPR-associated (Cas ) 系统对入侵外国 nucleic 酸提供适应免疫。以前的研究建议某些细菌采用他们的类型 II CRISPR-Cas 系统指向他们的自己的基因,因此躲避主人免疫。然而,另外的 CRISPR-Cas 系统是否在主机房间的细菌的侵略期间有类似的函数,仍然保持未知。这里,我们为类型识别一个新奇角色我在在 Pseudomonas aeruginosa 躲避主人防卫的 CRISPR-Cas 系统拉紧 UCBPP-PA14。类型我 PA14 的 CRISPR-Cas 系统指向细菌的察觉到治安法官的管理者 LasR 的 mRNA 阻抑由像使用费的受体的识别 4,因此减少在房间和鼠标模型的主机的支持 inflammatory 回答。机械学地,这调停核酸酶的 RNA 降级在类型的 Cas3 在目标 mRNA,和 HD 和 DExD/H 领域要求一个 5-GGN-3 识别主题我 CRISPR-Cas 系统。作为 LasR 和类型我 CRISPR-Cas 系统在细菌是无所不在地在场的,我们的调查结果阐明重要普通机制内在的细菌的毒力。 | Rongpeng Li Lizhu Fang Shirui Tan Min Yu Xuefeng Li Sisi He Yuquan Wei Guoping Li Jianxin Jiang Min Wu | 2016 | Cell Research2016，26，12： | 4 |
| 2 | Nutrition in Alzheimer's disease:a review of an underappreciated pathophysiological mechanism显示文摘Alzheimer's disease(AD)is the leading cause of dementia in older individuals and is an escalating challenge to global public health.Pharmacy therapy of AD is one of the well-funded areas;however,little progress has been made due to the complex pathogenesis.Recent evidence has demonstrated that modifying risk factors and lifestyle may prevent or delay the incidence of AD by 40%,which suggests that the management should pivot from single pharmacotherapy toward a multipronged approach because AD is a complex and multifaceted disease.Recently,the gut-microbiota-brain axis has gained tremendous traction in the pathogenesis of AD through bidirectional communication with multiple neural,immune,and metabolic pathways,providing new insights into novel therapeutic strategies.Dietary nutrition is an important and profound environmental factor that influences the composition and function of the microbiota.The Nutrition for Dementia Prevention Working Group recently found that dietary nutrition can affect cognition in AD-related dementia directly or indirectly through complex interactions of behavioral,genetic,systemic,and brain factors.Thus,considering the multiple etiologies of AD,nutrition represents a multidimensional factor that has a profound effect on AD onset and development.However,mechanistically,the effect of nutrition on AD is uncertain;therefore,optimal strategies or the timing of nutritional intervention to prevent or treat AD has not been established.Thus,this review summarizes the current state of knowledge concerning nutritional disorders,AD patient and caregiver burden,and the roles of nutrition in the pathophysiology of AD.We aim to emphasize knowledge gaps to provide direction for future research and to establish optimal nutrition-based intervention strategies for AD. | Jiwei Jiang Hanping Shi Shirui Jiang Anxin Wang Xinying Zou Yanli Wang Wenyi Li Yuan Zhang Mengfan Sun Qiwei Ren Jun Xu | 2023 | Science China(Life Sciences)2023，66，10： | 0 |
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