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| 1 | Combined assessment of myocardial damage and electrical disturbance in chronic heart failure显示文摘AIM To investigate feasibility of combined assessment of biochemical and electrophysiological myocardial impairment markers risk-stratifying patients with chronic heart failure(CHF). METHODS Serum levels of heart-type fatty acid binding protein(H-FABP) as a marker of ongoing myocardial damage and QRS duration on electrocardiogram were measured at admission in 322 consecutive patients with CHF. A prolonged QRS duration was defined as 120 ms or longer. The cut-off value for H-FABP level(4.5 ng/mL) was determined from a previous study. Patients were prospectively followed during a median follow up period of 534 d. The primary endpoint was cardiac deaths and rehospitalization for worsening CHF.RESULTS There were 117 primary events, including 27 cardiac deaths and 90 rehospitalizations. Patients were stratified into four groups according to H-FABP level and QRS duration(≥ 120 ms). Multivariate analysis demonstrated that high H-FABP levels [hazard ratio(HR) = 1.745, P = 0.021] and QRS prolongation(HR1.612, P = 0.0258) were independent predictors of cardiac events. Kaplan-Meier analysis demonstrated that the combination of high H-FABP levels and QRS prolongation could be used to reliably stratify patients at high risk for cardiac events(log rank test P < 0.0001).CONCLUSION Combined assessment of myocardial damage and electrical disturbance can be used to risk-stratify patients with CHF. | Shinpei Kadowaki Tetsu Watanabe Yoichiro Otaki Taro Narumi Yuki Honda Hiroki Takahashi Takanori Arimoto Tetsuro Shishido Takuya Miyamoto Isao Kubota | 2017 | World Journal of Cardiology2017，9，5： | 14 |
| 2 | Invasive group B streptococcal infection in a patient with post splenectomy for hypersplenism secondary to liver cirrhosis and portal hypertension显示文摘BACKGROUND:Splenectomy in patients with liver cirrhosis(LC)is expected to become more common owing to its efficacy on portal hemodynamics.In this report we describe an alarming case of group B streptococcus(GBS)infection after splenectomy in a patient with LC.METHODS:A 72-year-old woman with a history of LC was admitted to our emergency department because of respiratory failure.The patient had received left lateral segmentectomy of the liver and splenectomy three months before admission.Pulmonary examination revealed significant wheezing during inspiration and expiration,but no crackles and stridor.Chest radiography and CT showed no infiltrates.A presumptive diagnosis of bronchial asthma caused by upper respiratory infection was made.Four days after admission,GBS infection was confirmed by blood culture and penicillin G was administered.Antibiotics were given intravenously for a total of 12 days.RESULTS:The patient was discharged on the 12th day after admission.CONCLUSIONS:Although efficacy of splenectomy in patients with LC has been reported,immune status should be evaluated for a longer period.Patients who have undergone splenectomy are highly susceptible to bacteria;moreover,LC itself is an independent risk factor for mortality in patients with sepsis.Since prophylaxis against GBS has not been established,immediate action should be taken.Emergency physicians should be aware of invasive GBS infection in the context of the critical risk factors related to splenectomy and LC,particularly the expected increase of splenectomy performed in LC patients. | Tomoya Okazaki Toru Hifumi Arisa Manabe Hikari Matsumura Satoshi Egawa Hideyuki Hamaya Nastuyo Shinohara Koshiro Takano Hajime Shishido Yuko Abe Kenya Kawakita Masanobu Hagiike Yasuhiro Kuroda | 2016 | World Journal of Emergency Medicine2016，7，1： | 6 |
| 3 | Significance of a novel sucrose permeability test using serum in the diagnosis of early gastric cancer显示文摘AIM: To investigate the usefulness of sucrose permeability test using serum in the diagnosis of gastric diseases, with special reference to early gastric cancer (EGC).METHODS: A total of 63 subjects, including 11patients with gastric ulcer, 20 patients with gastric cancer (13, early; 7, advanced) and 32 healthy controls,were studied. Blood and urine samples were collected repeatedly for 5 h before and after the sucrose loading.Sucrose levels were measured by a newly developed enzymatic method.RESULTS: Serum sucrose levels started to increase15 min after loading, and peaked at 60 min in the gastric disease groups. The levels for gastric ulcer, EGC and advanced gastric cancer (AGC) at 60 min were significantly higher than that in the healthy controls(26.9±2.4, 34.4±5.0, and 71.8±15.6 vs 7.9±0.7 mol/L,respectively, P<0.01). The cut-off level set at 15.4 mol/L(60 min) offered the best distinction between EGC patients and healthy controls; and the sensitivity and specificity were 92.3% and 93.8%, respectively, while those of the urine method were 76.9% and 93.8%,respectively.CONCLUSIONS: The gastric permeability test using serum is reliable for the detection of EGC, and this test can provide results much earlier than the conventional urine method. This test may offer a useful alternative to more invasive tests for EGC. | Tadayuki Shishido Taketo Yamaguchi Takeo Odaka Masanori Seimiya Hiromitsu Saisho Fumio Nomura | 2005 | World Journal of Gastroenterology2005，11，44： | 5 |
| 4 | 拉丝模参数对棒材拉拔后残余应力的影响显示文摘 | Motoo Asakawa Wataru Sasaki Shunsuke Shishido 孙刘歌 | 2004 | 金属制品2004，30，B05： | 5 |
| 5 | Role of organic acids in the mechanisms of biological soil disinfestation (BSD)显示文摘 | Noriaki Momma Kazuhiro Yamamoto Peter Simandi Masahiro Shishido | 2006 | Journal of General Plant Pathology2006，，4： | 3 |
| 6 | Role of lipocalin 2 in intraventricular haemoglobin-induced brain injury显示文摘Objective:Our recent studies have shown that blood components,including haemoglobin and iron,contribute to hydrocephalus development and brain injury after intraventricular haemorrhage(IVH).The current study investigated the role of lipocalin 2(LCN2),a protein involved in iron handling,in the ventricular dilation and neuroinflammation caused by brain injury in a mouse model of IVH.Design:Female wild-type(WT)C57BL/6 mice and LCN2-deficient(LCN2^(−/−))mice had an intraventricular injection of haemoglobin,and control mice received an equivalent amount of saline.MRI was performed presurgery and postsurgery to measure ventricular volume and the brains were used for either immunohistochemistry or western blot.Results:Ventricular dilation was observed in WT mice at 24 h after haemoglobin(25 mg/mL,20µL)injection(12.5±2.4 vs 8.6±1.5 mm^(3) in the control,p<0.01).Western blotting showed that LCN2 was significantly upregulated in the periventricular area(p<0.01).LCN2 was mainly expressed in astrocytes,whereas the LCN2 receptor was detected in astrocytes,microglia/macrophages and neurons.Haemoglobin-induced ventricle dilation and glia activation were less in LCN2^(−/−)mice(p<0.01).Injection of high-dose haemoglobin(50 mg/mL)resulted in lower mortality in LCN2^(−/−)mice(27%vs 86%in WT;p<0.05).Conclusions:Intraventricular haemoglobin caused LCN2 upregulation and ventricular dilation.Haemoglobin resulted in lower mortality and less ventricular dilation in LCN2^(−/−)mice.These results suggest that LCN2 has a role in haemoglobin-induced brain injury and may be a therapeutic target for IVH. | Hajime Shishido Yasunori Toyota Ya Hua Richard F Keep Guohua Xi | 2016 | Stroke & Vascular Neurology2016，1，2： | 3 |
| 7 | Outcome of patients who have undergone total enteroscopy for obscure gastrointestinal bleeding显示文摘AIM:To assess the diagnostic success and outcome among patients with obscure gastrointestinal bleeding who underwent total enteroscopy with double-balloon endoscopy.METHODS:Total enteroscopy was attempted in 156 patients between August 2003 and June 2008 at Hiroshima University Hospital and achieved in 75 (48.1%).It is assessed whether sources of bleeding were identified,treatment methods,complications,and 1-year outcomes (including re-bleeding) after treatment,and we compared re-bleeding rates among patients.RESULTS:The source of small bowel bleeding was identified in 36 (48.0%) of the 75 total enteroscopy patients;the source was outside the small bowel in 11 patients (14.7%) and not identified in 28 patients (37.3%).Sixty-one of the 75 patients were followed up for more than 1 year (27.2 ± 13.3 mo).Four (6.6%) of these patients showed signs of re-bleeding during the first year,but bleeding did not recur after treatment.Although statistical significance was not reached,a marked difference was found in the re-bleeding rate between patients in whom total enteroscopy findings were positive (8.6%,3/35) and negative (3.8%,1/26) (3/35 vs 1/26,P=0.63).CONCLUSION:A good outcome can be expected for patients who undergo total enteroscopy and receive proper treatment for the source of bleeding in the small bowel. | Takayoshi Shishido Shiro Oka Shinji Tanaka Hiroki Imagawa Yoshito Takemura Shigeto Yoshida Kazuaki Chayama | 2012 | World Journal of Gastroenterology2012，18，7： | 2 |
| 8 | Damped Oscillation of Liquid Column in Vertical U-Tube for Newtonian and non-Newtonian Liquids显示文摘在垂直U试管的牛顿的液体的抑制摆动是众所周知的现象和这个液体运动的答案之一因为然而,在圆形的管子中的 laminar 流动政体一般来说被解决,就算由这个答案的 oscillational 运动的时期将近与试验性的结果的被与一致,有由解决的方程的时间的差错的抑制 oscillational 过程的评价不与试验性的结果的一致。因此为牛顿、非牛顿的液体在圆形的 U 试管在 oscillational 运动的速度分布的试验性的结果之上基于, Bingham 塑料流动的速度分发被假定。在直径 D=10mm, 20mm 和 40mm 的垂直 U 试管的免费表面的垂直掉落并且升起的速度的抑制摆动并且也的答案与为牛顿的液体的水和水甘油答案和非牛顿的液体的丙烯酸的共聚物解决方案相比。由新流动模型的这些解决的方程的比较在对试验性的结果的好同意被显示出。上述说的结果详细被描述。 | Akira Ogawa Suguru Tokiwa Masatoshi Mutou Kazutaka Mogi Tonau Sugawara Masahide Watanabe Kouhei Satou Toshikazu Kikawada Keitarou Shishido Naoya Matumoto | 2007 | Journal of Thermal Science2007，16，4： | 2 |
| 9 | Oxidation of lower alkanes over Mo2O3-V2O5 supported on YSZ-aided membrance reactor显示文摘 | K Takehira T Shishido N Sakai | 2002 | Desalination2002，144，： | 2 |
| 10 | Partial oxidation of methane over Ni/Mg-Al oxide catalysts prepared by solid phase crystallization method from Mg-Al hydrotalcite-like precursors显示文摘 | Tetsuya Shishido Masanori Sukenobu | 2002 | Appl Catal A:Gen2002，22，： | 2 |
| 11 | A phase II study of neoadjuvant bevacizumab plus capecitabine and concomitant radiotherapy in patients with locally advanced rectal cancer显示文摘 | Giampietro Gasparini Francesco Torino Takayuki Ueno Stefano Cascinu Teresa Troiani Alberto Ballestrero Rossana Berardi Junichi Shishido Akihiko Yoshizawa Yukiko Mori Satoshi Nagayama Paola Morosini Masakazu Toi | 2012 | Angiogenesis2012，，1： | 2 |
| 12 | Effects of rootstock varieties, leave and grafting conditions on scion growth in eggplant 显示文摘 | Shishido Y Zhang X L Kumakura H | 1995 | J Japan HortSci1995，64，3： | 1 |
| 13 | Novel amphiphilie diblock and triblock liquid-crystalline eopolymers with well-defined structures prepared by atom transfer radical polymerization显示文摘 | Shishido A Ikeda T | 2005 | Macmmol Rapid Commun2005，26，： | 1 |
| 14 | Autothermal reformling of CH4 over supported Ni prepared from Mg-Al hydrotalcite-like anionic clay显示文摘 | Takehira K Shishido T Wang P | 2004 | J Catal2004，221，1： | 1 |
| 15 | Drosophila Synapse Formation:Regulation by Transmembrane Protein with Leu-Rich Repeats,CAPRICIOUS显示文摘 | Shishido E Takeichi M Nose A | 1998 | Science1998，280，5372： | 1 |
| 16 | Inflammatory pseudotumor of the bladder in neonates显示文摘 | Asanuma H Nakai H Shishido S | 2000 | Int J Urol2000，7，： | 1 |
| 17 | Toll-like receptor-2 modulates ventricular remodeling after myocardial infarction显示文摘 | Shishido T Nozaki N Yamaguchi S | | 0，，： | 1 |
| 18 | A novel hydrogen-evolving photocatalyst InVO4 active under visible light irradiation 显示文摘 | YE J H ZOU Z OSHIK/RI M MATSUSHITA A SHIMODA M IMAI M SHISHIDO T | 2002 | Chem Phys Lett2002，356，： | 1 |
| 19 | Effect of die approach geometry and bearing length on residual stress after bar drawing显示文摘 | Asakawa Motoo Sasaki Wataru Shishido Shunsuke | 2002 | Wire Journal International2002，35，10： | 1 |
| 20 | Inhibition of liver matastasis of human pancreatic carcinoma by angiogenesis inhibitor TNP- 470 in combination with cisplalin 显示文摘 | Yasoshima T Denno R | 1998 | Jpn J Cancer Res1998，89，9： | 1 |
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