|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Spontaneous bacterial peritonitis显示文摘Since its initial description in 1964,research hastransformed spontaneous bacterial peritonitis (SBP)from a feared disease (with reported mortality of 90%)to a treatable complication of decompensated cirrhosis,albeit with steady prevalence and a high recurrencerate. Bacterial translocation,the key mechanism in thepathogenesis of SBP,is only possible because of theconcurrent failure of defensive mechanisms in cirrhosis.Variants of SBP should be treated. Leucocyte esterasereagent strips have managed to shorten the 'tap-to-shot' time,while future studies should look into theircombined use with ascitic fluid pH. Third generationcephalosporins are the antibiotic of choice becausethey have a number of advantages. Renal dysfunctionhas been shown to be an independent predictor ofmortality in patients with SBP. Albumin is felt to reducethe risk of renal impairment by improving effectiveintravascular volume,and by helping to bind pro-inflammatory molecules. Following a single episodeof SBP,patients should have long-term antibioticprophylaxis and be considered for liver transplantation. | Anastasios Koulaouzidis Shivaram Bhat Athar A Saeed | 2009 | World Journal of Gastroenterology2009，15，9： | 31 |
| 2 | Impact of sodium glucose cotransporter-2 inhibitors on liver steatosis/fibrosis/inflammation and redox balance in non-alcoholic fatty liver disease显示文摘BACKGROUND Sodium glucose cotransporter-2 inhibitors(SGLT2-I)are the most recently approved drugs for type 2 diabetes(T2D).Recent clinical trials of these compounds reported beneficial cardiovascular(CV)and renal outcomes.A major cause of vascular dysfunction and CV disease in diabetes is hyperglycemia associated with inflammation and oxidative stress.Pre-clinical studies demonstrated that SGLT2-I reduce glucotoxicity and promote anti-inflammatory effects by lowering oxidative stress.AIM To investigate the effects of SGLT2-I on markers of oxidative stress,inflammation,liver steatosis,and fibrosis in patients of T2D with non-alcoholic fatty liver disease(NAFLD).METHODS We referred fifty-two consecutive outpatients treated with metformin monotherapy and exhibiting poor glycemic control to our centre.We introduced the outpatients to an SGLT2-I(dapagliflozin,empagliflozin,or canagliflozin;n=26)or a different hypoglycemic drug[other glucose-lowering drugs(OTHER),n=26].We evaluated circulating interleukins and serum hydroxynonenal(HNE)-or malondialdehyde(MDA)-protein adducts,fatty liver index(FLI),NAFLD fibrosis score,aspartate aminotransferase(AST)/alanine aminotransferase(ALT)ratio,AST-to-platelet-ratio index(APRI),and fibrosis-4 on the day before(T0)and following treatment for six months(T1).We also performed transient elastography at T0 and T1.RESULTS Add-on therapy resulted in improved glycemic control and reduced fasting blood glucose in both groups.Of note,following treatment for six months,a reduction of FLI and APRI,as well as of the FibroScan result,was reported in patients treated with SGLT2-I,but not in the OTHER group;furthermore,in the SGLT2-I group,we reported lower circulating levels of interleukin(IL)-1β,IL-6,tumor necrosis factor,vascular endothelial growth factor,and monocyte chemoattractant protein-1,and higher levels of IL-4 and IL-10.We did not observe any modification in circulating interleukins in the OTHER group.Finally,serum HNE-and MDA-protein adducts decreased significantly in SGLT2-I rather than OTHER patients and correlated with liver steatosis and fibrosis scores.CONCLUSION The present data indicate that treatment with SGLT2-I in patients with T2D and NAFLD is associated with improvement of liver steatosis and fibrosis markers and circulating pro-inflammatory and redox status,more than optimizing glycemic control. | Francesco Bellanti Aurelio Lo Buglio MichałDobrakowski Aleksandra Kasperczyk Sławomir Kasperczyk Palok Aich Shivaram P Singh Gaetano Serviddio Gianluigi Vendemiale | 2022 | World Journal of Gastroenterology2022，28，26： | 3 |
| 3 | Tobacco Smoking Increases the Risk of High-Grade Dysplasia and Cancer Among Patients With Barrett’s Esophagus显示文摘 | Helen G. Coleman Shivaram Bhat Brian T. Johnston Damian McManus Anna T. Gavin Liam J. Murray | 2012 | Gastroenterology2012，，2： | 2 |
| 4 | Liver injury in COVID-19:The hepatic aspect of the respiratory syndrome-what we know so far显示文摘The 2019 novel coronavirus disease(COVID-19)pandemic due to severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)has posed a serious threat to global public health.Although primarily,the infection causes lung injury,liver enzyme abnormalities have also been reported to occur during the course of the disease.We conducted an extensive literature review using the PubMed database on articles covering a broad range of issues related to COVID-19 and hepatic injury.The present review summarizes available information on the spectrum of liver involvement,the possible mechanisms and risk factors of liver injury due to SARS-CoV-2 infection,and the prognostic significance of the presence of liver injury.Hopefully,this review will enable clinicians,especially the hepatologists,to understand and manage the liver derangements they may encounter in these patients better and provide guidance for further studies on the liver injury of COVID-19. | Prajna Anirvan Pankaj Bharali Mrinal Gogoi Paul J Thuluvath Shivaram P Singh Sanjaya K Satapathy | 2020 | World Journal of Hepatology2020，12，12： | 2 |
| 5 | Are executive stock options associated with future earnings?显示文摘 | Michelle Hanlon Shivaram Rajgopal Terry Shevlin | 2003 | Journal of Accounting and Economics2003，，1： | 2 |
| 6 | Expression, secretion and age-related downregulation of pigment epithelium-derived factor, a serpin with neurotrophic activity 显示文摘 | Tombran-Tink J Shivaram SM Chader G J | 1995 | Neurosci1995，15，： | 1 |
| 7 | Expression,secretion,and age-related downregulation of pigment epithelium-derived factor,a serpin with neurotrophic activity显示文摘 | Tombran-Tink J Shivaram S Chader G Johnson L Bok D | 1995 | Neuroscience1995，15，： | 1 |
| 8 | The role of internal coal in the reduction of composite pellets 显示文摘 | SHIVARAM A N SAKAR S B PRASAD K K | 1996 | SEAISI Quarterly1996，，2： | 1 |
| 9 | Cardiopulmonary responeses to continuous positive airway pressure in acute asthma显示文摘 | Shivaram U Miro A M Cash M E | 1993 | J Crit Care1993，8，2： | 1 |
| 10 | Temporal progres- sion of skeletal cystic angiomatosis显示文摘 | Shivaram GM Pal RK Ireland KB | 2007 | 36(12): 1199- 12042007，36，12： | 1 |
| 11 | Cardiopulmonary responses tocontinuous positive airway pressure in acute asthma显示文摘 | Shivaram U Miro AM Cash ME | 1993 | J Crit Care1993，8，2： | 1 |
| 12 | Expression, secretion, and age-related downregulation of pig-ment epithelium-derived factor, a seipin with neurotrophic ac-tivity 显示文摘 | Tombran-Tink J Shivaram SM Chader GJ Johnson LV Bok D | 1995 | J Neurosd1995，15，71： | 1 |
| 13 | Ex- pression, secretion, and age-related downregulation of pigment epithelium-derived factor, a serpin with neurotro- phic activity 显示文摘 | Tombran-Tink J Shivaram S M Chader G J | 1995 | J Neurosci1995，15，71： | 1 |
| 14 | CEOs′ outside employment opportunities and the lack of relative performance evaluation in compensation contracts显示文摘 | Shivaram Rajgopal Terry Shevlin Valentina Zamora | | 0，，08： | 1 |
| 15 | Are executive stock options associated with future earnings? 显示文摘 | Shivaram Rajgopal Terry Shevlin | 2003 | Journal of Accounting and Economics2003，36，： | 1 |
| 16 | Changes in clusterin expression associated with light-induced retinal damage in rats 显示文摘 | Wong P Kutty RK Darrow RM Shivaram S Kutty G Fletcher RT Wig gert B Chader G Organisciak DT | 1994 | Biochem Cell Biol1994，72，1112： | 1 |
| 17 | Synthesis and luminescence properties of Sm3+doped Ca Ti O3nanophosphor for application in white LED under NUV excitation显示文摘 | Shivaram M Nagabhushana H Sharma S C | 2014 | Spectrochimica Acta Part A:Molecular and Biomolecular Spectroscopy2014，128，： | 1 |
| 18 | Are executive stock options associated with future earning?显示文摘 | Michelle Hanlon Shivaram Rajgopal and Terry Shevlin | 2003 | Journal of Accounting and Economics2003，36，13： | 1 |
| 19 | Purpura fulminans,metastatic endophthalmitis,and thrombotic thrombocytopenic purpura in an HIVinfected patient显示文摘 | Shivaram U Cash M | | 0，，07： | 1 |
| 20 | Purpura fulminans,metastatic endophthalmitis,and thrombotic thrombocytopenic purpura in an HIV-infected patient显示文摘 | Shivaram U Cash M | 1992 | NY State J Med1992，92，7： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员