|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Gait Study and Pattern Generation of a Starfish-Like Soft Robot with Flexible Rays Actuated by SMAs显示文摘 | Shixin Mao Erbao Dong Hu Jin Min Xu Shiwu Zhang Jie Yang Kin Huat Low | 2014 | Journal of Bionic Engineering2014，11，3： | 26 |
| 2 | Initial Development of a Novel Amphibious Robot with Transformable Fin-Leg Composite Propulsion Mechanisms显示文摘 | Shiwu Zhang Xu Liang Lichao Xu Min Xu | 2013 | Journal of Bionic Engineering2013，10，4： | 14 |
| 3 | A Novel Implementation of a Flexible Robotic Fin Actuated by Shape Memory Alloy显示文摘 | Qin Yan Lei Wang Bo Liu Jie Yang Shiwu Zhang | 2012 | Journal of Bionic Engineering2012，9，2： | 9 |
| 4 | Osteoclast-derived apoptotic bodies couple bone resorption and formation in bone remodeling显示文摘Bone remodeling is precisely coordinated by bone resorption and formation.Apoptotic osteoclasts generate large amounts of apoptotic bodies(ABs)marking the end of the bone resorption phase,whereas the functions of osteoclast-derived ABs remain largely unknown.Here,we identified the molecular profile of ABs derived from osteoclasts at distinct differentiation stages and investigated their corresponding functions.ABs were isolated from apoptotic bone marrow macrophages,preosteoclasts,and mature osteoclasts induced by staurosporine.Proteomic signature analysis with liquid chromatography-tandem mass spectrometry suggested marked protein cargo differences among the different ABs.Further bioinformatic analysis showed that the proteomic signatures of the ABs were highly similar to those of their parental cells.Functionally,pOC-ABs induced endothelial progenitor cell differentiation and increased CD31hiEmcnhi endothelial cell formation in a murine bone defect model via their PDGF-BB cargo.mOC-ABs induced osteogenic differentiation of mesenchymal stem cells and facilitated osteogenesis via RANKL reverse signaling.In summary,we mapped the detailed proteomic landscapes of ABs derived from osteoclasts and showed that their potential biological roles are important in coupling bone formation with resorption during bone remodeling. | Qinyu Ma Mengmeng Liang Yutong Wu Fei Luo Zaisong Ma Shiwu Dong Jianzhong Xu Ce Dou | 2021 | Bone Research2021，9，1： | 8 |
| 5 | Chondrogenesis mediates progression of ankylosing spondylitis through heterotopic ossification显示文摘Ankylosing spondylitis(AS)is chronic inflammatory arthritis with a progressive fusion of axial joints.Anti-inflammatory treatments such as anti-TNF-αantibody therapy suppress inflammation but do not effectively halt the progression of spine fusion in AS patients.Here we report that the autoimmune inflammation of AS generates a microenvironment that promotes chondrogenesis in spine ligaments as the process of spine fusion.Chondrocyte differentiation was observed in the ligaments of patients with earlystage AS,and cartilage formation was followed by calcification.Moreover,a large number of giant osteoclasts were found in the inflammatory environment of ligaments and on bony surfaces of calcified cartilage.Resorption activity by these giant osteoclasts generated marrow with high levels of active TGF-β,which induced new bone formation in the ligaments.Notably,no Osterix+osteoprogenitors were found in osteoclast resorption areas,indicating uncoupled bone resorption and formation.Even at the late and maturation stages,the uncoupled osteoclast resorption in bony interspinous ligament activates TGF-βto induce the progression of ossification in AS patients.Osteoclast resorption of calcified cartilage-initiated ossification in the progression of AS is a similar pathologic process of acquired heterotopic ossification(HO).Our finding of cartilage formation in the ligaments of AS patients revealed that the pathogenesis of spinal fusion is a process of HO and explained why anti-inflammatory treatments do not slow ankylosing once there is new bone formation in spinal soft tissues.Thus,inhibition of HO formation,such as osteoclast activity,cartilage formation,or TGF-βactivity could be a potential therapy for AS. | Tao Yu Jianguo Zhang Wei Zhu Xiao Wang Yun Bai Bin Feng Qianyu Zhuang Chang Han Shengru Wang Qimiao Hu Senbo An Mei Wan Shiwu Dong Jianzhong Xu Xisheng Weng Xu Cao | 2021 | Bone Research2021，9，2： | 7 |
| 6 | Mn-containing bioceramics inhibit osteoclastogenesis and promote osteoporotic bone regeneration via scavenging ROS显示文摘Osteoporosis is caused by an osteoclast activation mechanism.People suffering from osteoporosis are prone to bone defects.Increasing evidence indicates that scavenging reactive oxygen species(ROS)can inhibit receptor activator of nuclear factorκB ligand(RANKL)-induced osteoclastogenesis and suppress ovariectomy-induced osteoporosis.It is critical to develop biomaterials with antioxidant properties to modulate osteoclast activity for treating osteoporotic bone defects.Previous studies have shown that manganese(Mn)can improve bone regeneration,and Mn supplementation may treat osteoporosis.However,the effect of Mn on osteoclasts and the role of Mn in osteoporotic bone defects remain unclear.In present research,a model bioceramic,Mn-containedβ-tricalcium phosphate(Mn-TCP)was prepared by introducing Mn intoβ-TCP.The introduction of Mn intoβ-TCP significantly improved the scavenging of oxygen radicals and nitrogen radicals,demonstrating that Mn-TCP bioceramics might have antioxidant properties.The in vitro and in vivo findings revealed that Mn^(2+)ions released from Mn-TCP bioceramics could distinctly inhibit the formation and function of osteoclasts,promote the differentiation of osteoblasts,and accelerate bone regeneration under osteoporotic conditions in vivo.Mechanistically,Mn-TCP bioceramics inhibited osteoclastogenesis and promoted the regeneration of osteoporotic bone defects by scavenging ROS via Nrf2 activation.These results suggest that Mn-containing bioceramics with osteoconductivity,ROS scavenging and bone resorption inhibition abilities may be an ideal biomaterial for the treatment of osteoporotic bone defect. | Jianmei Li Cuijun Deng Wanyuan Liang Fei Kang Yun Bai Bing Ma Chengtie Wu Shiwu Dong | 2021 | Bioactive Materials2021，6，11： | 7 |
| 7 | Locomotion Performance of the Amphibious Robot on Various Terrains and Underwater with Flexible Flipper Legs显示文摘 | Bin Zhong Youcheng Zhou Xiaoxiang Li Min Xu Shiwu Zhang | 2016 | Journal of Bionic Engineering2016，13，4： | 5 |
| 8 | The expression and regulation of microRNA25b in cancers显示文摘癌症是世界范围的死亡的领先的原因之一。有明确的需要让新奇途径改进癌症的诊断和治疗。导致癌的病理学的过程与与恶意相关的特定的基因的改变的表示被联系。MicroRNA-125b (miR-125b ) 是在几个不同生物过程起一个关键作用的小非编码的、多种用途的 miRNA。增加证据的数量显示 miR-125b 可以用作某些种癌症的诊断 biomarker。miR-125b 可能是合适的包括肿瘤的疾病在几人的疾病被用作一个 therapeutical 目标。这里,我们在在癌症相关的 miR-125b 和癌症之间的关系的鉴定和确认考察最近的进步,并且讨论调整疾病的许多过程的 miR-125b 的功能,包括房间增长,区别,和 apoptosis。 | Ke Huang Shiwu Dong Wei Li Zhao Xie | 2013 | Acta Biochimica et Biophysica Sinica2013，45，10： | 4 |
| 9 | Natural Feature-based Visual Servoing for Grasping Target with an Aerial Manipulator显示文摘Aerial transportation and manipulation have attracted increasing attention in the unmanned aerial vehicle field,and visual servoing methodology is widely used to achieve the autonomous aerial grasping of a target object.However,the existing marker-based solutions pose a challenge to the practical application of target grasping owing to the difficulty in attaching markers on targets.To address this problem,this study proposes a novel image-based visual servoing controller based on natural features instead of artificial markers.The natural features are extracted from the target images and further processed to provide servoing feature points.A six degree-of-freedom(6-DoF)aerial manipulator system is proposed with differential kinematics deduced to achieve aerial grasping.Furthermore,a controller is designed when the target object is outside a manipulator's workspace by utilizing both the degrees-of-freedom of nnmanned aerial vehicle and manipulator joints.Thereafter,a weight matrix is used as basis to develop a multi-tasking visual servoing framework to integrate the controllers inside and outside the manipulator's workspace.Lastly,experimental results are provided to verify the effectiveness of the proposed approach. | Bin Luo Haoyao Chen Fengyu Quan Shiwu Zhang Yunhui Liu | 2020 | Journal of Bionic Engineering2020，17，2： | 4 |
| 10 | The experimental rules of mica as a reference sample of AFM/FFM measurement显示文摘For the friction measurements with AFM/FFM, usually the relative values of friction signal can be obtained. In order to compare the micro-tribological properties of different samples, mica is often used as an reference sample for friction measurement. However, due to the friction force of new cleaved mica surface is unstable, it is urged to systematically investigate the tribological properties of mica to design the experimental rules of the reference sample mica for friction measurements. Experimental results show that the friction of mica varies with the cleaving time, humidity and surface state of tip. The friction measured with different tips on mica varies in the range of ±15%. For a new tip, the friction increases with the tip’s wear and then becomes stable. For new cleaved mica, the friction increases within thefirst two hours and then keeps unchanged. The friction of mica also decreases with the relative humidity because of its hydrophilicity. | QIAN Linmao LUO Jianbin WEN Shiwu XIAO Xudong | 2001 | Chinese Science Bulletin2001，46，4： | 3 |
| 11 | Bone-targeted pH-responsive cerium nanoparticles for anabolic therapy in osteoporosis显示文摘Antiresorptive drugs are widely used for treatment of osteoporosis and cancer bone metastasis,which function mainly through an overall inhibition of osteoclast.However,not all osteoclasts are“bone eaters”;preosteoclasts(pOCs)play anabolic roles in bone formation and angiogenesis through coupling with osteoblasts and secreting platelet derived growth factor-BB(PDGF-BB).In this study,a bone-targeted pH-responsive nanomaterial was designed for selectively eliminating mature osteoclasts(mOCs)without affecting pOCs.Biocompatible cerium nano-system(CNS)was guided to the acidic extracellular microenvironment created by mOCs and gained oxidative enzymatic activity.Oxidative CNS decreased the viability of mOCs through accumulating intracellular reactive oxygen species and enhancing calcium oscillation.Non-acid secreting anabolic pOCs were thus preserved and kept producing PDGF-BB,which lead to mesenchymal stem cell osteogenesis and endothelial progenitor cell angiogenesis via PI3K-Akt activated focal adhesion kinase.In treating osteoporotic ovariectomized mice,CNS showed better protective effects compare with the current first line antiresorptive drug due to the better anabolic effects marked by higher level of bone formation and vascularization.We provided a novel anabolic therapeutic strategy in treating bone disorders with excessive bone resorption. | Ce Dou Jianmei Li Jian He Fei Luo Tao Yu Qijie Dai Yueqi Chen Jianzhong Xu Xiaochao Yang Shiwu Dong | 2021 | Bioactive Materials2021，6，12： | 3 |
| 12 | Phosphorylation inhibition of protein-tyrosine phosphatase 1B tyrosine-152 induces bone regeneration coupled with angiogenesis for bone tissue engineering显示文摘A close relationship has been reported to exist between cadherin-mediated cell-cell adhesion and integrin-mediated cell mobility,and protein tyrosine phosphatase 1B(PTP1B)may be involved in maintaining this homeostasis.The stable residence of mesenchymal stem cells(MSCs)and endothelial cells(ECs)in their niches is closely related to the regulation of PTP1B.However,the exact role of the departure of MSCs and ECs from their niches during bone regeneration is largely unknown.Here,we show that the phosphorylation state of PTP1B tyrosine-152(Y152)plays a central role in initiating the departure of these cells from their niches and their subsequent recruitment to bone defects.Based on our previous design of a PTP1B Y152 region-mimicking peptide(152RM)that significantly inhibits the phosphorylation of PTP1B Y152,further investigations revealed that 152RM enhanced cell migration partly via integrinαvβ3 and promoted MSCs osteogenic differentiation partly by inhibiting ATF3.Moreover,152RM induced type H vessels formation by activating Notch signaling.Demineralized bone matrix(DBM)scaffolds were fabricated with mesoporous silica nanoparticles(MSNs),and 152RM was then loaded onto them by electrostatic adsorption.The DBM-MSN/152RM scaffolds were demonstrated to induce bone formation and type H vessels expansion in vivo.In conclusion,our data reveal that 152RM contributes to bone formation by coupling osteogenesis with angiogenesis,which may offer a potential therapeutic strategy for bone defects. | Yong Tang Keyu Luo Yin Chen Yueqi Chen Rui Zhou Can Chen Jiulin Tan Moyuan Deng Qijie Dai Xueke Yu Jian Liu Chengmin Zhang Wenjie Wu Jianzhong Xu Shiwu Dong Fei Luo | 2021 | Bioactive Materials2021，6，7： | 3 |
| 13 | Properties of color-flavor locked strange quark matter and strange stars in a new quark mass scaling显示文摘Considering the effect of one-gluon-exchange interaction between quarks,the color-flavor locked strange quark matter and strange stars are investigated in a new quark mass density-dependent model.It is found that the color-flavor locked strange quark matter can be more stable if the one-gluon-exchange effect is included.The lower density behavior of the sound velocity in this model is different from the previous results.Moreover,the new equation of state leads to a heavier acceptable maximum mass,supporting the recent observation of a compact star mass as large as about 2 times the solar mass. | CHANG Qian CHEN ShiWu PENG GuangXiong XU JianFeng | 2013 | Science China(Physics,Mechanics & Astronomy)2013，56，9： | 3 |
| 14 | Genotypic variation in spatiotemporal distribution of canopy light interception in relation to yield formation in cotton显示文摘Background: Within-canopy interception of photosynthetically active radiation(PAR) impacts yield and other agronomic traits in cotton(Gossypium hirsutum L.). Field experiments were conducted to investigate the influence of 6 cotton varieties(they belong to 3 different plant types) on yield, yield distribution, light interception(LI), LI distribution and the relationship between yield formation and LI in Anyang, Henan, in 2014 and 2015.Result: The results showed that cotton cultivars with long branches(loose-type) intercepted more LI than did cultivars with short branches(compact-type), due to increased LI in the middle and upper canopy. Although loose-type varieties had greater LI, they did not yield significantly higher than compact-type varieties, due to decreased harvest index. Therefore, improving the harvest index by adjusting the source-to-sink relationship may further increase cotton yield for loose-type cotton. In addition, there was a positive relationship between reproductive organ biomass accumulation and canopy-accumulated LI, indicating that enhancing LI is important for yield improvement for each cultivar. Furthermore, yield distribution within the canopy was significantly linearly related to vertical LI distribution.Conclusion: Therefore, optimizing canopy structure of different plant type and subsequently optimizing LI distribution within the cotton canopy can effectively enhance the yield. | XING Fangfang HAN Yingchun FENG Lu ZHI Xiaoyu WANG Guoping YANG Beifang FAN Zhengyi LEI Yaping DU Wenli WANG Zhanbiao XIONG Shiwu LI Xiaofei Ll Yabing | 2018 | Journal of Cotton Research2018，1，3： | 3 |
| 15 | Quantitative analysis on coupling of traction current into cab signaling in electrified railways显示文摘Cab signaling apparatus is the critical equipment for ground-vehicle communication in electrified railways.With the rapid development of high-speed and heavy-haul railways,the immunity to unbalanced traction current interference for cab signaling apparatus in the onboard train control system is increasingly demanded.This paper analyzes the interference coupling mechanism of the ZPW-2000 track circuit.Based on electromagnetic field theory and the actual working parameters,a calculation model is established to complete the quantitative research of the cab signal induction process and traction current interference.Then,a finite element model is built to simulate the process.The simulation results under the signal frequency,fundamental and harmonic interference are all consistent with the theoretical calculation results.The practical measurement data verify the coupling relationship between cab signal inductive voltage and rail current.Finally,an indirect immunity test method applying this relation for the cab signals is proposed,and the voltage indexes of the disturbance sources are determined,i.e.,the test limits.The results provide an accurate quantitative basis for the cab signaling research and design of the immunity test platform;besides,the proposed indirect test method can simplify the test configuration and improve test efficiency. | Chang Liu Shiwu Yang Yong Cui Jiaqi Lv | 2020 | Railway Engineering Science2020，28，3： | 2 |
| 16 | The role of dendritic cells derived osteoclasts in bone destruction diseases显示文摘The bone is previously considered as a dominant organ involved in the processes of locomotion.However,in the past two decades,a large number of studies have suggested that the skeletal system closely coordinated with the immune system so as to result in the emerging area of'osteoimmunology'.In the evolution of many kinds of bone destruction-related dis-eases,osteoclasts could differentiate from dendritic cells,which contributed to increased expression of osteoclast-related membrane receptors and relatively higher activity of bone destruction,inducing sewere bone destruction under inflammatory conditions.Numerous fac-tors could influence the interaction between osteoclasts and dendritic cells,contributing to the pathogenesis of several bone diseases in the context of inflammation,including both im-munocytes and a large number of cytokines.In addition,the products of osteoclasts released from bone destruction area serve as important signals for the differentiation and activation of immature dendritic cells.Therefore,the border between the dendritic cell-rela ted immune response and osteoclast-related bone destruction has gradually unravelled.Dendritic cells and osteoclasts cooperate with each other to mediate bone destruction and bone remodelling under inflammatory conditions.In this review,we will pay attention to the interactions be-tween dendritic cells and osteoclasts in physiological and pathological conditions to further understand the skeletal system and identifty potential new therapeutic targets for the future by summarizing their significant roles and molecular mechanisms in bone destruction. | Bo Wang Yutong Dong Zhansong Tian Yueqi Chen Shiwu Dong | 2021 | Genes & Diseases2021，8，4： | 2 |
| 17 | MicroRNAs regulate osteogenesis and chondrogenesis显示文摘 | Shiwu Dong Bo Yang Hongfeng Guo Fei Kang | 2012 | Biochemical and Biophysical Research Communications2012，，4： | 2 |
| 18 | Influence of environmental factors on corrosion damage of aircraft structure显示文摘Corrosion is one of the important structural integrity concerns of aging aircraft, and it is estimated that a significant portion of airframe maintenance budgets is directed towards corrosion-related problems for both military and commercial aircraft. In order to better understand how environmental factors influence the corrosion damage initiation and propagation on aircraft structure and to predict pre-corrosion test pieces of fatigue life and structural integrity of an effective approach, this paper uses the cellular automaton (CA) method to character the effect of electrolyte concentrations, dissolution probabilities, and temperature on the corrosion damage of a metal structure exposed to an aggressive environment, and the procedure for applying the local rules between the cells of the CA to simulate the corrosion damage evolution is formulated. The simulation results show that the different electrolyte concentrations, dissolution probabilities and temperature, the laws of the dissolution current with time are investigated and they obey the time power function. | Keliang Ren,) Shiwu Gao, Pingping Liu, and Yan Dong Department of Physics & Electrical Information, Ningxia University, Ningxia 750021, China | 2011 | Theoretical & Applied Mechanics Letters2011，1，6： | 2 |
| 19 | Properties of strangelets in a new quark mass confinement model with one-gluon-exchange interaction显示文摘The properties of strangelets at zero temperature with a new quark model that includes both the confinement and one-gluonexchange interactions is studied in a fully self-consistent method.The charge and parameter dependence of the stability of strangelets are discussed.It is found that the one-gluon-exchange interaction lowers the energy of a strangelet,and consequently allows the strangelet to be absolutely stable.The stable strangelet radius in the present model is smaller in comparison with the absence of one-gluon-exchange interaction,and can thus be much less than that of a normal nucleus with the same baryon number,according to the strength of the confinement and one-gluon-exchange interactions. | XIA ChengJun CHEN ShiWu PENG GuangXiong | 2014 | Science China(Physics,Mechanics & Astronomy)2014，57，7： | 2 |
| 20 | The mobilization of rat’s mesenchymal stem cells into peripheral blood by LiCL and its potency differentiation显示文摘Mesenchymal stem cells (MSCs) are multipotent cells, which can differentiate into different tissues. It is still controversial whether MSCs can be isolated from adult peripheral blood (PB) under normal conditions and whether they can be mobilized in a way similar to that of hematopoietic stem cells (HSCs). In this study, rat MSCs circulating in the PB under normal conditions can be isolated and cultured, and MSCs from PB and BM can be mobilized by LiCL. The mobilized MSCs can be induced to differentiate into neuron by such factors as β-mercaptoethanol and supernatants of nerve cell cultures. The present study provides a broader perspective on the repair of neural trauma. | DENG dun ZOU ZhongMin ZHOU TaoLi AI GuoPing WANG JunPing DONG ShiWu SU YongPing | 2008 | Chinese Science Bulletin2008，53，17： | 2 |
您所在的机构暂未开通此部分的功能，请联系管理员