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| 1 | 哈萨克斯坦麦卡因矿床火山岩地球化学、U-Pb年代学和Lu-Hf同位素及意义显示文摘麦卡因大型VMS型Au-Ag-Cu-Zn-Pb矿床位于中哈萨克斯坦西北部的Baidaulet-Akbastau地区。地质剖面测量和岩石薄片研究表明,麦卡因矿区发育中基性火山岩(玄武岩和安山岩)和次火山岩(辉绿-辉长岩和辉绿岩),矿化主要与安山岩有关。对矿区火山岩地球化学分析表明,矿区岩石分为两种类型:类型Ⅰ为拉斑-钙碱性系列中基性火山岩(玄武岩和安山岩)和次火山岩(辉绿-辉长岩和辉绿岩),岩石具平坦的稀土配分模式,亏损Nb和富集Th/Yb,显示俯冲特点;类型Ⅱ为钙碱性系列安山岩,具典型的右倾型稀土配分模式,亏损Nb和富集Th/Yb,指示其形成于岛弧环境。含矿岩石为类型Ⅱ安山岩。对类型Ⅱ安山岩进行了锆石Lu-Hf同位素和SIMS U-Pb年龄分析,结果表明,锆石εHf(t)为较高的正值(+4.28^+14.84),指示其是地幔物质部分熔融的产物,锆石SIMS U-Pb年龄为459.1±4.8Ma,指示其成岩年龄属于晚奥陶世。因此,哈萨克斯坦麦卡因大型VMS型矿床含矿火山岩为钙碱性系列安山岩,形成于晚奥陶世岛弧环境。对比研究认为,哈萨克斯坦早古生代波谢库尔-成吉思斑岩型-VMS型成矿带向东延伸到我国西准噶尔沙尔布提山,沙尔布提山具有形成VMS型矿床的岩浆条件和构造环境。 | 潘鸿迪 申萍 张林浩 SEITMURATOVA Eleonora JAKUPOVA Sholpan | 2015 | 岩石学报2015，31，2： | 4 |
| 2 | A new can didate vaccine for human brucellosis based on influenza viral vectors:a preliminary investigation for the development of an immunization schedule in a guinea pig model显示文摘Background:A new candidate vector vaccine against human brucellosis based on recombinant influenza viral vectors(rIVV)subtypes H5N1 expressing Brucella outer membrane protein(Omp)16,L7/L12,Omp19or Cu-Zn SOD proteins has been developed.This paper presents the results of the study of protection of the vaccine using on guinea pigs,including various options of administering,dose and frequency.Provided data of the novel vaccine candidate will contribute to its further movement into the preclinical stage study.Methods:General states of guinea pigs was assessed based on behavior and dynamics of a guinea pig weight-gain test.The effectiveness of the new anti-brucellosis vector vaccine was determined by studying its protective effect after conjunctival,intranasal and sublingual administration in doses 10^(5) EID50,10^(6) EID_(50) and 10^(7) EID_(50) during prime and boost vaccinations of animals,followed by challenge with a virulent strain of B.melitensis 16 M infection.For sake of comparison,the commercial ft melitensis Rev.1 vaccine was used as a control.The protective properties of vaccines were assessed by quantitation of Brucella colonization in organs and tissues of infected animals and compared to the control groups.Results:It was observed a gradual increase in body weight of guinea pigs after prime and booster immunization with the vacci ne using conjunctival,intra nasal and subli ngual routes of administration,as well as after using various doses of vaccine.The most optimal way of using the vaccine has been established:double intranasal immunization of guinea pigs at a dose of 10^(6) EID50, which provides 80%protection of guinea pigs from B.melitensis 16 M infection(P<0.05),which is comparable to the results of the effectiv en ess of the commercial B.melitensis Rev.1 vacci ne.Conclusions:We developed effective human vaccine candidate against brucellosis and developed its immunization protocol in guinea pig model.We believe that because of these studies,the proposed vaccine has achieved the best level of protection,which in turn provides a basis for its further promotion. | Dina Bugybayeva Zhailaubay Kydyrbayev Nadezhda Zinina Nurika Assanzhanova Bolat Yespembetov Yerken Kozhamkulov Kunsulu Zakarya Sholpan Ryskeldinova Kaissar Tabynov | 2021 | Infectious Diseases of Poverty2021，10，1： | 3 |
| 3 | Plants ectopically expressing the iron-binding protein,ferritin,are tolerant to oxidative damage and pathogens显示文摘 | DEAK M GBOR V H SHOLPAN D | 1999 | Nature Biotech1999，17，： | 1 |
| 4 | Ranking of Higher Education Institutions of Ka- zakhstan 显示文摘 | Sholpan Kalanova | 2010 | Journal of International Higher Education2010，3，4： | 1 |
| 5 | Cytosolic ascorbate peroxidase 1 is a central component of the reactive oxygen gene network of Arabidopsis 显示文摘 | Sholpan D Ludmila R | 2005 | The Plant Cell2005，17，1： | 1 |
| 6 | The Zinc-Finger Protein Zat12 Plays a Central Role in Reactive Oxygen and Abiotic Stress Signaling in Arabidopsis显示文摘 | Sholpan Davletova Karen Schlauch Jesse Coutu | 2005 | Plant Physiology2005，139，： | 1 |
| 7 | Plants ectopically expressing the iron-binding protein,ferritin,are tolerant to oxidative damage and pathogens显示文摘 | De6k M Gábor VH Sholpan D | | 0，，： | 1 |
| 8 | Field Tests of the Catalyst "Mukhamedzhan-l" for the Detoxification of Propellant UDMH in the Position the Space Center "Baikonur" in Kazakhstan显示文摘 | Aibassov Erkin Zhakenovich Baiguzhin Adil Alibekovich Serikbaeva Gulbarshyn Kuanyshkanovna Almuhametova Sholpan Uralovna | 2013 | Journal of Chemistry and Chemical Engineering2013，7，2： | 0 |
| 9 | Research of Physical Mechanical and Protective Properties of the Lignin Rust Modifier显示文摘 | Kulash Syrmanova Adyl Tuleuov Zhanat Kaldybekova Nurjan Botabaev Sholpan Baijanova Saule Sakibayeva Anastassiya Beloborodova | 2014 | 材料科学与工程(中英文B版)2014，4，10： | 0 |
| 10 | Immunogenic and Protective Properties of the First Kazakhstan Vaccine against Pandemic Influenza А(Н1N1) pdm09 in Ferrets显示文摘This paper presents the results of a pre-clinical study of the immunogenicity and efficacy of an egg-derived,inactivated,whole-virion adjuvanted vaccine (Refluvac) on ferret models.For this purpose,groups of eight ferrets (6 to 7 months old) were injected with 0.5 mL of vaccine specimens containing 3.75,7.5 or 15.0 μg of virus hemagglutinin.Administration was intramuscular and given either as a single dose or as two doses 14 days apart.All vaccine specimens manifested immunogenicity in ferrets for single (HI titer,from 51±7 to 160±23) and double (HI titer,from 697±120 to 829±117) administrations.To assess the protective effects of the vaccine,ferrets from the vaccinated and control groups were infected intranasally with pandemic virus А/California/7/09 (Н1N1) pdm09 at a dose of 106 EID 50/0.5 mL.Fourteen days post-infection,the ferrets inoculated with single or double vaccines containing 3.75,7.5 or 15.0 μg of hemagglutinin per dose showed no signs of influenza infection,weight loss,or body temperature rise,and no premature deaths occurred.The number of vaccinated ferrets shedding the virus via the upper airway,as well as the amount of virus shed after infection,was significantly reduced in comparison with animals from the control group.Based on our results,we suggest that a single vaccination at a dose of 3.75 or 7.5 μg hemagglutinin be used for Phase I clinical trials. | Kaissar Tabynov Zhailaubai Kydyrbayev Abylai Sansyzbay Berik Khairullin Sholpan Ryskeldinova Nurika Assanzhanova Yerken Kozhamkulov Dulat Inkarbekov | 2012 | Virologica Sinica2012，27，6： | 0 |
| 11 | The Elaboration of Horse Meat Products Technology显示文摘 | Abzhanova Sholpan Kizatova Maigul Mukhtarkhanova Rauan Tarakbaeva Raushan Abilmazhinova Nazum | 2012 | Journal of Life Sciences2012，6，10： | 0 |
| 12 | Study of Models for Heating Power Station Operator Training Systems显示文摘 | Sholpan Muratkyzy Baimatayeva Yuriy Vladimirovitch Shevyakov | 2013 | Journal of Energy and Power Engineering2013，7，1： | 0 |
| 13 | 哈萨克斯坦麦卡因VMS型矿床含矿岩石年代学和地球化学显示文摘火山成因块状硫化物(VMS)矿床经济价值仅次于斑岩铜矿,是一种重要的有色金属矿床类型,备受关注。中亚造山带西段发育许多大型VMS矿床,集中在哈萨克斯坦北部的矿区阿尔泰和中国新疆北部的阿尔泰地区,这些矿床为晚古生代泥盆纪VMS型Cu-Zn矿床。在其南部的哈萨克斯坦境内发育早古生代Cu-Pb-Zn-Au-Ag型VMS矿床,以Baidaulet-Akbastau地区发育的大型麦卡因(Maikain)矿床为代表。 | 潘鸿迪 申萍 张林浩 Eleonora Seitmuratova Sholpan Jakupova | 2014 | 矿床地质2014，33，S1： | 0 |
| 14 | Assessment of molecular markers and marker-assisted selection for drought tolerance in barley(Hordeum vulgare L.)显示文摘This review updates the present status of the field of molecular markers and marker-assisted selection(MAS),using the example of drought tolerance in barley.The accuracy of selected quantitative trait loci(QTLs),candidate genes and suggested markers was assessed in the barley genome cv.Morex.Six common strategies are described for molecular marker development,candidate gene identification and verification,and their possible applications in MAS to improve the grain yield and yield components in barley under drought stress.These strategies are based on the following five principles:(1)Molecular markers are designated as genomic‘tags’,and their‘prediction’is strongly dependent on their distance from a candidate gene on genetic or physical maps;(2)plants react differently under favourable and stressful conditions or depending on their stage of development;(3)each candidate gene must be verified by confirming its expression in the relevant conditions,e.g.,drought;(4)the molecular marker identified must be validated for MAS for tolerance to drought stress and improved grain yield;and(5)the small number of molecular markers realized for MAS in breeding,from among the many studies targeting candidate genes,can be explained by the complex nature of drought stress,and multiple stress-responsive genes in each barley genotype that are expressed differentially depending on many other factors. | Akmaral Baidyussen Gulmira Khassanova Maral Utebayev Satyvaldy Jatayev Rystay Kushanova Sholpan Khalbayeva Aigul Amangeldiyeva Raushan Yerzhebayeva KulpashBulatova Carly Schramm Peter Anderson Colin L.D.Jenkins Kathleen LSoole Yuri Shavrukov | 2024 | Journal of Integrative Agriculture2024，23，1： | 0 |
| 15 | Ethno-Linguistic Processes in a Globalizing World: The Study of Cultural and Language Behavior of the Kazakhstani Repatriates in the Socio-Linguistic Aspect显示文摘 | Sholpan Zharkynbekova Assel Akzhigitova, Lyazzat Dalbergenova | 2013 | US-China Foreign Language2013，11，1： | 0 |
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