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| 1 | Adoptively transferred donor IL-17-producing CD4^(+) T cells augment, but IL-17 alleviates, acute graft-versus-host disease显示文摘The role of IL-17 and IL-17-producing CD4^(+) T cells in acute graft-versus-host disease(GVHD)has been controversial in recent mouse and human studies.We carried out studies in a murine acute GVHD model of fully major histocompatibility complex-mismatched myeloablative bone marrow transplantation.We showed that donor wild-type CD4^(+) T cells exacerbated acute GVHD compared with IL-17−/−CD4^(+) T cells,while IL-17 reduced the severity of acute GVHD.The augmentation of acute GVHD by transferred donor IL-17-producing CD4^(+) T cells was associated with increased Th1 responses,while IL-17 decreased the percentages of Th1 cells in the GVHD target organs.Furthermore,IL-17 reduced the infiltration of macrophages into the GVHD tissues.In vitro study showed that IL-17 could downregulate Th1 responses,possibly through inhibiting IL-12 production by donor macrophages.Depletion of macrophages in vivo diminished the protective effect of IL-17.Our results demonstrated the differential roles of adoptively transferred donor IL-17-producing CD4^(+) T cells and IL-17 in the same acute GVHD model. | Yifeng Cai Shoubao Ma Yuejun Liu Huanle Gong Qiao Cheng Bo Hu Yan Wu Xiao Yu Chen Dong Kai Sun Depei Wu Haiyan Liu | 2018 | Cellular & Molecular Immunology2018，15，3： | 3 |
| 2 | The S 1P, receptor-selective agonist CYM-5442 reduces the severity of acute GVHD byinhibiting macrophage recruitment显示文摘FTY720,为五已知的 sphingosine-1-phosphate (S1P ) 中的四个的收缩筋受体,被报导了禁止尖锐 graft-versus-host 疾病(aGVHD ) 。因为 FTY720 通过多重 S1P 受体工作,通过至少一这些受体的行动的机制可以说明它的副作用。因此,更选择的 S1P 受体调节的人被需要评估不同 S1P 受体和他们的治疗学的功效的角色。在这研究,我们调查了 S1P 1-selective 收缩筋的效果, CYM-5442,在 aGVHD 的前进上。我们显示出显著地禁止的那 CYM-5442 但是没阻止 aGVHD。CYM-5442 没影响施主 T 细胞的渗入进目标器官,当在 GVHD 器官的巨噬细胞的数字被 CYM-5442 处理显著地减少时。在 vivo 增长,试金证明巨噬细胞的增长没被 CYM-5442 压制。用人的 endothelial 房间的进一步的研究在 endothelial 房间表明了那 CYM-5442 处理 downregulated CCL2 和 CCL7 表情,因此减少单核白血球,从纸巾,巨噬细胞发源的迁居。我们的数据在 aGVHD 和它行动的可能的机制表明 S1P 1-selective 收缩筋的治疗学的功效。结果建议进一步的调查为 aGVHD 作为潜在的治疗学的政体关于 CYM-5442 被需要。 | Qiao Cheng Shoubao Ma Dandan Lin Yu Mei Huanle Gong Lei Lei Yuanyuan Chen Ye Zhao Bo Hut Yan Wu Xiao Yu Lixiang Zhao Haiyan Liu | 2015 | Cellular & Molecular Immunology2015，12，6： | 2 |
| 3 | The highly efficient delivery of exogenous proteins into cells mediated by biodegradable chimaeric polymersomes显示文摘 | Guijing Liu Shoubao Ma Shaoke Li Ru Cheng Fenghua Meng Haiyan Liu Zhiyuan Zhong | 2010 | Biomaterials2010，，29： | 1 |
| 4 | High stearic acid diet modulates gut microbiota and aggravates acute graft-versus-host disease显示文摘Dear Editor,Acute graft-versus-host disease(aGVHD)is the leading cause of transplantation-related mortality,and limits therapeutic benefits of allogeneic bone marrow transplantation(allo-BMT).New insight is needed into the development of aGVHD.Most nutritional metabolites contribute to host health and immune homeostasis. | Bingyu Yang Xianfeng Zhang Huanle Gong Yuhui Huang Chang Wang Haiyan Liu Chen Dong Shoubao Ma Xiaojin Wu Depei Wu | 2021 | Signal Transduction and Targeted Therapy2021，6，8： | 0 |
| 5 | Dendritic cell-derived IL-27 p28 regulates T cell program in pathogenicity and alleviates acute graft-versus-host disease显示文摘Interleukin 27(IL-27),a heterodimeric cytokine composed of Epstein-Barr virus-induced 3 and p28,is a pleiotropic cytokine with both pro-and anti-inflammatory properties.However,the precise role of IL-27 in acute graft-versus-host disease is not yet fully understood.In this study,utilizing mice with IL-27 p28 deficiency in dendritic cells(DCs),we demonstrated that IL-27 p28 deficiency resulted in impaired Treg cell function and enhanced effector T cell responses,corresponding to aggravated aGVHD in mice.In addition,using single-cell RNA sequencing,we found that loss of IL-27 p28 impaired Treg cell generation and promoted IL1R2^(+)TIGIT^(+)pathogenic CD4+T cells in the thymus at a steady state.Mechanistically,IL-27 p28 deficiency promoted STAT1 phosphorylation and Th1 cell responses,leading to the inhibition of Treg cell differentiation and function.Finally,patients with high levels of IL-27 p28 in serum showed a substantially decreased occurrence of grade II-IV aGVHD and more favorable overall survival than those with low levels of IL-27 p28.Thus,our results suggest a protective role of DC-derived IL-27 p28 in the pathogenesis of aGVHD through modulation of the Treg/Teff cell balance during thymic development.IL-27 p28 may be a valuable marker for predicting aGVHD development after transplantation in humans. | Huanle Gong Shoubao Ma Jia Chen Bingyu Yang Shuangzhu Liu Xin Liu Jingjing Han Xiaojin Wu Lei Lei Zhinan Yin Hongjian Sun Di Yu Haiyan Liu Yang Xu Depei Wu | 2022 | Signal Transduction and Targeted Therapy2022，7，10： | 0 |
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