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| 1 | Transcriptomic landscape regulated by the 14 types of bone morphogenetic proteins(BMPs)in lineage commitment and differentiation of mesenchymal stem cells(MSCs)显示文摘Mesenchymal stem cells(MSCs)are ubiquitously-existing multipotent progenitors that can self-renew and differentiate into multiple lineages including osteocytes,chondrocytes,adipocytes,tenocytes and myocytes.MSCs represent one of the most commonly-used adult progenitors and serve as excellent progenitor cell models for investigating lineagespecific differentiation regulated by various cellular signaling pathways,such as bone morphogenetic proteins(BMPs).As members of TGFb superfamily,BMPs play diverse and important roles in development and adult tissues.At least 14 BMPs have been identified in mammals.Different BMPs exert distinct but overlapping biological functions.Through a comprehensive analysis of 14 BMPs in MSCs,we demonstrated that BMP9 is one of the most potent BMPs in inducing osteogenic differentiation of MSCs.Nonetheless,a global mechanistic view of BMP signaling in regulating the proliferation and differentiation of MSCs remains to be fully elucidated.Here,we conducted a comprehensive transcriptomic profiling in the MSCs stimulated by 14 types of BMPs.Hierarchical clustering analysis classifies 14 BMPs into three subclusters:an osteo/chondrogenic/adipogenic cluster,a tenogenic cluster,and BMP3 cluster.We also demonstrate that six BMPs(e.g.,BMP2,BMP3,BMP4,BMP7,BMP8,and BMP9)can induce ISmads effectively,while BMP2,BMP3,BMP4,BMP7,and BMP11 up-regulate Smad-independent MAP kinase pathway.Furthermore,we show that many BMPs can upregulate the expression of the signal mediators of Wnt,Notch and PI3K/AKT/mTOR pathways.While the reported transcriptomic changes need to be further validated,our expression profiling represents the first-of-its-kind to interrogate a comprehensive transcriptomic landscape regulated by the 14 types of BMPs in MSCs. | Linghuan Zhang Qing Luo Yi Shu Zongyue Zeng Bo Huang Yixiao Feng Bo Zhang Xi Wang Yan Lei Zhenyu Ye Ling Zhao Daigui Cao Lijuan Yang Xian Chen Bin Liu William Wagstaff Russell R*Reid Hue H*Luu Rex C*Haydon Michael J*Lee Jennifer Moriatis Wolf Zhou Fu Tong-Chuan He Quan Kang | 2019 | Genes & Diseases2019，6，3： | 11 |
| 2 | Prognostic value of perioperative leukocyte count in resectable gastric cancer显示文摘AIM: To investigate the prognostic significance of perioperative leukopenia in patients with resected gastric cancer.METHODS: A total of 614 eligible gastric cancer patients who underwent curative D2 gastrectomy and adjuvant chemotherapy were enrolled in this study. The relationship between pre- and postoperative hematologic parameters and overall survival was assessed statistically, adjusted for known prognostic factors.RESULTS: The mean white blood cell count(WBC) significantly decreased after surgery, and 107/614(17.4%) patients developed p-leukopenia, which was defined as a preoperative WBC ≥ 4.0 × 109/L and postoperative WBC < 4.0 × 109/L, with an absolute decrease ≥ 0.5 × 109/L. The neutrophil count decreased significantly more than the lymphocyte count. P-leukopenia significantly correlated with poor tumor differentiation and preoperative WBC. A higher preoperative WBC and p-leukopenia were independent negative prognostic factors for survival [hazard ratio(HR) = 1.602, 95% confidence interval(CI): 1.185-2.165; P = 0.002, and HR = 1.478, 95%CI: 1.149-1.902; P = 0.002, respectively] after adjusting for histology, Borrmann type, p TNM stage, vascular or neural invasion, gastrectomy method, resection margins, chemotherapy regimens, and preoperative WBC count. The patients with both higher preoperative WBC and p- leukopenia had a worse prognosis compared to those with lower baseline WBC and no p-leukopenia(27.5 mo vs 57.3 mo, P < 0.001). CONCLUSION: Preoperative leukocytosis alone or in combination with postoperative leukopenia could be independent prognostic factors for survival in patients with resectable gastric cancer. | Xiao-Feng Chen Jing Qian Dong Pei Chen Zhou Oluf Dimitri R?e Fang Zhu Shao-Hua He Ying-Ying Qian Yue Zhou Jun Xu Jin Xu Xiao Li Guo-Qiang Ping Yi-Qian Liu Ping Wang Ren-Hua Guo Yong-Qian Shu | 2016 | World Journal of Gastroenterology2016，22，9： | 4 |
| 3 | Agricultural pesticide use and food safety:California's model显示文摘Pesticides have been an essential part of agriculture to protect crops and livestock from pest infestations and yield reduction for many decades. Despite their usefulness,pesticides could pose potential risks to food safety and the environment as well as human health. This paper reviews the positive benefits of agricultural pesticide use as well as some potential negative impacts on the environment and food safety. In addition,using the case of California,we discuss the need for both residue monitoring and effective pest management to promote food safety. Twenty years' pesticide residue data from California's pesticide residue monitoring program were analyzed. Results showed that more than 95% of food samples were in compliance with US pesticide residue standards(tolerances). However,certain commodities from certain sources had high percentages of residues above tolerance levels. Even when residues above tolerance levels were detected,most were at levels well below 1 mg kg–1,and most posed negligible acute health risk. However,a few detected residues had the potential to cause health effects. Therefore,establishing an effective food residue monitoring program is important to ensure food quality throughout the marketplace. | Minghua Zhang Michael R Zeiss Shu Geng | 2015 | Journal of Integrative Agriculture2015，14，11： | 4 |
| 4 | Dexmedetomidine attenu- ates isoflurane-induced neurocognitive impairment in neonatal rats 显示文摘 | SANDERS R D XU J SHU Y | 2009 | Anesthesiology2009，110，5： | 1 |
| 5 | Comparison of arch width,alveolar width and buccolingual inclination of teeth between ClassⅡdivision 1 malocclusion and Class I occlusion显示文摘 | Shu R Han X Wang Y | 2013 | Angle Orthod2013，83，2： | 1 |
| 6 | Highly efficient blue-light-emitting diodes from polyfluorene containing bipolar pendant groups显示文摘 | Dodda R Wu F I | 2003 | Macromolecules2003，36，： | 1 |
| 7 | Atmospheric lifetimes and fates of a series of sesquiterpenes 显示文摘 | Shu Y H Atkinson R | 1995 | Journal of Geophysical Research- atmospheres1995，100，4： | 1 |
| 8 | Transgenic rice with a synthetic crylAb gene from Bacillus thuringiensis is highly resistant to eight lepidopteran insects显示文摘 | Shu Q Y Ye G Y Cui H R Cheng X Xiang Y Wu D Gao M Xia Y Hu C Sardana R Altosaar I | 2000 | Mol Breed2000，，6： | 1 |
| 9 | Simultaneous deposition of Pd and Ag on porous stainless steel by electroless plating 显示文摘 | SHU J GRANDJEAN B P A GHALI R | 1993 | J Membr Sci1993，77，： | 1 |
| 10 | Forecasting the wind generation using a two-stage network based on meteorological information显示文摘 | Fan Shu Liao J R Yokoyama R | 2009 | IEEE Transactions on Energy Conversion2009，24，2： | 1 |
| 11 | Dexmedetomidine attenuates isoflurane-induced neuroeognitive impairment in neonatal rats 显示文摘 | Sanders R D Xu J Shu Y | 2009 | Anesthesiology2009，110，5： | 1 |
| 12 | Physical activity and the incidence of type 2 diabetes in the Shanghai women~ health study 显示文摘 | VILLEGAS R SHU X 0 LI H | 2006 | Int J Epidemiol2006，35，6： | 1 |
| 13 | Wire Bond Loop Profile Development for Fine Pitch-Long Wire Assembly显示文摘 | Groover R Shu W K Lee S S | 1994 | IEEE Transactions on Semiconductor Manufacturing1994，7，3： | 1 |
| 14 | Transgenic rice plants with a synthetic cry1 Ab gene from Bacillus thuringiensis were highly resistant to eight lepidopteran rice pest species显示文摘 | Shu Q Y Ye G Y Cui H R | 2000 | Molecular Breeding2000，6，： | 1 |
| 15 | Asynchronous Multicarrier DS- CDMA Using Mutually Orthogonal Complementary Sets of Sequenees显示文摘 | Shu Ming Tseng Mark R Bell | 2000 | IEEE Transaction on Communications2000，48，1： | 1 |
| 16 | Ontology-based semantic matchmaking approach显示文摘 | GAO SHU OMER F R NICK J A | 2007 | Advances in Engineering Software2007，38，1： | 1 |
| 17 | Effects of elevated CO2 levels on root morphological traits and Cd uptakes of two Lolium species under Cd stress显示文摘 | Jia Y Tang S R Ju X H Shu L N Tu S X Feng R W Giusti L | 2011 | Journal of Zhejiang University of Science2011，12，4： | 1 |
| 18 | Trekking across the brain: the journey of neuronal migration显示文摘 | Ayala R Shu T Tsai LH | 2007 | Cell2007，128，： | 1 |
| 19 | Highly efficient blue-light-emitting diodes from polyfluorene conlaining bipolar pendant groups显示文摘 | Shu C F Dodda R Wu F I el al | 2003 | Macromolecules2003，36，18： | 1 |
| 20 | A sharp upper bound on the largest eigenvalue of the Laplacian matrix of a graph显示文摘 | SHU J L HONG Y WEN K R | 2002 | Linear Algebra Appl2002，347，： | 1 |
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