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| 1 | Differential Diagnostic CYFRA21-1 level for benign and malignant pleural effusions: a meta-analysis in the Chinese population 显示文摘 | Biaoxue R Shuanying Y Xiguang C | 2012 | Arch MedSci2012，8，5： | 1 |
| 2 | Differential diagnostic CYFRA 21-1 level for benign and malignant pleural effusions:a recta-analysis in the Chinese population 显示文摘 | Biaoxue R Shuanying Y Xiguang C | 2012 | Arch Med Sci2012，8，5： | 1 |
| 3 | Differential diagnostic CYFRA 21-1 level for benign and malignant pleural effusions:a meta-analysis in the Chinese population 显示文摘 | Biaoxue R Shuanying Y Xiguang C | 2012 | Arch Med Sci2012，8，5： | 1 |
| 4 | Study of distinct protein profiles for early diagnosis of NSCLC using LCM and SELDI-TOF-MS显示文摘 | Shuanying Yang Yandong Nan Yingxuan Tian Wei Zhang Bin Zhou Lina Bu Shufen Huo Guoan Chen Jiekai Yu Shu Zheng | 2008 | Medical Oncology2008，，4： | 1 |
| 5 | Upregulation of Hsp90-betaand annexin Al correlates with poor survival and lymphatic metasta-sis in lung cancer patients 显示文摘 | Biaoxue R Xiling J Shuanying Y | 2012 | J Exp Clin Cancer Res2012，28，31： | 1 |
| 6 | Analysis of the expression protein profiles of lung squamous carcinoma cell using shot-gun proteomics strategy显示文摘 | Yandong Nan Shuanying Yang Yingxuan Tian Wei Zhang Bin Zhou Lina Bu Shufen Huo | 2009 | Medical Oncology2009，，2： | 1 |
| 7 | Upregulation of HSP90-beta and annexin A1 correlates with poor sur- vival and lymphatic metastasis in lung cancer patients 显示文摘 | Biaoxue R Shuanying Y Xiling J | 2012 | J Exp Clin Cancer Res2012，31，1： | 1 |
| 8 | Annexin A1 in malignant tumors:current opinions and controversies显示文摘 | Biaoxue R Xiguang C Shuanying Y | 2014 | Int J Biol Markers2014，29，1： | 1 |
| 9 | Maintenance ther- apy of gefitinib for non-small-cell lung cancer after first-line chemotherapy regardless of epidermal growth factor receptor mutation: a review in Chinese patients显示文摘 | Biaoxue R Shuanying Y Wei L | 2012 | Curr Med Res Opin2012，28，1： | 1 |
| 10 | Maintenance therapy of ge- fitinib for non - small - cell lung cancer after first - line chemo- therapy regardless of epidermal growth factor receptor mutation : a review in Chinese patients 显示文摘 | Biaoxue R Shuanying Y Wei L | 2012 | Curt Med Res Opin2012，28，10： | 1 |
| 11 | NuA4核心复合物通过双重识别机理乙酰化核小体组蛋白H4显示文摘NuA4催化核小体组蛋白H4的乙酰化是一个广为人知的表观遗传学现象,在酵母中参与调控多种基因组过程。在这个工作中,本研究报道了NuA4核心复合物的晶体结构以及结合核小体的电子显微镜结构。这些结构表明,乙酰转移酶的组蛋白结合口袋发生重排,暗示了该酶的一种激活机理。 | Peng Xu Chengmin Li Zhihong Chen Shuanying Jiang Shilong Fan Jiawei Wang Junbiao Dai 朱平 陈柱成 | 2017 | 科学新闻2017，19，4： | 0 |
| 12 | miR-195-5p exerts tumor-suppressive functions in human lung cancer cells through targeting TrxR2显示文摘miR-195-5p has been widely explored in various cancers and is considered as a tumor-suppressive microRNA.However,its roles in human lung cancer pathogenesis are not fully elucidated.In this study,we aimed to explore how miR-195-5p is involved in malignant behaviors of lung adenocarcinoma(LUAD)cells.miR-195-5p expression was examined in the tumor tissues of patients with LUAD and human LUAD cell lines including A549 and PC-9.Thioredoxin reductase 2(TrxR2)was predicted to be an mRNA target of miR-195-5p using online tools and validated by the Dual-Luciferase Reporter Assay.Lentivirus infection was used for gene overexpression,while gene knockdown was achieved by RNA interference.Cell proliferation was determined by Cell Counting Kit-8 and 5-ethynyl-2′-deoxyuridine methods,and cell migration and invasion were assayed with transwell experiments.Cell apoptosis was determined by annexin V staining-based flow cytometry.The antitumor effects of miR-195-5p were also evaluated in nude mice xenografted with A549 cells.We found that miR-195-5p was lowly expressed in human LUAD cells,and its overexpression markedly suppressed cell proliferation,migration,and invasion and increased the apoptosis of LUAD cells in vitro.TrxR2 knockdown phenocopied the tumor-suppressive effects of miR-195-5p overexpression,while simultaneous TrxR2 overexpression remarkably reversed the effects of miR-195-5p overexpression on malignant behaviors of A549 and PC-9 cells.Additionally,miR-195-5p overexpression inhibited the growth of xenografted A549 tumor in nude mice.Our work verified that miR-195-5p exerts tumor-suppressive functions in LUAD cells through targeting TrxR2 and suggested that the miR-195-5p/TrxR2 axis is a potential biomarker for LUAD therapy. | Lina Bu Yingxuan Tian Hongqing Wen Weihong Jia Shuanying Yang | 2021 | Acta Biochimica et Biophysica Sinica2021，53，2： | 0 |
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