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| 1 | Gastrin as an autocrine growth factor in colorectal carcinoma:implications for therapy显示文摘Thereisnowconsiderableexperimentalsupportforthehypothesisthatprogastrinderivedpeptidesstimulateproliferationofthenormalcolon... | Graham S. Baldwin and Arthur Shulkes | 1998 | World Journal of Gastroenterology1998，4，6： | 3 |
| 2 | Histamine 3 receptor activation mediates inhibition of acid secretion during Helicobacter-induced gastritis显示文摘AIM:To test the hypothesis that histamine 3 receptor (H3R)activation during Helicobacter infection inhibits gastric acid secretion in vivo and in vitro.METHODS:Helicobacter felis(H.felis)infected and uninfected C57Bl/6 mice were infused with either PBS or the H3 receptor antagonist thioperamide(THIO)for 12 wk.After treatment,mice were analyzed for morphological changes and gastric acid content.Total RNA was prepared from the stomachs of each group and analyzed for changes in somatostatin and gastrin mRNA abundance by real time-polymerase chain reaction(RTPCR).Location of H3 receptors in the stomach was analyzed by co-localization using antibodies specific for the H3 receptor and parietal cell marker H + ,K + -ATPase βsubunit. RESULTS:Inflammation and parietal cell atrophy was observed after 12 wk of H.felis infection.Interestingly, treatment with the H3R antagonist thioperamide(THIO) prior to and during infection prevented H.felis-induced inflammation and atrophy.Compared to the uninfected controls,infected mice also had significantly decreased gastric acid.After eradication of H.felis with THIO treatment,gastric acidity was restored.Compared to the control mice,somatostatin mRNA abundance was decreased while gastrin gene expression was elevated during infection.Despite elevated gastric acid levels, after eradication of H.felis with THIO,somatostatin mRNA was elevated whereas gastrin mRNA was suppressed.Immunofluorescence revealed the presence of H3 receptors on the parietal cells,somatostatin-secreting D-cells as well as the inflammatory cells. CONCLUSION:This study shows that during H.felis infection,gastric acidity is suppressed as a consequence of an inhibitory effect on the parietal cell by H3R activation.The stimulation of gastric mucosal H3Rs increases gastrin expression and release by inhibiting release of somatostatin. | Yana Zavros Nisreen Mesiwala Meghna Waghray Andrea Todisco Arthur Shulkes Juanita L Merchant | 2010 | World Journal of Gastrointestinal Pathophysiology2010，1，5： | 2 |
| 3 | Gastrins, cholecystokinins and gastrointestinal cancer显示文摘 | Aly A Shulkes A Baldwin GS | 2004 | Bioehim Biophys Acta2004，1704，： | 1 |
| 4 | Gastrin,gastrin receptors and colorectal carcinoma显示文摘 | Baldwin G.S Shulkes A | | 0，，04： | 1 |
| 5 | Phylogenetic analysis of the sequences of gastrin-releasing peptide and its receptors:biological implications显示文摘 | Baldwin GS Patel O Shulkes A | 2007 | RegulPept2007，143，13： | 1 |
| 6 | Gastrins,cholecystokinins and gastrointestinalcancer显示文摘 | Aly A Shulkes A Baldwin GS | 2004 | Biochim Biophys Acta2004，1704，1： | 1 |
| 7 | Gastrin-releasing peptide and cancer显示文摘 | Pate1 O Shulkes A Baldwin GS | | 0，，01： | 1 |
| 8 | Gas/tin-releasing peptide : Differ- ent forms, different functions 显示文摘 | Ischia J Patel O Shulkes A | 2009 | Biofactors2009，35，1： | 1 |
| 9 | Mitogenic effects of both amidated and glycine-extended gastrin-releasing peptide in defunctioned and azoxymethane-treated rat colon in vivo显示文摘 | Nezor Houli Su-wen Loh Andrew S. Giraud Graham S. Baldwin Arthur Shulkes | 2005 | Regulatory Peptides2005，，1： | 1 |
| 10 | Gastrin-releasing peptide: diffent forms, diffent functions显示文摘 | Ischia J Palel O Shulkes A el al | 2009 | Biofactors2009，35，1： | 1 |
| 11 | Expression of receptors regulating gastric acidity in the developing sheep stomach 显示文摘 | Kolivas S Volombello T Shulkes A | 2001 | Regul Pept2001，101，： | 1 |
| 12 | Comparison of continuous versus intermittent ischaemia-reperfusion during liver resection in an experimental model 显示文摘 | Hardy KJ Tancheroen S Shulkes A | 1995 | Br J Surg1995，82，6： | 1 |
| 13 | Gastrin-releasing peptide: differ- ent forms, different functions 显示文摘 | Ischia J Patel O Shulkes A | 2009 | Biofactors2009，35，1： | 1 |
| 14 | Gastrin-releasing peptide and cancer 显示文摘 | Patel O Shulkes A Baldwin GS | 2006 | Biochim Biophys Acta2006，1766，1： | 1 |
| 15 | Phylogenetic analysis of the sequences of gastrin-releasing peptide and its receptors: biological implications显示文摘 | Baldwin GS Patel O Shulkes A | 2007 | Regul Pept2007，143，13： | 1 |
| 16 | Active immunoneutralization of somatostatin in the sheep: effects on gastrointestinal somatostatin expression, storage and secretion 显示文摘 | Shulkes A Moore C Kolivas S | 1999 | Regulatory Peptides1999，82，： | 1 |
| 17 | Gastrin-releasing peptide and cancer显示文摘 | Patel O Shulkes A Blfein GS | 2006 | Biochim Biophys Acta2006，1766，： | 1 |
| 18 | Expression of gastrin pre- cursors by CD133-positive coloreetal cancer ceils is crucial for tumour growth 显示文摘 | Ferrand A Sandrin M S Shulkes A | 2009 | Biochim Biophys Acta2009，1793，3： | 1 |
| 19 | Active immunoneutralization of somatostatin in the sheep: effects on gastrointestinal somatostatin expression, storage and secretion显示文摘 | Arthur Shulkes Caroline Moore Sotirios Kolivas Jane Whitley | 1999 | Regulatory Peptides1999，，1： | 1 |
| 20 | Gastrin-- releasing peptide and caneer显示文摘 | Patel O Shulkes A Baldwin GS | 2006 | Bioehim Biophys Aeta2006，1766，1： | 1 |
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