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| 1 | Chiral Amino Acids-Derived Catalysts and Ligands显示文摘 | Xiaohua Liu Shunxi Dong Lili Lin Xiaoming Feng | 2018 | Chinese Journal of Chemistry2018，36，9： | 8 |
| 2 | Catalytic asymmetric synthesis of chiral azo compounds via interrupted Japp-Klingemann reaction with aryldiazonium salts显示文摘Asymmetric synthesis of enantioenriched azo compounds bearing tetrasubstituted stereocenter was achieved through chiral N,N′-dioxide/metal Lewis acid promoted interrupted Japp-Klingemann reaction of aryldiazonium tetrafluoroborate salts with nucleophiles under mild conditions. This protocol features wide substrate scope and good functional group compatibility.Azaarene-containing chiral azo compounds were stable enough in Japp-Klingemann reaction condition. The key to success of the reaction was the employment of metal salt/N,N′-dioxide ligand and the dual-task roles of the base. Moreover, the X-ray crystal structure of Ni(II)/N,N′-dioxide/substrate complex confirmed that the substrate was activated by bidentate coordination, which shed light on the origin of chiral control of the reaction. | Yan Wang Aying Yihuo Lifeng Wang Shunxi Dong Xiaoming Feng | 2022 | Science China Chemistry2022，65，3： | 1 |
| 3 | C–H alkylation of pyridines with olefins catalyzed by imidazolin-2-iminato-ligated rare-earth alkyl complexes显示文摘An array of rare-earth bis(aminobenzyl)complexes supported by imidazolin-2-iminato ligands were synthesized and structurally characterized.These complexes showed high activity towards ortho-Csp^(2)–H alkylation of 2-alkylpyridines and benzylic Csp^(3)–H alkylation of 2,6-dialkylpyridines with alkenes.A wide range of alkyl or aryl substituted olefin substrates are compatible,providing an atom-economical route to linear or branched alkylated pyridine derivatives in moderate to high yields(45 examples,up to 99%yield).The primary study suggested that the asymmetric version of Csp^(3)–H alkylation of 2,4,6-collidine with allylbenzene was feasible with chiral imidazolin-2-iminato-ligated scandium(III)complexes,and good yield with moderate enantioselectivity was obtained(84%yield,84:16 er).Mechanistic investigations including kinetic isotope effect(KIE)experiments and density functional theory(DFT)calculations shed light on the catalytic cycle and the origin of enantiocontrol. | Dawei Li Lichao Ning Qiliang Luo Shiyu Wang Xiaoming Feng Shunxi Dong | 2023 | Science China Chemistry2023，66，6： | 0 |
| 4 | New chiral N-heterocyclic olefin bifunctional organocatalysis inα-functionalization ofβ-ketoesters显示文摘N-heterocyclic olefins(NHOs)possess an electron-rich and highly polarized C=C double bond due to the donating property of nitrogen atoms.This feature imparts exocyclic carbon atom of NHOs with strong basicity and high nucleophilicity.Although NHOs have been emerging as a new type of organocatalyst and ligand for metal complexes in organic synthesis,chiral NHOmediated highly enantioselective organic transformations were still elusive.Herein,we developed a new type of chiral aminederived C_(2)-symmetric NHOs and employed them as efficient chiral bifunctional organocatalysts for asymmetricα-functionalization ofβ-ketoesters.With as low as 0.1 mol%catalyst loading,the desired amination and trifluoromethylthiolation products were afforded in good yields with high enantioselectivities(up to 99%yield and 99%ee).Experimental studies and theoretical calculation disclosed that hydrogen-bonding interaction upon protonation and other weak interaction between substrate and catalyst were crucial for the enantiocontrol. | Sijing Wang Cefei Zhang Da Li Yuqiao Zhou Zhishan Su Xiaoming Feng Shunxi Dong | 2023 | Science China Chemistry2023，66，1： | 0 |
| 5 | Asymmetric Catalytic α-Selective Allylation of Ketones with Allyltrifluoroborates Using Dual-Functional Chiral In^(Ⅲ)/N,N'-Dioxide Complex显示文摘Comprehensive Summary Asymmetric catalytic allylation of halo-substituted ketones and ketoesters was accomplished to yield a number of homoallylic tertiary alcohols in excellent reactivity and enantioselectivity.In the presence of chiral In^(Ⅲ)/N,N-dioxide catalyst,unusual α-selective allylation ofγ-substituted potassium allyltrifluoroborates to ketones was demonstrated.The control experiments and DFT calculation reveal that chiral In^(Ⅲ)/N,N'-dioxide catalyst plays dual-tasking roles:the formation of allylindium species via transmetalation and Lewis acid activation.Apossiblereaction pathwaywas provided tounderstandα-selectivity overy-selectivity. | Xiaoxue Tang Zhishan Su Qianchi Lin Lili Lin Shunxi Dong Xiaoming Feng | 2022 | Chinese Journal of Chemistry2022，40，15： | 0 |
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