|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | A Summary and Evaluation of Current Evidence for Myocardial Infarction with Chinese Medicine显示文摘Objective: To provide evidence-based recommendations for clinical application and provoke thoughts for future researchers by conducting a comprehensive summary and evaluation of the current evidence profile for the role of Chinese medicine(CM) in treating myocardial infarction(MI). Methods: Online databases including Pub Med, EMBase, Cochrane Library, Chinese National Knowledge Infrastructure(CNKI), Chinese Biomedical Medicine(CBM), VIP Journal Integration Platform, and Wanfang database were systematically searched for literatures on CM in treating MI. After screening, studies were categorized into 5 types, i.e. systematic review(SR), randomized controlled trial(RCT), observational study, case report and basic research. General information was abstracted, and the quality levels of these studies and their conclusions were summarized and assessed. Results: A total of 452 studies including 10 SRs, 123 RCTs, 47 observational studies, 28 case reports, and 244 basic researches were selected. Clinical studies centered primarily on herbal decoction and mostly were not rigorously performed. High-quality studies were predominantly on Chinese patent medicines(CPMs) such as Danshen Injection(丹参注射液), Shenmai Injection(参麦注射液), Shengmai Injection(生脉注射液) and Qishen Yiqi Dripping Pills(芪参益气滴丸). The most frequently observed pattern of drug combination was decoction plus injection. Results of SRs and clinical studies showed that CM may reduce mortality, decrease risk of complication, reduce myocardial injury, improve cardiac function and inhibit ventricular remodeling. Findings from basic researches also supported the positive role of CM in reducing infarct size and myocardial injury, promoting angiogenesis, preventing ventricular remodeling and improving cardiac function. According to the current evidence body, CM has proven effects in the prevention and treatment of MI. It is also found that the effects of CPMs vary with indications. For instance, Shenmai Injection has been found to be especially effective for reducing the incidence of acute clinical events, while CPMs with qi-nourishing and bloodcirculating properties have been proven to be effective in inhibiting ventricular remodeling. High quality evidence supports the use of CM injection for acute MI and CPM for secondary prevention. Reports on adverse events and other safety outcomes associated with CM for MI are scarce. Conclusions: Sufficient evidence supported the use of CM as an adjuvant to Western medicine for preventing and treating MI. The choice of drug use varies with disease stage and treatment objective. However, the quality of the evidence body remains to be enhanced. | WANG Yue XIAO Lu MU Wei YU Hai-long ZHANG Shuo TIAN Gui-hua SHANG Hong-cai | 2017 | Chinese Journal of Integrative Medicine2017，23，12： | 12 |
| 2 | Mechanism of taurine-induced apoptosis in human colon cancer cells显示文摘公牛(字形物) 被显示了拥有癌症通过 apoptosis 的正式就职的治疗学的效果,当它的反癌症效果的内在的 molecularmechanism 很好没被理解时。美洲狮(apoptosis 的 p53-upregulated 调节的人) 在 p53 依赖、独立的 manners.However 在在许多人的肿瘤房间感应的 apoptosis 的过程玩 importantrole,美洲狮是否在癌症房间涉及导致字形物的 apoptosis 的过程,很好没被学习。在 thepresent 学习,我们与不同 concentrationsof 字形物对待人的 colorectal 癌症房间 HT-29 (变异的 p53 ) 和 LoVo (野类型的 p53 ) ,它在两根房间线导致了房间增长和 apoptosis 的正式就职的压抑。同时,我们 alsoobserved 美洲狮和高度的增加的表示 Bax/Bcl-2 比率。在导致字形物的 apoptosis 决定美洲狮的角色,我们使用了小介入的 RNA 干扰压制美洲狮表示。作为结果, apoptosis 在反应 toTau 治疗被减少。所有这些结果显示那美洲狮在人的 colorectalcancer 房间在导致字形物的 apoptosis 小径起一个关键作用。涉及字形物的反肿瘤效果的分子的机制的示范可能在为 p53 缺乏的 colorectal 癌症的 therapeutictarget 选择是有用的。 | Xiali Zhang Shuo Tu Yibing Wang Baohua Mu Fusheng Wan | 2014 | Acta Biochimica et Biophysica Sinica2014，46，4： | 12 |
| 3 | A multi-channel collagen scaffold loaded with neural stem cells for the repair of spinal cord injury显示文摘Collagen scaffolds possess a three-dimensional porous structure that provides sufficient space for cell growth and proliferation,the passage of nutrients and oxygen,and the discharge of metabolites.In this study,a porous collagen scaffold with axially-aligned luminal conduits was prepared.In vitro biocompatibility analysis of the collagen scaffold revealed that it enhances the activity of neural stem cells and promotes cell extension,without affecting cell differentiation.The collagen scaffold loaded with neural stem cells improved the hindlimb motor function in the rat model of T8 complete transection and promoted nerve regeneration.The collagen scaffold was completely degraded in vivo within 5 weeks of implantation,exhibiting good biodegradability.Rectal temperature,C-reactive protein expression and CD68 staining demonstrated that rats with spinal cord injury that underwent implantation of the collagen scaffold had no notable inflammatory reaction.These findings suggest that this novel collagen scaffold is a good carrier for neural stem cell transplantation,thereby enhancing spinal cord repair following injury.This study was approved by the Animal Ethics Committee of Nanjing Drum Tower Hospital(the Affiliated Hospital of Nanjing University Medical School),China(approval No.2019AE02005)on June 15,2019. | Shuo Liu Yuan-Yuan Xie Liu-Di Wang Chen-Xu Tai Dong Chen Dan Mu Yan-Yan Cui Bin Wang | 2021 | Neural Regeneration Research2021，16，11： | 6 |
| 4 | The Game Theoretical Approach for Multi-phase Complex Systems in Chemical Engineering显示文摘This paper explores the application of noncooperative game theory together with the concept of Nash equilibrium to the investigation of some basic problems on multi-scale structure, especially the meso-scale structure in the multi-phase complex systems in chemical engineering. The basis of this work is the energy-minimization-multi-scale(EMMS) model proposed by Li and Kwauk(1994) and Li, et al.(2013) which identifies the multi-scale structure as a result of ‘compromise-in-competition between dominant mechanisms' and tries to solve a multi-objective optimization problem. However,the existing methods often integrate it into a problem of single objective optimization, which does not clearly reflect the ‘compromise-in-competition' mechanism and causes heavy computation burden as well as uncertainty in choosing suitable weighting factors. This paper will formulate the compromise in competition mechanism in EMMS model as a noncooperative game with constraints, and will describe the desired stable system state as a generalized Nash equilibrium. Then the authors will investigate the game theoretical approach for two typical systems in chemical engineering, the gas-solid fluidization(GSF) system and turbulent flow in pipe. Two different cases for generalized Nash equilibrium in such systems will be well defined and distinguished. The generalize Nash equilibrium will be solved accurately for the GSF system and a feasible method will be given for turbulent flow in pipe. These results coincide with the existing computational results and show the feasibility of this approach, which overcomes the disadvantages of the existing methods and provides deep insight into the mechanisms of multi-scale structure in the multi-phase complex systems in chemical engineering. | LI Yan MU Yifen YUAN Shuo GUO Lei | 2017 | Journal of Systems Science & Complexity2017，30，1： | 5 |
| 5 | Single-/fused-band dual-mode mid-infrared imaging with colloidal quantum-dot triple-junctions显示文摘Image data acquired with fused multispectral information can be used for effective identification and navigation owing to additional information beyond human vision,including thermal distribution,night vision,and molecular composition.However,the construction of photodetectors with such capabilities is hindered by the structural complexity arising from the integration of multiple semiconductor junctions with distinct energy gaps and lattice constants.In this work,we develop a colloidal quantum-dot dual-mode detector capable of detecting,separating,and fusing photons from various wavelength ranges.Using three vertically stacked colloidal quantum-dot homojunctions with alternating polarity,single-band short-wave infrared imaging and fused-band imaging(short-wave and mid-wave infrared)can be achieved with the same detector by controlling bias polarity and magnitude.The dual-mode detectors show detectivity up to 8×10^(10)Jones at the fused-band mode and 3.1×10^(11)Jones at the single-band mode,respectively.Without image post-processing algorithms,the dual-mode detectors could provide both night vision and thermal information-enhanced night vision imaging capability.To the best of our knowledge,this is the first colloidal quantum-dot detector that can achieve such functionality.The operation mode can be changed at a high frequency up to 1.7 MHz,making it possible to achieve simultaneously dual-mode imaging and remote temperature sensing. | SHUO ZHANG GE MU JIE CAO YUNING LUO QUN HAO MENGLU CHEN YIMEI TAN PENGFEI ZHAO XIN TANG | 2022 | Photonics Research2022，10，8： | 3 |
| 6 | SNP-based linkage mapping for validation of adult plant stripe rust resistance QTL in common wheat cultivar Chakwal 86显示文摘Wheat crops in China are constantly challenged by stripe rust. Deployment of cultivars with diverse resistances is the best strategy to control the disease. A recombinant inbred line(RIL) population derived from a cross between the resistant cultivar Chakwal 86 and susceptible landrace Mingxian 169 was studied in multiple environments to examine the underlying genetics and to identify quantitative trait loci(QTL) for stripe rust resistance.One hundred and twenty-eight RILs were genotyped with wheat 35 K SNP array and a genome-wide linkage map with 1480 polymorphic SNP markers, or bins, was constructed.Two major QTL on chromosomes 1BL and 3BS, and one minor QTL on 6BS had significant effects in reducing stripe rust severity. The QTL were validated using composite interval mapping(CIM) and inclusive composite interval mapping(ICIM). These methods explained59.0%–74.1% of the phenotype variation in disease response. The QTL on chromosome 1 BL was confirmed to be Yr29/Lr46 and the one on 3BS was the resistance allele identified in CIMMYT germplasm but was not Yr30/Sr2. The QTL on 6BS probably corresponded to previously known QTL. RILs with combined QTL were more resistant than those with single or no QTL. Kompetitive allele-specific PCR(KASP) assays for the QTL with largest effect QTL on chromosome 3BS were performed on a subset of RILs and 150 unrelated wheat lines. The QTL on 3BS with its linked KASP markers can be used in marker-assisted selection to improve stripe rust resistance in breeding programs. | Qingdong Zeng Jianhui Wu Shuo Huang Fengping Yuan Shengjie Liu Qilin Wang Jingmei Mu Shizhou Yu Li Chen Dejun Han Zhensheng Kang | 2019 | The Crop Journal2019，7，2： | 2 |
| 7 | Molecular Detection of Anaerobic Ammonium-Oxidizing (Anammox) Bacteria in High-Temperature Petroleum Reservoirs显示文摘 | Hui Li Shuo Chen Bo-Zhong Mu Ji-Dong Gu | 2010 | Microbial Ecology2010，，4： | 1 |
| 8 | Is Deqi an Indicator of Clinical Efficacy of Acupuncture? A Systematic Review显示文摘 | SHUO ZHANG MU WEI XiAO LU | 2013 | Evidence-Based Complementary and Alternative Medicine2013，，75： | 1 |
| 9 | Game-theoretical explorations of the mesoscale flow structure and regime transitions in bubble columns显示文摘Understanding the mesoscale structure and regime transition in bubble columns is of great significance for reactor design and scaleup.Based on the energy-minimization multiscale(EMMS)model,a noncooperative game model with constraints is proposed to investigate the structural properties of gas-liquid systems in which small and large bubbles are chosen as players and the energy consumption form the objective function.The conservation equations of the system can be regarded as the constraints of the game.For the formulated noncooperative game model,the concept of the generalized Nash equilibrium(GNE)is used to characterize the solution.An algorithm is developed to numerically compute the GNE and some important structural parameters in the system.The numerical results show the existence of the GNE for all values of the superficial gas velocity Ug.As Ug varies,the trends in the state variables can be observed and the critical point of Ug identified.The overall trend of the flow regime transition agrees with the original EMMS model and experimental results,although the GNE calculation also reveals different single-bubble dominant mechanisms with increasing Ug. | Shuo Yuan Yifen Mu Xiaoping Guan Zhixin Liu Jianhua Chen Ning Yang Lin Zhang | 2020 | Particuology2020，18，1： | 1 |
| 10 | Coronavirus Mask Protection Algorithm:A New Bio-inspired Optimization Algorithm and Its Applications显示文摘Nowadays,meta-heuristic algorithms are attracting widespread interest in solving high-dimensional nonlinear optimization problems.In this paper,a COVID-19 prevention-inspired bionic optimization algorithm,named Coronavirus Mask Protection Algorithm(CMPA),is proposed based on the virus transmission of COVID-19.The main inspiration for the CMPA originated from human self-protection behavior against COVID-19.In CMPA,the process of infection and immunity consists of three phases,including the infection stage,diffusion stage,and immune stage.Notably,wearing masks correctly and safe social distancing are two essential factors for humans to protect themselves,which are similar to the exploration and exploitation in optimization algorithms.This study simulates the self-protection behavior mathematically and offers an optimization algorithm.The performance of the proposed CMPA is evaluated and compared to other state-of-the-art metaheuristic optimizers using benchmark functions,CEC2020 suite problems,and three truss design problems.The statistical results demonstrate that the CMPA is more competitive among these state-of-the-art algorithms.Further,the CMPA is performed to identify the parameters of the main girder of a gantry crane.Results show that the mass and deflection of the main girder can be improved by 16.44%and 7.49%,respectively. | Yongliang Yuan Qianlong Shen Shuo Wang Jianji Ren Donghao Yang Qingkang Yang Junkai Fan Xiaokai Mu | 2023 | Journal of Bionic Engineering2023，20，4： | 0 |
| 11 | Wide measurement range and high sensitivity spongy MWCNT/polydimethylsiloxane pressure sensor based on a single-electrode enhanced triboelectric nanogenerator显示文摘Flexible pressure sensors have broad application prospects,such as human motion monitoring and personalized recognition.However,their applicability is limited by complex structures,low output performance,low sensitivity,and narrow measurement range.In this study,we report a single-electrode spongy triboelectric sensor(SSTS)mainly composed of spongy composite multi-walled carbon nanotubes/polydimethylsiloxane(MWCNT/PDMS)film and conductive fabric,which can simultaneously generate contact electrification and electrostatic induction coupling in a single-electrode contact-separation mode.The SSTS combines the triboelectric effect,properties of doping material,and spongy porous structure(soft sugar as a sacrificial template).An SSTS with an MWCNT content of 10 wt%and a porosity of 64%exhibits high sensitivity,a wide measurement range,and excellent linearity.It also displays two sensitivity regions(slopes):1.324 V/kPa from 1.5 to 28 kPa in the low-pressure range and 0.096 V/kPa from 28 to 316.5 kPa in the high-pressure range,with linearities of 0.980 and 0.979,respectively.Furthermore,the SSTS delivers a high-performance output and high stability,thus enhancing the monitoring of hand pressure changes,human movement,personalized spatial recognition,and other detection tasks.This new strategy for human motion monitoring shows great potential in the healthcare fields,sports rehabilitation,and human-computer interactions. | XIE Xin HOU XiaoJuan QIAN Shuo HOU JianWei ZHANG Jie BI XiaoXue GENG WenPing MU JiLiang HE Jian CHOU XiuJian | 2023 | Science China(Technological Sciences)2023，66，6： | 0 |
| 12 | A New Consistency Test forΛCDM Cosmology Using Galaxy Surveys显示文摘We propose a new consistency test for theΛCDM cosmology using baryonic acoustic oscillations(BAO)and redshift space distortion(RSD)measurements from galaxy redshift surveys.Specifically,we determine the peak position of fσ8(z)in redshift z offered by an RSD measurement,and compare it to the one predicted by the BAO observables assuming a flatΛCDM cosmology.We demonstrate this new test using the simulated data for the DESI galaxy survey,and argue that this test complements those using the background observables alone,and is less subject to systematics in the RSD analysis,compared to traditional methods using values of fσ8(z)directly. | Jinglan Zheng Gong-Bo Zhao Yuting Wang Xiaoyong Mu Ruiyang Zhao Weibing Zhang Shuo Yuan David Bacon Kazuya Koyama | 2022 | Research in Astronomy and Astrophysics2022，22，6： | 0 |
| 13 | Flexible multilayer MEMS coils and their application in energy harvesters显示文摘Electromagnetic vibration energy harvesters are promising for the power supply of wireless sensor nodes,small electronic devices,and wearable electronics.Conventional electromagnetic harvesters usually increase output by increasing the size of coils and magnets,limiting the improvement of energy conversion efficiency and power density.In this study,multilayer microelectromechanical system(MEMS)coils were prepared using flexible electronics,and their high integration performance in arbitrary space was utilized to greatly improve the utilization of the space magnetic field by the electromagnetic harvester.The core magnet of the generator was magnetically balanced to achieve levitation,which improved the sensitivity and reduced fatigue damage compared with traditional spring structures.The wound coils on the top and bottom of the magnet and the flexible coils on the sides worked together to improve the energy efficiency and output of the devices.The output performance of the device with different number distributions was simulated using mathematical models to obtain the optimal structural parameters.The results show that by introducing flexible multilayer MEMS coils on the side surface of the energy harvester,the open-circuit voltage of the energy generators increased from 7 to 10 V by more than 43%.Flexible multilayer MEMS coils can enhance energy conversion rates and possess compact dimensions,making them suitable for integration onto complex surfaces.After the vibration energy harvesting system testing,the maximum peak power of the harvester was 7.1 m W at an acceleration of1 g and a resonant frequency of 11 Hz with a resistor of 3.5 kΩinternal resistance.Moreover,a 470μF capacitor can be charged to 3.5 V within 10 s to drive a hygrothermograph to work for more than 80 s and can supply a light bulb continuously.This strategy shows the great potential of vibration-energy-driven electromagnetic generators for powering small electronics in limited spaces. | ZHANG Jie HOU XiaoJuan QIAN Shuo BI XiaoXue HU DongXu LIU JianJun GENG WenPing MU JiLiang HE Jian CHOU XiuJian | 2024 | Science China(Technological Sciences)2024，67，4： | 0 |
| 14 | Transcriptomic Analysis of Metastatic Colorectal Tumor with Low Mutational Burden显示文摘Objective:To identify potential drug targets for metastasis colorectal cancer(CRC)patients with low mutational burden by examining differences in immune-related gene expression.Methods:For this study,623 samples were collected from The Cancer Genome Atlas(TCGA)database,comprising tumor mutational burden(TMB),RNA sequencing(RNA-Seq),and clinical data.Differential gene expression analysis,Gene Ontology(GO),and Kyoto Encyclopedia of Genes and Genomes(KEGG)enrichment analysis of the identified genes were conducted using the R package.Additionally,a comparative analysis of immune infiltrating cell composition in metastatic and non-metastatic groups was performed.Hub genes,exhibiting high levels of interaction,were selected using the Search Tool for the Retrieval of Interacting Genes/Proteins(STRING)database.The Drug Gene Interaction Database(DGIdb)was then utilized to estimate drugs targeting the identified hub genes.Results:The transcriptome data of 326 colorectal cancer patients with low TMB were analyzed,comprising 58 patients with metastasis and 268 patients without metastasis.Among the differential expression in 1,111 genes for patients with metastasis compared to those without metastasis,733 genes were upregulated,and 378 genes were downregulated.KEGG and GO enrichment analysis indicated significant differences in gene expression in CRC metastatic patients with low TMB compared to non-metastasis patients with low TMB.Enriched pathways included humoral immune response,immunoglobulin production,and regulation of AMPA receptor activity.Two genes related to interleukin-12 were identified through secondary enrichment for immune-related genes.Analysis of tumor-infiltrating immune cell data revealed significant differences in memory-activated T cell CD4 and T cell CD8.Conclusions:This analysis of RNA sequencing data and immune-filtrating cell data revealed significant differences between metastatic colorectal cancer patients with low TMB and their non-metastatic counterparts.These distinctions suggest the possibility of identifying more effective drugs or therapies for metastatic colorectal cancer patients with low TMB. | Ke Wang Shuo Mu | 2024 | Proceedings of Anticancer Research2024，8，1： | 0 |
| 15 | A high-power and high-efficiency mini generator for scavenging energy from human foot movement显示文摘Harvesting energy from human movement and converting it into electricity is a promising method to address the issue of sustainable power supply for wearable electronic devices.Using traditional energy harvesters for practical applications is difficult due to their low output power.In this paper,an energy harvester with high power and efficiency is reported based on the principle of electromagnetic induction.It adopts a tiny compound mechanism comprising symmetrical lever-sector gear,which can amplify the vertical displacement of the human heel of 1.44 times without affecting the flexibility and comfort of human movement.The lever-sector gear and gear acceleration mechanism can achieve high output power from the tiny vertical movements of the heel.The results demonstrated that the average power and energy harvesting efficiency of the device are 1 W and 63%,respectively.Moreover,combining a novel controllable electric switch and energy management circuit allows the energy harvester to be worn by individuals with different weights and functions as a continuous real-time power supply for various electronic devices(mobile phones,smartwatches,etc.).Therefore,this research provides a new approach for the highly efficient harvesting of human motion energy and sustainable power supply of wearable electronics. | WU Hui QIAN Shuo HOU XiaoJuan ZHAO JuanHong ZHANG Jie SONG XiaoGuang LIU YanLi SHI ShuZheng GENG WenPing MU JiLiang HE Jian CHOU XiuJian | 2023 | Science China(Technological Sciences)2023，66，12： | 0 |
| 16 | Structural insights into dimerization and activation of the mGlu2-mGlu3 and mGlu2-mGlu4 heterodimers显示文摘Nicotinamide adenine dinucleotide(NAD+)is a central metabolite in cellular processes.Depletion of NAD+has been demonstrated to be a prevalent theme in both prokaryotic and eukaryotic immune responses.Short prokaryotic Argonaute proteins(Agos)are associated with NADase domain-containing proteins(TIR-APAZ or SIR2-APAZ)encoded in the same operon.They confer immunity against mobile genetic elements,such as bacteriophages and plasmids,by inducing NAD+depletion upon recognition of target nucleic acids.However,the molecular mechanisms underlying the activation of such prokaryotic NADase/Ago immune systems remain unknown.Here,we report multiple cryo-EM structures of NADase/Ago complexes from two distinct systems(TIR-APAZ/Ago and SIR2-APAZ/Ago).Target DNA binding triggers tetramerization of the TIR-APAZ/Ago complex by a cooperative self-assembly mechanism,while the heterodimeric SIR2-APAZ/Ago complex does not assemble into higher-order oligomers upon target DNA binding.However,the NADase activities of these two systems are unleashed via a similar closed-to-open transition of the catalytic pocket,albeit by different mechanisms.Furthermore,a functionally conserved sensor loop is employed to inspect the guide RNA–target DNA base pairing and facilitate the conformational rearrangement of Ago proteins required for the activation of these two systems.Overall,our study reveals the mechanistic diversity and similarity of Ago protein-associated NADase systems in prokaryotic immune response. | Xinwei Wang Mu Wang Tuo Xu Ye Feng Qiang Shao Shuo Han Xiaojing Chu Yechun Xu Shuling Lin Qiang Zhao Beili Wu | 2023 | Cell Research2023，33，10： | 0 |
| 17 | Structural insights into ligand recognition and selectivity of somatostatin receptors显示文摘Somatostatin receptors(SSTRs)play versatile roles in inhibiting the secretion of multiple hormones such as growth hormone and thyroid-stimulating hormone,and thus are considered as targets for treating multiple tumors.Despite great progress made in therapeutic development against this diverse receptor family,drugs that target SSTRs still show limited efficacy with preferential binding affinity and conspicuous side-effects.Here,we report five structures of SSTR2 and SSTR4 in different states,including two crystal structures of SSTR2 in complex with a selective peptide antagonist and a non-peptide agonist,respectively,a cryo-electron microscopy(cryo-EM)structure of Gi1-bound SSTR2 in the presence of the endogenous ligand SST-14,as well as two cryo-EM structures of Gi1-bound SSTR4 in complex with SST-14 and a small-molecule agonist J-2156,respectively.By comparison of the SSTR structures in different states,molecular mechanisms of agonism and antagonism were illustrated.Together with computational and functional analyses,the key determinants responsible for ligand recognition and selectivity of different SSTR subtypes and multiform binding modes of peptide and non-peptide ligands were identified.Insights gained in this study will help uncover ligand selectivity of various SSTRs and accelerate the development of new molecules with better efficacy by targeting SSTRs. | Wenli Zhao Shuo Han Na Qiu Wenbo Feng Mengjie Lu Wenru Zhang Mu Wang Qingtong Zhou Shutian Chen Wei Xu Juan Du Xiaojing Chu Cuiying Yi Antao Dai Liaoyuan Hu Michelle YShen Yaping Sun Qing Zhang Yingli Ma Wenge Zhong Dehua Yang Ming-Wei Wang Beili Wu Qiang Zhao | 2022 | Cell Research2022，32，8： | 0 |
| 18 | Structural insights into signal transduction of the purinergic receptors P2Y_(1)R and P2Y_(12)R显示文摘Dear Editor,The purinergic receptors(P2YRs)are involved in a variety of physiological processes,including proliferation,chemotaxis,cancer metastasis,cardiovascular events,neurodegenerative diseases and aging(Weisman et al.,2012).Thus far,eight human P2YRs have been characterized and are classified into two subfamilies based on their sequence homology and signal transduction mechanisms,including P2Y1 R-like receptors that signal preferentially through Gq/11 proteins and P2Y12R-like receptors that activate Gi/o proteins(Abbracchio et al.,2006). | Beibei Li Shuo Han Mu Wang Yu Yu Limin Ma Xiaojing Chu Qiuxiang Tan Qiang Zhao Beili Wu | 2023 | Protein & Cell2023，14，5： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员