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| 1 | Dupilumab治疗常年性变应性鼻炎并发哮喘患者的疗效和安全性显示文摘背景Dupilumab是一种抗IL-4受体α亚基的抗体,可以阻断IL-4/IL-13的信号转导。IL-4/IL-13是2型/Th2型免疫疾病(如特应性/过敏性疾病)的关键驱动因子。一项重要的2b期临床研究(NCT01854047)显示,在使用了中高剂量吸入激素联合长效β2受体激动剂(ICS/LABA)后仍控制不佳的持续性哮喘患者中,dupilumab可减少哮喘重度急性发作,改善患者的肺功能和生活质量,且耐受性良好。目的探讨在哮喘并发常年性变应性鼻炎(PAR)患者中,dupilumab对SNOT-22的总分及其中变应性鼻炎(AR)相关症状评分的影响。方法对2b临床研究中每2周(q2w) 200 mg和300 mg dupilumab治疗后的数据进行析因分析。这两种剂量的dupilumab目前正在3期临床研究(NCT02414854)中进行验证。PAR定义为:在研究开始时,患者出现对典型的常年性抗原产生特异性应答(Ig E≥0. 35 Ku/L)。结果总共241例(61%)患者患有PAR。与安慰剂相比,每两周300 mg dupilumab显著改善了在哮喘并发PAR的患者中SNOT-22的总分(最小二乘平均差,-5. 98; 95%CI,-10. 45~-1. 5; P=0. 009)和4项AR相关症状的评分(鼻塞,-0. 60; 95%CI,-0. 96~-0. 25;流鼻涕,-0. 67; 95%CI,-1. 04~-0. 31;打喷嚏,-0. 55; 95%CI,-0. 89~-0. 21;鼻后分泌物,-0. 49;95%CI,-0. 83~-0. 16; 4项评分都P <0. 01);每两周200 mg dupilumab治疗减少了并发PAR的患者的SNOT-22总分(-1. 82; 95%CI,-6. 46~2. 83; P=0. 443)和AR相关的症状评分,但与安慰剂相比无统计学差异。在无PAR的哮喘患者中,dupilumab与安慰剂治疗这些评分无差异。结论每两周300 mg dupilumab治疗显著改善了在控制不佳的持续性哮喘并发PAR患者中的AR相关的鼻部症状。 | Steven F.Weinstein Rohit Katial Shyamalie Jayawardena Gianluca Pirozzi Heribert Staudinger Laurent Eckert Vijay N.Joish Nikhil Amin Jaman Maroni Paul Rowe Neil M.H.Graham Ariel Teper 黄庭萱(翻译) 刘春涛(审校) | 2018 | 中华临床免疫和变态反应杂志2018，12，5： | 2 |
| 2 | Fluorescence studies of native and modified nettrophysisins 显示文摘 | Shyamali S S | 1979 | Effects of Peptides and Ph Biochemistry1979，18，： | 1 |
| 3 | Nox4 NAD-PH oxidase mediates oxidative stress and apoptosis caused by TNF-alpha in cerebral vascular endothelial cells显示文摘 | Shyamali Basuroy Sujoy Bhattacharya Chaxles W | | 0，，03： | 1 |
| 4 | Development andcharacterization of chitosan-PEG-TAT nanoparticles for the intracellu-lar delivery of siRNA 显示文摘 | Meenakshi M Catherine TD Shyamali S | 2013 | International Journal of Nanomedicine2013，67，3： | 1 |
| 5 | Factors controlling transpiration of mature field-grown tea andits relationship with yield显示文摘 | Anandacoomaraswamy A De Costa W A J M Shyamalie H W | 2000 | Agricultural and Forest Meteorology2000，103，4： | 1 |
| 6 | Effect of orally administered L . fermentum NCIMB 5221 on markers of metabolic syndrome: an in vivo analysis using ZDF rats显示文摘 | Catherine Tomaro-Duchesneau Shyamali Saha Meenakshi Malhotra Mitchell L. Jones Alain Labbé Laetitia Rodes Imen Kahouli Satya Prakash | 2014 | Applied Microbiology and Biotechnology2014，，1： | 1 |
| 7 | The characteristic ultrasound features of specific types of ovarianpathology (Review)显示文摘 | Ahmad Sayasneh Christine Ekechi Laura Ferrara Jeroen Kaijser Catriona Stalder Shyamaly Sur Dirk Timmerman Tom Bourne | 2015 | International Journal of Oncology2015，，： | 1 |
| 8 | Fruit physiology and development studies in some Asian soft pear varieties显示文摘 | Dhillon WS Shyamali GGV | 2008 | Indian Journal of Plant Physiology2008，13，1： | 1 |
| 9 | Identification of lutein, a dietary antioxidant carotenoid in guinea pig tissues显示文摘 | Michael W S Somdutta S R Shyamali M | 2008 | Biochemical and Biophysical Research Communications2008，374，2： | 1 |
| 10 | High levels of psychosocial distress among Australian frontline healthcare workers during the COVID-19 pandemic: a cross- sectional survey显示文摘Background The coronavirus disease 2019(COVID-19)pandemic has had a profound and prolonged impact on healthcare services and healthcare workers.Aims The Australian COVID-19 Frontline Healthcare Workers Study aimed to investigate the severity and prevalence of mental health issues,as well as the social,workplace and financial disruptions experienced by Australian healthcare workers during the COVID-19 pandemic.Methods A nationwide,voluntary,anonymous,single timepoint,online survey was conducted between 27 August and 23 October 2020.Individuals self-identifying as frontline healthcare workers in secondary or primary care were invited to participate.Participants were recruited through health organisations,professional associations or colleges,universities,government contacts and national media.Demographics,home and work situation,health and psychological well-being data were collected.Results A total of 9518 survey responses were received;of the 9518 participants,7846(82.4%)participants reported complete data.With regard to age,4110(52.4%)participants were younger than 40 years;6344(80.9%)participants were women.Participants were nurses(n=3088,39.4%),doctors(n=2436,31.1%),allied health staff(n=1314,16.7%)or in other roles(n=523,6.7%).In addition,1250(15.9%)participants worked in primary care.Objectively measured mental health symptoms were common:mild to severe anxiety(n=4694,59.8%),moderate to severe burnout(n=5458,70.9%)and mild to severe depression(n=4495,57.3%).Participants were highly resilient(mean(SD)=3.2(0.66)).Predictors for worse outcomes on all scales included female gender;younger age;pre-existing psychiatric condition;experiencing relationship problems;nursing,allied health or other roles;frontline area;being worried about being blamed by colleagues and working with patients with COVID-19.Conclusions The COVID-19 pandemic is associated with significant mental health symptoms in frontline healthcare workers.Crisis preparedness together with policies and practices addressing psychological well-being are needed. | Natasha Smallwood Leila Karimi Marie Bismark Mark Putland Douglas Johnson Shyamali Chandrika Dharmage Elizabeth Barson Nicola Atkin Claire Long Irene Ng Anne Holland Jane E Munro Irani Thevarajan Cara Moore Anthony McGillion Debra Sandford Karen Willis | 2021 | General Psychiatry2021，34，5： | 0 |
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